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Cited by 37Effects and risks of endocrine disrupting chemicalsPhytoestrogen effects and researchNeuroendocrine regulation and behavior

Effects of early embryonic exposure to genistein on male copulatory behavior and vasotocin system of Japanese quail

Viglietti-Panzica, Carla, Mura, Elena, Panzica, GianCarlo·2007·Hormones and Behavior
DOI 10.1016/j.yhbeh.2006.12.003
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Abstract

Genistein is a phytoestrogen, particularly abundant in soybeans that can bind estrogen receptors and sex hormone binding proteins, exerting both estrogenic and antiestrogenic activity. In this study we used the Japanese quail embryo as a test end-point to investigate the effects of early embryonic exposure to genistein on male copulatory behavior and on vasotocin parvocellular system. Both differentiate by the organizational effects of estradiol during development and may therefore represent an optimal model to study the effects of xenoestrogens. We injected two doses of genistein (100 and 1000 microg) into the yolk of 3-day-old Japanese quail eggs. Other eggs were treated with either 25 microg of estradiol benzoate or sesame oil as positive and negative controls. At the age of 6 weeks, behavioral tests revealed a significant decrease of all aspects of copulatory behavior (in comparison to the control group) in estradiol-treated birds. In contrast, genistein-treated animals demonstrated various degrees of decrease in the mean frequencies of some aspects of the sexual behavior. The computerized analysis of vasotocin innervation in medial preoptic, stria terminalis and lateral septum nuclei revealed a statistically significant decreased immunoreactivity in treated animals compared to control ones. These results demonstrate that genistein, similarly to estradiol, has an organizational effect on quail parvocellular vasotocin system and on copulatory behavior. In conclusion, prese…

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  • GEN alters AVP and OT neuron numbers and innervation of sexually dimorphic regions associated with social and aggressive behaviors in multiple species, and is anxiogenic in males of multiple species.

    “Altered AVP and OT neuron numbers and innervation of sexually dimorphic regions associated with social and aggressive behaviors in multiple species; anxiogenic in males of multiple species”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [69]

  • Multiple aspects of the quail VT system are vulnerable to EDCs including BPA, DES, and high doses of the phytoestrogen GEN.

    “Seminal research dating back decades has consistently and repeatedly shown that multiple aspects of the quail VT system is vulnerable to EDCs including bisphenol A (BPA), diethylstilbestrol (DES), and high doses of the phytoestrogen genistein (GEN) (69, 70).”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [69]

  • Demasculinization of VT-ir was induced by embryonic GEN and p,p′-DDE.

    “Demasculinization of VT-ir was induced by embryonic GEN, and p,p′-DDE [a long-lived metabolite of dichlorodiphenyltrichloroethane (DDT)] (69).”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [69]

  • Reduced male copulatory behavior was observed following embryonic exposure to high doses of the phytoestrogen genistein (GEN).

    “Reduced male copulatory behavior was also observed following embryonic exposure to high doses of the phytoestrogen genistein (GEN) (69), which is one of the most potent EDCs on nuclear estrogen receptors (ERs), particularly ERβ”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [69]

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Authors
Viglietti-Panzica, C., Mura, E., & Panzica, G.
Affiliations
University of Turin (IT)
Corresponding author
Panzica, GianCarlo
ORCID
Panzica, GianCarlo
Venue
Hormones and Behavior
Publisher
Elsevier BV
Published
2007-03
Volume
51
Issue
3
Pages
355-363
ISSN
0018-506X (ISSN-L)
DOI
10.1016/j.yhbeh.2006.12.003
OpenAlex
W2002999453
Cited by
37
References
69
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2021: 1 · 2019: 4 · 2018: 1 · 2017: 5 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
FWCI
2.54
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Hormones and Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
genistein, phytoestrogens, embryonic exposure, Japanese quail, male copulatory behavior, parvocellular neurons, sexual differentiation of the brain, xenoestrogens, estradiol benzoate, yolk injection, medial preoptic nucleus, stria terminalis, lateral septum, avian model
MeSH terms
Animals, Copulation, Coturnix, Estradiol, Female, Hypothalamus, Male, Pituitary Gland, Sex Differentiation, Vasotocin, Genistein, Models, Animal

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