Cited by 334Posttraumatic Stress Disorder ResearchFunctional Brain Connectivity StudiesTraumatic Brain Injury Research

ABERRANT RESTING-STATE BRAIN ACTIVITY IN POSTTRAUMATIC STRESS DISORDER: A META-ANALYSIS AND SYSTEMATIC REVIEW: Theoretical Review: Brain Activity in PTSD during Rest

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Koch, Saskia B. J., van Zuiden, Mirjam, Nawijn, Laura, Frijling, Jessie L., Veltman, Dick J., Olff, Miranda·2016·Depression and Anxiety

Abstract

BACKGROUND: About 10% of trauma-exposed individuals develop PTSD. Although a growing number of studies have investigated resting-state abnormalities in PTSD, inconsistent results suggest a need for a meta-analysis and a systematic review. METHODS: We conducted a systematic literature search in four online databases using keywords for PTSD, functional neuroimaging, and resting-state. In total, 23 studies matched our eligibility criteria. For the meta-analysis, we included 14 whole-brain resting-state studies, reporting data on 663 participants (298 PTSD patients and 365 controls). We used the activation likelihood estimation approach to identify concurrence of whole-brain hypo- and hyperactivations in PTSD patients during rest. Seed-based studies could not be included in the quantitative meta-analysis. Therefore, a separate qualitative systematic review was conducted on nine seed-based functional connectivity studies. RESULTS: The meta-analysis showed consistent hyperactivity in the ventral anterior cingulate cortex and the parahippocampus/amygdala, but hypoactivity in the (posterior) insula, cerebellar pyramis and middle frontal gyrus in PTSD patients, compared to healthy controls. Partly concordant with these findings, the systematic review on seed-based functional connectivity studies showed enhanced salience network (SN) connectivity, but decreased default mode network (DMN) connectivity in PTSD. CONCLUSIONS: Combined, these altered resting-state connectivity and activity patterns could represent neurobiological correlates of increased salience processing and hypervigilance (SN), at the cost of awareness of internal thoughts and autobiographical memory (DMN) in PTSD. However, several discrepancies between findings of the meta-analysis and systematic review were observed, stressing the need for future studies on resting-state abnormalities in PTSD patients.

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Authors
Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M.
Affiliations
  • Amsterdam UMC Location University of Amsterdam (NL)
  • Department of Psychiatry; Academic Medical Center; University of Amsterdam; Amsterdam the Netherlands
  • Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Corresponding author
Koch, Saskia B. J.
Venue
Depression and Anxiety
Publisher
Wiley
Published
2016-02-25
Volume
33
Issue
7
Pages
592-605
ISSN
1091-4269 (ISSN-L)
OpenAlex
W2274028393
Cited by
334
References
78
Citations by year
2026: 27 · 2025: 35 · 2024: 28 · 2023: 40 · 2022: 41 · 2021: 41 · 2020: 41 · 2019: 34 · 2018: 25 · 2017: 14 · 2016: 7
FWCI
3.96
Type
journal article
Language
en
Open access
Locations
  • Depression and Anxiety (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion, other-oa)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
  • ZonMw, The Netherlands organization for Health Research and Development (40-00812-98-10041)
  • Academic Medical Center Research Council (110614)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
Keywords
post-traumatic stress disorder, resting-state brain activity, functional connectivity, ventral anterior cingulate cortex, amygdala, parahippocampal cortex, posterior insula, salience network, default mode network, hypervigilance, autobiographical memory, trauma exposure
MeSH terms
Brain, Diagnostic Imaging, Humans, Rest, Stress Disorders, Post-Traumatic, Functional Neuroimaging

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