The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Intranasal administration of oxytocin increases human aggressive behavior
Abstract
Considering its role in prosocial behaviors, oxytocin (OT) has been suggested to diminish levels of aggression. Nevertheless, recent findings indicate that oxytocin may have a broader influence on increasing the salience of social stimuli and may therefore, under certain circumstances, increase antisocial behaviors such as aggression. This controversy led to the following speculations: If indeed oxytocin promotes primarily prosocial behavior, administration of OT is expected to diminish levels of aggression. However, if oxytocin mainly acts to increase the salience of social stimuli, it is expected to elevate levels of aggression following provocation. In order to test this assumption we used the Social Orientation Paradigm (SOP), a monetary game played against a fictitious partner that allows measuring three types of responses in the context of provocation: an aggressive response - reducing a point from the fictitious partner, an individualistic response - adding a point to oneself, and a collaborative response - adding half a point to the partner and half a point to oneself. In the current double-blind, placebo-controlled, within-subject study design, 45 participants completed the SOP task following the administration of oxytocin or placebo. The results indicated that among subjects naïve to the procedure oxytocin increased aggressive responses in comparison with placebo. These results support the saliency hypothesis of oxytocin and suggest that oxytocin plays a complex role in the modulation of human behavior.
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“Oxytocin has been implicated in many social behaviors, from promoting trust, generosity and cooperation 21,22,46,47 to aggravating mistrust and aggressive behavior 48,49 .”
From Oxytocin modulates social value representations in the amygdala (2019) · cites this paper as [48]
Citations
Cites
Oxytocin increases trust in humans
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Sex Differences in Aggression in Real-World Settings: A Meta-Analytic Review
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Social effects of oxytocin in humans: context and person matter
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.002 · Cited by 1,581 · cited 1×
“For example, oxytocin was found to increase envy and gloating (Shamay-Tsoory et al., 2009), decrease trust and the tendency to cooperate in individuals with borderline personality disorder (Bartz et al., 2011), and facilitate outgroup derogation (De Dreu et al, 2011).”
BackgroundDodge, K. A., Lochman, J. E., Harnish, J. D., Bates, J. E., & al, E. (1997) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.106.1.37 · Cited by 975
The Social Salience Hypothesis of Oxytocin
Shamay-Tsoory, S. G., & Abu-Akel, A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.020 · Cited by 904
Self-citationOxytocin promotes human ethnocentrism
De Dreu, C. K. W., Greer, L. L., Van Kleef, G. A., Shalvi, S., & Handgraaf, M. J. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015316108 · Cited by 870 · cited 1×
“For example, oxytocin was found to increase envy and gloating (Shamay-Tsoory et al., 2009), decrease trust and the tendency to cooperate in individuals with borderline personality disorder (Bartz et al., 2011), and facilitate outgroup derogation (De Dreu et al, 2011).”
BackgroundDodge, K. A., Lochman, J. E., Harnish, J. D., et al. (1997) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.106.1.37 · Cited by 727
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The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
Quintana, D. S., Lischke, A., Grace, S., Scheele, D., Ma, Y., & Becker, B. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00864-7 · Cited by 263
Aggression in Women: Behavior, Brain and Hormones
Denson, T. F., O’Dean, S., Blake, K. R., & Beames, J. R. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00081 · Cited by 189
The neuroscience of empathy and compassion in pro-social behavior
Stevens, F. L., & Taber, K. H. (2021) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2021.107925 · Cited by 198
The Oxytocin–Vasopressin Pathway in the Context of Love and Fear
Carter, C. S. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00356 · Cited by 170
“Treatment with OT also has been implicated in increased aggressive tendencies in certain kinds of computer games, an effect that was attributed to an OT-induced increase in social salience (136).”
Background
Metadata
- Authors
- Ne'eman, R., Perach-Barzilay, N., Fischer-Shofty, M., Atias, A., & Shamay-Tsoory, S. G.
- Affiliations
- University of Haifa (IL)
- Corresponding author
- Ne'eman, R.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 80
- Pages
- 125-131
- ISSN
- 0018-506X (ISSN-L)
- OpenAlex
- W2268363832
- Semantic Scholar
- 202965e347297abe368daf908ec49167b1ddb6ef
- Cited by
- 121
- References
- 47
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 7 · 2023: 12 · 2022: 9 · 2021: 24 · 2020: 26 · 2019: 13 · 2018: 11 · 2017: 8 · 2016: 2
- FWCI
- 15.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Social Psychology › Bullying, Victimization, and Aggression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, aggression, intranasal administration, provocation, social salience, prosocial behavior, antisocial behavior
- MeSH terms
- Administration, Intranasal, Adult, Aggression, Arousal, Cooperative Behavior, Double-Blind Method, Female, Humans, Male, Middle Aged, Oxytocin, Social Behavior, Young Adult
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