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Alzheimer's disease: synaptic dysfunction and Aβ

Shankar, Ganesh M, Walsh, Dominic M·2009·Molecular Neurodegeneration
DOI 10.1186/1750-1326-4-48PMC PMC2788538
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  • In Alzheimer's disease, accumulation, aggregation, and deposition of Aβ peptides in the brain are critical steps in pathogenesis.

    “Increasing evidence supports the hypothesis that accumulation, aggregation, and deposition of amyloid-β (Aβ) peptides in the brain are critical steps in its pathogenesis (Selkoe, 2001; Shankar and Walsh, 2009).”

    From Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-β Uptake (2011) · cites this paper as Shankar and Walsh, 2009

    In the Introduction section “Aβ exists in many different assembly forms” (page unavailable), the paper describes a proposed pathogenic cascade beginning with Aβ accumulation and discusses its aggregation into multiple forms. It does not establish deposition in plaques as a critical step; instead, it notes that plaque quantity and progression correlate poorly with clinical progression. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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Metadata

Authors
Shankar, G. M., & Walsh, D. M.
Venue
Molecular Neurodegeneration
Publisher
Springer Science and Business Media LLC
Published
2009
Volume
4
Issue
1
Pages
48
ISSN
1750-1326
DOI
10.1186/1750-1326-4-48
PMC
PMC2788538
Cited by
486
References
40
Language
en

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