Distinct functional networks associated with improvement of affective symptoms and cognitive function during citalopram treatment in geriatric depression
Open accessAbstract
Variability in the affective and cognitive symptom response to antidepressant treatment has been observed in geriatric depression. The underlying neural circuitry is poorly understood. This study evaluated the cerebral glucose metabolic effects of citalopram treatment and applied multivariate, functional connectivity analyses to identify brain networks associated with improvements in affective symptoms and cognitive function. Sixteen geriatric depressed patients underwent resting positron emission tomography (PET) studies of cerebral glucose metabolism and assessment of affective symptoms and cognitive function before and after 8 weeks of selective serotonin reuptake inhibitor treatment (citalopram). Voxel‐wise analyses of the normalized glucose metabolic data showed decreased cerebral metabolism during citalopram treatment in the anterior cingulate gyrus, middle temporal gyrus, precuneus, amygdala, and parahippocampal gyrus. Increased metabolism was observed in the putamen, occipital cortex, and cerebellum. Functional connectivity analyses revealed two networks which were uniquely associated with improvement of affective symptoms and cognitive function during treatment. A subcortical‐limbic‐frontal network was associated with improvement in affect (depression and anxiety), while a medial temporal‐parietal‐frontal network was associated with improvement in cognition (immediate verbal learning/memory and verbal fluency). The regions that comprise the cognitive network overlap with the regions that are affected in Alzheimer's dementia. Thus, alterations in specific brain networks associated with improvement of affective symptoms and cognitive function are observed during citalopram treatment in geriatric depression. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.
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sgACC connectivity with limbic, thalamic, and striatal regions has been associated with the degree of response to treatment.
“and associated with the degree of response to treatment (Anand et al, 2005, 2009; Diaconescu et al, 2011; Kozel et al, 2011).”
From Resting-state cortico-thalamic-striatal connectivity predicts response to dorsomedial prefrontal rTMS in major depressive disorder (2014) · cites this paper as Diaconescu et al, 2011
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- Authors
- Diaconescu, A. O., Kramer, E., Hermann, C., Ma, Y., Dhawan, V., Chaly, T., Eidelberg, D., McIntosh, A. R., & Smith, G. S.
- Affiliations
- Baycrest Hospital (CA)
- Zucker Hillside Hospital (US)
- Northwell Health (US)
- ORCID
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2010-09-30
- Volume
- 32
- Issue
- 10
- Pages
- 1677-1691
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC3021765
- OpenAlex
- W2132942753
- Cited by
- 54
- References
- 71
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 7 · 2015: 5 · 2014: 6 · 2013: 8 · 2012: 5
- FWCI
- 3.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Institute of Health (MH 01621, MH 49936, MH 57078, MH 64823, M01 RR 018535)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- geriatric depression, citalopram, selective serotonin reuptake inhibitors, brain glucose metabolism, functional connectivity, brain networks, affective symptoms, cognitive function, Alzheimer's dementia, treatment response variability
- MeSH terms
- Aged, Aged, 80 and over, Analysis of Variance, Brain Mapping, Cerebral Cortex, Cognition Disorders, Depression, Female, Geriatrics, Glucose, Humans, Male, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Reaction Time, Citalopram, Antidepressive Agents, Second-Generation, Fluorodeoxyglucose F18, Positron-Emission Tomography
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