Cited by 669Virus-based gene therapy researchImmunotherapy and Immune ResponsesSARS-CoV-2 and COVID-19 Research

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Adenoviruses as vaccine vectors

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Tatsis, Nia, Ertl, Hildegund C.J.·2004·Molecular Therapy

DOI 10.1016/j.ymthe.2004.07.013PMC PMC7106330

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Abstract

Adenoviruses have transitioned from tools for gene replacement therapy to bona fide vaccine delivery vehicles. They are attractive vaccine vectors as they induce both innate and adaptive immune responses in mammalian hosts. Currently, adenovirus vectors are being tested as subunit vaccine systems for numerous infectious agents ranging from malaria to HIV-1. Additionally, they are being explored as vaccines against a multitude of tumor-associated antigens. In this review we describe the molecular biology of adenoviruses as well as ways the adenovirus vectors can be manipulated to enhance their efficacy as vaccine carriers. We describe methods of evaluating immune responses to transgene products expressed by adenoviral vectors and discuss data on adenoviral vaccines to a selected number of pathogens. Last, we comment on the limitations of using human adenoviral vectors and provide alternatives to circumvent these problems. This field is growing at an exciting and rapid pace, thus we have limited our scope to the use of adenoviral vectors as vaccines against viral pathogens.

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Authors: Tatsis, N., & Ertl, H. C. J.
Affiliations: The Wistar Institute (US)
Corresponding author: Ertl, Hildegund C.J.
ORCID: Ertl, Hildegund C.J.
Venue: Molecular Therapy
Publisher: Elsevier BV
Published: 2004-10
Volume: 10
Issue: 4
Pages: 616-629
ISSN: 1525-0016 (ISSN-L)
DOI: 10.1016/j.ymthe.2004.07.013
PMC: PMC7106330
OpenAlex: W1972258033
Cited by: 669
References: 134
Citations by year: 2026: 16 · 2025: 28 · 2024: 31 · 2023: 60 · 2022: 58 · 2021: 69 · 2020: 26 · 2019: 25 · 2018: 19 · 2017: 20 · 2016: 26 · 2015: 24 · 2014: 21 · 2013: 28 · 2012: 23
FWCI: 3.15
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 4389 d)
Locations: Molecular Therapy (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Keywords: adenoviral vector, vaccine vectors, subunit vaccine, viral vaccines, innate immune response, adaptive immune response, transgene expression, HIV-1 vaccine, malaria vaccine, tumor-associated antigens
MeSH terms: Adenoviridae, Adenoviridae Infections, Genes, Viral, Genetic Vectors, Humans, Peptides, Viral Vaccines

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Adenoviruses as vaccine vectors

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