Cited by 169Fungal and yeast genetics researchSignaling Pathways in DiseaseFungal Infections and Studies

The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.

Coping with stress: calmodulin and calcineurin in model and pathogenic fungi

Kraus, Peter R, Heitman, Joseph·2003·Biochemical and Biophysical Research Communications

Open this paper in CoChat — free account

Abstract

Calcium signaling via calmodulin and calcineurin is critical for the regulation of stress responses in fungi. The functions of calmodulin and calcineurin are largely conserved among pathogenic fungi and model fungi, however, the mechanisms of action have diverged. Saccharomyces cerevisiae is an excellent model for understanding the framework of calcium-mediated signal transduction pathways, and considerable progress has been made in understanding the details of how Ca(2+)-calmodulin and calcineurin control adaptation to environmental stress. Studies using the divergent human pathogenic fungi Candida albicans and Cryptococcus neoformans reveal that calcineurin is critical for virulence, yet it acts via distinct mechanisms in each fungus. These differences in function may reflect the requirements of each pathogen to survive inside the host, and illustrate that studies must be conducted in each organism in order to elucidate the details of the molecular mechanisms of calmodulin and calcineurin-mediated signaling pathways.

Integrity signals

Registry

Crossref · 10.1016/s0006-291x(03)01528-6

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Protein Data Bank
Berman, H. M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.235 · Cited by 40,196
Nonfilamentous C. albicans Mutants Are Avirulent
Lo, H.-J., Köhler, J. R., DiDomenico, B., Loebenberg, D., Cacciapuoti, A., & Fink, G. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80358-x · Cited by 1,809
Calmodulin: a prototypical calcium sensor
Chin, D., & Means, A. R. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01800-6 · Cited by 1,531
Structure of calmodulin refined at 2.2 Å resolution
Babu, Y. S., Bugg, C. E., & Cook, W. J. (1988) · Journal of Molecular Biology · doi:10.1016/0022-2836(88)90608-0 · Cited by 1,026
Candida and candidiasis.
Calderone, R. (2012) · ASM Press eBooks · Cited by 912
Crystal structures of human calcineurin and the human FKBP12–FK506–calcineurin complex
Kissinger, C. R., Parge, H. E., Knighton, D. R., Lewis, C. T., Pelletier, L. A., Tempczyk, A., Kalish, V. J., Tucker, K. D., Showalter, R. E., Moomaw, E. W., et al. (1995) · Nature · doi:10.1038/378641a0 · Cited by 768
Calcium-induced conformational transition revealed by the solution structure of apo calmodulin
Zhang, M., Tanaka, T., & Ikura, M. (1995) · Nature Structural & Molecular Biology · doi:10.1038/nsb0995-758 · Cited by 696
Calcium binding and conformational response in EF-hand proteins
Ikura, M. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(06)80021-6 · Cited by 664
Calcineurin is required for virulence of Cryptococcus neoformans
Odom, A., Muir, S., Lim, E., Toffaletti, D. L., Perfect, J., & Heitman, J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.10.2576 · Cited by 516
Self-citation
The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response.Preprint
Kamada, Y., Jung, U. S., Piotrowski, J., & Levin, D. E. (1995) · Genes & Development · doi:10.1101/gad.9.13.1559 · Cited by 488

Show all 66 references

Sorted by citations

Items 101–168 of 168

Global Protein–Protein Interaction Network of Rice Sheath Blight Pathogen
Lei, D., Lin, R., Yin, C., Li, P., & Zheng, A. (2014) · Journal of Proteome Research · doi:10.1021/pr500069r · Cited by 19
Signal Transduction and Morphogenesis in Candida albicans
Brown, A. J. P., & Gow, N. A. R. (2001) · Springer eBooks · doi:10.1007/978-3-662-06101-5_3 · Cited by 18
Functional characterization of orchardgrass cytosolic Hsp70 (DgHsp70) and the negative regulation by Ca2+/AtCaM2 binding
Cha, J., Su’udi, M., Kim, W., Kim, D. R., Kwak, Y., & Son, D. (2012) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2012.06.006 · Cited by 18
The Cch1-Mid1 High-Affinity Calcium Channel Contributes to the Virulence of Cryptococcus neoformans by Mitigating Oxidative Stress
Vu, K., Bautos, J. M., & Gelli, A. (2015) · Eukaryotic Cell · doi:10.1128/ec.00100-15 · Cited by 16
Metabolic engineering of
Lin, Z., Xu, Z., Li, Y., Wang, Z., Chen, T., & Zhao, X. (2014) · Microbial Cell Factories · doi:10.1186/s12934-014-0104-5 · Cited by 132
The tricarboxylic acid cycle, cell wall integrity pathway, cytokinesis and intracellular pH homeostasis are involved in the sensitivity of Candida albicans cells to high levels of extracellular calcium
Xu, H., Whiteway, M. S., & Jiang, L. (2018) · Genomics · doi:10.1016/j.ygeno.2018.08.001 · Cited by 15
Interaction of calcium responsive proteins and transcriptional factors with the PHO regulon in yeasts and fungi
Martı́n, J. F. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1225774 · Cited by 14
Golgi‐localized calcium/manganese transporters FgGdt1 and FgPmr1 regulate fungal development and virulence by maintaining Ca 2+ and Mn 2+ homeostasis in Fusarium graminearum
Wu, C., Guo, Z., Zhang, M., Chen, H., Peng, M., Abubakar, Y. S., Zheng, H., Yun, Y., Zheng, W., Wang, Z., et al. (2022) · Environmental Microbiology · doi:10.1111/1462-2920.16128 · Cited by 14
Protein Kinase C Overexpression Suppresses Calcineurin-Associated Defects in Aspergillus nidulans and Is Involved in Mitochondrial Function
Colabardini, A. C., Ries, L. N. A., Brown, N. A., Savoldi, M., Dinamarco, T. M., Kress, M. R. V. Z., Goldman, M. H. S., & Goldman, G. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104792 · Cited by 14
Dynamics of Chemical Diversity during Co‐Cultures: An Integrative Time‐Scale Metabolomics Study of Fungal Endophytes Cophinforma mamane and Fusarium solani
Triastuti, A., Haddad, M., Barakat, F., Mejía, K., Rabouille, G., Fabre, N., Guerra, C. A. A., Jargeat, P., & Vansteelandt, M. (2020) · Chemistry & Biodiversity · doi:10.1002/cbdv.202000672 · Cited by 14
Signal Transduction and Morphogenesis in Candida albicans
Brown, A. J., Argimón, S., & Gow, N. A. R. (2007) · Springer eBooks · doi:10.1007/978-3-540-70618-2_7 · Cited by 14
Knr4 N‐terminal domain controls its localization and function during sexual differentiation and vegetative growth
Dagkessamanskaia, A., Azzouzi, K. E., Kikuchi, Y., Timmers, T., Ohya, Y., François, J., & Martin‐Yken, H. (2010) · Yeast · doi:10.1002/yea.1804 · Cited by 13
Identification of immunogenic proteins from Paracoccidioides brasiliensis antigenic fractions F0, FII and FIII
Góes, T. S., Goes, V. S., Kalapothakis, E., Leite, M. F., & Goes, A. M. (2005) · Immunology Letters · doi:10.1016/j.imlet.2005.04.007 · Cited by 13
RNAi silencing: A tool for functional genomics research on fungi
Armas-Tizapantzi, A., & Montiel-González, A. M. (2016) · Fungal Biology Reviews · doi:10.1016/j.fbr.2016.05.003 · Cited by 12
Synergistic effects of putative Ca 2+ -binding sites of calmodulin in fungal development, temperature stress and virulence of Aspergillus fumigatus
Li, X., Feng, R., Luo, P., Zhang, Y., & Lü, L. (2023) · Virulence · doi:10.1080/21505594.2023.2290757 · Cited by 12
Identification of a novel gene required for competitive growth at high temperature in the thermotolerant yeast Kluyveromyces marxianus
Montini, N., Doughty, T. W., Domenzain, I., Fenton, D. A., Baranov, P. V., Harrington, R. S., Nielsen, J., Siewers, V., & Morrissey, J. P. (2022) · Microbiology · doi:10.1099/mic.0.001148 · Cited by 11
De novo sequencing and transcriptome analysis of Ustilaginoidea virens by using Illumina paired-end sequencing and development of simple sequence repeat markers
Yu, M., Yu, J., Gu, C., Nie, Y.-F., Chen, Z., Yin, X., & Liu, Y. (2014) · Gene · doi:10.1016/j.gene.2014.06.008 · Cited by 11
Pathogenesis of Cryptococcus neoformans
McClelland, E. E., Casadevall, A., & Eisenman, H. C. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6397-8_6 · Cited by 11
The calcineurin inhibitor gossypol impairs growth, cell signalling and development inDictyostelium discoideum
Weissenmayer, B., Boelckeler, K., Lahrz, A., & Mutzel, R. (2004) · FEMS Microbiology Letters · doi:10.1016/j.femsle.2004.10.035 · Cited by 11
The L-type Ca2+ Channel Blocker Nifedipine Inhibits Mycelial Growth, Sporulation, and Virulence of Phytophthora capsici
Liu, P., Gong, J., Ding, X., Jiang, Y., Chen, G., Li, B., Weng, Q., & Chen, Q. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01236 · Cited by 10
Calcium signaling components in the human pathogenCryptococcus neoformans
Kmetzsch, L., Staats, C. C., Rodrigues, M. L., Schrank, A., & Vainstein, M. H. (2011) · Communicative & Integrative Biology · doi:10.4161/cib.4.2.14271 · Cited by 10
Calcium Binding Protein Ncs1 Is Calcineurin Regulated in Cryptococcus neoformans and Essential for Cell Division and Virulence
Squizani, E. D., Reuwsaat, J. C. V., Lev, S., Motta, H., Sperotto, J., Kaufman‐Francis, K., Desmarini, D., Vainstein, M. H., Staats, C. C., Djordjevic, J. T., et al. (2020) · mSphere · doi:10.1128/msphere.00761-20 · Cited by 10
Genome‐wide differentiation corresponds to climatic niches in two species of lichen‐forming fungi
Wong, E. L. Y., Valim, H. F., & Schmitt, I. (2024) · Environmental Microbiology · doi:10.1111/1462-2920.16703 · Cited by 8
Characterization of medicinal plant-associated biocontrol Bacillus subtilis (SSL2) by liquid chromatography-mass spectrometry and evaluation of compounds by in silico and in vitro methods
Jinal, H. N., & Amaresan, N. (2019) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2019.1581091 · Cited by 8
Quantitative Proteomics of an Amphibian Pathogen, Batrachochytrium dendrobatidis, following Exposure to Thyroid Hormone
Thekkiniath, J., Zabet‐Moghaddam, M., Kottapalli, K. R., Pasham, M. R., Francisco, S. S., & Francisco, M. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123637 · Cited by 7
Morphological responses of filamentous fungi to stressful environmental conditions
Fomina, M., Gromozova, O. M., & Gadd, G. M. (2024) · Advances in applied microbiology · doi:10.1016/bs.aambs.2024.07.001 · Cited by 7
Stress-driven metabolites of desert soil fungi
Alwakeel, S., Alothman, N., Ameén, F., Alotaibi, M. O., Mohammed, A. E., & Alhomaidi, E. A. H. (2023) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2023.2182537 · Cited by 7
Cryptococcus neoformans Ca2+ homeostasis requires a chloride channel/antiporter Clc1 in JEC21, but not in H99
Li, D., Zhang, X., Li, Z., Yang, J., Pan, J., & Zhu, X. (2011) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2011.00763.x · Cited by 7
Calcium: a central player in Cryptococcus biology
Squizani, E. D., Reuwsaat, J. C. V., Motta, H., Tavanti, A. G., & Kmetzsch, L. (2021) · Fungal Biology Reviews · doi:10.1016/j.fbr.2021.03.004 · Cited by 11
Costimulatory blockade and infectious risk in solid organ transplantation
Fishman, J. A., Kirk, A. D., & Hosseini-Moghaddam, S. M. (2026) · American Journal of Transplantation · doi:10.1016/j.ajt.2025.12.284 · Cited by 6
Aequorin as a Useful Calcium-Sensing Reporter in Candida albicans
Sanglard, D. (2021) · Journal of Fungi · doi:10.3390/jof7040319 · Cited by 7
A high-throughput screen to identify novel calcineurin inhibitors
Margassery, L. M., Kennedy, J., O’Gara, F., Dobson, A. D. W., & Morrissey, J. P. (2011) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2011.10.012 · Cited by 6
The calcium-binding protein EpANN from the lichenized fungus Endocarpon pusillum enhances stress tolerance in yeast and plants
Zhang, Y., Li, H., Wang, Y., & Wei, J. (2017) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2017.09.003 · Cited by 6
The Neurospora crassa cmd, trm-9, and nca-2 Genes Play a Role in Growth, Development, and Survival in Stress conditions
Ranjan, T. (2015) · Genomics and Applied Biology · doi:10.5376/gab.2015.06.0007 · Cited by 6
Diseases Caused by Aspergillus fumigatus
Garcia‐Rubio, R., & Alcázar‐Fuoli, L. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809633-8.12078-3 · Cited by 7
Cardiolipin mediates cross talk between the mitochondria and the vacuole
Chen, S., Tarsio, M., Kane, P. M., & Greenberg, M. L. (2008) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2008.05.052 · Cited by 5
Identification of the divergent calmodulin binding motif in yeast Ssb1/Hsp75 protein and in other HSP70 family members
Heinen, R. C., Diniz‐Mendes, L., Silva, J. T., & Paschoalin, V. M. F. (2006) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2006001100003 · Cited by 5
Calcineurin activity in Fonsecaea pedrosoi: tacrolimus and cyclosporine A inhibited conidia growth, filamentation and showed synergism with itraconazole
Sousa, I. S., Tavares, L. F. S., Silva, B. A., Moreno, D. S. A., Alviano, C. S., dos Santos, A. L. S., & Kneipp, L. F. (2024) · Brazilian Journal of Microbiology · doi:10.1007/s42770-024-01463-2 · Cited by 4
Transcriptional and Post-Translational Roles of Calcineurin in Cationic Stress and Glycerol Biosynthesis in Cryptococcus neoformans
Santos, R. S., Martins-Silva, G., Padilla, A. A. Á., Possari, M., Degello, S. D., Brustolini, O. J. B., de Vasconcelos, A. T. R., Vallim, M. A., & Pascon, R. C. (2024) · Journal of Fungi · doi:10.3390/jof10080531 · Cited by 4
Signal Transduction in the Interactions of Fungal Pathogens and Mammalian Hosts
Whiteway, M. S., & Bachewich, C. (2014) · ASM Press eBooks · doi:10.1128/9781555815776.ch10 · Cited by 4
Cryptococcus neoformans Pathogenicity
Nelson, R. T., & Lodge, J. K. (2006) · Springer eBooks · doi:10.1007/3-540-30809-1_13 · Cited by 4
Transcription Factors and Intracellular Proteins Orchestrate Phenotypic Adaptation in Cryptococcus neoformans for Survival and Human InfectionsPreprint
Folorunso, O. S., & Sebolai, O. M. (2023) · Preprints.org · doi:10.20944/preprints202301.0461.v1 · Cited by 3
Sensing Extracellular Signals in Cryptococcus neoformans
Idnurm, A., Bahn, Y., Shen, W.-C., Rutherford, J. C., & Mühlschlegel, F. A. (2014) · ASM Press eBooks · doi:10.1128/9781555816858.ch14 · Cited by 4
Molecular Pathogenesis of Fungal Infections
Segal, B. H. (2007) · Humana Press eBooks · doi:10.1007/978-1-59259-963-9_95 · Cited by 3
The Genetic Profiles of TIF1 and TIF2 Duplicate Genes
Venturi, V. (2012) · Open Access Victoria University of Wellington | Te Herenga Waka (Figshare) · doi:10.26686/wgtn.16999348.v1 · Cited by 1
Diseases Caused by Aspergillus fumigatus
Garcia‐Rubio, R., & Alcázar‐Fuoli, L. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-819990-9.12078-5 · Cited by 2
The Molecular Cloning and Bioactivity Characterization of Calmodulin from Medicinal Fungus Agrocybe aegerita
梁, 一. (2012) · Medical Diagnosis · doi:10.12677/md.2012.22002 · Cited by 1
Interplay of Protein Phosphatases with Cytoskeleton Signaling in Response to Stress Factors in Plants
Samofalova, D. O., Karpov, P. A., Rayevsky, A. V., & Blume, Y. B. (2020) · Springer eBooks · doi:10.1007/978-3-030-48733-1_14 · Cited by 1
Calmodulin, Calcium/Calmodulin-Dependent Kinases-1 and 2 Regulate Expression of the Heat Shock Proteins for Heat Shock Tolerance and Pheromone Signaling Genes for Sexual Development in Neurospora crassa
Marak, C. N. K., & Tamuli, R. (2023) · Indian Journal of Microbiology · doi:10.1007/s12088-023-01091-8 · Cited by 1
Fungi as Eukaryotes: Understanding the Antifungal Effects of Immunosuppressive Drugs
Schaenman, J. M. D., Khuu, T., & Kubak, B. (2014) · Current Fungal Infection Reports · doi:10.1007/s12281-013-0169-3 · Cited by 1
Reactive Oxygen Intermediates, pH, and Calcium
Bignell, E. (2014) · ASM Press eBooks · doi:10.1128/9781555815523.ch17 · Cited by 1
Metabolic engineering of Saccharomyces cerevisiae for C4-dicarboxylic acid production
Zelle, R. M. (2011) · Data Archiving and Networked Services (DANS) · Cited by 1
An Nrf2/Yap1-like bZIP protein drives UV-induced oxidative stress response in a Sporobolomyces yeast with evolutionary conservationPreprint
Gaćeša, R., Chung, R., Santos, S. N., Padilla, G., de Melo, I. S., & Long, P. F. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.17.676916 · Cited by 1
Caracterização molecular de genes preferencialmente expressos na fase leveduriforme patogênica de ´Paracoccidioides brasiliensis´ através das técnicas de ´Macroarray´ e de SSH (Suppression Substractive Hybridization)
Marques, E. D. R. (2005) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.60.2005.tde-27042006-091522
Análise do Perfil Transcricional do Dermatófito Trichophyton rubrum durante a Interação com o Agente Inibidor Acriflavina
Persinoti, G. F. (2012) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2012.tde-22042013-113234
Candida Albicans: New Insights in Infection, Disease, and Treatment
MacCallum, D. M. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6397-8_5
Fosfolipase C e sua interação com a fonte de carbono, cálcio, PKC e o ciclo de divisão celular em Aspergillus nidulans
Arakawa, J. A. R. (2009) · doi:10.11606/t.60.2009.tde-24042009-084612
Antifungal Activity of Tamoxifen and its Analogs Against the Opportunistic Pathogen, Candida albicans
Tabroff, J. M., & DiDone, L. (2011)
The Molecular Cloning and Bioactivity Characterization of Calmodulin from Medicinal Fungus Agrocybe aegerita
Liang, Y. W., & Sun, H. Z. (2012)
Calcineurin-NFAT Signaling in Cardiac Hypertrophy: In Sickness and In Health?
Wilkins, B. J. (2004) · OhioLink ETD Center (Ohio Library and Information Network)
Análises de transcritos de Paracoccidioides brasiliensis durante a transição dimórfica de micélio para levedura
Bastos, K. P. (2006)
The Roles of Hsp90 and Calcineurin in Antifungal Drug Resistance
Singh, S. (2012) · TSpace (University of Toronto)
Backbone and side-chain resonance assignments of (Ca2+)4–calmodulin bound to beta calcineurin A CaMBD peptide
Fowler, C. A., Hernandez, M. F. N., O’Donnell, S. E., Yu, L. P., & Shea, M. A. (2017) · Biomolecular NMR Assignments · doi:10.1007/s12104-017-9762-7
Función de la fosfatasa calcineurina en la citocinesis de Schizosaccharomyces pombe
Antón, V. A. (2019) · Gredos (University of Salamanca) · doi:10.14201/gredos.143511
Environmental Stress-Sensing and Pathogenicity in Cryptococcus neoformans
Fu, M. S., Hall, R. A., & Mühlschlegel, F. A. (2009) · Springer eBooks · doi:10.1007/978-3-642-03150-2_9
Identification of the divergent calmodulin binding motif in yeast Ssb1/Hsp75 protein and in other HSP70 family members
Heinen, R. C., Diniz‐Mendes, L., Silva, J. T., & Paschoalin, V. M. F. (2006) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2006005000019
Opportunistic Pathogens of the Genus Cryptococcus in Louis Pasteur Days and in 200th Anniversary of his Birth
Dyląg, M. (2022) · Postępy Mikrobiologii - Advancements of Microbiology · doi:10.2478/am-2022-025
L'interaction Hsp90/co-chaperonnes : nouvelle cible pour le traitement des candidoses invasives
Rouges, C. (2023) · theses.fr (ABES) · doi:10.70675/40b24a3fz159ez4d8ez8a34zdd8ffa1c22fa

Authors: Kraus, P. R., & Heitman, J.
Affiliations: Duke Medical Center (US)
Howard Hughes Medical Institute (US)
Corresponding author: Heitman, Joseph
ORCID: Heitman, Joseph
Venue: Biochemical and Biophysical Research Communications
Publisher: Elsevier BV
Published: 2003-11
Volume: 311
Issue: 4
Pages: 1151-1157
ISSN: 0006-291X (ISSN-L)
DOI: 10.1016/s0006-291x(03)01528-6
OpenAlex: W2066800858
Cited by: 169
References: 66
Citations by year: 2026: 1 · 2025: 1 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 8 · 2015: 8 · 2014: 21 · 2013: 6 · 2012: 12
FWCI: 3.00
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochemical and Biophysical Research Communications (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Keywords: calmodulin, calcineurin, calcium signaling, stress response, fungal virulence, Candida albicans, Cryptococcus neoformans, Saccharomyces cerevisiae, environmental stress adaptation, fungal pathogens
MeSH terms: Calmodulin, Candida albicans, Cryptococcus neoformans, Fungi, Saccharomyces cerevisiae, Species Specificity, Transcriptional Activation, Gene Expression Regulation, Fungal, Calcineurin, Calcium Signaling

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Coping with stress: calmodulin and calcineurin in model and pathogenic fungi

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks