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Intranasal administration of oxytocin increases human aggressive behavior
Abstract
Considering its role in prosocial behaviors, oxytocin (OT) has been suggested to diminish levels of aggression. Nevertheless, recent findings indicate that oxytocin may have a broader influence on increasing the salience of social stimuli and may therefore, under certain circumstances, increase antisocial behaviors such as aggression. This controversy led to the following speculations: If indeed oxytocin promotes primarily prosocial behavior, administration of OT is expected to diminish levels of aggression. However, if oxytocin mainly acts to increase the salience of social stimuli, it is expected to elevate levels of aggression following provocation. In order to test this assumption we used the Social Orientation Paradigm (SOP), a monetary game played against a fictitious partner that allows measuring three types of responses in the context of provocation: an aggressive response - reducing a point from the fictitious partner, an individualistic response - adding a point to oneself, and a collaborative response - adding half a point to the partner and half a point to oneself. In the current double-blind, placebo-controlled, within-subject study design, 45 participants completed the SOP task following the administration of oxytocin or placebo. The results indicated that among subjects naïve to the procedure oxytocin increased aggressive responses in comparison with placebo. These results support the saliency hypothesis of oxytocin and suggest that oxytocin plays a complex role in the modulation of human behavior.
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“Oxytocin has been implicated in many social behaviors, from promoting trust, generosity and cooperation 21,22,46,47 to aggravating mistrust and aggressive behavior 48,49 .”
From Oxytocin modulates social value representations in the amygdala (2019) · cites this paper as [48]
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“…setup to test both social and individual behavioral characteristics in two mouse models of increased aggression: i) aggression due to early and prolonged exposure to environmental enrichment (EE) and ii) aggression due to developmental deficiency of the oxytocin receptor (OxtR) (22,23).”
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Metadata
- Authors
- Ne'eman, R., Perach-Barzilay, N., Fischer-Shofty, M., Atias, A., & Shamay-Tsoory, S. G.
- Affiliations
- University of Haifa (IL)
- Corresponding author
- Ne'eman, R.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 80
- Pages
- 125-131
- ISSN
- 0018-506X (ISSN-L)
- OpenAlex
- W2268363832
- Semantic Scholar
- 202965e347297abe368daf908ec49167b1ddb6ef
- Cited by
- 121
- References
- 47
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 7 · 2023: 12 · 2022: 9 · 2021: 24 · 2020: 26 · 2019: 13 · 2018: 11 · 2017: 8 · 2016: 2
- FWCI
- 15.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Social Psychology › Bullying, Victimization, and Aggression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, aggression, intranasal administration, provocation, social salience, prosocial behavior, antisocial behavior
- MeSH terms
- Administration, Intranasal, Adult, Aggression, Arousal, Cooperative Behavior, Double-Blind Method, Female, Humans, Male, Middle Aged, Oxytocin, Social Behavior, Young Adult
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