Molecular mechanisms and cellular events involved in the neuroprotective actions of estradiol. Analysis of sex differences

Inflammasome signalling in brain function and neurodegenerative disease

Heneka, M. T., McManus, R. M., & Latz, E. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0055-7 · Cited by 836

Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines

Gillies, G. E., & McArthur, S. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002071 · Cited by 733

Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women

Sherwin, B. B. (1988) · Psychoneuroendocrinology · doi:10.1016/0306-4530(88)90060-1 · Cited by 705

Estrogen Signaling Multiple Pathways to Impact Gene Transcription

Marino, M., Galluzzo, P., & Ascenzi, P. (2006) · Current Genomics · doi:10.2174/138920206779315737 · Cited by 618

Estrogen: A master regulator of bioenergetic systems in the brain and body

Rettberg, J. R., Yao, J., & Brinton, R. D. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.08.001 · Cited by 534

The neuroprotective actions of oestradiol and oestrogen receptors

Arévalo, M., Azcoitia, Í., & García‐Segura, L. M. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3856 · Cited by 478

Brain estrogen deficiency accelerates Aβ plaque formation in an Alzheimer's disease animal model

Yue, X., Lu, M. G. W., Lancaster, T., Cao, P., Honda, S., Staufenbiel, M., Harada, N., Zhong, Z., Shen, Y., & Li, R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505203102 · Cited by 404

Aromatase expression by astrocytes after brain injury: implications for local estrogen formation in brain repair

García‐Segura, L. M., Wozniak, A., Azcoitia, Í., Rodríguez, J., Hutchison, R. E., & Hutchison, J. B. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00340-6 · Cited by 379

Brain aromatase is neuroprotective

Azcoitia, Í., Sierra, A., Veiga, S. J., Honda, S., Harada, N., & García‐Segura, L. M. (2001) · Journal of Neurobiology · doi:10.1002/neu.1038 · Cited by 272

Microglial phagocytosis of newborn cells is induced by endocannabinoids and sculpts sex differences in juvenile rat social play

VanRyzin, J. W., Marquardt, A. E., Argue, K. J., Vecchiarelli, H. A., Ashton, S. E., Arambula, S. E., Hill, M. N., & McCarthy, M. M. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.006 · Cited by 272

Estrogen-mediated gut microbiome alterations influence sexual dimorphism in metabolic syndrome in mice

Kaliannan, K., Robertson, R. C., Murphy, K., Stanton, C., Kang, C., Wang, B., Hao, L., Bhan, A. K., & Kang, J. X. (2018) · Microbiome · doi:10.1186/s40168-018-0587-0 · Cited by 271

Estradiol upregulates Bcl-2 expression in adult brain neurons

García‐Segura, L. M., Cardona‐Gómez, G. P., Naftolin, F. N., & Chowen, J. A. (1998) · Neuroreport · doi:10.1097/00001756-199803090-00006 · Cited by 253

Estrogen Attenuates Ischemic Oxidative Damage via an Estrogen Receptor α-Mediated Inhibition of NADPH Oxidase Activation

Zhang, Q.-G., Raz, L., Wang, R., Han, D. K., Sevilla, L. M. D., Yang, F., Vadlamudi, R. K., & Brann, D. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3574-09.2009 · Cited by 242

Neuroprotective actions of sex steroids in Parkinson’s disease

Bourque, M., Dluzen, D. E., & Paolo, T. D. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.014 · Cited by 239

Increased Synaptic Sprouting in Response to Estrogen via an Apolipoprotein E-Dependent Mechanism: Implications for Alzheimer’s Disease

Stone, D. J., Rozovsky, I., Morgan, T. E., Anderson, C. P., & Finch, C. E. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03180.1998 · Cited by 237

Oophorectomy, estrogen, and dementia: A 2014 update

Rocca, W. A., Grossardt, B. R., & Shuster, L. T. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.01.020 · Cited by 230

Neuroprotective effects of estrogens following ischemic stroke

Suzuki, S., Brown, C. M., & Wise, P. M. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.007 · Cited by 223

Estradiol rescues neurons from global ischemia-induced cell death: Multiple cellular pathways of neuroprotection

Lebesgue, D., Chevaleyre, V., Zukin, R. S., & Etgen, A. M. (2009) · Steroids · doi:10.1016/j.steroids.2009.01.003 · Cited by 218

Aromatase Cytochrome P450 and Extragonadal Estrogen Play a Role in Ischemic Neuroprotection

McCullough, L. D., Blizzard, K. K., Simpson, E. R., Öz, O. K., & Hurn, P. D. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08701.2003 · Cited by 214

Estrogen Receptor Protein Interaction with Phosphatidylinositol 3-Kinase Leads to Activation of Phosphorylated Akt and Extracellular Signal-Regulated Kinase 1/2 in the Same Population of Cortical Neurons: A Unified Mechanism of Estrogen Action

Mannella, P., & Brinton, R. D. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1443-06.2006 · Cited by 213

17β-Estradiol Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females

Oberlander, J. G., & Woolley, C. S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4437-15.2016 · Cited by 213

Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive aging and brain injury

Engler-Chiurazzi, E. B., Brown, C. M., Povroznik, J. M., & Simpkins, J. W. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.12.008 · Cited by 209

Mitochondrial mechanisms of estrogen neuroprotection

Simpkins, J. W., Yi, K. D., Yang, S., & Dykens, J. A. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.11.013 · Cited by 207

Estrogen receptor α and β differentially regulate intracellular Ca2+ dynamics leading to ERK phosphorylation and estrogen neuroprotection in hippocampal neurons

Zhao, L., & Brinton, R. D. (2007) · Brain Research · doi:10.1016/j.brainres.2007.06.092 · Cited by 205

The novel estrogenic receptor GPR30 alleviates ischemic injury by inhibiting TLR4-mediated microglial inflammation

Zhang, Z., Qin, P., Deng, Y., Ma, Z., Guo, H., Guo, H., Hou, Y., Wang, S., Zou, W., Sun, Y., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1246-x · Cited by 199

Developmental and hormone-induced epigenetic changes to estrogen and progesterone receptor genes in brain are dynamic across the life span

Schwarz, J. M., Nugent, B. M., & McCarthy, M. M. (2010) · Endocrinology · doi:10.1210/en.2010-0142 · Cited by 198

Contribution of estrogen receptors alpha and beta to the effects of estradiol in the brain

Morissette, M., Saux, M. L., D’Astous, M., Jourdain, S., Al-Sweidi, S., Morin, N., Estrada-Camarena, E. M., Méndez, P., García‐Segura, L. M., & Paolo, T. D. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.09.011 · Cited by 195

17β‐estradiol and progesterone prevent cuprizone provoked demyelination of corpus callosum in male mice

Ács, P., Kipp, M., Norkutė, A., Johann, S., Clarner, T., Braun, A., Berente, Z., Komoly, S., & Beyer, C. (2008) · Glia · doi:10.1002/glia.20806 · Cited by 194

Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus

Tabatadze, N., Huang, G., May, R. M., Jain, A., & Woolley, C. S. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1067-15.2015 · Cited by 191

Sex differences in microglial phagocytosis in the neonatal hippocampus

Nelson, L. H., Warden, S., & Lenz, K. M. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.03.010 · Cited by 189

PI3 kinase/Akt activation mediates estrogen and IGF‐1 nigral DA neuronal neuroprotection against a unilateral rat model of Parkinson's disease

Quesada, A., Lee, B. Y., & Micevych, P. E. (2008) · Developmental Neurobiology · doi:10.1002/dneu.20609 · Cited by 187

The X-linked histone demethylase Kdm6a in CD4+ T lymphocytes modulates autoimmunity

Itoh, Y., Golden, L. C., Itoh, N., Matsukawa, M. A., Ren, E., Tse, V., Arnold, A. P., & Voskuhl, R. R. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126250 · Cited by 185

Estrogen Mediates Neuroprotection and Anti-Inflammatory Effects during EAE through ER Signaling on Astrocytes But Not through ER Signaling on Astrocytes or Neurons

Spence, R. D., Wisdom, A. J., Cao, Y., Hill, H., Mongerson, C. R., Stapornkul, B., Itoh, N., Sofroniew, M. V., & Voskuhl, R. R. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0886-13.2013 · Cited by 183

Role of Dickkopf-1, an Antagonist of the Wnt/β-Catenin Signaling Pathway, in Estrogen-Induced Neuroprotection and Attenuation of Tau Phosphorylation

Zhang, Q.-G., Wang, R., Khan, M. B., Mahesh, V. B., & Brann, D. W. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2752-08.2008 · Cited by 183

A developmental sex difference in hippocampal neurogenesis is mediated by endogenous oestradiol

Bowers, J. M., Waddell, J., & McCarthy, M. M. (2010) · Biology of Sex Differences · doi:10.1186/2042-6410-1-8 · Cited by 181

The Endogenous Estrogen Status Regulates Microglia Reactivity in Animal Models of Neuroinflammation

Vegeto, E., Belcredito, S., Ghisletti, S., Meda, C., Etteri, S., & Maggi, A. C. (2006) · Endocrinology · doi:10.1210/en.2005-1330 · Cited by 178

Estrogen and Bcl-2: Gene Induction and Effect of Transgene in Experimental Stroke

Alkayed, N. J., Goto, S., Sugo, N., Joh, H.-D., Klaus, J. A., Crain, B. J., Bernard, O., Traystman, R. J., & Hurn, P. D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07543.2001 · Cited by 177

Neuroprotective actions of brain aromatase

Saldanha, C. J., Duncan, K. A., & Walters, B. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.016 · Cited by 171

Estrogen Can Act via Estrogen Receptor α and β to Protect Hippocampal Neurons against Global Ischemia-Induced Cell Death

Miller, N. R., Jover, T., Cohen, H. W., Zukin, R. S., & Etgen, A. M. (2005) · Endocrinology · doi:10.1210/en.2004-1515 · Cited by 163

Extranuclear Estrogen Receptors Mediate the Neuroprotective Effects of Estrogen in the Rat Hippocampus

Yang, L.-C., Zhang, Q.-G., Zhou, C.-F., Yang, F., Zhang, Y.-D., Wang, R.-M., & Brann, D. W. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009851 · Cited by 163

Selective estrogen receptor modulators decrease the production of interleukin‐6 and interferon‐γ‐inducible protein‐10 by astrocytes exposed to inflammatory challenge in vitro

Cerciat, M., Unkila, M., García‐Segura, L. M., & Arévalo, M. (2009) · Glia · doi:10.1002/glia.20904 · Cited by 160

Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemia

Wen, Y., Yang, S., Liu, R., Perez, E., Yi, K. D., Koulen, P., & Simpkins, J. W. (2004) · Brain Research · doi:10.1016/j.brainres.2004.02.019 · Cited by 155

G-Protein-Coupled Receptor 30 Mediates Rapid Neuroprotective Effects of Estrogen via Depression of NR2B-Containing NMDA Receptors

Liu, S.-B., Zhang, N., Guo, Y.-Y., Zhao, R., Shi, T.-R., Feng, S.-F., Wang, S.-Q., Yang, Q., Li, X.-Q., Wu, Y.-M., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5828-11.2012 · Cited by 154

Estrogen neuroprotection and the critical period hypothesis

Scott, E. L., Zhang, Q.-G., Wang, R., Vadlamudi, R. K., & Brann, D. W. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.10.001 · Cited by 152

Treatment with an Estrogen Receptor Ligand Is Neuroprotective in Experimental Autoimmune Encephalomyelitis

Morales, L. B. J., Loo, K. K., Liu, H.-B., Peterson, C., Tiwari-Woodruff, S. K., & Voskuhl, R. R. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0453-06.2006 · Cited by 149

Estradiol inhibits ongoing autoimmune neuroinflammation and NFκB-dependent CCL2 expression in reactive astrocytes

Giraud, S., Caron, C., Pham-Dinh, D., Kitabgi, P., & Nicot, A. (2010) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0910627107 · Cited by 147

Acute Administration of Non-Classical Estrogen Receptor Agonists Attenuates Ischemia-Induced Hippocampal Neuron Loss in Middle-Aged Female Rats

Lebesgue, D., Traub, M., Butte-Smith, M. D., Chen, C. H., Zukin, R. S., Kelly, M. J., & Etgen, A. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008642 · Cited by 146

Involvement of Insulin/Phosphoinositide 3-Kinase/Akt Signal Pathway in 17β-Estradiol-mediated Neuroprotection

Yu, X., Rajala, R. V. S., McGinnis, J. F., Li, F., Anderson, R. E., Yan, X., Li, S., Elias, R. V., Knapp, R. R., Zhou, X., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313283200 · Cited by 143

Astrocyte-Derived Transforming Growth Factor-β Mediates the Neuroprotective Effects of 17β-Estradiol: Involvement of Nonclassical Genomic Signaling Pathways

Dhandapani, K. M., Wade, F. M., Mahesh, V. B., & Brann, D. W. (2005) · Endocrinology · doi:10.1210/en.2005-0014 · Cited by 142

Neuroprotective actions of estradiol revisited

Azcoitia, Í., Arévalo, M., Nicola, A. F. D., & García‐Segura, L. M. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.08.002 · Cited by 141

Estrogen Enhances Neurogenesis and Behavioral Recovery after Stroke

Li, J., Siegel, M., Yuan, M., Zeng, Z., Finnucan, L., Persky, R., Hurn, P. D., & McCullough, L. D. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.181 · Cited by 138

Neuroprotection by a selective estrogen receptor β agonist in a mouse model of global ischemia

Carswell, H. V. O., Macrae, I. M., Gallagher, L., Harrop, E. J., & Horsburgh, K. J. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00227.2004 · Cited by 138

Neurodegeneration Is Associated to Changes in Serum Insulin-like Growth Factors

Busiguina, S., Fernandez, A. M., Barrios, V., Clark, R., Tolbert, D. L., Berciano, J., & Torres‐Alemán, I. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0311 · Cited by 137

Cross-talk between estrogen receptors and insulin-like growth factor-I receptor in the brain: Cellular and molecular mechanisms

Mendez, P., Wandosell, F., & Garcia-Segura, L. M. (2006) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2006.09.001 · Cited by 133

Comparison of plasma and cerebrospinal fluid levels of neuroactive steroids with their brain, spinal cord and peripheral nerve levels in male and female rats

Caruso, D., Pesaresi, M., Abbiati, F., Calabrese, D., Giatti, S., García‐Segura, L. M., & Melcangi, R. C. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.04.016 · Cited by 133

XY sex chromosome complement, compared with XX, in the CNS confers greater neurodegeneration during experimental autoimmune encephalomyelitis

Du, S., Itoh, N., Askarinam, S., Hill, H., Arnold, A. P., & Voskuhl, R. R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307091111 · Cited by 131

Regulation of astroglia by gonadal steroid hormones under physiological and pathological conditions

Acaz‐Fonseca, E., Ávila-Rodriguez, M., García‐Segura, L. M., & Barreto, G. E. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.06.002 · Cited by 131

Estrogen receptor β ligand therapy activates PI3K/Akt/mTOR signaling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis

Kumar, S., Patel, R., Moore, S. M., Crawford, D. K., Suwanna, N., Mangiardi, M., & Tiwari-Woodruff, S. K. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.04.005 · Cited by 129

Cholesterol‐promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus

Fester, L., Zhou, L., Bütow, A., Huber, C., von Lossow, R., Prange‐Kiel, J., Jarry, H., & Rune, G. M. (2009) · Hippocampus · doi:10.1002/hipo.20548 · Cited by 129

Memory-Related Synaptic Plasticity Is Sexually Dimorphic in Rodent Hippocampus

Wang, W., Le, A. A., Hou, B., Lauterborn, J. C., Cox, C. D., Levin, E. R., LYNCH, G. S., & Gall, C. M. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0801-18.2018 · Cited by 128

Estradiol and G1 Reduce Infarct Size and Improve Immunosuppression after Experimental Stroke

Zhang, B., Subramanian, S., Dziennis, S., Jia, J., Uchida, M., Akiyoshi, K., Migliati, E., Lewis, A. D., Vandenbark, A. A., Offner, H., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902339 · Cited by 127

Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons

Honda, K., Shimohama, S., Sawada, H., Kihara, T., Nakamizo, T., Shibasaki, H., & Akaike, A. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1098 · Cited by 126

Sex differences in the phagocytic and migratory activity of microglia and their impairment by palmitic acid

Yanguas‐Casás, N., Crespo‐Castrillo, A., CEBALLOS, M. L. D., Chowen, J. A., Azcoitia, Í., Arévalo, M., & García‐Segura, L. M. (2017) · Glia · doi:10.1002/glia.23263 · Cited by 126

Brain-derived estrogen exerts anti-inflammatory and neuroprotective actions in the rat hippocampus

Zhang, Q.-G., Wang, R., Tang, H., Dong, Y., Chan, A., Sareddy, G. R., Vadlamudi, R. K., & Brann, D. W. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.12.019 · Cited by 124

Central regulation of energy metabolism by estrogens

Xu, Y., & López, M. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.05.012 · Cited by 124

Sex Differences in Synaptic Plasticity: Hormones and Beyond

Hyer, M. M., Phillips, L. L., & Neigh, G. N. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00266 · Cited by 121

Estrogen Attenuates Local Inflammasome Expression and Activation after Spinal Cord Injury

Zendedel, A., Mönnink, F., Hassanzadeh, G., Zaminy, A., Ansar, M. M., Habib, P., Slowik, A., Kipp, M., & Beyer, C. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0400-2 · Cited by 119

Estrogen Regulates Bcl-w and Bim Expression: Role in Protection against β-Amyloid Peptide-Induced Neuronal Death

Yao, M., Nguyen, T. V., & Pike, C. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2382-06.2007 · Cited by 118

Do Microglial Sex Differences Contribute to Sex Differences in Neurodegenerative Diseases?

Kodama, L., & Gan, L. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.05.001 · Cited by 118

Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotection

Xu, Y., Zhang, W. H., Klaus, J. A., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602932103 · Cited by 115

Interaction of insulin-like growth factor-I and estradiol signaling pathways on hypothalamic neuronal differentiation

Dueñas, M., Torres‐Alemán, I., Naftolin, F. N., & García‐Segura, L. M. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00142-x · Cited by 114

Role of Signal Transducer and Activator of Transcription-3 in Estradiol-Mediated Neuroprotection

Dziennis, S., Jia, T., Rønnekleiv, O. K., Hurn, P. D., & Alkayed, N. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1558-07.2007 · Cited by 114

Estradiol prevents kainic acid-induced neuronal loss in the rat dentate gyrus

Azcoitia, Í., Sierra, A., & García‐Segura, L. M. (1998) · Neuroreport · doi:10.1097/00001756-199809140-00029 · Cited by 114

Stroke sensitivity in the aged: sex chromosome complement vs. gonadal hormones

McCullough, L. D., Mirza, M. A., Xu, Y., Bentivegna, K., Steffens, E. B., Ritzel, R. M., & Liu, F. (2016) · Aging · doi:10.18632/aging.100997 · Cited by 114

Alzheimer, mitochondria and gender

Grimm, A., Mensah‐Nyagan, A. G., & Eckert, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.04.012 · Cited by 111

Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-β or hyperphosphorylated tau protein

Grimm, A., Biliouris, E. E., Lang, U. E., Götz, J., Mensah‐Nyagan, A. G., & Eckert, A. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1988-x · Cited by 110

Role of astrocytes in the neuroprotective actions of 17β-estradiol and selective estrogen receptor modulators

Acaz‐Fonseca, E., Sánchez‐González, R., Azcoitia, Í., Arévalo, M., & García‐Segura, L. M. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.01.009 · Cited by 109

Neuroactive steroids, neurosteroidogenesis and sex

Giatti, S., García‐Segura, L. M., Barreto, G. E., & Melcangi, R. C. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.06.007 · Cited by 107

How does estrogen work on autophagy?

Xiang, J., Liu, X., Ren, J., Chen, K., Wang, H.-L., Miao, Y., & Qi, M. (2018) · Autophagy · doi:10.1080/15548627.2018.1520549 · Cited by 107

Implication of the Phosphatidylinositol-3 Kinase/Protein Kinase B Signaling Pathway in the Neuroprotective Effect of Estradiol in the Striatum of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mice

D’Astous, M., Méndez, P., Morissette, M., García‐Segura, L. M., & Paolo, T. D. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.018671 · Cited by 105

Selective Estrogen Receptor Modulators Decrease Reactive Astrogliosis in the Injured Brain: Effects of Aging and Prolonged Depletion of Ovarian Hormones

Barreto, G. E., Santos‐Galindo, M., Diz-Chaves, Y., Pernía, O., Carrero, P., Azcoitia, Í., & García‐Segura, L. M. (2009) · Endocrinology · doi:10.1210/en.2009-0352 · Cited by 103

Latent sex differences in molecular signaling that underlies excitatory synaptic potentiation in the hippocampus

Jain, A., Huang, G. Z., & Woolley, C. S. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1897-18.2018 · Cited by 102

Multiple functional therapeutic effects of the estrogen receptor β agonist indazole-Cl in a mouse model of multiple sclerosis

Moore, S. M., Khalaj, A. J., Kumar, S., Winchester, Z., Yoon, J., Yoo, T. S., Martinez‐Torres, L., Yasui, N., Katzenellenbogen, J. A., & Tiwari-Woodruff, S. K. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411294111 · Cited by 101

Estradiol and neurodegenerative oxidative stress

Nilsen, J. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.12.005 · Cited by 98

Neuroprotection by estrogen via extracellular signal‐regulated kinase against quinolinic acid‐induced cell death in the rat hippocampus

Kuroki, Y., Fukushima, K., Kanda, Y., Mizuno, K., & Watanabe, Y. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2000.01409.x · Cited by 98

Levels and actions of neuroactive steroids in the nervous system under physiological and pathological conditions: Sex-specific features

Melcangi, R. C., Giatti, S., & García‐Segura, L. M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.09.023 · Cited by 98

Estrogen receptor–α in medial amygdala neurons regulates body weight

Xu, P., Cao, X., He, Y., Zhu, L., Yang, Y., Saito, K., Wang, C., Yan, X., Hinton, A. O., Jr., Zou, F., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80941 · Cited by 97

Regulation of Hypoxia-Induced Inflammatory Responses and M1-M2 Phenotype Switch of Primary Rat Microglia by Sex Steroids

Habib, P., Slowik, A., Zendedel, A., Johann, S., Dang, J., & Beyer, C. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0137-y · Cited by 96

The role of estrogens in seizures and epilepsy: The bad guys or the good guys?

Velı́šková, J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.005 · Cited by 95

Differential regulation of BDNF, synaptic plasticity and sprouting in the hippocampal mossy fiber pathway of male and female rats

Scharfman, H. E., & MacLusky, N. J. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.029 · Cited by 94

17β‐Oestradiol Anti‐Inflammatory Effects in Primary Astrocytes Require Oestrogen Receptor β‐Mediated Neuroglobin Up‐Regulation

Marinis, E. D., Acaz‐Fonseca, E., Arévalo, M., Ascenzi, P., Fiocchetti, M., Marino, M., & García‐Segura, L. M. (2012) · Journal of Neuroendocrinology · doi:10.1111/jne.12007 · Cited by 94

Sex differences in behavioral and neurochemical effects of gonadectomy and aromatase inhibition in rats

Kokras, N., Pastromas, N., Papasava, D., de Bournonville, C., Cornil, C. A., & Dalla, C. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.10.007 · Cited by 94

17beta‐estradiol protects oligodendrocytes from cytotoxicity induced cell death

Takao, T., Flint, N., Lee, L., Ying, X., Merrill, J., & Chandross, K. J. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02370.x · Cited by 93

Brain Endogenous Estrogen Levels Determine Responses to Estrogen Replacement Therapy via Regulation of BACE1 and NEP in Female Alzheimer’s Transgenic Mice

Li, R., He, P., Cui, J., Staufenbiel, M., Harada, N., & Shen, Y. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8377-3 · Cited by 93

GPR30 Regulates Glutamate Transporter GLT-1 Expression in Rat Primary Astrocytes

Lee, E.-S., Sidoryk‐Wȩgrzynowicz, M., Wang, N., Webb, A., Son, D.-S., Lee, K., & Aschner, M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.341867 · Cited by 92

Progesterone reverses 17β‐estradiol‐mediated neuroprotection and BDNF induction in cultured hippocampal slices

Aguirre, C., & Baudry, M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06591.x · Cited by 91

Sex-Dependent Regulation of Aromatase-Mediated Synaptic Plasticity in the Basolateral Amygdala

Bender, R. A., Zhou, L., Vierk, R., Brandt, N., Keller, A., Gee, C. E., Schäfer, M. K. E., & Rune, G. M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1532-16.2016 · Cited by 91

17 β -Estradiol Confers Protection after Traumatic Brain Injury in the Rat and Involves Activation of G Protein-Coupled Estrogen Receptor 1

Day, N. L., Floyd, C. L., D'Alessandro, T. L., Hubbard, W. J., & Chaudry, I. H. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2013.2854 · Cited by 90

Estrogen-Receptor-Mediated Protection of Cerebral Endothelial Cell Viability and Mitochondrial Function after Ischemic Insult in vitro

Guo, J., Krause, D. N., Horne, J. N., Weiss, J. H., Li, X.-J., & DUCKLES, S. P. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.226 · Cited by 89

G‐Protein Oestrogen Receptor 1: Trials and Tribulations of a Membrane Oestrogen Receptor

Srivastava, D. P., & Evans, P. D. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12071 · Cited by 89

Estrogens and SERMS as adjunctive treatments for schizophrenia

Kulkarni, J., Butler, S., & Riecher‐Rössler, A. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.03.002 · Cited by 88

Glia Mediates the Neuroprotective Action of Estradiol on β-Amyloid-Induced Neuronal Death

Sortino, M. A., Chisari, M., Merlo, S., Vancheri, C., Caruso, M., Nicoletti, F., Canonico, P. L., & Copani, A. (2004) · Endocrinology · doi:10.1210/en.2004-0973 · Cited by 87

Estradiol attenuates hyperoxia‐induced cell death in the developing white matter

Gerstner, B., Sifringer, M., Dzietko, M., Schüller, A., Lee, J., Simons, S., Obladen, M., Volpe, J. J., Rosenberg, P. A., & Felderhoff‐Mueser, U. (2007) · Annals of Neurology · doi:10.1002/ana.21118 · Cited by 85

Ovariectomy-Induced Mitochondrial Oxidative Stress, Apoptosis, and Calcium Ion Influx Through TRPA1, TRPM2, and TRPV1 Are Prevented by 17β-Estradiol, Tamoxifen, and Raloxifene in the Hippocampus and Dorsal Root Ganglion of Rats

Yazğan, Y., & Nazıroğlu, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0232-5 · Cited by 85

Estrogen suppresses IL-1β-mediated induction of COX-2 pathway in rat cerebral blood vessels

Ospina, J. A., Brevig, H., Krause, D. N., & DUCKLES, S. P. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00481.2003 · Cited by 84

NLRP3 Inflammasome Activation in the Brain after Global Cerebral Ischemia and Regulation by 17β‐Estradiol

Thakkar, R., Wang, R., Sareddy, G. R., Wang, J., Thiruvaiyaru, D. S., Vadlamudi, R. K., Zhang, Q., & Brann, D. W. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8309031 · Cited by 84

17β-Estradiol prevents cell death and mitochondrial dysfunction by an estrogen receptor-dependent mechanism in astrocytes after oxygen–glucose deprivation/reperfusion

Guo, J., DUCKLES, S. P., Weiss, J. H., Li, X., & Krause, D. N. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.03.005 · Cited by 83

Estrogen-IGF-1 interactions in neuroprotection: Ischemic stroke as a case study

Sohrabji, F. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.05.003 · Cited by 83

Oestrogen Receptors and Signalling Pathways: Implications for Neuroprotective Effects of Sex Steroids in Parkinson’s Disease

Al-Sweidi, S., Sánchez, M. G., Bourque, M., Morissette, M., Dluzen, D. E., & Paolo, T. D. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02193.x · Cited by 82

Sex steroids and neuroprotection in spinal cord injury: A review of preclinical investigations

Elkabes, S., & Nicot, A. B. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.01.008 · Cited by 82

Plasma membrane oestrogen receptor mediates neuroprotection against β‐amyloid toxicity through activation of Raf‐1/MEK/ERK cascade in septal‐derived cholinergic SN56 cells

Guerra, B., Díaz, M. L., Alonso, R., & Marín, R. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02695.x · Cited by 82

Independent influences of sex steroids of systemic and central origin in a rat model of Parkinson's disease: A contribution to sex-specific neuroprotection by estrogens

Gillies, G. E., & McArthur, S. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.06.002 · Cited by 82

Neuroprotection by the steroids pregnenolone and dehydroepiandrosterone is mediated by the enzyme aromatase

Veiga, S. J., García‐Segura, L. M., & Azcoitia, Í. (2003) · Journal of Neurobiology · doi:10.1002/neu.10249 · Cited by 82

Injury-Induced Neurogenesis

Yu, T., Washington, P. M., & Kernie, S. G. (2014) · The Neuroscientist · doi:10.1177/1073858414563616 · Cited by 80

The Role of Genetic Sex in Affect Regulation and Expression of GABA-Related Genes Across Species

Seney, M. L., Chang, L.-C., Oh, H., Wang, X., Tseng, G. C., Lewis, D. A., & Sibille, E. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00104 · Cited by 78

Sex and regional differences in estradiol content in the prefrontal cortex, amygdala and hippocampus of adult male and female rats

Barker, J. M., & Galea, L. A. M. (2009) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2009.05.008 · Cited by 78

17β‐estradiol protects against hypoxic/ischemic white matter damage in the neonatal rat brain

Gerstner, B., Lee, J., DeSilva, T. M., Jensen, F. E., Volpe, J. J., & Rosenberg, P. A. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22023 · Cited by 78

Neuronal Estrogen Receptor-α Mediates Neuroprotection by 17β-Estradiol

Elzer, J., Muhammad, S., Wintermantel, T. M., Régnier‐Vigouroux, A., Ludwig, J., Schütz, G., & Schwaninger, M. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.258 · Cited by 76

Tibolone protects astrocytic cells from glucose deprivation through a mechanism involving estrogen receptor beta and the upregulation of neuroglobin expression

Ávila-Rodriguez, M., García‐Segura, L. M., Hidalgo‐Lanussa, O., Báez-Jurado, E., González, J., & Barreto, G. E. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.05.024 · Cited by 76

Sex differences in brain mitochondrial metabolism: influence of endogenous steroids and stroke

Gaignard, P., Fréchou, M., Lière, P., Thérond, P., Schumacher, M., Slama, A., & Guennoun, R. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12497 · Cited by 76

Neurosteroids in Adult Hippocampus of Male and Female Rodents: Biosynthesis and Actions of Sex Steroids

Hojo, Y., & Kawato, S. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00183 · Cited by 76

Steroid Protection in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis

Garay, L. I., Deniselle, M. C. G., Gierman, L. M., Meyer, M., Lima, A. E., Roig, P., & Nicola, A. F. D. (2008) · NeuroImmunoModulation · doi:10.1159/000135627 · Cited by 75

Gonadal hormones and the control of reactive gliosis

Arévalo, M., Santos‐Galindo, M., Acaz‐Fonseca, E., Azcoitia, Í., & García‐Segura, L. M. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.02.021 · Cited by 74

Hippocampal Neuropathology of Diabetes Mellitus is Relieved by Estrogen Treatment

Saravia, F., Beauquis, J., Revsin, Y., Homo‐Delarche, F., de Kloet, E. R., & Nicola, A. F. D. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9096-y · Cited by 74

Astrocyte-derived growth factors and estrogen neuroprotection: Role of transforming growth factor-α in estrogen-induced upregulation of glutamate transporters in astrocytes

Karki, P., Smith, K., Johnson, J., & Lee, E. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.01.010 · Cited by 73

G protein-coupled estrogen receptor is required for the neuritogenic mechanism of 17β-estradiol in developing hippocampal neurons

Ruiz-Palmero, I., Hernando, M. J., García‐Segura, L. M., & Arévalo, M. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.03.018 · Cited by 72

Estrogen deficiency exacerbates Aβ-induced memory impairment through enhancement of neuroinflammation, amyloidogenesis and NF-ĸB activation in ovariectomized mice

Yun, J., Yeo, I. J., Hwang, C. J., Choi, D., Im, H.-S., Kim, J. Y., Choi, W. R., Jung, M. H., Han, S., & Hong, J. T. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.05.013 · Cited by 72

Selective estrogen receptor modulators regulate reactive microglia after penetrating brain injury

Barreto, G. E., Santos‐Galindo, M., & García‐Segura, L. M. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00132 · Cited by 71

Sexual dimorphism in the white matter of rodents

Cerghet, M., Skoff, R. P., Swamydas, M., & Bessert, D. A. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.06.039 · Cited by 70

Seladin-1 Is a Fundamental Mediator of the Neuroprotective Effects of Estrogen in Human Neuroblast Long-Term Cell Cultures

Luciani, P., Deledda, C., Rosati, F., Benvenuti, S., Cellai, I., Dichiara, F., Morello, M., Vannelli, G. B., Danza, G., Serio, M., et al. (2008) · Endocrinology · doi:10.1210/en.2007-1795 · Cited by 70

Long-term administration of estrogen or tamoxifen to ovariectomized rats affords neuroprotection to hippocampal neurons by modulating the expression of Bcl-2 and Bax

Sharma, K., & Mehra, R. D. (2008) · Brain Research · doi:10.1016/j.brainres.2008.01.080 · Cited by 70

Protection by Neuroglobin Expression in Brain Pathologies

Báez, E., Echeverría, V., Cabezas, R., Avila-Rodriguez, M. F., Garcia-Segura, L., & Barreto, G. (2016) · Frontiers in Neurology · doi:10.3389/fneur.2016.00146 · Cited by 70

Inhibition of Rho kinase mediates the neuroprotective effects of estrogen in the MPTP model of Parkinson's disease

Rodriguez-Perez, A. I., Dominguez‐Meijide, A., Lanciego, J. L., Guerra, M. J., & Labandeira-García, J. L. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.06.004 · Cited by 69

Administration of 17β-Estradiol Improves Motoneuron Survival and Down-regulates Inflammasome Activation in Male SOD1(G93A) ALS Mice

Heitzer, M., Kaiser, S., Kanagaratnam, M., Zendedel, A., Hartmann, P., Beyer, C., & Johann, S. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0322-4 · Cited by 69

Sciatic nerve injury induces apoptosis of dorsal root ganglion satellite glial cells and selectively modifies neurosteroidogenesis in sensory neurons

Schaeffer, V., Meyer, L., Patte‐Mensah, C., Eckert, A., & Mensah‐Nyagan, A. G. (2009) · Glia · doi:10.1002/glia.20910 · Cited by 68

Post-ischemic estradiol treatment reduced glial response and triggers distinct cortical and hippocampal signaling in a rat model of cerebral ischemia

Pérez-Álvarez, M. J., Maza, M. D. C., Anton, M., Ordóñez‐Gutiérrez, L., & Wandosell, F. G. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-157 · Cited by 68

Estrogen attenuates glutamate-induced cell death by inhibiting Ca2+ influx through L-type voltage-gated Ca2+ channels

Sribnick, E. A., Re, A. M. D., Ray, S. K., Woodward, J. J., & Banik, N. L. (2009) · Brain Research · doi:10.1016/j.brainres.2009.04.022 · Cited by 68

Neuroprotective effects of oestrogen against oxidative toxicity through activation of G‐protein‐coupled receptor 30 receptor

Liu, S., Han, J., Zhang, N., Tian, Z., Li, X., & Zhao, M. (2011) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2011.05549.x · Cited by 66

Survivin Is a Transcriptional Target of STAT3 Critical to Estradiol Neuroprotection in Global Ischemia

Sehara, Y., Sawicka, K., Hwang, J.-Y., Latuszek-Barrantes, A., Etgen, A. M., & Zukin, R. S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1852-13.2013 · Cited by 66

Sex Differences in the Rapid Cell Signaling Mechanisms Underlying the Memory-Enhancing Effects of 17β-Estradiol

Koss, W. A., Haertel, J. M., Philippi, S. M., & Frick, K. M. (2018) · eNeuro · doi:10.1523/eneuro.0267-18.2018 · Cited by 66

17β-Estradiol Ameliorates Tight Junction Disruption via Repression of MMP Transcription

Na, W., Lee, J. Y., Kim, W., Yune, T. Y., & Ju, B. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1124 · Cited by 65

2-Methoxyestradiol Attenuates Autophagy Activation After Global Ischemia

Xin, X., Pan, J., Wang, X., Ma, J., Ding, J., Yang, G., & Chen, S. (2011) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s031716710001218x · Cited by 64

Estrogen induces multiple regulatory B cell subtypes and promotes M2 microglia and neuroprotection during experimental autoimmune encephalomyelitis

Benedek, G., Zhang, J., Bodhankar, S., Nguyen, H., Kent, G., Jordan, K. R., Manning, D., Vandenbark, A. A., & Offner, H. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.02.009 · Cited by 63

Menopause and Parkinson’s disease. Interaction between estrogens and brain renin-angiotensin system in dopaminergic degeneration

Labandeira-García, J. L., Rodriguez-Perez, A. I., Valenzuela, R., Costa-Besada, M. A., & Guerra, M. J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.09.003 · Cited by 63

Role of mTORC1 Controlling Proteostasis after Brain Ischemia

Pérez-Álvarez, M. J., Villa-González, M., Benito‐Cuesta, I., & Wandosell, F. G. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00060 · Cited by 63

Molecular mechanisms involved in the protective actions of Selective Estrogen Receptor Modulators in brain cells

Báez-Jurado, E., Rincon‐Benavides, M. A., Hidalgo‐Lanussa, O., Guio-Vega, G. P., Ashraf, G. M., Sahebkar, A., Echeverrı́a, V., García‐Segura, L. M., & Barreto, G. E. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.09.001 · Cited by 63

Tibolone protects T98G cells from glucose deprivation

Ávila-Rodriguez, M., García‐Segura, L. M., Cabezas, R., Torrente, D., Capani, F., González, J., & Barreto, G. E. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.07.009 · Cited by 61

Selective estrogen receptor modulators (SERMs) enhance neurogenesis and spine density following focal cerebral ischemia

Khan, M. M., Wakade, C. G., Sevilla, L. M. D., & Brann, D. W. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.05.001 · Cited by 61

Repurposing sex steroids and related drugs as potential treatment for Parkinson's disease

Bourque, M., Morissette, M., & Paolo, T. D. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.04.005 · Cited by 61

Estrogen inhibits Fas-mediated apoptosis in experimental stroke

Jia, J., Guan, D., Zhu, W., Alkayed, N. J., Wang, M. M., Hua, Z., & Xu, Y. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.09.015 · Cited by 60

17β-estradiol protects male mice from cuprizone-induced demyelination and oligodendrocyte loss

Taylor, L. C., Puranam, K. L., Gilmore, W., Ting, J. P. ‐., & Matsushima, G. K. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.03.016 · Cited by 60

SIRT 1‐dependent AMPK pathway in the protection of estrogen against ischemic brain injury

Guo, J., He, S., Wang, L., et al. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12686 · Cited by 60

Modulation of the endocannabinoid system by focal brain ischemia in the rat is involved in neuroprotection afforded by 17β‐estradiol

Amantea, D., Spagnuolo, P., Bari, M., Fezza, F., Mazzei, C., Tassorelli, C., Morrone, L. A., Corasaniti, M. T., Maccarrone, M., & Bagetta, G. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05975.x · Cited by 59

Oestrogen receptor α agonist improved long-term ovariectomy-induced spatial cognition deficit in young rats

Qu, N., Wang, L., Liu, Z.-C., Tian, Q., & Zhang, Q. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000958 · Cited by 59

Effects of Estradiol on Autophagy and Nrf-2/ARE Signals after Cerebral Ischemia

Li, L., Chen, J., Sun, S., Zhao, J., Dong, X., & Wang, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000475433 · Cited by 59

Estrogen Interactions With Lipid Rafts Related to Neuroprotection. Impact of Brain Ageing and Menopause

Marín, R., & Díaz, M. L. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00128 · Cited by 59

Sex hormones and stroke: Beyond estrogens

Sohrabji, F., Okoreeh, A. K., & Panta, A. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.10.010 · Cited by 59

Estrogen receptor beta signaling alters cellular inflammasomes activity after global cerebral ischemia in reproductively senescence female rats

Vaccari, J. P. D. R., Patel, H. H., Brand, F. J., Pérez‐Pinzón, M. A., Bramlett, H. M., & Raval, A. P. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13404 · Cited by 58

Neuroprotection by estradiol: A role of aromatase against spine synapse loss after blockade of GABAA receptors

Zhou, L., Lehan, N., Wehrenberg, U., Disteldorf, E. M., von Lossow, R., Mares, U., Jarry, H., & Rune, G. M. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.07.020 · Cited by 58

Pretreatment with a single estradiol-17β bolus activates cyclic-AMP response element binding protein and protects CA1 neurons against global cerebral ischemia

Raval, A. P., Saul, I., Dave, K. R., DeFazio, R. A., Pérez‐Pinzón, M. A., & Bramlett, H. M. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.02.065 · Cited by 58

Neuroinflammation induces glial aromatase expression in the uninjured songbird brain

Duncan, K. A., & Saldanha, C. J. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-81 · Cited by 58

Roles of 17 -Estradiol Involve Regulation of Reelin Expression and Synaptogenesis in the Dentate Gyrus

Bender, R. A., Zhou, L., Wilkars, W., Fester, L., Lanowski, J.-S., Paysen, D., Konig, A., & Rune, G. M. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq047 · Cited by 58

Effects of Chronic and Acute Oestrogen Replacement Therapy in Aged Animals after Experimental Stroke

Liu, F., Benashski, S. E., Xu, Y., Siegel, M., & McCullough, L. D. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02248.x · Cited by 57

Neuroprotection in Parkinsonian-treated mice via estrogen receptor α activation requires G protein-coupled estrogen receptor 1

Bourque, M., Morissette, M., & Paolo, T. D. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.04.006 · Cited by 56

Endogenous Estrogen Formation Is Neuroprotective in Model of Cerebellar Ataxia

Sierra, A., Azcoitia, Í., & García‐Segura, L. M. (2003) · Endocrine · doi:10.1385/endo:21:1:43 · Cited by 56

Actions of 17β-estradiol and testosterone in the mitochondria and their implications in aging

Vasconsuelo, A., Milanesi, L., & Boland, R. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.09.001 · Cited by 55

Protective Effect of 17β-Estradiol Upon Hippocampal Spine Density and Cognitive Function in an Animal Model of Vascular Dementia

Zhu, Y., Zhang, Q., Zhang, W., Li, N., Dai, Y., Tu, J., Yang, F., Brann, D. W., & Wang, R. (2017) · Scientific Reports · doi:10.1038/srep42660 · Cited by 55

Sexually Dimorphic Effects of Aromatase on Neurobehavioral Responses

Shay, D. A., Vieira‐Potter, V. J., & Rosenfeld, C. S. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00374 · Cited by 55

Roles of estrogen receptors alpha and beta in sexually dimorphic neuroprotection against glutamate toxicity

Bryant, D. N., & Dorsa, D. M. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.019 · Cited by 54

Estrogen replacement therapy-induced neuroprotection against brain ischemia-reperfusion injury involves the activation of astrocytes via estrogen receptor β

Ma, Y., Guo, H., Zhang, L., Tao, L., Yin, A., Liu, Z., Li, Y., Dong, H., Xiong, L., & Hou, W. (2016) · Scientific Reports · doi:10.1038/srep21467 · Cited by 54

Inhibition of injury‐induced glial aromatase reveals a wave of secondary degeneration in the songbird brain

Wynne, R. D., Walters, B. J., Bailey, D. J., & Saldanha, C. J. (2007) · Glia · doi:10.1002/glia.20594 · Cited by 53

Inhibition of Autophagy by Estradiol Promotes Locomotor Recovery after Spinal Cord Injury in Rats

Lin, C., Chen, B., Huang, K., Dai, Y., & Teng, H. (2016) · Neuroscience Bulletin · doi:10.1007/s12264-016-0017-x · Cited by 53

Neuroprotection by estrogen against MPP+-induced dopamine neuron death is mediated by ERα in primary cultures of mouse mesencephalon

Bains, M., Cousins, J. C., & Roberts, J. L. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.01.020 · Cited by 51

Inhibition of miR-181a protects female mice from transient focal cerebral ischemia by targeting astrocyte estrogen receptor-α

Stary, C. M., Xu, L., Li, L., Sun, X., Ouyang, Y.-B., Xiong, X., Zhao, J., & Giffard, R. G. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2017.05.004 · Cited by 49

New insights into the gene expression associated to amyotrophic lateral sclerosis

Recabarren-Leiva, D., & Alarcón, M. A. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.12.016 · Cited by 49

17β-estradiol rescues spinal motoneurons from AMPA-induced toxicity: A role for glial cells

Platania, P., Seminara, G., Aronica, E., et al. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.03.025 · Cited by 48

Neural-derived estradiol regulates brain plasticity

Azcoitia, Í., Arévalo, M., & García‐Segura, L. M. (2017) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2017.04.004 · Cited by 48

17β-Estradiol via SIRT1/Acetyl-p53/NF-kB Signaling Pathway Rescued Postnatal Rat Brain Against Acute Ethanol Intoxication

Khan, M., Shah, S. A., & Kim, M. O. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0520-8 · Cited by 48

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