Cited by 368MicroRNA in disease regulationCardiac Ischemia and ReperfusionCardiac Fibrosis and Remodeling

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

MicroRNA-21 protects against the H2O2-induced injury on cardiac myocytes via its target gene PDCD4

Open access

Cheng, Yunhui, Liu, Xiaojun, Zhang, Shuo, Lin, Ying, Yang, Jian, Zhang, Chunxiang·2009·Journal of Molecular and Cellular Cardiology

DOI 10.1016/j.yjmcc.2009.01.008PMC PMC3593965

Open this paper in CoChat — free account

Abstract

Reactive oxygen species (ROS)-induced cardiac cell injury via expression changes of multiple genes plays a critical role in the pathogenesis of numerous heart diseases. MicroRNAs (miRNAs) comprise a novel class of endogenous, small, noncoding RNAs that negatively regulate about 30% of the genes in a cell via degradation or translational inhibition of their target mRNAs. Currently, the effects of ROS on miRNA expression and the roles of miRNAs in ROS-mediated injury on cardiac myocytes are uncertain. Using quantitative real-time RT-PCR (qRT-PCR), we demonstrated that microRNA-21 (miR-21) was upregulated in cardiac myocytes after treatment with hydrogen peroxide (H2O2). To determine the potential roles of miRNAs in H2O2-mediated gene regulation and cellular injury, miR-21 expression was downregulated by miR-21 inhibitor and upregulated by pre-miR-21. H2O2-induced cardiac cell death and apoptosis were increased by miR-21 inhibitor and was decreased by pre-miR-21. Programmed cell death 4 (PDCD4) that was regulated by miR-21 and was a direct target of miR-21 in cardiac myocytes. Pre-miR-21-mediated protective effect on cardiac myocyte injury was inhibited in H2O2-treated cardiac cells via adenovirus-mediated overexpression of PDCD4 without miR-21 binding site. Moreover, Activator protein 1 (AP-1) was a downstream signaling molecule of PDCD4 that was involved in miR-21-mediated effect on cardiac myocytes. The results suggest that miR-21 is sensitive to H2O2 stimulation. miR-21 participates in H2O2-mediated gene regulation and functional modulation in cardiac myocytes. miR-21 might play an essential role in heart diseases related to ROS such as cardiac hypertrophy, heart failure, myocardial infarction, and myocardial ischemia/reperfusion injury.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.yjmcc.2009.01.008

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Untitled work
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
Thum, T., Gross, C., Fiedler, J., Fischer, T., Kissler, S., Bussen, M., Galuppo, P., Just, S., Rottbauer, W., Frantz, S., et al. (2008) · Nature · doi:10.1038/nature07511 · Cited by 2,349
MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
Asangani, I. A., Rasheed, S. A. K., Nikolova, D. A., Leupold, J. H., Colburn, N. H., Post, S., & Allgayer, H. (2008) · Oncogene · doi:10.1038/sj.onc.1210856 · Cited by 1,882
Identification of hundreds of conserved and nonconserved human microRNAs
Bentwich, I., Avniel, A., Karov, Y., Aharonov, R., Gilad, S., Barad, O., Barzilai, A., Einat, P., Einav, U., Meiri, E., et al. (2005) · Nature Genetics · doi:10.1038/ng1590 · Cited by 1,841
AP-1 in cell proliferation and survival
Shaulian, E., & Karin, M. (2001) · Oncogene · doi:10.1038/sj.onc.1204383 · Cited by 1,733
The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution
Farh, K. K.-H., Grimson, A., Jan, C., Lewis, B. P., Johnston, W. K., Lim, L. P., Burge, C. B., & Bartel, D. P. (2005) · Science · doi:10.1126/science.1121158 · Cited by 1,484
Phylogenetic Shadowing and Computational Identification of Human microRNA Genes
Berezikov, E., Guryev, V., van de Belt, J., Wienholds, E., Plasterk, R. H. A., & Cuppen, E. (2005) · Cell · doi:10.1016/j.cell.2004.12.031 · Cited by 1,270
MicroRNA Pathways in Flies and Worms
Ambros, V. (2003) · Cell · doi:10.1016/s0092-8674(03)00428-8 · Cited by 1,218
Programmed Cell Death 4 (PDCD4) Is an Important Functional Target of the MicroRNA miR-21 in Breast Cancer Cells
Frankel, L. B., Christoffersen, N. R., Jacobsen, A., Lindow, M., Krogh, A., & Lund, A. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707224200 · Cited by 1,141

Flagged first, then by citations

Show all 36 references

Sorted by citations

Items 101–200 of 368

Regulation of Myocardial Fibrosis by MicroRNAs
Bauersachs, J. K. (2010) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181ee81df · Cited by 74
Screening of microRNAs associated with Alzheimer's disease using oxidative stress cell model and different strains of senescence accelerated mice
Zhang, R., Zhang, Q., Niu, J., Lu, K., Xie, B., Cui, D., & Xu, S. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.12.017 · Cited by 75
MicroRNA: A matter of life or death
Wang, Z. (2010) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v1.i4.41 · Cited by 74
Oxidative Stress Mediated-Alterations of the MicroRNA Expression Profile in Mouse Hippocampal Neurons
Xu, S., Zhang, R., Niu, J., Cui, D., Xie, B., Zhang, B., Lu, K., Yu, W., Wang, X., & Zhang, Q. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131216945 · Cited by 75
Novel techniques and targets in cardiovascular microRNA research
Dangwal, S., Bang, C., & Thum, T. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr297 · Cited by 72
Non-Coding RNAs: Prevention, Diagnosis, and Treatment in Myocardial Ischemia–Reperfusion Injury
Marinescu, M.-C., Lazăr, A.-L., Marta, M. M., Cozma, A., & Cătană, C.-S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052728 · Cited by 72
miRNAs as potential therapeutic targets for age-related macular degeneration
Wang, S., Koster, K. M., He, Y., & Zhou, Q. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.11.176 · Cited by 67
miR-19b attenuates H2O2-induced apoptosis in rat H9C2 cardiomyocytesviatargeting PTEN
Xu, J., Tang, Y., Bei, Y., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7678 · Cited by 66
MicroRNAs and vascular (dys)function
Hartmann, D., & Thum, T. (2011) · Vascular Pharmacology · doi:10.1016/j.vph.2011.07.005 · Cited by 67
Small molecules, big effects: the role of microRNAs in regulation of cardiomyocyte death
Skommer, J., Rana, I., Marques, F. Z., Zhu, W., Du, Z., & Charchar, F. J. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.287 · Cited by 66
Global microRNA expression profiling: curcumin (diferuloylmethane) alters oxidative stress-responsive microRNAs in human ARPE-19 cells.
Howell, J. C., Chun, E., Farrell, A., Hur, E. Y., Caroti, C. M., Iuvone, P. M., & Haque, M. R. (2013) · Europe PMC (PubMed Central) · Cited by 66
A functionalized collagen-I scaffold delivers microRNA 21-loaded exosomes for spinal cord injury repair
Liu, X., Zhang, L., Xu, Z., Xiong, X., Yu, Y., Wu, H., Qiao, H., Zhong, J., Zhao, Z., Dai, J., et al. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.10.027 · Cited by 66
Self-citation
The Role of MicroRNA in Chemical Carcinogenesis
Chen, T. (2010) · Journal of Environmental Science and Health Part C · doi:10.1080/10590501.2010.481477 · Cited by 65
MicroRNA regulation of macrophages in human pathologies
Wei, Y., & Schober, A. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2254-6 · Cited by 65
The role of epigenetics in age-related macular degeneration
Gemenetzi, M. K., & Lotery, A. J. (2014) · Eye · doi:10.1038/eye.2014.225 · Cited by 63
An Analysis of the Global Expression of MicroRNAs in an Experimental Model of Physiological Left Ventricular Hypertrophy
Martinelli, N. C., Cohen, C. R., dos Santos, K. G., Castro, M. A. A., Biolo, A., Frick, L. M., Silvello, D., Lopes, A. G., Schneider, S., Andrades, M. É., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093271 · Cited by 62
Serum-Derived Extracellular Vesicles Protect Against Acute Myocardial Infarction by Regulating miR-21/PDCD4 Signaling Pathway
Gu, H., Liu, Z., Li, Y., Xie, Y., Yao, J., Zhu, Y., Xu, J., Dai, Q., Zhong, C., Zhu, H., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00348 · Cited by 62
Up-regulation of miR-26a promotes apoptosis of hypoxic rat neonatal cardiomyocytes by repressing GSK-3β protein expression
Suh, J. H., Choi, E., Cha, M., et al. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.05.138 · Cited by 61
MicroRNA-21 Attenuates Renal Ischemia Reperfusion Injury via Targeting Caspase Signaling in Mice
Hu, H., Jiang, W., Xi, X., et al. (2014) · American Journal of Nephrology · doi:10.1159/000368202 · Cited by 61
Expression and Function of MicroRNAs in Heart Disease
Ikeda, S., & Pu, W. T. (2010) · Current Drug Targets · doi:10.2174/138945010791591304 · Cited by 62
Circulating microRNAs in response to exercise
Xu, T., Liu, Q., Yao, J., et al. (2015) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12421 · Cited by 60
Essential Role of NADPH Oxidase-Dependent Reactive Oxygen Species Generation in Regulating MicroRNA-21 Expression and Function in Prostate Cancer
Jajoo, S., Mukherjea, D., Kaur, T., Sheehan, K. E., Sheth, S., Borse, V., Rybak, L. P., & Ramkumar, V. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4820 · Cited by 62
MicroRNAs in Cardiac Apoptosis
Li, P. (2010) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-010-9175-9 · Cited by 59
MicroRNAs in Stem Cell Function and Regenerative Therapy of the Heart
Seeger, F. H., Zeiher, A. M., & Dimmeler, S. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.300138 · Cited by 59
Role of microRNA in metabolic shift during heart failure
Pinti, M. V., Hathaway, Q. A., & Hollander, J. M. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00341.2016 · Cited by 59
The protective effect of microRNA-21 in neurons after spinal cord injury
Zhang, T., Ni, S., Luo, Z., Lang, Y., Hu, J., & Lu, H. (2019) · Spinal Cord · doi:10.1038/s41393-018-0180-1 · Cited by 59
MicroRNAs and cardiac sarcoplasmic reticulum calcium ATPase-2 in human myocardial infarction: expression and bioinformatic analysis
Boštjančič, E., Zidar, N., & Glavač, D. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-552 · Cited by 58
Deciphering Non-coding RNAs in Cardiovascular Health and Disease
Das, A., Samidurai, A., & Salloum, F. N. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00073 · Cited by 56
Non-Coding RNAs: The “Dark Matter” of Cardiovascular Pathophysiology
Iaconetti, C., Gareri, C., Polimeni, A., & Indolfi, C. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141019987 · Cited by 58
Have Tumor Suppressor PDCD4 and its Counteragent Oncogenic miR-21 Gone Rogue?
Young, M. R., Santhanam, A. N., Yoshikawa, N., & Colburn, N. H. (2010) · Molecular Interventions · doi:10.1124/mi.10.2.5 · Cited by 55
Identification of differentially expressed microRNAs and their PKC‐isoform specific gene network prediction during hypoxic pre‐conditioning and focal cerebral ischemia of mice
Liu, C., Peng, Z., Zhang, N., Yu, L., Han, S., Li, D., & Li, J. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07624.x · Cited by 54
Differential expression of microRNAs in ischemic heart disease
Song, M., Paradis, A. N., Gay, M. S., Shin, J. Y., & Zhang, L. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.10.004 · Cited by 53
MiR-21 confers resistance against CVB3-induced myocarditis by inhibiting PDCD4-mediated apoptosis
He, J., Yue, Y., Dong, C., & Xiong, S. (2013) · Clinical and investigative medicine · doi:10.25011/cim.v36i2.19573 · Cited by 53
MiR-499-5p protects cardiomyocytes against ischaemic injury via anti-apoptosis by targeting PDCD4
Li, Y.-Q., Lu, J., Bao, X., Wang, X., Wu, J., Li, X., & Hong, W.-Q. (2016) · Oncotarget · doi:10.18632/oncotarget.9597 · Cited by 53
miR-21 suppression prevents cardiac alterations induced by d-galactose and doxorubicin
Bei, Y., Wu, X., Crețoiu, D., Shi, J., Zhou, Q., Lin, S., Wang, H., Cheng, Y., Zhang, H., Xiao, J., et al. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.01.007 · Cited by 51
Self-citation
Endoplasmic reticulum stress serves an important role in cardiac ischemia/reperfusion injury (Review)
Ruan, Y., Zeng, J., Jin, Q., Chu, M., Ji, K., Wang, Z., & Li, L. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.9398 · Cited by 55
Cell type–specific microRNA therapies for myocardial infarction
Liu, B., Wang, B., Zhang, X., Lock, R., Nash, T., & Vunjak-Novakovic, G. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abd0914 · Cited by 53
miRNAs as Therapeutic Targets in Ischemic Heart Disease
Frost, R. J., & van Rooij, E. (2010) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-010-9173-y · Cited by 51
Exosomes Derived from Senescent Endothelial Cells Contain Distinct Pro-angiogenic miRNAs and Proteins
Shaban, S. A., Rezaie, J., & Nejati, V. (2022) · Cardiovascular Toxicology · doi:10.1007/s12012-022-09740-y · Cited by 52
Coxsackievirus-Induced miR-21 Disrupts Cardiomyocyte Interactions via the Downregulation of Intercalated Disk Components
Ye, X., Zhang, H. M., Qiu, Y., Hanson, P., Hemida, M. G., Wei, W., Hoodless, P. A., Chu, F. S. F., & Yang, D. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004070 · Cited by 51
QSKL protects against myocardial apoptosis on heart failure via PI3K/Akt-p53 signaling pathway
Chang, H., Li, C., Wang, Q., Lu, L., Zhang, Q., Zhang, Y., Zhang, N., Wang, Y., & Wang, W. (2017) · Scientific Reports · doi:10.1038/s41598-017-17163-x · Cited by 51
Role of miRNA-1 and miRNA-21 in Acute Myocardial Ischemia-Reperfusion Injury and Their Potential as Therapeutic Strategy
Jayawardena, E., Medzikovic, L., Ruffenach, G., & Eghbali, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031512 · Cited by 50
MicroRNA and Pathogenesis of Enterovirus Infection
Ho, B., Yang, P., & Yu, S. (2016) · Viruses · doi:10.3390/v8010011 · Cited by 52
MicroRNAs as Potential Pharmaco-Targets in Ischemia-Reperfusion Injury Compounded by Diabetes
Dehaini, H., Awada, H., EL‐Yazbi, A. F., Zouein, F. A., Issa, K., Eid, A. A., Ibrahim, M., Badran, A., Baydoun, E., Pintus, G., et al. (2019) · Cells · doi:10.3390/cells8020152 · Cited by 50
PPARγ Ligands Attenuate Hypoxia-Induced Proliferation in Human Pulmonary Artery Smooth Muscle Cells through Modulation of MicroRNA-21
Green, D. E., Murphy, T. C., Kang, B., Searles, C. D., & Hart, C. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133391 · Cited by 49
Redox Regulation and Noncoding RNAs
Leisegang, M. S., Schröder, K., & Brandes, R. P. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7276 · Cited by 51
Oxidative stress modulates the expression of apoptosis-associated microRNAs in bovine granulosa cells in vitro
Sohel, M. M. H., Akyüz, B., Konca, Y., Arslan, K., Sarıözkan, S., & Çınar, M. U. (2019) · Cell and Tissue Research · doi:10.1007/s00441-019-02990-3 · Cited by 48
Diabetic cardiomyopathy: The role of microRNAs and long non-coding RNAs
Mačvanin, M., Gluvic, Z. M., Radovanović, J., Essack, M., Gao, X., & Isenović, E. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1124613 · Cited by 47
MicroRNA-21 Mediates the Protective Effect of Cardiomyocyte-Derived Conditioned Medium on Ameliorating Myocardial Infarction in Rats
Chen, C., Hsu, S.-Y., Chiu, C., & Leu, S. (2019) · Cells · doi:10.3390/cells8080935 · Cited by 47
Targeted miR-21 loaded liposomes for acute myocardial infarction
Li, M., Tang, X., Liu, X., et al. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01821j · Cited by 47
Self-citation
MicroRNA-214 in Health and Disease
Amin, M. M. J., Trevelyan, C. J., & Turner, N. A. (2021) · Cells · doi:10.3390/cells10123274 · Cited by 50
Effects of vitamin E on expressions of eight microRNAs in the liver of Nile tilapia (Oreochromis niloticus)
Tang, X., Xu, M., Li, Z., Pan, Q., & Fu, J.-H. (2013) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2013.03.353 · Cited by 46
MicroRNA 199a-5p induces apoptosis by targeting JunB
Yan, M., Yang, S., Meng, F., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-24932-9 · Cited by 46
Systematic review and network analysis of microRNAs involved in cardioprotection against myocardial ischemia/reperfusion injury and infarction: Involvement of redox signalling
Makkos, A., Ágg, B., Petrovich, B., Varga, Z. V., Görbe, A., & Ferdinandy, P. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.04.034 · Cited by 49
Dissecting micro RNA dysregulation in age‐related macular degeneration: new targets for eye gene therapy
Askou, A. L., Alsing, S., Holmgaard, A., Bek, T., & Corydon, T. J. (2017) · Acta Ophthalmologica · doi:10.1111/aos.13407 · Cited by 46
Up-regulation of MicroRNA-21 Mediates Isoflurane-induced Protection of Cardiomyocytes
Olson, J. M. G., Yan, Y., Bai, X., Ge, Z., Liang, M., Kriegel, A. J., Twaroski, D. M., & Bosnjak, Z. J. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000567 · Cited by 44
A meta-analysis of microRNA expression profiling studies in heart failure
Gholaminejad, A., Zare, N., Dana, N., Shafie, D., Mani, A., & Javanmard, S. H. (2021) · Heart Failure Reviews · doi:10.1007/s10741-020-10071-9 · Cited by 44
Inflammation-Mediated Regulation of MicroRNA Expression in Transplanted Pancreatic Islets
Bravo-Egana, V., Rosero, S., Klein, D., Jiang, Z., Vargas, N., Tsinoremas, N., Doni, M., Podetta, M., Ricordi, C., Molano, R. D., et al. (2012) · Journal of Transplantation · doi:10.1155/2012/723614 · Cited by 43
Silibinin protects H9c2 cardiac cells from oxidative stress and inhibits phenylephrine-induced hypertrophy: potential mechanisms
Anestopoulos, I., Kavo, A. E., Tentes, I. K., Kortsaris, A., Panayiotidis, M. I., Lazou, A., & Pappa, A. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.02.009 · Cited by 43
Micro-RNA and mRNA myocardial tissue expression in biopsy specimen from patients with heart failure
Lai, K., Sanderson, J. E., Izzat, M. B., & Yu, C. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.07.043 · Cited by 43
MicroRNAs Are Involved in End-Organ Damage During Hypertension
Heggermont, W., & Heymans, S. R. B. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.187104 · Cited by 42
Mitochondrial function in cardiac hypertrophy
Zhou, L., Liu, J., Wang, K., Gao, J., Ding, S.-L., Jiao, J.-Q., & Li, P. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.09.082 · Cited by 42
Upregulation of MicroRNA-214 Contributes to the Development of Vascular Remodeling in Hypoxia-induced Pulmonary Hypertension Via Targeting CCNL2
Liu, H., Yin, T., Chen, M., Yü, J., Li, W., Tao, L., Li, Y., & Li, F. (2016) · Scientific Reports · doi:10.1038/srep24661 · Cited by 41
MiR-532-5p alleviates hypoxia-induced cardiomyocyte apoptosis by targeting PDCD4
Ma, J., Zhang, J., Wang, Y., Long, K., Wang, X., Jin, L. G., Tang, Q., Zhu, L., Tang, G., Li, X., et al. (2018) · Gene · doi:10.1016/j.gene.2018.06.087 · Cited by 42
Meta‐Analysis of the Potential Role of miRNA‐21 in Cardiovascular System Function Monitoring
Krzywińska, O., Bracha, M., Jeannière, C., Recchia, E., Kornatowska, K. K., & Kozakiewicz, M. (2020) · BioMed Research International · doi:10.1155/2020/4525410 · Cited by 42
Angiogenesis, mediated by miR-21, is involved arsenite-induced carcinogenesis
Zhao, Y., Xu, Y., Luo, F., et al. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.08.020 · Cited by 40
An essential role of PDCD4 in vascular smooth muscle cell apoptosis and proliferation: implications for vascular disease
Liu, X., Cheng, Y., Yang, J., Krall, T. J., Huo, Y., & Zhang, C. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00413.2009 · Cited by 40
Self-citation
MiRNA Deregulation in Cardiac Aging and Associated Disorders
Verjans, R., van Bilsen, M., & Schroen, B. L. M. (2017) · International review of cytology · doi:10.1016/bs.ircmb.2017.03.004 · Cited by 39
Clinical Value of Circulating Microribonucleic Acids miR-1 and miR-21 in Evaluating the Diagnosis of Acute Heart Failure in Asymptomatic Type 2 Diabetic Patients
Al-Hayali, M. A., Sözer, V., Durmuş, S., Erdenen, F., Altunoğlu, E., Gelışgen, R., Atukeren, P., Atak, P. G., & Uzun, H. (2019) · Biomolecules · doi:10.3390/biom9050193 · Cited by 39
Insulin ameliorates miR-1-induced injury in H9c2 cells under oxidative stress via Akt activation
Chen, T., Ding, G., Jin, Z., Wagner, M. B., & Yuan, Z. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1379-7 · Cited by 38
Role of microRNAs in Vascular Remodeling
Fang, Y., & Yeh, C. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150921105031 · Cited by 38
Mediation of association between polycyclic aromatic hydrocarbon exposure and semen quality by spermatogenesis-related microRNAs: A pilot study in an infertility clinic
Yang, P., Chen, D., Wang, Y., Zhang, L., Huang, L., Lu, W., & Zeng, Q. (2019) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2019.121431 · Cited by 38
Prediction of long-term outcome after acute myocardial infarction using circulating miR-145
Dong, Y., Liu, X., Wei, G., Da, Y.-N., Cha, L., & Ma, C. (2014) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2014.981855 · Cited by 37
Self-citation
miRNAs in Heart Development and Disease
Lozano-Velasco, E., Inácio, J. M., Sousa, I., Guimarães, A. R., Franco, D., Moura, G. R., & Belo, J. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031673 · Cited by 42
MicroRNA and Transcription Factor Mediated Regulatory Network Analysis Reveals Critical Regulators and Regulatory Modules in Myocardial Infarction
Zhang, G., Shi, H., Wang, L., Zhou, M., Wang, Z., Liu, X., Cheng, L., Li, W., & Li, X. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135339 · Cited by 39
Self-citation
MicroRNAs in myocardial ischemia: identifying new targets and tools for treating heart disease. New frontiers for miR-medicine
Sala, V., Bergerone, S., Gatti, S., Gallo, S., Ponzetto, A., Ponzetto, C., & Crepaldi, T. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1504-0 · Cited by 37
Cell-Based and Selected Cell-Free Therapies for Myocardial Infarction: How Do They Compare to the Current Treatment Options?
Csöbönyeiová, M., Beerová, N., Klein, M., Čeháková, M., & Danišovič, Ľ. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810314 · Cited by 38
Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury
Choi, E., Cha, M., & Hwang, K. (2014) · Cells · doi:10.3390/cells3030899 · Cited by 36
Role of noncoding RNAs in regulation of cardiac cell death and cardiovascular diseases
Dong, Y., Liu, C.-Y., Zhao, Y., Ponnusamy, M., Li, P., & Wang, K. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2640-8 · Cited by 36
Retracted: Upregulation of long noncoding RNA TUG1 contributes to the development of laryngocarcinoma by targeting miR‐145‐5p/ROCK1 axis
Zhuang, S., Liu, F., & Wu, P. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28614 · Cited by 36
Retracted
Non-coding RNAs in Cardiac Regeneration
Yuan, T., & Krishnan, J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.650566 · Cited by 35
Diagnostic, Prognostic, and Therapeutic Value of Circulating miRNAs in Heart Failure Patients Associated with Oxidative Stress
Sheikh, M. S. A., Salma, U., Zhang, B., Chen, J., Zhuang, J., & Ping, Z. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/5893064 · Cited by 36
miR-21 increases c-kit+ cardiac stem cell proliferation in vitro through PTEN/PI3K/Akt signaling
Shi, B., Deng, W., Long, X., Zhao, R., Wang, Y., Chen, W., Xu, G., Sheng, J., Wang, D., & Cao, S. (2017) · PeerJ · doi:10.7717/peerj.2859 · Cited by 35
MicroRNA-21 ablation exacerbates aldosterone-mediated cardiac injury, remodeling, and dysfunction
Syed, M., Ball, J. P., Mathis, K. W., Hall, M. E., Ryan, M. J., Rothenberg, M. E., Cardozo, L. L. Y., & Romero, D. G. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00155.2018 · Cited by 35
Deficiency of programmed cell death 4 results in increased IL-10 expression by macrophages and thereby attenuates atherosclerosis in hyperlipidemic mice
Jiang, Y., Gao, Q., Wang, L., Guo, C., Zhu, F., Wang, B., Wang, Q., Gao, F., Chen, Y., & Zhang, L. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2015.47 · Cited by 48
miR‐21 Reduces Hydrogen Peroxide‐Induced Apoptosis in c‐kit+ Cardiac Stem Cells In Vitro through PTEN/PI3K/Akt Signaling
Deng, W., Wang, Y., Long, X., Zhao, R., Wang, Z., Liu, Z., Cao, S., & Shi, B. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/5389181 · Cited by 34
Reduced camptothecin sensitivity of estrogen receptor‐positive human breast cancer cells following exposure to di(2‐ethylhexyl)phthalate (DEHP) is associated with DNA methylation changes
Chou, C., Huang, H., Yang, C., Dahms‬, H.-U., Liang, S., Wang, T., Kuo, P., Hsi, E., Tsai, E., & Chiu, C. (2019) · Environmental Toxicology · doi:10.1002/tox.22694 · Cited by 34
Tanshinone IIA alleviates acute ethanol‐induced myocardial apoptosis mainly through inhibiting the expression of PDCD4 and activating the PI3K /Akt pathway
Deng, H., Yu, B., & Li, Y. (2021) · Phytotherapy Research · doi:10.1002/ptr.7102 · Cited by 34
Inhibitory effect of microRNA-21 on pathways and mechanisms involved in cardiac fibrosis development
Khalaji, A., Mehrtabar, S., Jabraeilipour, A., Doustar, N., Youshanlouei, H. R., Tahavvori, A., Fattahi, P., Alavi, S. M. A., Taha, S. R., Naghibi, A. F., et al. (2024) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/17539447241253134 · Cited by 38
Grape Seed Procyanidin B2 Protects Porcine Ovarian Granulosa Cells against Oxidative Stress-Induced Apoptosis by Upregulating let-7a Expression
Zhang, J., Wang, X.-W., Chen, J., Ren, Q., Wang, J., Gao, B., Shi, Z., Zhang, Z., Bai, X., & Xing, B. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/1076512 · Cited by 32
Overexpression of microRNA-145 protects against rat myocardial infarction through targeting PDCD4.
Xu, H., Cao, H., Zhu, G., et al. (2017) · PubMed · Cited by 33
The microRNAs as potential biomarkers for predicting the onset of aflatoxin exposure in human beings: a review
Quintana, R. V., Sánchez-Alarcón, J., Arvide, M. G. T., Deng, Y., Montiel-González, J. M. R., Gómez‐Arroyo, S., Villalobos‐Pietrini, R., Cortés‐Eslava, J., Flores-Márquez, A. R., & Arenas‐Huertero, F. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00102 · Cited by 32
Non‐coding RNAs in cardiac hypertrophy
Ottaviani, L., & Martins, P. A. D. C. (2017) · The Journal of Physiology · doi:10.1113/jp273129 · Cited by 33
Association Between the Deletion Allele of Ins/Del Polymorphism (Rs145204276) in the Promoter Region of GAS5 with the Risk of Atherosclerosis
Shen, Z., & She, Q. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000493447 · Cited by 32
MiR-124 attenuates doxorubicin-induced cardiac injury via inhibiting p66Shc-mediated oxidative stress
Liu, Y., Li, Y., Ni, J., Shu, Y., Wang, H., & Hu, T. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.10.157 · Cited by 34
Circulating miRNA-21 as a diagnostic biomarker in elderly patients with type 2 cardiorenal syndrome
Wang, Y., Liang, Y., Zhao, W., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-61836-z · Cited by 32
Circular RNA Rbms1 inhibited the development of myocardial ischemia reperfusion injury by regulating miR-92a/BCL2L11 signaling pathway
Jin, L., Zhang, Y., Jiang, Y., Tan, M., & Liu, C. (2022) · Bioengineered · doi:10.1080/21655979.2022.2025696 · Cited by 33
Implication of microRNAs in atrial natriuretic peptide and nitric oxide signaling in vascular smooth muscle cells
Kumar, K. U., Hesabi, B., & Danziger, R. S. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00088.2011 · Cited by 32
Diagnostic and prognostic value of circulating microRNAs in heart failure with preserved and reduced ejection fraction
Schulte, C. (2015) · World Journal of Cardiology · doi:10.4330/wjc.v7.i12.843 · Cited by 33
MicroRNA-21/PDCD4 Proapoptotic Signaling From Circulating CD34+ Cells to Vascular Endothelial Cells: A Potential Contributor to Adverse Cardiovascular Outcomes in Patients With Critical Limb Ischemia
Spinetti, G., Sangalli, E., Tagliabue, E., Maselli, D., Colpani, O., Ferland-McCollough, D., Carnelli, F., Orlando, P., Paccagnella, A., Furlan, A., et al. (2020) · Diabetes Care · doi:10.2337/dc19-2227 · Cited by 32

Authors: Cheng, Y., Liu, X., Zhang, S., Lin, Y., Yang, J., & Zhang, C.
Affiliations: Rutgers New Jersey Medical School (US)
Corresponding author: Zhang, Chunxiang
ORCID: Liu, Xiaojun
Zhang, Shuo
Lin, Ying
Yang, Jian
Zhang, Chunxiang
Venue: Journal of Molecular and Cellular Cardiology
Publisher: Elsevier BV
Published: 2009-07
Volume: 47
Issue: 1
Pages: 5-14
ISSN: 0022-2828 (ISSN-L)
DOI: 10.1016/j.yjmcc.2009.01.008
PMC: PMC3593965
OpenAlex: W2141570739
Semantic Scholar: 1fbe4e1a56db9230d95dce535ef1d9e12a4d760a
Cited by: 368
References: 36
Citations by year: 2026: 8 · 2025: 9 · 2024: 14 · 2023: 11 · 2022: 16 · 2021: 20 · 2020: 24 · 2019: 25 · 2018: 23 · 2017: 18 · 2016: 29 · 2015: 23 · 2014: 26 · 2013: 28 · 2012: 29
FWCI: 10.27
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Molecular and Cellular Cardiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (HL 080133, R01HL095707, R01HL080133)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords: miR-21, PDCD4, hydrogen peroxide, reactive oxygen species, cardiomyocytes, oxidative stress, apoptosis, cardioprotection, AP-1, microRNA target regulation, heart disease
MeSH terms: Animals, Hydrogen Peroxide, Necrosis, Blotting, Western, Rats, Sprague-Dawley, Apoptosis, Transcription Factor AP-1, Reverse Transcriptase Polymerase Chain Reaction, Myocytes, Cardiac, MicroRNAs, Apoptosis Regulatory Proteins, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

MicroRNA-21 protects against the H2O2-induced injury on cardiac myocytes via its target gene PDCD4

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks