The DOI matches its Crossref record; 132 of the 134 references it cites were found in a registry or an index.
Adenoviruses as vaccine vectors
Open accessAbstract
Adenoviruses have transitioned from tools for gene replacement therapy to bona fide vaccine delivery vehicles. They are attractive vaccine vectors as they induce both innate and adaptive immune responses in mammalian hosts. Currently, adenovirus vectors are being tested as subunit vaccine systems for numerous infectious agents ranging from malaria to HIV-1. Additionally, they are being explored as vaccines against a multitude of tumor-associated antigens. In this review we describe the molecular biology of adenoviruses as well as ways the adenovirus vectors can be manipulated to enhance their efficacy as vaccine carriers. We describe methods of evaluating immune responses to transgene products expressed by adenoviral vectors and discuss data on adenoviral vaccines to a selected number of pathogens. Last, we comment on the limitations of using human adenoviral vectors and provide alternatives to circumvent these problems. This field is growing at an exciting and rapid pace, thus we have limited our scope to the use of adenoviral vectors as vaccines against viral pathogens.
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“In addition, most humans have been infected with AdV since infancy and have generated neutralizing antibodies at least towards common serotypes of AdV [29,33].”
From Viral Delivery Systems for CRISPR (2019) · cites this paper as [29]
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“Furthermore, the use of two immunisations gives a durable and long-lasting immune response.8, 9”
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“The AdV genome remains extrachromosomal following injection and does not integrate into the host genome [29].”
From Viral Delivery Systems for CRISPR (2019) · cites this paper as [29]
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Cites
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Logunov, D. Y., Dolzhikova, I. V., Shcheblyakov, D. V., Tukhvatulin, A. I., Zubkova, O. V., Dzharullaeva, A. S., Kovyrshina, A. V., Lubenets, N. L., Grousova, D. M., Erokhova, A. S., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00234-8 · Cited by 1,747
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
Darrah, P. A., Patel, D. T., Luca, P. M. D., Lindsay, R. W. B., Davey, D. F., Flynn, B. J., Hoff, S. T., Andersen, P. L., Reed, S. G., Morris, S. L., et al. (2007) · Nature Medicine · doi:10.1038/nm1592 · Cited by 1,364
Logunov, D. Y., Dolzhikova, I. V., Zubkova, O. V., Tukhvatulin, A. I., Shcheblyakov, D. V., Dzharullaeva, A. S., Grousova, D. M., Erokhova, A. S., Kovyrshina, A. V., Botikov, A. G., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31866-3 · Cited by 1,055
Viral Vectors for Gene Therapy: Translational and Clinical Outlook
Kotterman, M. A., Chalberg, T. W., & Schaffer, D. V. (2015) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071813-104938 · Cited by 424
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Metadata
- Authors
- Tatsis, N., & Ertl, H. C. J.
- Affiliations
- The Wistar Institute (US)
- Corresponding author
- Ertl, Hildegund C.J.
- ORCID
- Ertl, Hildegund C.J.
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 10
- Issue
- 4
- Pages
- 616-629
- ISSN
- 1525-0016 (ISSN-L)
- PMC
- PMC7106330
- OpenAlex
- W1972258033
- Cited by
- 669
- References
- 134
- Citations by year
- 2026: 16 · 2025: 28 · 2024: 31 · 2023: 60 · 2022: 58 · 2021: 69 · 2020: 26 · 2019: 25 · 2018: 19 · 2017: 20 · 2016: 26 · 2015: 24 · 2014: 21 · 2013: 28 · 2012: 23
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Molecular Therapy (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- adenoviral vector, vaccine vectors, subunit vaccine, viral vaccines, innate immune response, adaptive immune response, transgene expression, HIV-1 vaccine, malaria vaccine, tumor-associated antigens
- MeSH terms
- Adenoviridae, Adenoviridae Infections, Genes, Viral, Genetic Vectors, Humans, Peptides, Viral Vaccines
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