Cited by 111Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Appearance of Sodium Dodecyl Sulfate-Stable Amyloid β-Protein (Aβ) Dimer in the Cortex During Aging

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Enya, Miho, Morishima-Kawashima, Maho, Yoshimura, Masahiro, Shinkai, Yasuhisa, Kusui, Kaoru, Khan, Karen, Games, Dora, Schenk, Dale, Sugihara, Shiro, Yamaguchi, Haruyasu, Ihara, Yasuo·1999·The American Journal of Pathology

DOI 10.1016/s0002-9440(10)65273-xPMC PMC1853431

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Abstract

We previously noted that some aged human cortical specimens containing very low or negligible levels of amyloid beta-protein (As) by enzyme immunoassay (EIA) provided prominent signals at 6 approximately 8 kd on the Western blot, probably representing sodium dodecyl sulfate (SDS)-stable Abeta dimer. Re-examination of the specificity of the EIA revealed that BAN50- and BNT77-based EIA, most commonly used for the quantitation of Abeta, capture SDS-dissociable Abeta but not SDS-stable Abeta dimer. Thus, all cortical specimens in which the levels of Abeta were below the detection limits of EIA were subjected to Western blot analysis. A fraction of such specimens contained SDS-stable dimer at 6 approximately 8 kd, but not SDS-dissociable A(beta) monomer at approximately 4 kd, as judged from the blot. This A(beta) dimer is unlikely to be generated after death, because (i) specimens with very short postmortem delay contained the A(beta) dimer, and (ii) until 12 hours postmortem, such SDS-stable A(beta) dimer is detected only faintly in PDAPP transgenic mice. The presence of A(beta) dimer in the cortex may characterize the accumulation of A(beta) in the human brain, which takes much longer than that in PDAPP transgenic mice.

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Additional file 1 of Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer’s disease immunotherapeutics
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Additional file 5 of Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer’s disease immunotherapeutics
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Additional file 2 of Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer’s disease immunotherapeutics
Wang, Z., Jin, M., Hong, W., Liu, W., Reczek, D., Lagomarsino, V. N., Hu, Y., Weeden, T., Frosch, M. P., Young‐Pearse, T. L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26574277

Authors: Enya, M., Morishima-Kawashima, M., Yoshimura, M., Shinkai, Y., Kusui, K., Khan, K., Games, D., Schenk, D., Sugihara, S., Yamaguchi, H., & Ihara, Y.
Affiliations: Japan Science and Technology Agency (JP)
Kyoto Prefectural University of Medicine (JP)
Tokyo Women's Medical University (JP)
Gunma Prefectural Cancer Center (JP)
Gunma University (JP)
Corresponding author: Ihara, Yasuo
ORCID: Yoshimura, Masahiro
Ihara, Yasuo
Venue: The American Journal of Pathology
Publisher: Elsevier BV
Published: 1999-01
Volume: 154
Issue: 1
Pages: 271-279
ISSN: 0002-9440 (ISSN-L)
DOI: 10.1016/s0002-9440(10)65273-x
PMC: PMC1853431
OpenAlex: W2088449278
Cited by: 111
References: 42
Citations by year: 2026: 2 · 2024: 10 · 2023: 4 · 2021: 5 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 6 · 2014: 4 · 2012: 5
FWCI: 3.78
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: American Journal Of Pathology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Health, Labour and Welfare
Ministry of Education, Culture, Sports, Science and Technology (09835003)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: amyloid-beta, amyloid-beta dimers, cerebral cortex, brain aging, postmortem delay, amyloid accumulation, Alzheimer's disease
MeSH terms: Adult, Aged, Aged, 80 and over, Aging, Animals, Antibodies, Monoclonal, Cerebral Cortex, Drug Stability, Female, Humans, Immunoenzyme Techniques, Male, Mice, Transgenic, Middle Aged, Molecular Conformation, Sodium Dodecyl Sulfate, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Dimerization, Mice

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Appearance of Sodium Dodecyl Sulfate-Stable Amyloid β-Protein (Aβ) Dimer in the Cortex During Aging

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