Cited by 382Posttraumatic Stress Disorder ResearchTraumatic Brain Injury ResearchChild Abuse and Trauma

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Reduced hippocampal volume and total white matter volume in posttraumatic stress disorder

Villarreal, Gerardo, Hamilton, Derek A, Petropoulos, Helen, Driscoll, Ira, Rowland, Laura M, Griego, Jaqueline A, Kodituwakku, Piyadasa W, Hart, Blaine L, Escalona, Rodrigo, Brooks, William M·2002·Biological Psychiatry

DOI 10.1016/s0006-3223(02)01359-8

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Abstract

Background Reduced hippocampal volumes in posttraumatic stress disorder (PTSD) patients are thought to reflect specific changes of this structure. Previous magnetic resonance imaging (MRI) studies have not consistently examined indices of overall brain atrophy, therefore it cannot be completely ruled out that hippocampal changes are explained by whole-brain atrophy. The purpose of this study was to assess hippocampal and whole-brain volume in civilian PTSD. Methods Twelve subjects with PTSD and 10 control subjects underwent brain MRI. Hippocampal volumes were visually quantified using a computerized volumetric program. Whole-brain volumes were obtained with automated k-means-based segmentation. Results No differences were found in intracranial volumes (ICV). Subjects with PTSD had higher cerebrospinal fluid (CSF)/ICV ratios and lower white matter/ICV ratios, consistent with generalized white matter (WM) atrophy. The effect of age on CSF/ICV was more pronounced in the PTSD group. Subjects with PTSD had smaller absolute and normalized bilateral hippocampal volumes. These differences persisted after adjusting for lifetime weeks of alcohol intoxication. Posttraumatic stress disorder and depression scores correlated negatively with left hippocampal volume, but PTSD scores were a better predictor of hippocampal volumes. Conclusions Our results replicate previous findings of reduced hippocampal volume in PTSD but also suggest independent, generalized, white matter atrophy.

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Method
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Authors: Villarreal, G., Hamilton, D. A., Petropoulos, H., Driscoll, I., Rowland, L. M., Griego, J. A., Kodituwakku, P. W., Hart, B. L., Escalona, R., & Brooks, W. M.
Affiliations: University of New Mexico (US)
ORCID: Villarreal, Gerardo
Hamilton, Derek A
Driscoll, Ira
Rowland, Laura M
Kodituwakku, Piyadasa W
Hart, Blaine L
Brooks, William M
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2002-07
Volume: 52
Issue: 2
Pages: 119-125
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/s0006-3223(02)01359-8
OpenAlex: W2020961462
Cited by: 382
References: 36
Citations by year: 2026: 5 · 2025: 3 · 2024: 11 · 2023: 10 · 2022: 12 · 2021: 9 · 2020: 14 · 2019: 6 · 2018: 13 · 2017: 15 · 2016: 17 · 2015: 16 · 2014: 20 · 2013: 13 · 2012: 9
FWCI: 32.33
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords: post-traumatic stress disorder, hippocampal volume, white matter atrophy, whole brain atrophy, intracranial volume, cerebrospinal fluid, brain atrophy, depression, alcohol intoxication, civilian trauma
MeSH terms: Adult, Analysis of Variance, Atrophy, Brain, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Stress Disorders, Post-Traumatic

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Reduced hippocampal volume and total white matter volume in posttraumatic stress disorder

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