The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.
Perinatal exposure to bisphenol-A impairs learning-memory by concomitant down-regulation of N-methyl-d-aspartate receptors of hippocampus in male offspring mice
Abstract
Bisphenol-A (BPA) has been shown to influence development of the brain and behaviors. The purpose of the present report was to investigate the effects of perinatal exposure to BPA on learning/memory and its mechanism of action, especially focusing on N-methyl-d-aspartate receptor (NMDAR). Perinatal maternal exposure to BPA at 0.5, 5, and 50mg/kg/d significantly extended the escape length to find the hidden platform in Morris water maze, and BPA at 0.5 or 5mg/kg/d markedly decreased the percentage of time spent in the quadrant where the platform had been during training both in postnatal day (PND) 21 and PND 56 mice. The results of passive avoidance test showed that the error frequency to step down from a platform after received footshock was significantly increased, and the latency of the step-down response onto the grid floor 24h after received footshock was obviously reduced by exposure to BPA at 5 and 50mg/kg/d (P<0.01) in the PND 21 offspring or at 50mg/kg/d in the PND 56 offspring (P<0.01). Furthermore, perinatal exposure to BPA significantly inhibited the expressions of NMDAR subunits NR1, NR2A, and 2B in the hippocampus during the development stage, especially in PND 56 mice. The expressions of estrogen receptor beta (ERbeta) in both PND 21 and PND 56 mice were markedly down-regulated by BPA at 0.5, 5, and 50mg/kg/d. These results indicate that perinatal exposure to BPA affects normal behavioral development in both spatial memory and avoidance memory, and also permanen…
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“Pre- and/or peri-natal exposure to BPA in rodents is associated with cognitive impairments and decreased exploration in a novel environment [12], [13], [14].”
From Gestational Exposure to Low Dose Bisphenol A Alters Social Behavior in Juvenile Mice (2011) · cites this paper as [13]
In the citing paper
“In rodents, pre- and perinatal exposures to BPA at or below the TDI (tolerable daily intake; ⩽50 μg/kg/day) have resulted in adverse effects on memory processes [4–9].”
From The Rapid Effect of Bisphenol-A on Long-Term Potentiation in Hippocampus Involves Estrogen Receptors and ERK Activation (2017) · cites this paper as [4]
In the citing paper
“It is well known that LTP expression includes the presynaptic locus associated with PPF ratio changes.31”
From Bisphenol A Impairs Synaptic Plasticity by Both Pre‐ and Postsynaptic Mechanisms (2017) · cites this paper as [31]
Citations
Cites
Morris water maze: procedures for assessing spatial and related forms of learning and memory
Vorhees, C. V., & Williams, M. T. (2006) · Nature Protocols · doi:10.1038/nprot.2006.116 · Cited by 4,629
Long-Term Potentiation and Memory
Lynch, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00014.2003 · Cited by 2,074
In vivo effects of bisphenol A in laboratory rodent studies
Richter, C. A., Birnbaum, L. S., Farabollini, F., Newbold, R. R., Rubin, B. S., Talsness, C. E., Vandenbergh, J. G., Walser-Kuntz, D. R., & vom Saal, F. S. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.06.004 · Cited by 1,147
Welshons, W. V., Nagel, S. C., & Saal, F. S. V. (2006) · Endocrinology · doi:10.1210/en.2005-1159 · Cited by 990
Izquierdo, I., & Medina, J. H. (1997) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1997.3799 · Cited by 959
Estradiol and the Developing Brain
McCARTHY, M. M. (2008) · Physiological Reviews · doi:10.1152/physrev.00010.2007 · Cited by 885 · cited 2×
“The high level of ERβ expression in the hippocampus suggests an important role in cognition (McCarthy, 2008).”
BackgroundDevelopmental changes in distribution of NMDA receptor channel subunit mRNAs
Watanabe, M., Inoue, Y., Sakimura, K., & Mishina, M. (1992) · Neuroreport · doi:10.1097/00001756-199212000-00027 · Cited by 721
Woolley, C. S., & McEwen, B. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-12-07680.1994 · Cited by 679
Rapid bidirectional switching of synaptic NMDA receptors.
Bellone, C., & Nicoll, R. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.035 · Cited by 357
Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats
Kubo, K., Arai, O., Omura, M., Watanabe, R., Ogata, R., & Aou, S. (2003) · Neuroscience Research · doi:10.1016/s0168-0102(02)00251-1 · Cited by 311
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Chen, X., Wang, Y., Xu, F., Wei, X., Zhang, J., Wang, C., Wei, H., Xu, S., Yan, P., Zhou, W., et al. (2017) · Neural Plasticity · doi:10.1155/2017/5196958 · Cited by 24
“Research Article The Rapid Effect of Bisphenol-A on Long-Term Potentiation in Hippocampus Involves Estrogen Receptors and ERK Activation Xiaowei Chen,1 Yu Wang,1,2 Fang Xu,1 Xiaofei Wei,1 Junfang Zhang,1 Chuang Wang,1 Hua Wei,1 Shujun Xu,1 Peiyun Yan,1 Wenhua Zhou,1 Istvan Mody,1 Xiaohong Xu,2 and Qinwen Wang1 1Ningbo…”
BackgroundSelf-citationDias, G. R. M., Giusti, F. C. V., de Novais, C. O., de Oliveira, M. A. L., Paiva, A. G., Kalil-Cutti, B., Mahoney, M. M., & Graceli, J. B. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1571689 · Cited by 14
Metadata
- Authors
- Xu, X.-H., Zhang, J., Wang, Y.-M., Ye, Y.-P., & Luo, Q.-Q.
- Affiliations
- Zhejiang Normal University (CN)
- ORCID
- Zhang, Jing
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 58
- Issue
- 2
- Pages
- 326-333
- ISSN
- 0018-506X (ISSN-L)
- OpenAlex
- W2085280717
- Cited by
- 211
- References
- 53
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 12 · 2021: 16 · 2020: 17 · 2019: 12 · 2018: 11 · 2017: 13 · 2016: 19 · 2015: 17 · 2014: 14 · 2013: 19 · 2012: 9
- FWCI
- 11.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Keywords
- bisphenol A, perinatal exposure, NMDA receptor, hippocampus, learning and memory, spatial memory, avoidance memory, estrogen receptor beta, NR1, NR2A, NR2B, endocrine disruptors, maternal exposure, postnatal development, offspring behavior
- MeSH terms
- Bisphenol A Compounds, Aging, Animals, Animals, Newborn, Benzhydryl Compounds, Dose-Response Relationship, Drug, Estrogens, Non-Steroidal, Female, Hippocampus, Learning Disabilities, Male, Memory Disorders, Mice, Inbred ICR, Phenols, Pregnancy, Prenatal Exposure Delayed Effects, Random Allocation, Down-Regulation, Receptors, N-Methyl-D-Aspartate, Estrogen Receptor beta, Mice
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