ABERRANT RESTING-STATE BRAIN ACTIVITY IN POSTTRAUMATIC STRESS DISORDER: A META-ANALYSIS AND SYSTEMATIC REVIEW: Theoretical Review: Brain Activity in PTSD during Rest
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BACKGROUND: About 10% of trauma-exposed individuals develop PTSD. Although a growing number of studies have investigated resting-state abnormalities in PTSD, inconsistent results suggest a need for a meta-analysis and a systematic review. METHODS: We conducted a systematic literature search in four online databases using keywords for PTSD, functional neuroimaging, and resting-state. In total, 23 studies matched our eligibility criteria. For the meta-analysis, we included 14 whole-brain resting-state studies, reporting data on 663 participants (298 PTSD patients and 365 controls). We used the activation likelihood estimation approach to identify concurrence of whole-brain hypo- and hyperactivations in PTSD patients during rest. Seed-based studies could not be included in the quantitative meta-analysis. Therefore, a separate qualitative systematic review was conducted on nine seed-based functional connectivity studies. RESULTS: The meta-analysis showed consistent hyperactivity in the ventral anterior cingulate cortex and the parahippocampus/amygdala, but hypoactivity in the (posterior) insula, cerebellar pyramis and middle frontal gyrus in PTSD patients, compared to healthy controls. Partly concordant with these findings, the systematic review on seed-based functional connectivity studies showed enhanced salience network (SN) connectivity, but decreased default mode network (DMN) connectivity in PTSD. CONCLUSIONS: Combined, these altered resting-state connectivity and activity patterns could represent neurobiological correlates of increased salience processing and hypervigilance (SN), at the cost of awareness of internal thoughts and autobiographical memory (DMN) in PTSD. However, several discrepancies between findings of the meta-analysis and systematic review were observed, stressing the need for future studies on resting-state abnormalities in PTSD patients.
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Excessive salience processing within the SN serves as a mechanism of abnormal hyper-monitoring of the external environment in PTSD.
“suggesting excessive salience processing within the SN serves as a mechanism of abnormal hyper-monitoring the external environment (Koch et al., 2016).”
From Cortico-striatal-thalamic loop circuits of the salience network: A central pathway in psychiatric disease and treatment (2016) · cites this paper as Koch et al., 2016
PTSD patients display enhanced connectivity within the SN.
“One recent meta-analysis showed that PTSD patients display enhanced connectivity within the SN,”
From Cortico-striatal-thalamic loop circuits of the salience network: A central pathway in psychiatric disease and treatment (2016) · cites this paper as Koch et al., 2016
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- Authors
- Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Department of Psychiatry; Academic Medical Center; University of Amsterdam; Amsterdam the Netherlands
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Koch, Saskia B. J.
- Venue
- Depression and Anxiety
- Publisher
- Wiley
- Published
- 2016-02-25
- Volume
- 33
- Issue
- 7
- Pages
- 592-605
- ISSN
- 1091-4269 (ISSN-L)
- OpenAlex
- W2274028393
- Cited by
- 334
- References
- 78
- Citations by year
- 2026: 27 · 2025: 35 · 2024: 28 · 2023: 40 · 2022: 41 · 2021: 41 · 2020: 41 · 2019: 34 · 2018: 25 · 2017: 14 · 2016: 7
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- ZonMw, The Netherlands organization for Health Research and Development (40-00812-98-10041)
- Academic Medical Center Research Council (110614)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- post-traumatic stress disorder, resting-state brain activity, functional connectivity, ventral anterior cingulate cortex, amygdala, parahippocampal cortex, posterior insula, salience network, default mode network, hypervigilance, autobiographical memory, trauma exposure
- MeSH terms
- Brain, Diagnostic Imaging, Humans, Rest, Stress Disorders, Post-Traumatic, Functional Neuroimaging
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