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Adenoviruses as vaccine vectors
Open accessAbstract
Adenoviruses have transitioned from tools for gene replacement therapy to bona fide vaccine delivery vehicles. They are attractive vaccine vectors as they induce both innate and adaptive immune responses in mammalian hosts. Currently, adenovirus vectors are being tested as subunit vaccine systems for numerous infectious agents ranging from malaria to HIV-1. Additionally, they are being explored as vaccines against a multitude of tumor-associated antigens. In this review we describe the molecular biology of adenoviruses as well as ways the adenovirus vectors can be manipulated to enhance their efficacy as vaccine carriers. We describe methods of evaluating immune responses to transgene products expressed by adenoviral vectors and discuss data on adenoviral vaccines to a selected number of pathogens. Last, we comment on the limitations of using human adenoviral vectors and provide alternatives to circumvent these problems. This field is growing at an exciting and rapid pace, thus we have limited our scope to the use of adenoviral vectors as vaccines against viral pathogens.
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“In addition, most humans have been infected with AdV since infancy and have generated neutralizing antibodies at least towards common serotypes of AdV [29,33].”
From Viral Delivery Systems for CRISPR (2019) · cites this paper as [29]
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“Furthermore, the use of two immunisations gives a durable and long-lasting immune response.8, 9”
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“The AdV genome remains extrachromosomal following injection and does not integrate into the host genome [29].”
From Viral Delivery Systems for CRISPR (2019) · cites this paper as [29]
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Metadata
- Authors
- Tatsis, N., & Ertl, H. C. J.
- Affiliations
- The Wistar Institute (US)
- Corresponding author
- Ertl, Hildegund C.J.
- ORCID
- Ertl, Hildegund C.J.
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 10
- Issue
- 4
- Pages
- 616-629
- ISSN
- 1525-0016 (ISSN-L)
- PMC
- PMC7106330
- OpenAlex
- W1972258033
- Cited by
- 669
- References
- 134
- Citations by year
- 2026: 16 · 2025: 28 · 2024: 31 · 2023: 60 · 2022: 58 · 2021: 69 · 2020: 26 · 2019: 25 · 2018: 19 · 2017: 20 · 2016: 26 · 2015: 24 · 2014: 21 · 2013: 28 · 2012: 23
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Molecular Therapy (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- adenoviral vector, vaccine vectors, subunit vaccine, viral vaccines, innate immune response, adaptive immune response, transgene expression, HIV-1 vaccine, malaria vaccine, tumor-associated antigens
- MeSH terms
- Adenoviridae, Adenoviridae Infections, Genes, Viral, Genetic Vectors, Humans, Peptides, Viral Vaccines
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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