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The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia
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Concentrations of soluble Aβ species, not the presence of plaques, seem to strongly correlate with cognitive deficits in mouse models and AD pathology in patients.
“As recent works suggest, the concentrations of soluble Aβ species, not the presence of plaques, seem to strongly correlate with the cognitive deficits in mouse models (54) and AD pathology in patients (55,56).”
From Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier (2015) · cites this paper as [56]
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Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Self-citationAlzheimer's Disease Is a Synaptic Failure
Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420
Self-citationShankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685
Self-citationAmyloid deposition as the central event in the aetiology of Alzheimer’s disease
Hardy, J., & Allsop, D. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90609-v · Cited by 2,538
Aβ Oligomers – a decade of discovery
Walsh, D. M., & Selkoe, D. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04426.x · Cited by 1,938
Self-citationCorrelation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline
Näslund, J. (2000) · JAMA · doi:10.1001/jama.283.12.1571 · Cited by 1,268
Katzman, R., Terry, R., DeTeresa, R., Brown, T., Davies, P., Fuld, P., Renbing, X., & Peck, A. (1988) · Annals of Neurology · doi:10.1002/ana.410230206 · Cited by 1,225
Age, Neuropathology, and Dementia
Savva, G. M., Wharton, S. B., Ince, P. G., Forster, G., Matthews, F. E., & Brayne, C. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0806142 · Cited by 900
Self-citationWang, J., Dickson, D. W., Trojanowski, J. Q., & Lee, V. M.-Y. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7085 · Cited by 567
Klyubin, I., Betts, V., Welzel, A. T., Blennow, K., Zetterberg, H., Wallin, A., Lemere, C. A., Cullen, W. K., Peng, Y., Wisniewski, T., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5161-07.2008 · Cited by 321
Self-citationMatthews, F. E., Brayne, C., Lowe, J., McKeith, I., Wharton, S. B., & Ince, P. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000180 · Cited by 279
Self-citationLue, L.-F., Brachova, L., Civin, H. W., & Rogers, J. (1996) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199655100-00008 · Cited by 246
Appearance of Sodium Dodecyl Sulfate-Stable Amyloid β-Protein (Aβ) Dimer in the Cortex During Aging
Enya, M., Morishima-Kawashima, M., Yoshimura, M., Shinkai, Y., Kusui, K., Khan, K., Games, D., Schenk, D., Sugihara, S., Yamaguchi, H., et al. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65273-x · Cited by 111
Flagged first, then by citations
Research works printed but not linked: 25
- Ball, 1997, Consensus recommendations for the postmortem diagnosis of Alzheimers-disease, Neurobiol Aging, 18, S12
- Brayne, 2006, Medical Research Council Cognitive Function and Ageing Study (CFAS). Cohort profile: the Medical Research Council Cognitive Function and Ageing Study (CFAS), Int J Epidemiol, 35, 1140, 10.1093/ije/dyl199 · DOI
- Copeland, 1990, Dementia and depression in elderly persons: AGECAT compared with DSM III and pervasive illness, Int J Geriatr Psychiatry, 5, 47, 10.1002/gps.930050108 · DOI
- Dickson, 1991, Identification of normal and pathological aging in prospectively studied nondemeneted elderly individuals, Neurobiol Aging, 13, 179, 10.1016/0197-4580(92)90027-U · DOI · Paper page
- Funato, 1999, Presence of sodium dodecyl sulfate-stable amyloid β-protein in the hippocampus CA1 not exhibiting neurofibrillary tangle formation, Am J Pathol, 155, 23, 10.1016/S0002-9440(10)65094-8 · DOI
- Funato, 1998, Quantitation of amyloid beta-protein (Aβ) in the cortex during aging and in Alzheimer’s-disease, Am J Pathol, 152, 1633
- Huppert, 1995, CAMCOG-a concise neuropsychological test to assist dementia diagnosis: sociodemographic determinants in an elderly population sample, Br J Clin Psychol, 34, 529, 10.1111/j.2044-8260.1995.tb01487.x · DOI
- Ida, 1996, Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay, J Biol Chem, 271, 22908, 10.1074/jbc.271.37.22908 · DOI
- Johnson-Wood, 1997, Amyloid precursor protein processing and Aß42 deposition in a transgenic mouse model of Alzheimer disease, Proc Natl Acad Sci, 94, 1550, 10.1073/pnas.94.4.1550 · DOI
- Klein, 2001, Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?, Trends Neurosci, 24, 219, 10.1016/S0166-2236(00)01749-5 · DOI · Paper page
- Kuo, 1996, Water-soluble Aβ (N-40, N-42) oligomers in normal and Alzheimer disease brains, J Biol Chem, 271, 4077, 10.1074/jbc.271.8.4077 · DOI · Paper page
- Lue, 1999, Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease, Am J Pathol, 155, 853, 10.1016/S0002-9440(10)65184-X · DOI · Paper page
- McLean, 1999, Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease, Ann Neurol, 46, 860, 10.1002/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M · DOI
- Mirra, 1991, The Consortium to Establish a Registry for Alzheimer's disease (CERAD), Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology, 41, 479
- Morishima-Kawashima, 1998, The presence of amyloid ß-protein in the detergent-insoluble membrane compartment of human neuroblastoma cells, Biochemistry, 37, 15247, 10.1021/bi981843u · DOI
- Piert, 1996, Diminished glucose transport and phosphorylation in Alzheimer's disease determined by dynamic FDG-PET, J Nucl Med, 37, 201
- Roher, 1993, β-amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer's disease, Proc Natl Acad Sci, 90, 10836, 10.1073/pnas.90.22.10836 · DOI · Paper page
- Schagger, 1987, Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa, Anal Biochem, 166, 368, 10.1016/0003-2697(87)90587-2 · DOI
- Selkoe, 1991, The molecular pathology of Alzheimer's disease, Neuron, 6, 487, 10.1016/0896-6273(91)90052-2 · DOI · Paper page
- Steinerman, 2008, Distinct pools of beta-amyloid in alzheimer disease-affected brain, Arch Neurol, 65, 906, 10.1001/archneur.65.7.906 · DOI · Paper page
- Stenh, 2005, Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay, Ann Neurol, 58, 147, 10.1002/ana.20524 · DOI · Paper page
- Tamaoka, 1994, Biochemical evidence for the long-tail form (Abeta 1-42/43) of amyloid beta protein as a seed molecule in cerebral deposits of Alzheimer's disease, Biochem Biophys Res Commun, 205, 834, 10.1006/bbrc.1994.2740 · DOI
- Terry, 1991, Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment, Ann Neurol, 30, 572, 10.1002/ana.410300410 · DOI · Paper page
- Walsh, 2003, The many faces of Aß: Structures and activity, Curr Med Chem Immununol EndocrMetab Agent, 3, 277, 10.2174/1568013033483311 · DOI
- Walsh, 2000, Detection of intracellular oligomers of amyloid ß-protein in cells derived from human brain, Biochemistry, 39, 10831, 10.1021/bi001048s · DOI · Paper page
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Sorted by citations
Neuropathological alterations in Alzheimer disease
Serrano-Pozo, A., Frosch, M. P., Masliah, E., & Hyman, B. T. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006189 · Cited by 3,345
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
Benilova, I., Karran, E., & De Strooper, B. (2012) · Nature Neuroscience · doi:10.1038/nn.3028 · Cited by 1,962
The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade
Cline, E. N., Bicca, M. A., Viola, K. L., & Klein, W. L. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179941 · Cited by 870
Busche, M. A., Chen, X., Henning, H. A., Reichwald, J., Staufenbiel, M., Sakmann, B., & Konnerth, A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206171109 · Cited by 715
Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease
Morris, G. P., Clark, I. A., & Vissel, B. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0135-5 · Cited by 522
Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier
Storck, S. E., Meister, S., Nahrath, J., Meißner, J. N., Schubert, N., Di Spiezio, A., Baches, S., Vandenbroucke, R. E., Bouter, Y., Prikulis, I., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci81108 · Cited by 477
Dissecting phenotypic traits linked to human resilience to Alzheimer’s pathology
Perez-Nievas, B. G., Stein, T. D., Tai, H.-C., Dols-Icardo, O., Scotton, T. C., Barroeta-Espar, I., Fernandez-Carballo, L., de Munain, E. L., Perez, J., Marquie, M., et al. (2013) · Brain · doi:10.1093/brain/awt171 · Cited by 387
Soluble Aβ oligomer production and toxicity
Larson, M. E., & Lesné, S. E. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07478.x · Cited by 356
Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β
Koffie, R. M., Hashimoto, T., Tai, H.-C., Kay, K. R., Serrano-Pozo, A., Joyner, D., Hou, S., Kopeikina, K. J., Frosch, M. P., Lee, V. M., et al. (2012) · Brain · doi:10.1093/brain/aws127 · Cited by 327
Amyloid β-protein oligomers and Alzheimer’s disease
Hayden, E. Y., & Teplow, D. B. (2013) · Alzheimer's Research & Therapy · doi:10.1186/alzrt226 · Cited by 276
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O'Nuallain, B., Freir, D. B., Nicoll, A. J., Risse, E., Ferguson, N., Herron, C. E., Collinge, J., & Walsh, D. M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3537-10.2010 · Cited by 259
Self-citationBarry, A. E., Klyubin, I., Mc Donald, J. M., Mably, A. J., Farrell, M. A., Scott, M., Walsh, D. M., & Rowan, M. J. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6500-10.2011 · Cited by 237
Self-citationSoluble Aβ Seeds Are Potent Inducers of Cerebral β-Amyloid Deposition
Langer, F., Eisele, Y. S., Fritschi, S. K., Staufenbiel, M., Walker, L. C., & Jucker, M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3088-11.2011 · Cited by 237
Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer’s Disease
Cioffi, F., Adam, R. H. I., & Broersen, K. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190863 · Cited by 204
Ketones block amyloid entry and improve cognition in an Alzheimer's model
Yin, J. X., Maalouf, M., Han, P., Zhao, M., Gao, M., Dharshaun, T., Ryan, C., Whitelegge, J., Wu, J., Eisenberg, D., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.11.018 · Cited by 151
Neuropathology after active Aβ42 immunotherapy: implications for Alzheimer’s disease pathogenesis
Boche, D., Denham, N., Holmes, C., & Nicoll, J. A. R. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0719-5 · Cited by 135
Alzheimer’s disease as oligomeropathy
Ono, K. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2017.08.010 · Cited by 129
The keystone of Alzheimer pathogenesis might be sought in Aβ physiology
Puzzo, D., Gulisano, W., Arancio, O., & Palmeri, A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.039 · Cited by 116
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YAO, Y., LI, J., NIU, Y., YU, J.-Q., YAN, L., MIAO, Z.-H., ZHAO, X.-X., LI, Y.-J., YAO, W.-X., ZHENG, P., et al. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4199 · Cited by 55
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Nehls, M. (2016) · Journal of Molecular Psychiatry · doi:10.1186/s40303-016-0018-8 · Cited by 41
Metadata
- Authors
- Mc Donald, J. M., Savva, G. M., Brayne, C., Welzel, A. T., Forster, G., Shankar, G. M., Selkoe, D. J., Ince, P. G., & Walsh, D. M.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-04-19
- Volume
- 133
- Issue
- 5
- Pages
- 1328-1341
- ISSN
- 1460-2156
- 0006-8950
- Cited by
- 234
- References
- 14
- Language
- en
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