Reduced hippocampal volume and total white matter volume in posttraumatic stress disorder
Abstract
Background Reduced hippocampal volumes in posttraumatic stress disorder (PTSD) patients are thought to reflect specific changes of this structure. Previous magnetic resonance imaging (MRI) studies have not consistently examined indices of overall brain atrophy, therefore it cannot be completely ruled out that hippocampal changes are explained by whole-brain atrophy. The purpose of this study was to assess hippocampal and whole-brain volume in civilian PTSD. Methods Twelve subjects with PTSD and 10 control subjects underwent brain MRI. Hippocampal volumes were visually quantified using a computerized volumetric program. Whole-brain volumes were obtained with automated k-means-based segmentation. Results No differences were found in intracranial volumes (ICV). Subjects with PTSD had higher cerebrospinal fluid (CSF)/ICV ratios and lower white matter/ICV ratios, consistent with generalized white matter (WM) atrophy. The effect of age on CSF/ICV was more pronounced in the PTSD group. Subjects with PTSD had smaller absolute and normalized bilateral hippocampal volumes. These differences persisted after adjusting for lifetime weeks of alcohol intoxication. Posttraumatic stress disorder and depression scores correlated negatively with left hippocampal volume, but PTSD scores were a better predictor of hippocampal volumes. Conclusions Our results replicate previous findings of reduced hippocampal volume in PTSD but also suggest independent, generalized, white matter atrophy.
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PTSD is associated with smaller hippocampal volume.
“Smaller hipocampal volume MRI: Villarreal et al. (2002); Hedges et al. (2003); Kitayama et al. (2005); Pavić et al. (2007); Morey et al. (2012)”
From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Villarreal et al. (2002)
Cites
The development of a Clinician-Administered PTSD Scale
Blake, D. D., Weathers, F. W., Nagy, L. M., Kaloupek, D. G., Gusman, F. D., Charney, D. S., & Keane, T. M. (1995) · Journal of Traumatic Stress · doi:10.1002/jts.2490080106 · Cited by 5,024 · see citing works
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693 · see citing works
Hippocampal atrophy in recurrent major depression
Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.3908 · Cited by 1,932 · see citing works
Hippocampal Volume Reduction in Major Depression
Bremner, J. D., Narayan, M., Anderson, E. R., Staib, L. H., Miller, H. L., & Charney, D. S. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.115 · Cited by 1,670 · see citing works
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.7.973 · Cited by 1,610 · see citing works
Sheline, Y. I., Sanghavi, M., Mintun, M. A., & Gado, M. H. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-12-05034.1999 · Cited by 1,382 · cited 1× · see citing works
“The brain imaging literature in depression is conflicting, with some studies reporting smaller hippocampal volumes (Bremner et al 2000; Sheline et al 1996, 1999), whereas others, typically using lower resolution scanners, do not (Ashtari et al 1999; Axelson et al 1993; Dupont et al 1995).”
MethodBremner, J. D., Randall, P., Vermetten, E., Staib, L., Bronen, R. A., Mazure, C., Capelli, S., McCarthy, G., Innis, R. B., & Charney, D. S. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00162-x · Cited by 1,283 · see citing works
Sugahara, T., Korogi, Y., Kochi, M., Ikushima, I., Shigematu, Y., Hirai, T., Okuda, T., Liang, L., Ge, Y., Komohara, Y., et al. (1999) · Journal of Magnetic Resonance Imaging · doi:10.1002/(sici)1522-2586(199901)9:1 · Cited by 1,151 · see citing works
Self-citationDevelopmental traumatology part II: brain development∗∗See accompanying Editorial, in this issue.
De Bellis, M. D., Keshavan, M. S., Clark, D. B., Casey, B. J., Giedd, J. N., Boring, A. M., Frustaci, K., & Ryan, N. D. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00045-1 · Cited by 974 · see citing works
Effects of age on tissues and regions of the cerebrum and cerebellum.
Jernigan, T., Archibald, S., Fennema-Notestine, C., Gamst, A., Stout, J. C., Bonner, J. C., & Hesselink, J. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00217-2 · Cited by 958 · see citing works
Hippocampal volume in women victimized by childhood sexual abuse
STEIN, M. B., KOVEROLA, C., HANNA, C., TORCHIA, M. G., & McCLARTY, B. (1997) · Psychological Medicine · doi:10.1017/s0033291797005242 · Cited by 924 · see citing works
Gurvits, T. V., Shenton, M. E., Hokama, H., Ohta, H., Lasko, N. B., Gilbertson, M. W., Orr, S. P., Kikinis, R., Jolesz, F. A., McCarley, R. W., et al. (1996) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00229-6 · Cited by 899 · see citing works
Magariños, A. M., McEwen, B. S., Flügge, G., & Fuchs, E. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03534.1996 · Cited by 864 · see citing works
Hippocampal damage associated with prolonged and fatal stress in primates
Uno, H., Tarara, R., Else, J., Suleman, M., & Sapolsky, R. (1989) · The Journal of Neuroscience · doi:10.1523/jneurosci.09-05-01705.1989 · Cited by 728 · see citing works
Bremner, J. D. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00009-8 · Cited by 703 · see citing works
Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging
Watson, C. E., Andermann, F., GLOOR, P., Jones‐Gotman, M., Peters, T. M., Evans, A. C., Olivier, A., Melanson, D., & Leroux, G. (1992) · Neurology · doi:10.1212/wnl.42.9.1743 · Cited by 665 · see citing works
A Group-Test for Assessing Hand- and Eye-Dominance
Crovitz, H. F., & Zener, K. (1962) · The American Journal of Psychology · doi:10.2307/1419611 · Cited by 524 · see citing works
Sheline, Y. I. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00994-x · Cited by 485 · see citing works
Quantitative Cerebral Anatomy in Depression
Coffey, C. E. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820130009002 · Cited by 457 · see citing works
Longitudinal MRI Study of Hippocampal Volume in Trauma Survivors With PTSD
Bonne, O. B., Brandes, D., Gilboa, A., Gomori, J. M., Shenton, M. E., Pitman, R. K., & Shalev, A. Y. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.8.1248 · Cited by 430 · see citing works
Sánchez, M. M., Young, L. J., Plotsky, P. M., & Insel, T. R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04657.2000 · Cited by 420 · see citing works
Attenuation of frontal asymmetry in pediatric posttraumatic stress disorder
Carrion, V. G., Weems, C. F., Eliez, S., Patwardhan, A., Brown, W., Ray, R. D., & Reiss, A. L. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01218-5 · Cited by 400 · see citing works
Stress Effects on Morphology and Function of the Hippocampusa
McEwen, B. S., & Magariños, A. M. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48286.x · Cited by 393 · see citing works
Hippocampal Volume in Patients With Alcohol Dependence
Agartz, I., Momenan, R., Rawlings, R. R., Kerich, M. J., & Hommer, D. W. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.4.356 · Cited by 360 · see citing works
Anterior Hippocampal Volume Deficits in Nonamnesic, Aging Chronic Alcoholics
Sullivan, E. V., Marsh, L., Mathalon, D. H., Lim, K. O., & Pfefferbaum, A. (1995) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb01478.x · Cited by 343 · see citing works
Bellis, M. D. D., Hall, J., Boring, A. M., Frustaci, K., & Moritz, G. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01105-2 · Cited by 334 · see citing works
Hypercortisolemia and hippocampal changes in depression
Axelson, D., Doraiswamy, P. M., McDonald, W. M., Boyko, O. B., Tupler, L. A., Patterson, L. J., Nemeroff, C. B., Ellinwood, E. H., & Krishnan, K. R. R. (1993) · Psychiatry Research · doi:10.1016/0165-1781(93)90046-j · Cited by 285 · see citing works
Kaufman Brief Intelligence Test
Gray, S. A. O. (2012) · Springer eBooks · doi:10.1007/978-1-4419-1698-3_237 · Cited by 260 · see citing works
Magnetic Resonance Imaging and Mood Disorders
Dupont, R. M. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950210041009 · Cited by 229 · see citing works
Glucocorticoid endangerment of hippocampal neurons is NMDA-receptor dependent
Armanini, M. P., Hutchins, C., Stein-Behrens, B., & Sapolsky, R. M. (1990) · Brain Research · doi:10.1016/0006-8993(90)91734-x · Cited by 205 · see citing works
A volumetric MRI study of the hippocampus in type 1 and 2 alcoholism
Laakso, M. P., Vaurio, O., Savolainen, L., Repo, E., Soininen, H. S., Aronen, H. J., & Tiihonen, J. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00172-2 · Cited by 162 · see citing works
Hippocampal/amygdala volumes in geriatric depression
Ashtari, M., GREENWALD, B. S., Kramer‐Ginsberg, E., Hu, J. Y., Wu, H., Patel, M. C., Aupperle, P. M., & POLLACK, S. (1999) · Psychological Medicine · doi:10.1017/s0033291799008405 · Cited by 153 · see citing works
Barta, P. E., Dhingra, L. K., Royall, R. M., & Schwartz, E. (1997) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(97)00049-6 · Cited by 134 · see citing works
Early Life Stress and Inherited Variation in Monkey Hippocampal Volumes
Lyons, D. M., Yang, C., Sawyer-Glover, A. M., Moseley, M. E., & Schatzberg, A. F. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.12.1145 · Cited by 134 · see citing works
Hippocampal diminution in PTSD: (more or less?) than meets the eye
Pitman, R. K. (2001) · Hippocampus · doi:10.1002/hipo.1022 · Cited by 66 · see citing works
MRI Reveals Gross Structural Abnormalities in PTSD
Cañive, J. M., Lewine, J. D., Orrison, W. W., Edgar, C. J., PROVENCAL, S. L., Davis, J. T., Paulson, K. M., GRAEBER, D., Roberts, B., Escalona, P. R., et al. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48318.x · Cited by 39 · see citing works
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The Neurocircuitry of Fear, Stress, and Anxiety Disorders
Shin, L. M., & Liberzon, I. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.83 · Cited by 2,083 · see citing works
Amygdala, medial prefrontal cortex, and hippocampal function in PTSD
SHIN, L. M., RAUCH, S. L., & PITMAN, R. K. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.007 · Cited by 1,203 · see citing works
A meta-analysis of structural brain abnormalities in PTSD
KARL, A., SCHAEFER, M., MALTA, L., DORFEL, D., ROHLEDER, N., & WERNER, A. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.03.004 · Cited by 881 · see citing works
Traumatic stress: effects on the brain
Bremner, J. D. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/jbremner · Cited by 738 · see citing works
Bremner, J. D. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00009-8 · Cited by 703 · see citing works
Posttraumatic stress disorder: a state-of-the-science review
Nemeroff, C. B., Bremner, J. D., Foa, E. B., Mayberg, H. S., North, C. S., & Stein, M. B. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.07.005 · Cited by 675 · see citing works
Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?
Kuchinad, A., Schweinhardt, P., Seminowicz, D. A., Wood, P. B., Chizh, B. A., & Bushnell, M. C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0098-07.2007 · Cited by 613 · see citing works
Vermetten, E., Vythilingam, M., Southwick, S. M., Charney, D. S., & Bremner, J. D. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00634-6 · Cited by 487 · see citing works
Logue, M. W., van Rooij, S. J. H., Dennis, E. L., Davis, S. L., Hayes, J. P., Stevens, J. S., Densmore, M., Haswell, C. C., Ipser, J., Koch, S. B. J., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.09.006 · Cited by 487 · see citing works
Early Life Stress and Morphometry of the Adult Anterior Cingulate Cortex and Caudate Nuclei
Cohen, R. A., Grieve, S., Hoth, K. F., Paul, R. H., Sweet, L., Tate, D., Gunstad, J., Stroud, L., McCaffery, J., Hitsman, B., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.12.016 · Cited by 439 · see citing works
Chronic Stress-induced Hippocampal Vulnerability: The Glucocorticoid Vulnerability Hypothesis
Conrad, C. D. (2008) · Reviews in the Neurosciences · doi:10.1515/revneuro.2008.19.6.395 · Cited by 425 · see citing works
Kitayama, N., Vaccarino, V., Kutner, M., Weiss, P., & Bremner, J. D. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.05.014 · Cited by 423 · see citing works
Woon, F. L., & Hedges, D. W. (2008) · Hippocampus · doi:10.1002/hipo.20437 · Cited by 416 · see citing works
Woon, F. L., Sood, S., & Hedges, D. W. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.06.016 · Cited by 410 · see citing works
MR-based in vivo hippocampal volumetrics: 2. Findings in neuropsychiatric disorders
Geuze, E., Vermetten, E., & Bremner, J. D. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001579 · Cited by 412 · see citing works
Smith, M. E. (2005) · Hippocampus · doi:10.1002/hipo.20102 · Cited by 395 · see citing works
Yamasue, H., Kasai, K., Iwanami, A., Ohtani, T., Yamada, H., Abe, O., Kuroki, N., Fukuda, R., Tochigi, M., Furukawa, S., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1530467100 · Cited by 381 · see citing works
O'Doherty, D. C. M., Chitty, K. M., Saddiqui, S., Bennett, M. R., & Lagopoulos, J. (2015) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2015.01.002 · Cited by 375 · see citing works
Structural and functional plasticity of the human brain in posttraumatic stress disorder
Bremner, J. D., Elzinga, B. M., Schmahl, C. G., & Vermetten, E. H. G. J. M. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)67012-5 · Cited by 368 · see citing works
Kundaković, M., & Rocks, D. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.101010 · Cited by 333 · see citing works
Zoladz, P. R., & Diamond, D. M. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.03.024 · Cited by 308 · see citing works
Functional neuroimaging studies of post-traumatic stress disorder
Hughes, K. C., & Shin, L. M. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.198 · Cited by 290 · see citing works
Hippocampal function in posttraumatic stress disorder
Shin, L. M., Shin, P. S., Heckers, S., Pogoda, T. K., Macklin, M. L., Orr, S. P., Lasko, N. B., Segal, E., Makris, N., Richert, K. A., et al. (2004) · Hippocampus · doi:10.1002/hipo.10183 · Cited by 272 · see citing works
Posttraumatic stress disorder: An empirical evaluation of core assumptions
Rosen, G. M., & Lilienfeld, S. O. (2007) · Clinical Psychology Review · doi:10.1016/j.cpr.2007.12.002 · Cited by 265 · see citing works
Human vulnerability to stress depends on amygdala's predisposition and hippocampal plasticity
Admon, R., Lubin, G., Stern, O., Rosenberg, K., Lee, S.-L., Ben-Ami, H., & Hendler, T. (2009) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0903183106 · Cited by 250 · see citing works
Bremner, J., Vermetten, E., Afzal, N., & Vythilingam, M. (2004) · Journal of Nervous and Mental Disease · doi:10.1097/01.nmd.0000142027.52893.c8 · Cited by 200 · see citing works
Aging, stress and the hippocampus
Miller, D. B., & O’Callaghan, J. P. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.03.002 · Cited by 206 · see citing works
Smaller hippocampal volume in patients with recent-onset posttraumatic stress disorder.
Wignall, E., Dickson, J., Vaughan, P., Farrow, T., Wilkinson, I., Hunter, M., & Woodruff, P. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.09.015 · Cited by 209 · see citing works
Asymmetry of the hippocampus and amygdala in MRI volumetric measurements of normal adults
Pedraza, O., Bowers, D., & Gilmore, R. L. (2004) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617704105080 · Cited by 202 · see citing works
Hayes, J. P., LaBar, K. S., McCarthy, G., Selgrade, E. S., Nasser, J. D., Dolcos, F., & Morey, R. A. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.10.007 · Cited by 190 · see citing works
Increased gray matter density in young women with chronic vulvar pain
Schweinhardt, P., Kuchinad, A., Pukall, C. F., & Bushnell, M. C. (2008) · Pain · doi:10.1016/j.pain.2008.09.014 · Cited by 192 · see citing works
Measuring cumulative trauma dose, types, and profiles using a development-based taxonomy of traumas.
Kira, I. A., Lewandowski, L., Templin, T., Ramaswamy, V., Ozkan, B., & Mohanesh, J. (2008) · Traumatology · doi:10.1177/1534765608319324 · Cited by 186 · see citing works
Gilbertson, M. W., Paulus, L. A., Williston, S. K., Gurvits, T. V., Lasko, N. B., Pitman, R. K., & Orr, S. P. (2006) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.115.3.484 · Cited by 186 · see citing works
MR-based in vivo hippocampal volumetrics: 1. Review of methodologies currently employed
Geuze, E., Vermetten, E., & Bremner, J. D. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001580 · Cited by 185 · see citing works
Reduced size and abnormal asymmetry of parietal cortex in women with borderline personality disorder
Irle, E., Lange, C., & Sachsse, U. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.004 · Cited by 182 · see citing works
De Bellis, M. D., Woolley, D. P., & Hooper, S. R. (2013) · Child Maltreatment · doi:10.1177/1077559513497420 · Cited by 183 · see citing works
Segmented Hippocampal Volume in Children and Adolescents with Posttraumatic Stress Disorder
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Smaller hippocampal volume in Dutch police officers with posttraumatic stress disorder
Lindauer, R., Vlieger, E.-J., Jalink, M., Olff, M., Carlier, I. V. E., Majoie, C. B. L. M., den Heeten, G. J., & Gersons, B. P. R. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.05.021 · Cited by 183 · see citing works
Adjunctive risperidone in the treatment of chronic combat-related posttraumatic stress disorder
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Lindauer, R., Olff, M., van Meijel, E. P. M., Carlier, I. V. E., & Gersons, B. P. R. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.033 · Cited by 179 · see citing works
PTSD-related neuroimaging abnormalities in brain function, structure, and biochemistry
Harnett, N. G., Goodman, A. M., & Knight, D. C. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113331 · Cited by 185 · see citing works
Pitman, R. K., Gilbertson, M. W., Gurvits, T. V., May, F. S., Lasko, N. B., Metzger, L. J., Shenton, M. E., Yehuda, R., Orr, S. P., & for the Harvard/VA PTSD Twin Study Investigators (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.019 · Cited by 178 · see citing works
Gray Matter Volumes of Pain-Related Brain Areas Are Decreased in Fibromyalgia Syndrome
Robinson, M. E., Craggs, J. G., Price, D. D., Perlstein, W. M., & Staud, R. M. (2010) · Journal of Pain · doi:10.1016/j.jpain.2010.10.003 · Cited by 175 · see citing works
Stress and hippocampal abnormalities in psychiatric disorders
Sala, M. (2004) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2003.12.005 · Cited by 169 · see citing works
Valet, M., Gündel, H., Sprenger, T., Sorg, C., Mühlau, M., Zimmer, C., Henningsen, P., & Tölle, T. R. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31818d1e02 · Cited by 167 · see citing works
Hippocampal Volume in Adult Burn Patients With and Without Posttraumatic Stress Disorder
Winter, H., & Irle, E. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.12.2194 · Cited by 166 · see citing works
Association of Neighborhood-Level Disadvantage With Cerebral and Hippocampal Volume
Hunt, J. F. V., Buckingham, W. J., Kim, A. J., Oh, J. M., Vogt, N. M., Jonaitis, E. M., Hunt, T. K. A., Zuelsdorff, M. L., Powell, W. R., Norton, D., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2019.4501 · Cited by 166 · see citing works
Bremner, J. D. (2006) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152706778559309 · Cited by 163 · see citing works
Neuroimaging in Posttraumatic Stress Disorder and Other Stress-Related Disorders
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Age-related differences in glucocorticoid receptor mRNA levels in the human brain
Perlman, W. R., Webster, M. J., Herman, M. M., Kleinman, J. E., & Weickert, C. S. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.01.010 · Cited by 152 · see citing works
Neuropsychological functioning in posttraumatic stress disorder and alcohol abuse.
Samuelson, K. W., Neylan, T. C., Metzler, T. J., Lenoci, M., ROTHLIND, J. C., Henn‐Haase, C., Choucroun, G., Weiner, M. W., & Marmar, C. R. (2006) · Neuropsychology · doi:10.1037/0894-4105.20.6.716 · Cited by 150 · see citing works
Dell’Osso, L., Carmassi, C., Debbio, A. D., Dell’Osso, M. C., Bianchi, C., Pozzo, E. D., Origlia, N., Domenici, L., Massimetti, G., Marazziti, D., et al. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.04.018 · Cited by 148 · see citing works
Hippocampal volume and total cell numbers in major depressive disorder
Cobb, J. A., Simpson, J., Mahajan, G., Overholser, J. C., Jurjus, G., Dieter, L., Herbst, N. P., May, W., Rajkowska, G., & Stockmeier, C. A. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.10.020 · Cited by 144 · see citing works
Herringa, R., Phillips, M., Almeida, J., Insana, S., & Germain, A. (2012) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2012.02.005 · Cited by 143 · see citing works
Long-Term Occupational Stress Is Associated with Regional Reductions in Brain Tissue Volumes
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Resting regional cerebral perfusion in recent posttraumatic stress disorder
Bonne, O., Gilboa, A., Louzoun, Y., Brandes, D., Yona, I., Lester, H., Barkai, G., Freedman, N., Chisin, R., & Shalev, A. Y. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00525-0 · Cited by 142 · see citing works
Weniger, G., Lange, C., Sachsse, U., & Irle, E. (2008) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2008.01246.x · Cited by 140 · see citing works
Cicchetti, D., & Curtis, W. J. (2015) · Wiley eBooks · doi:10.1002/9780470939390.ch1 · Cited by 136 · see citing works
Saigh, P. A., Yasik, A. E., Oberfield, R. A., Halamandaris, P. V., & Bremner, J. D. (2006) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.115.2.332 · Cited by 137 · see citing works
Abnormal size of the amygdala predicts impaired emotional memory in major depressive disorder
WENIGER, G., LANGE, C., & IRLE, E. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.04.017 · Cited by 135 · see citing works
Nakao (2005) · doi:10.1016/j.pscychresns.2005.04.003 · Cited by 132 · see citing works
Abe, O., Yamasue, H., Kasai, K., Yamada, H., Aoki, S., Iwanami, A., Ohtani, T., Masutani, Y., Kato, N., & Ohtomo, K. (2006) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2006.01.004 · Cited by 129 · see citing works
Fibromyalgia: A Disorder of the Brain?
Schweinhardt, P., Sauro, K. M., & Bushnell, M. C. (2007) · The Neuroscientist · doi:10.1177/1073858407312521 · Cited by 131 · see citing works
Wingenfeld, K., Spitzer, C., Rullkötter, N., & Löwe, B. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.09.014 · Cited by 126 · see citing works
A review on brain structures segmentation in magnetic resonance imaging
González-Villà, S., Oliver, A., Valverde, S., Wang, L., Reyer Zwiggelaar, A., & Lladó, X. (2016) · Artificial Intelligence in Medicine · doi:10.1016/j.artmed.2016.09.001 · Cited by 132 · see citing works
Structural Changes of the Brain in Relation to Occupational Stress
Savic, I. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht348 · Cited by 133 · see citing works
Effects of Traumatic Stress on Brain Structure and Function: Relevance to Early Responses to Trauma
Bremner, J. D. (2005) · Journal of Trauma & Dissociation · doi:10.1300/j229v06n02_06 · Cited by 128 · see citing works
Sanjuan, P. M., Thoma, R., Claus, E. D., Mays, N., & Caprihan, A. (2013) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2013.09.002 · Cited by 125 · see citing works
Bonne, O. B., Grillon, C., Vythilingam, M., Neumeister, A., & Charney, D. S. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.12.001 · Cited by 124 · see citing works
The Relationship Between Cognitive and Brain Changes in Posttraumatic Stress Disorder
Bremner, J. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.008 · Cited by 137 · see citing works
Regional differences of the prefrontal cortex in pediatric PTSD: an MRI study
Richert, K. A., Carrion, V. G., Karchemskiy, A., & Reiss, A. L. (2006) · Depression and Anxiety · doi:10.1002/da.20131 · Cited by 118 · see citing works
JATZKO, A., ROTHENHOFER, S., SCHMITT, A., GASER, C., DEMIRAKCA, T., WEBERFAHR, W., WESSA, M., MAGNOTTA, V, & BRAUS, D. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.03.010 · Cited by 116 · see citing works
Zhang, D., Wang, X., Wang, B., Garza, J. C., Fang, X., Wang, J., Scherer, P., Brenner, R., Zhang, W., & Lu, X.-Y. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.58 · Cited by 115 · see citing works
Gilbertson, M. W., Williston, S. K., Paulus, L. A., Lasko, N. B., Gurvits, T. V., Shenton, M. E., Pitman, R. K., & Orr, S. P. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.12.023 · Cited by 114 · see citing works
Brain imaging in anxiety disorders
Bremner, J. D. (2004) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.4.2.275 · Cited by 111 · see citing works
Changes in Gray Matter Density in Fibromyalgia: Correlation With Dopamine Metabolism
Wood, P. B., Glabus, M. F., Simpson, R., & Patterson, J. C. (2009) · Journal of Pain · doi:10.1016/j.jpain.2008.12.008 · Cited by 112 · see citing works
Attention, Learning, and Memory in Posttraumatic Stress Disorder
Neylan, T., Lenoci, M., Rothlind, J. C., Metzler, T. J., Schuff, N., Du, A.-T., Franklin, K. W., Weiss, D. S., Weiner, M., & Marmar, C. (2004) · Journal of Traumatic Stress · doi:10.1023/b:jots.0000014675.75686.ee · Cited by 107 · see citing works
Yehuda, R., Golier, J. A., Tischler, L., Harvey, P. D., Newmark, R. E., Yang, R. K., & Buchsbaum, M. S. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.12.002 · Cited by 111 · see citing works
Twin studies of posttraumatic stress disorder: Differentiating vulnerability factors from sequelae
Kremen, W. S., Koenen, K. C., Afari, N., & Lyons, M. J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.03.012 · Cited by 106 · see citing works
Neurocircuitry of anxiety disorders
Kent, J., & Rauch, S. (2003) · Current Psychiatry Reports · doi:10.1007/s11920-003-0055-8 · Cited by 113 · see citing works
Henigsberg, N., Kalember, P., Petrović, Z. K., & Šečić, A. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.11.003 · Cited by 105 · see citing works
Golier, J. A., Yehuda, R., De Santi, S., Segal, S., Dolan, S., & de Leon, M. J. (2005) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2005.02.007 · Cited by 105 · see citing works
Neurobiology of PTSD: A Review of Neuroimaging Findings
Garfinkel, S. N., & Liberzon, I. (2009) · Psychiatric Annals · doi:10.3928/00485713-20090527-01 · Cited by 102 · see citing works
Neural Correlates of Anxiety in Healthy Volunteers: A Voxel-Based Morphometry Study
Spampinato, M. V., Wood, J. N., Simone, V. D., & Grafman, J. H. (2009) · Journal of Neuropsychiatry · doi:10.1176/jnp.2009.21.2.199 · Cited by 99 · see citing works
Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder
Schuff, N. W., Neylan, T. C., Fox‐Bosetti, S., Lenoci, M., Samuelson, K. W., Studholme, C., Kornak, J., Marmar, C. R., & Weiner, M. W. (2008) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.04.011 · Cited by 100 · see citing works
The Neurocircuitry of Fear, Stress, and Anxiety Disorders
Shin, L. M., & Liberzon, I. (2011) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.9.3.foc311 · Cited by 104 · see citing works
Nicotine modulation of fear memories and anxiety: Implications for learning and anxiety disorders
Kutlu, M. G., & Gould, T. J. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.029 · Cited by 97 · see citing works
Duration of posttraumatic stress disorder predicts hippocampal grey matter loss
Felmingham, K. L., Williams, L. M., Whitford, T. J., Falconer, E. M., Kemp, A. H., Peduto, A. J., & Bryant, R. A. (2009) · Neuroreport · doi:10.1097/wnr.0b013e3283300fbc · Cited by 98 · see citing works
Neuroanatomical Changes Associated with Pharmacotherapy in Posttraumatic Stress Disorder
Bremner, J. D., & Vermetten, E. H. G. J. M. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1314.012 · Cited by 98 · see citing works
Hermelink, K., Voigt, V., Kaste, J., Neufeld, F., Wuerstlein, R., Bühner, M., Münzel, K., Rjosk-Dendorfer, D., Grandl, S., Braun, M., et al. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv099 · Cited by 97 · see citing works
Goodman, J., Leong, K.-C., & Packard, M. G. (2012) · Reviews in the Neurosciences · doi:10.1515/revneuro-2012-0049 · Cited by 97 · see citing works
Anxiety and Hippocampus Volume in the Rat
Kalisch, R., Schubert, M., Jacob, W., Keßler, M. S., Hemauer, R., Wigger, A., Landgraf, R., & Auer, D. P. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300910 · Cited by 96 · see citing works
Meng, Y., Qiu, C., Zhu, H., Lama, S., Lui, S., Gong, Q., & Zhang, W. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.05.021 · Cited by 96 · see citing works
Reduced area of the corpus callosum in posttraumatic stress disorder
Villarreal, G., Hamilton, D. A., Graham, D. P., Driscoll, I. F., Qualls, C., Petropoulos, H., & Brooks, W. M. (2004) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2004.05.002 · Cited by 96 · see citing works
Self-citationTargeting Voltage-Gated Calcium Channels for Neuropathic Pain Management
Perret, D. M., & Luo, Z. D. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.07.006 · Cited by 95 · see citing works
Neuropsychological Functioning in Children with Posttraumatic Stress Disorder
Samuelson, K. W., Krueger, C. E., Burnett, C., & Wilson, C. K. (2009) · Child Neuropsychology · doi:10.1080/09297040903190782 · Cited by 95 · see citing works
Evidence for evolutionary specialization in human limbic structures
Barger, N., Hanson, K. L., Teffer, K., Schenker-Ahmed, N. M., & Semendeferi, K. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00277 · Cited by 94 · see citing works
Rosso, I. M., Crowley, D. J., Silveri, M. M., Rauch, S. L., & Jensen, J. E. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.32 · Cited by 92 · see citing works
Gracely, R. H., & Ambrose, K. (2011) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2011.02.003 · Cited by 91 · see citing works
Advances in neuroimaging of traumatic brain injury and posttraumatic stress disorder
Boven, R. W. V., Harrington, G. S., Hackney, D. B., Ebel, A., Gauger, G. E., Bremner, J. D., D’Esposito, M., Detre, J. A., Haacke, E. M., Jack, C. R., et al. (2009) · The Journal of Rehabilitation Research and Development · doi:10.1682/jrrd.2008.12.0161 · Cited by 91 · see citing works
- Authors
- Villarreal, G., Hamilton, D. A., Petropoulos, H., Driscoll, I., Rowland, L. M., Griego, J. A., Kodituwakku, P. W., Hart, B. L., Escalona, R., & Brooks, W. M.
- Affiliations
- University of New Mexico (US)
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2002-07
- Volume
- 52
- Issue
- 2
- Pages
- 119-125
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2020961462
- Cited by
- 382
- References
- 36
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 11 · 2023: 10 · 2022: 12 · 2021: 9 · 2020: 14 · 2019: 6 · 2018: 13 · 2017: 15 · 2016: 17 · 2015: 16 · 2014: 20 · 2013: 13 · 2012: 9
- FWCI
- 32.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- post-traumatic stress disorder, hippocampal volume, white matter atrophy, whole brain atrophy, intracranial volume, cerebrospinal fluid, brain atrophy, depression, alcohol intoxication, civilian trauma
- MeSH terms
- Adult, Analysis of Variance, Atrophy, Brain, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Stress Disorders, Post-Traumatic
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