Deficits in hippocampal and anterior cingulate functioning during verbal declarative memory encoding in midlife major depression

Bremner, J. Douglas; Vythilingam, Meena; Vermetten, Eric; Vaccarino, Viola; Charney, Dennis S.

doi:10.1176/appi.ajp.161.4.637

Cited by 192Memory and Neural MechanismsNeural and Behavioral Psychology StudiesTreatment of Major Depression

Deficits in hippocampal and anterior cingulate functioning during verbal declarative memory encoding in midlife major depression

Bremner, J. Douglas, Vythilingam, Meena, Vermetten, Eric, Vaccarino, Viola, Charney, Dennis S.·2004·American Journal of Psychiatry

DOI 10.1176/appi.ajp.161.4.637

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Abstract

OBJECTIVE: Prior studies showed that subjects with major depression have deficits in hippocampal-based verbal declarative memory (e.g., recall of a paragraph) and in hippocampal and prefrontal cortical functioning and structure. The purpose of the present study was to assess hippocampal and prefrontal functioning during performance of a verbal declarative memory task in subjects with midlife major depression. METHOD: Subjects with midlife major depression (N=18) and healthy subjects (N=9) underwent positron emission tomography imaging during a control task and verbal encoding of a paragraph. RESULTS: During the verbal memory encoding task the comparison subjects, but not the subjects with depression, activated the right hippocampus and prefrontal cortex (anterior cingulate), as well as the cuneus and cerebellum. CONCLUSIONS: These results are consistent with a failure of hippocampal and anterior cingulate activation in depression, and they support the hypothesis of deficits in hippocampal and anterior cingulate functioning in depression.

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Girls may use the cuneus and lingual gyrus, which are involved in emotional face processing, for socio-emotional processing as a distinct mechanism supporting connectivity patterns that manifest as sexually dimorphic social behavior.
“Alternatively, girls may rely on regions such as the cuneus and LG, which are implicated in emotional face processing (Bremner et al., 2004, Kitada et al., 2010, Kret et al., 2011), for socio-emotional processing as a distinct mechanism supporting neural functional connectivity patterns that in turn manifest into sexually dimorphic social behavior.”
From Developmental sex differences in resting state functional connectivity of amygdala sub-regions (2015) · cites this paper as Bremner et al., 2004

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Authors: Bremner, J. D., Vythilingam, M., Vermetten, E., Vaccarino, V., & Charney, D. S.
Affiliations: Emory University (US)
ORCID: Bremner, J. Douglas
Vythilingam, Meena
Vermetten, Eric
Vaccarino, Viola
Charney, Dennis S.
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 2004-04-01
Volume: 161
Issue: 4
Pages: 637-645
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/appi.ajp.161.4.637
OpenAlex: W2104092750
Cited by: 192
References: 104
Citations by year: 2026: 3 · 2025: 2 · 2023: 1 · 2022: 7 · 2021: 9 · 2020: 3 · 2019: 11 · 2018: 9 · 2017: 10 · 2016: 9 · 2015: 14 · 2014: 13 · 2013: 11 · 2012: 11
FWCI: 4.53
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH 56120, R01MH056120)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: major depressive disorder, verbal declarative memory, memory encoding, hippocampus, anterior cingulate cortex, prefrontal cortex, brain activation, cuneus, cerebellum
MeSH terms: Brain, Cerebellum, Cerebrovascular Circulation, Major Depressive Disorder, Female, Gyrus Cinguli, Hippocampus, Humans, Functional Laterality, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Severity of Illness Index, Tomography, Emission-Computed, Verbal Behavior, Diagnostic and Statistical Manual of Mental Disorders

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Deficits in hippocampal and anterior cingulate functioning during verbal declarative memory encoding in midlife major depression

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