Neonatal agonism of ERβ impairs male reproductive behavior and attractiveness

Sullivan, Alana W.; Hamilton, Peter; Patisaul, Heather B.

doi:10.1016/j.yhbeh.2011.04.006

Cited by 19Effects and risks of endocrine disrupting chemicalsSexual Differentiation and DisordersEstrogen and related hormone effects

Neonatal agonism of ERβ impairs male reproductive behavior and attractiveness

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Sullivan, Alana W., Hamilton, Peter, Patisaul, Heather B.·2011·Hormones and Behavior

DOI 10.1016/j.yhbeh.2011.04.006PMC PMC3126896

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Abstract

The organization of the developing male rodent brain is profoundly influenced by endogenous steroids, most notably estrogen. This process may be disrupted by estrogenic endocrine disrupting compounds (EDCs) resulting in altered sex behavior and the capacity to attract a mate in adulthood. To better understand the relative role each estrogen receptor (ER) subtype (ERα and ERβ) plays in mediating these effects, we exposed male Long Evans rats to estradiol benzoate (EB, 10 μg), vehicle, or agonists specific for ERβ (DPN, 1 mg/kg) or ERα (PPT, 1 mg/kg) daily for the first four days of life, and then assessed adult male reproductive behavior and attractiveness via a partner preference paradigm. DPN had a greater adverse impact than PPT on reproductive behavior, suggesting a functional role for ERβ in the organization of these male-specific behaviors. Therefore the impact of neonatal ERβ agonism was further investigated by repeating the experiment using vehicle, EB and additional DPN doses (0.5 mg/kg, 1 mg/kg, and 2 mg/kg bw). Exposure to DPN suppressed male reproductive behavior and attractiveness in a dose dependent manner. Finally, males were exposed to EB or an environmentally relevant dose of genistein (GEN, 10 mg/kg), a naturally occurring xenoestrogen, which has a higher relative binding affinity for ERβ than ERα. Sexual performance was impaired by GEN but not attractiveness. In addition to suppressing reproductive behavior and attractiveness, EB exposure significantly lowered the testis to body weight ratio, and circulating testosterone levels. DPN and GEN exposure only impaired behavior, suggesting that disrupted androgen secretion does not underlie the impairment.

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ERβ in the PVN and associated structures, including the BnST, plays a fundamental role in mediating motivational and anxiety-related behaviors.
“Although the functional role of limbic ERβ remains ambiguous, ERβ in the PVN and associated structures, including the BnST, plays a fundamental role in mediating motivational and anxiety-related behaviors (134–136).”
From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [136]
The Discussion links ERβ in the mPOA to appetitive aspects of male sexual behavior, and the Methods describe measures of sexual motivation. The paper does not establish a role for ERβ in the PVN or BnST in mediating motivational or anxiety-related behaviors; a mention of anxiety-related behavior appears only in a reference title. Page numbers were not available in our copy. (LLM, conf=0.78)
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Authors: Sullivan, A. W., Hamilton, P., & Patisaul, H. B.
Affiliations: North Carolina State University (US)
Corresponding author: Patisaul, Heather B.
ORCID: Hamilton, Peter
Patisaul, Heather B.
Venue: Hormones and Behavior
Publisher: Elsevier BV
Published: 2011-07
Volume: 60
Issue: 2
Pages: 185-194
ISSN: 0018-506X (ISSN-L)
DOI: 10.1016/j.yhbeh.2011.04.006
PMC: PMC3126896
OpenAlex: W2065980791
Cited by: 19
References: 93
Citations by year: 2020: 2 · 2019: 1 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 5 · 2013: 3 · 2012: 3
FWCI: 2.54
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Hormones and Behavior (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Environmental Health Sciences (R01ES016001)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords: estrogen receptor beta, neonatal estrogen exposure, male reproductive behavior, mate attractiveness, mate preferences, endocrine disruptors, diethylstilbestrol, genistein, xenoestrogens, estradiol benzoate, testosterone, sexual differentiation of the brain, Long-Evans rats
MeSH terms: Animals, Dose-Response Relationship, Drug, Estradiol, Estrogens, Male, Nitriles, Phenols, Propionates, Pyrazoles, Sexual Behavior, Animal, Genistein, Rats, Long-Evans, Estrogen Receptor alpha, Estrogen Receptor beta, Phytoestrogens, Rats, Mating Preference, Animal

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Neonatal agonism of ERβ impairs male reproductive behavior and attractiveness

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