Effects of exposure to bisphenol A and ethinyl estradiol on the gut microbiota of parents and their offspring in a rodent model
Open accessAbstract
Gut dysbiosis may result in various diseases, such as metabolic and neurobehavioral disorders. Exposure to endocrine disrupting chemicals (EDCs), including bisphenol A (BPA) and ethinyl estradiol (EE), especially during development, may also increase the risk for such disorders. An unexplored possibility is that EDC-exposure might alter the gut microbial composition. Gut flora and their products may thus be mediating factors for the disease-causing effects of these chemicals. To examine the effects of EDCs on the gut microbiome, female and male monogamous and biparental California mice (Peromyscus californicus) were exposed to BPA (50 mg/kg feed weight) or EE (0.1 ppb) or control diet from periconception through weaning. 16s rRNA sequencing was performed on bacterial DNA isolated from fecal samples, and analyses performed for P0 and F1 males and females. Both BPA and EE induced generational and sex-dependent gut microbiome changes. Many of the bacteria, e.g. Bacteroides, Mollicutes, Prevotellaceae, Erysipelotrichaceae, Akkermansia, Methanobrevibacter, Sutterella, whose proportions increase with exposure to BPA or EE in the P0 or F1 generation are associated with different disorders, such as inflammatory bowel disease (IBD), metabolic disorders, and colorectal cancer. However, the proportion of the beneficial bacterium, Bifidobacterium, was also elevated in fecal samples of BPA- and EE-exposed F1 females. Intestinal flora alterations were also linked to changes in various metabolic and other pathways. Thus, BPA and EE exposure may disrupt the normal gut flora, which may in turn result in systemic effects. Probiotic supplementation might be an effective means to mitigate disease-promoting effects of these chemicals.
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Exposure to endocrine-disrupting chemicals such as bisphenol A and ethinyl estradiol, by incorporation into the diet from periconception through weaning, induced generational and sex-dependent gut microbiome changes in mice, including increased relative abundances of Bacteroides, Prevotellaceae, and Akkermansia.
“Exposure to endocrine-disrupting chemicals such as bisphenol A and ethinyl estradiol, by incorporation into the diet from periconception through weaning, induced generational and sex-dependent gut microbiome changes in mice, including increased relative abundances of Bacteroides, Prevotellaceae, and Akkermansia (Javurek et al., 2016).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Javurek et al., 2016
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Research works printed but not linked: 3
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- Authors
- Javurek, A. B., Spollen, W. G., Johnson, S. A., Bivens, N. J., Bromert, K. H., Givan, S. A., & Rosenfeld, C. S.
- Affiliations
- University of Missouri (US)
- Corresponding author
- Rosenfeld, Cheryl S.
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2016-09-13
- Volume
- 7
- Issue
- 6
- Pages
- 471-485
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC5103659
- OpenAlex
- W2519327751
- Cited by
- 160
- References
- 76
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 21 · 2023: 13 · 2022: 19 · 2021: 23 · 2020: 27 · 2019: 15 · 2018: 10 · 2017: 13 · 2016: 1
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Gut Microbes (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIH (5R21ES023150)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- bisphenol A, ethinyl estradiol, endocrine disruptors, gut microbiota, gut dysbiosis, intergenerational exposure, sex effects, California mouse, Bifidobacterium, Akkermansia, Methanobrevibacter, Sutterella, probiotic supplementation, early life exposure, inflammatory bowel disease, metabolic disorders, colorectal cancer
- MeSH terms
- Gastrointestinal Microbiome, Bisphenol A Compounds, Animals, Bacteria, Benzhydryl Compounds, Disease Models, Animal, Ethinyl Estradiol, Female, Male, Peromyscus, Phenols, Gastrointestinal Tract
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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