Resting regional cerebral perfusion in recent posttraumatic stress disorder
Abstract
Background Brain imaging research in posttraumatic stress disorder has been largely performed on patients with chronic disease, often heavily medicated, with current or past alcohol and substance abuse. Additionally, virtually only activation brain imaging paradigms have been done in posttraumatic stress disorder, whereas in other mental disorders both resting and activation studies have been performed. Methods Twenty-eight (11 posttraumatic stress disorder) trauma survivors underwent resting state hexamethylpropyleneamineoxime single photon emission computed tomography and magnetic resonance imaging 6 months after trauma. Eleven nontraumatized subjects served as healthy controls. Results Regional cerebral blood flow in the cerebellum was higher in posttraumatic stress disorder than in both control groups. Regional cerebral blood flow in right precentral, superior temporal, and fusiform gyri in posttraumatic stress disorder was higher than in healthy controls. Cerebellar and extrastriate regional cerebral blood flow were positively correlated with continuous measures of depression and posttraumatic stress disorder. Cortisol level in posttraumatic stress disorder was negatively correlated with medial temporal lobe perfusion. Anterior cingulate perfusion and cortisol level were positively correlated in posttraumatic stress disorder and negatively correlated in trauma survivors without posttraumatic stress disorder. Conclusions Recent posttraumatic stress disorder is accompanied by elevated regional cerebral blood flow, particularly in the cerebellum. This warrants attention because the cerebellum is often used as a reference region in regional cerebral blood flow studies. The inverse correlation between plasma cortisol and medial temporal lobe perfusion may herald hippocampal damage.
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The number of neuroimaging studies involving energetic brain metabolism is considerably low.
“Number of the neuroimaging studies involving energetic brain metabolism is considerably low (Bonne et al., 2003;Molina et al., 2007).”
From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Bonne et al., 2003
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- Authors
- Bonne, O., Gilboa, A., Louzoun, Y., Brandes, D., Yona, I., Lester, H., Barkai, G., Freedman, N., Chisin, R., & Shalev, A. Y.
- Affiliations
- Hadassah Medical Center (IL)
- Corresponding author
- Bonne, Omer
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 54
- Issue
- 10
- Pages
- 1077-1086
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2015493659
- Cited by
- 142
- References
- 7
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 7 · 2021: 1 · 2020: 7 · 2019: 5 · 2018: 6 · 2017: 7 · 2016: 10 · 2015: 7 · 2014: 8 · 2013: 6 · 2012: 6
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- post-traumatic stress disorder, regional cerebral blood flow, cortisol, hippocampal lesions, depression, trauma survivors
- MeSH terms
- Adult, Cerebral Cortex, Cerebrovascular Circulation, Depression, Female, Humans, Hydrocortisone, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Oximes, Perfusion, Psychometrics, Regional Blood Flow, Stress Disorders, Post-Traumatic, Tomography, Emission-Computed, Single-Photon, Case-Control Studies
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