Oxytocin attenuates deficits in social interaction but not recognition memory in a prenatal valproic acid-induced mouse model of autism
Abstract
Recent studies have reported that oxytocin ameliorates behavioral abnormalities in both animal models and individuals with autism spectrum disorders (ASD). However, the mechanisms underlying the ameliorating effects of oxytocin remain unclear. In this study, we examined the effects of intranasal oxytocin on impairments in social interaction and recognition memory in an ASD mouse model in which animals are prenatally exposed to valproic acid (VPA). We found that a single intranasal administration of oxytocin restored social interaction deficits for up to 2h in mice prenatally exposed to VPA, but there was no effect on recognition memory impairments. Additionally, administration of oxytocin across 2weeks improved prenatal VPA-induced social interaction deficits for at least 24h. In contrast, there were no effects on the time spent sniffing in control mice. Immunohistochemical analysis revealed that intranasal administration of oxytocin increased c-Fos expression in the paraventricular nuclei (PVN), prefrontal cortex, and somatosensory cortex, but not the hippocampal CA1 and CA3 regions of VPA-exposed mice, suggesting the former regions may underlie the effects of oxytocin. These findings suggest that oxytocin attenuates social interaction deficits through the activation of higher cortical areas and the PVN in an ASD mouse model.
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Oxytocin reverses social deficits in several mouse models of ASD.
“Treatment with oxytocin reverses social deficits in several mouse models of ASD (Buffington et al., 2016; Hara et al., 2017; Harony-Nicolas et al., 2017; Penagarikano et al., 2015).”
From Mechanisms underlying microbial-mediated changes in social behavior in mouse models of autism spectrum disorder (2019) · cites this paper as Hara et al., 2017
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- Authors
- Hara, Y., Ago, Y., Higuchi, M., Hasebe, S., Nakazawa, T., Hashimoto, H., Matsuda, T., & Takuma, K.
- Affiliations
- The University of Osaka (JP)
- Kanazawa University (JP)
- Corresponding author
- Takuma, Kazuhiro
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 96
- Pages
- 130-136
- ISSN
- 0018-506X (ISSN-L)
- OpenAlex
- W2757365386
- Cited by
- 61
- References
- 53
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 9 · 2022: 8 · 2021: 10 · 2020: 11 · 2019: 6 · 2018: 8 · 2017: 1
- FWCI
- 10.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- JSPS (JP13J05359, JP25460099, JP16K08268, JP26293020, JP26670122, JP15H01288, 17H03989, JP16K15126)
- Dainippon Sumitomo Pharma Co., Ltd.
- Dainippon Sumitomo Pharma Joint Research Fund
- Uehara Memorial Foundation
- Research Foundation for Pharmaceutical Sciences
- JSPS Program for Advancing Strategic International Networks to Accelerate the Circulation of Talented Researchers
- AMED
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- oxytocin, autism spectrum disorder, valproic acid, prenatal valproic acid exposure, social interaction deficits, recognition memory, intranasal administration, Fos expression, paraventricular nucleus, prefrontal cortex, somatosensory cortex, mouse model
- MeSH terms
- Social Learning, Animals, Autistic Disorder, Behavior, Animal, Disease Models, Animal, Female, Hippocampus, Interpersonal Relations, Male, Mice, Inbred ICR, Oxytocin, Pregnancy, Prenatal Exposure Delayed Effects, Social Behavior, Valproic Acid, Proto-Oncogene Proteins c-fos, Prefrontal Cortex, Recognition, Psychology, Mice
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