Disruption of oligodendrogenesis impairs memory consolidation in adult mice
Open accessAbstract
The generation of myelin-forming oligodendrocytes persists throughout life and is regulated by neural activity. Here we tested whether experience-driven changes in oligodendrogenesis are important for memory consolidation. We found that water maze learning promotes oligodendrogenesis and de novo myelination in the cortex and associated white matter tracts. Preventing these learning-induced increases in oligodendrogenesis without affecting existing oligodendrocytes impaired memory consolidation of water maze, as well as contextual fear, memories. These results suggest that de novo myelination tunes activated circuits, promoting coordinated activity that is important for memory consolidation. Consistent with this, contextual fear learning increased the coupling of hippocampal sharp wave ripples and cortical spindles, and these learning-induced increases in ripple-spindle coupling were blocked when oligodendrogenesis was suppressed. Our results identify a non-neuronal form of plasticity that remodels hippocampal-cortical networks following learning and is required for memory consolidation.
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Even small changes in myelination can exert profound effects on neural circuit dynamics and consequently on cognitive function.
“even small changes in myelination can exert profound effects on neural circuit dynamics and consequently on cognitive function (Steadman et al., 2020; Noori et al., 2020; Pajevic et al., 2014).”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Steadman et al., 2020
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- Authors
- Steadman, P. E., Xia, F., Ahmed, M., Mocle, A. J., Penning, A. R. A., Geraghty, A. C., Steenland, H. W., Monje, M., Josselyn, S. A., & Frankland, P. W.
- Affiliations
- University of Toronto (CA)
- Hospital for Sick Children (CA)
- Stanford University (US)
- Canadian Institute for Advanced Research (CA)
- Corresponding author
- Frankland, Paul W.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 105
- Issue
- 1
- Pages
- 150-164.e6
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC7579726
- OpenAlex
- W2983638220
- Cited by
- 426
- References
- 57
- Citations by year
- 2026: 52 · 2025: 61 · 2024: 67 · 2023: 60 · 2022: 66 · 2021: 73 · 2020: 44 · 2019: 2
- FWCI
- 17.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Canadian Institutes of Health Research (FDN143227, PJT156164, MOP74650)
- CIHR (Vanier graduate scholarship, Arnie Aberman fellowship, McLaughlin MD/PhD studentship)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- oligodendrogenesis, memory consolidation, water maze learning, contextual fear memory, sharp-wave ripples, white matter
- MeSH terms
- Memory Consolidation, Animals, Cell Differentiation, Cerebral Cortex, Conditioning, Psychological, Electric Stimulation, Fear, Female, Hippocampus, Male, Mice, Transgenic, Myelin Sheath, Neural Pathways, Oligodendroglia, Transcription Factors, Maze Learning, Mice
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