Cited by 211Effects and risks of endocrine disrupting chemicalsPharmacological Effects and Toxicity StudiesAnesthesia and Neurotoxicity Research

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Perinatal exposure to bisphenol-A impairs learning-memory by concomitant down-regulation of N-methyl-d-aspartate receptors of hippocampus in male offspring mice

Xu, Xiao-hong, Zhang, Jing, Wang, Ya-min, Ye, Yin-ping, Luo, Qing-qing·2010·Hormones and Behavior

DOI 10.1016/j.yhbeh.2010.02.012

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Abstract

Bisphenol-A (BPA) has been shown to influence development of the brain and behaviors. The purpose of the present report was to investigate the effects of perinatal exposure to BPA on learning/memory and its mechanism of action, especially focusing on N-methyl-d-aspartate receptor (NMDAR). Perinatal maternal exposure to BPA at 0.5, 5, and 50mg/kg/d significantly extended the escape length to find the hidden platform in Morris water maze, and BPA at 0.5 or 5mg/kg/d markedly decreased the percentage of time spent in the quadrant where the platform had been during training both in postnatal day (PND) 21 and PND 56 mice. The results of passive avoidance test showed that the error frequency to step down from a platform after received footshock was significantly increased, and the latency of the step-down response onto the grid floor 24h after received footshock was obviously reduced by exposure to BPA at 5 and 50mg/kg/d (P<0.01) in the PND 21 offspring or at 50mg/kg/d in the PND 56 offspring (P<0.01). Furthermore, perinatal exposure to BPA significantly inhibited the expressions of NMDAR subunits NR1, NR2A, and 2B in the hippocampus during the development stage, especially in PND 56 mice. The expressions of estrogen receptor beta (ERbeta) in both PND 21 and PND 56 mice were markedly down-regulated by BPA at 0.5, 5, and 50mg/kg/d. These results indicate that perinatal exposure to BPA affects normal behavioral development in both spatial memory and avoidance memory, and also permanen…

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Inhalation Toxicity of Bisphenol A and Its Effect on Estrous Cycle, Spatial Learning, and Memory in Rats upon Whole-Body Exposure
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Authors: Xu, X.-H., Zhang, J., Wang, Y.-M., Ye, Y.-P., & Luo, Q.-Q.
Affiliations: Zhejiang Normal University (CN)
ORCID: Zhang, Jing
Venue: Hormones and Behavior
Publisher: Elsevier BV
Published: 2010-07
Volume: 58
Issue: 2
Pages: 326-333
ISSN: 0018-506X (ISSN-L)
DOI: 10.1016/j.yhbeh.2010.02.012
OpenAlex: W2085280717
Cited by: 211
References: 53
Citations by year: 2026: 8 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 12 · 2021: 16 · 2020: 17 · 2019: 12 · 2018: 11 · 2017: 13 · 2016: 19 · 2015: 17 · 2014: 14 · 2013: 19 · 2012: 9
FWCI: 11.67
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Hormones and Behavior (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
Keywords: bisphenol A, perinatal exposure, NMDA receptor, hippocampus, learning and memory, spatial memory, avoidance memory, estrogen receptor beta, NR1, NR2A, NR2B, endocrine disruptors, maternal exposure, postnatal development, offspring behavior
MeSH terms: Bisphenol A Compounds, Aging, Animals, Animals, Newborn, Benzhydryl Compounds, Dose-Response Relationship, Drug, Estrogens, Non-Steroidal, Female, Hippocampus, Learning Disabilities, Male, Memory Disorders, Mice, Inbred ICR, Phenols, Pregnancy, Prenatal Exposure Delayed Effects, Random Allocation, Down-Regulation, Receptors, N-Methyl-D-Aspartate, Estrogen Receptor beta, Mice

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Perinatal exposure to bisphenol-A impairs learning-memory by concomitant down-regulation of N-methyl-d-aspartate receptors of hippocampus in male offspring mice

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