Cited by 797Stress Responses and CortisolNeuroendocrine regulation and behaviorAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 99 of the 100 references it cites were found in a registry or an index.

Sex differences in stress responses: social rejection versus achievement stress

Stroud, Laura R, Salovey, Peter, Epel, Elissa S·2002·Biological Psychiatry

Abstract

Background Sex differences in stress responses may be one mechanism underlying gender differences in depression. We hypothesized that men and women would show different adrenocortical responses to different stressors. In particular, we predicted that women would show greater responses to social rejection stressors, whereas men would demonstrate greater responses to achievement stressors.Methods Following a rest session in which they habituated to the laboratory, 50 healthy volunteers (24 men and 26 women, mean age 19.1, SD = 1.13) were randomly assigned to achievement or rejection stress conditions. The achievement condition involved a mathematical and a verbal challenge; the rejection condition involved two social interaction challenges. Self-reported affect and salivary cortisol were measured throughout each stress session (baseline, stress, and poststress periods).Results There were no sex differences in mood ratings following the stressors; however, cortisol responses showed the predicted gender by condition by time interaction. Men showed significantly greater cortisol responses to the achievement challenges, but women showed greater cortisol responses to the social rejection challenges.Conclusions Women appear more physiologically reactive to social rejection challenges, but men react more to achievement challenges. Women's greater reactivity to rejection stress may contribute to the increased rates of affective disorders in women.

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Crossref · 10.1016/s0006-3223(02)01333-1

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Metadata

Authors
Stroud, L. R., Salovey, P., & Epel, E. S.
Affiliations
  • Brown University (US)
  • Yale University (US)
  • University of California, San Francisco (US)
Corresponding author
Stroud, Laura R
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2002-08
Volume
52
Issue
4
Pages
318-327
ISSN
0006-3223 (ISSN-L)
OpenAlex
W2024158767
Cited by
797
References
100
Citations by year
2026: 26 · 2025: 28 · 2024: 21 · 2023: 31 · 2022: 33 · 2021: 39 · 2020: 39 · 2019: 37 · 2018: 48 · 2017: 45 · 2016: 51 · 2015: 44 · 2014: 47 · 2013: 47 · 2012: 35
FWCI
4.26
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Center for Research Resources (M01RR000125, RR00125)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
sex differences, stress response, social rejection, salivary cortisol, adrenocortical reactivity, gender differences in depression, mood disorders, mood, stress hormones
MeSH terms
Achievement, Adolescent, Adrenal Cortex, Adult, Affect, Arousal, Female, Gender Identity, Humans, Hydrocortisone, Male, Rejection, Psychology, Saliva, Stress, Psychological

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