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Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer’s disease brain
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Only a limited fraction of highly diffusible small Aβ oligomers have adverse effects, such as disruption of synaptic activity.
“recent data suggest that only a limited fraction of highly diffusible small oligomers have adverse effects, for instance on the disruption of synaptic activity (Hong et al., 2018)”
From Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP (2019) · cites this paper as Hong et al., 2018
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Citations
Cites
The amyloid hypothesis of Alzheimer's disease at 25 years
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Self-citationIsolation and quantification of soluble Alzheimer's β-peptide from biological fluids
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Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis
Viola, K. L., & Klein, W. L. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1386-3 · Cited by 628
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Self-citationη-Secretase processing of APP inhibits neuronal activity in the hippocampus
Willem, M., Tahirovic, S., Busche, M. A., Ovsepian, S. V., Chafai, M., Kootar, S., Hornburg, D., Evans, L. D. B., Moore, S., Daria, A., et al. (2015) · Nature · doi:10.1038/nature14864 · Cited by 398 · cited 4×
“However, recent evidence suggests that a variety of APP fragments which contain all or part of the Aβ sequence may have disease-relevant activity [56, 57].”
InfluentialSelf-citationAnti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis
Kim, J., Eltorai, A. E. M., Jiang, H., Liao, F., Verghese, P. B., Kim, J., Stewart, F. R., Basak, J. M., & Holtzman, D. M. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20121274 · Cited by 160 · cited 1×
“HJ2 Monoclonal Aβ terminating at Val40 1 Holtzman lab/[20]”
Appearance of Sodium Dodecyl Sulfate-Stable Amyloid β-Protein (Aβ) Dimer in the Cortex During Aging
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Metadata
- Authors
- Hong, W., Wang, Z., Liu, W., O’Malley, T. T., Jin, M., Willem, M., Haass, C., Frosch, M. P., & Walsh, D. M.
- Venue
- Acta Neuropathologica
- Published
- 2018-04-23
- Volume
- 136
- Issue
- 1
- Pages
- 19-40
- ISSN
- 0001-6322
- 1432-0533
- PMC
- PMC6647843
- Cited by
- 163
- References
- 10
- Language
- en
- Funders
- Massachusetts Alzheimer’s Disease Research Center
- National Institutes of Health (AG046275)
- BrightFocus Foundation
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