Cited by 122Neuroendocrine regulation and behaviorBullying, Victimization, and AggressionNeurotransmitter Receptor Influence on Behavior

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Intranasal administration of oxytocin increases human aggressive behavior

Ne'eman, R., Perach-Barzilay, N., Fischer-Shofty, M., Atias, A., Shamay-Tsoory, S.G.·2016·Hormones and Behavior

DOI 10.1016/j.yhbeh.2016.01.015

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Abstract

Considering its role in prosocial behaviors, oxytocin (OT) has been suggested to diminish levels of aggression. Nevertheless, recent findings indicate that oxytocin may have a broader influence on increasing the salience of social stimuli and may therefore, under certain circumstances, increase antisocial behaviors such as aggression. This controversy led to the following speculations: If indeed oxytocin promotes primarily prosocial behavior, administration of OT is expected to diminish levels of aggression. However, if oxytocin mainly acts to increase the salience of social stimuli, it is expected to elevate levels of aggression following provocation. In order to test this assumption we used the Social Orientation Paradigm (SOP), a monetary game played against a fictitious partner that allows measuring three types of responses in the context of provocation: an aggressive response - reducing a point from the fictitious partner, an individualistic response - adding a point to oneself, and a collaborative response - adding half a point to the partner and half a point to oneself. In the current double-blind, placebo-controlled, within-subject study design, 45 participants completed the SOP task following the administration of oxytocin or placebo. The results indicated that among subjects naïve to the procedure oxytocin increased aggressive responses in comparison with placebo. These results support the saliency hypothesis of oxytocin and suggest that oxytocin plays a complex role in the modulation of human behavior.

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“Treatment with OT also has been implicated in increased aggressive tendencies in certain kinds of computer games, an effect that was attributed to an OT-induced increase in social salience (136).”
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Authors: Ne'eman, R., Perach-Barzilay, N., Fischer-Shofty, M., Atias, A., & Shamay-Tsoory, S. G.
Affiliations: University of Haifa (IL)
Corresponding author: Ne'eman, R.
Venue: Hormones and Behavior
Publisher: Elsevier BV
Published: 2016-04
Volume: 80
Pages: 125-131
ISSN: 0018-506X (ISSN-L)
DOI: 10.1016/j.yhbeh.2016.01.015
OpenAlex: W2268363832
Semantic Scholar: 202965e347297abe368daf908ec49167b1ddb6ef
Cited by: 121
References: 47
Citations by year: 2026: 1 · 2025: 8 · 2024: 7 · 2023: 12 · 2022: 9 · 2021: 24 · 2020: 26 · 2019: 13 · 2018: 11 · 2017: 8 · 2016: 2
FWCI: 15.55
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Hormones and Behavior (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Social Sciences › Psychology › Social Psychology › Bullying, Victimization, and Aggression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: oxytocin, aggression, intranasal administration, provocation, social salience, prosocial behavior, antisocial behavior
MeSH terms: Administration, Intranasal, Adult, Aggression, Arousal, Cooperative Behavior, Double-Blind Method, Female, Humans, Male, Middle Aged, Oxytocin, Social Behavior, Young Adult

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Intranasal administration of oxytocin increases human aggressive behavior

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