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Cited by 513Stress Responses and CortisolNeural and Behavioral Psychology StudiesAdvanced MRI Techniques and Applications

Perfusion functional MRI reveals cerebral blood flow pattern under psychological stress

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Wang, Jiongjiong, Rao, Hengyi, Wetmore, Gabriel S., Furlan, Patricia M., Korczykowski, Marc, Dinges, David F., Detre, John A.·2005·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0503082102PMC PMC1292988
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Abstract

Despite the prevalence of stress in everyday life and its impact on happiness, health, and cognition, little is known about the neural substrate of the experience of everyday stress in humans. We use a quantitative and noninvasive neuroimaging technique, arterial spin-labeling perfusion MRI, to measure cerebral blood flow (CBF) changes associated with mild to moderate stress induced by a mental arithmetic task with performance monitoring. Elicitation of stress was verified by self-report of stress and emotional state and measures of heart rate and salivary-cortisol level. The change in CBF induced by the stress task was positively correlated with subjective stress rating in the ventral right prefrontal cortex (RPFC) and left insula/putamen area. The ventral RPFC along with right insula/putamen and anterior cingulate showed sustained activation after task completion in subjects reporting a high stress level during arithmetic tasks. Additionally, variations of baseline CBF in the ventral RPFC and right orbitofrontal cortex were found to correlate with changes in salivary-cortisol level and heart rate caused by undergoing stress tasks. We further demonstrated that the observed right prefrontal activation could not be attributed to increased cognitive demand accompanying stress tasks and extended beyond neural pathways associated with negative emotions. Our results provide neuroimaging evidence that psychological stress induces negative emotion and vigilance and that the ventral RPFC plays a key role in the central stress response.

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  • The dual-hormone profile of increased testosterone and reduced cortisol is related to adaptive decision-making in stressful social settings.

    “the dual-hormone profile of increased testosterone and reduced cortisol is related to adaptive decision-making in stressful social settings (Wang et al., 2005).”

    From Salivary testosterone and cortisol response in acute stress modulated by seven sessions of mindfulness meditation in young males (2024) · cites this paper as Wang et al., 2005

    The Results report that salivary cortisol peaked after a high-stress task, and the Discussion relates cortisol to cerebral blood flow. Searches for testosterone, a dual-hormone profile, and decision-making found no passage addressing whether increased testosterone and reduced cortisol are associated with adaptive decisions in stressful social settings. (LLM, conf=0.77)

    Experimental — accuracy not yet measured

  • Functional imaging of individuals undergoing ordinary stressors, such as counting backwards, shows lasting changes in neural activity.

    “there are indications from functional imaging of individuals undergoing ordinary stressors, such as counting backwards that there are lasting changes in neural activity (Wang et al., 2005).”

    From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Wang et al., 2005

  • Functional imaging of individuals undergoing ordinary stressors, such as counting backwards, indicates lasting changes in neural activity.

    “Although there is very little evidence regarding the effects of ordinary life stressors on brain structure, there are indications from functional imaging of individuals undergoing ordinary stressors, such as counting backwards, that there are lasting changes in neural activity.101”

    From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [101]

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Authors
Wang, J., Rao, H., Wetmore, G. S., Furlan, P. M., Korczykowski, M., Dinges, D. F., & Detre, J. A.
Affiliations
University of Pennsylvania (US)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2005-11-23
Volume
102
Issue
49
Pages
17804-17809
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0503082102
PMC
PMC1292988
OpenAlex
W2104007404
Cited by
513
References
49
Citations by year
2026: 8 · 2025: 8 · 2024: 17 · 2023: 16 · 2022: 21 · 2021: 15 · 2020: 24 · 2019: 20 · 2018: 25 · 2017: 24 · 2016: 26 · 2015: 24 · 2014: 33 · 2013: 45 · 2012: 40
FWCI
9.52
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (R21MH072576, MH072576)
  • National Institute on Drug Abuse (DA-015149, R01DA015149)
  • National Institute of Neurological Disorders and Stroke (P30NS045839, NS-045839)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
psychological stress, cerebral blood flow, arterial spin labeling, insula, putamen, anterior cingulate cortex, salivary cortisol, heart rate, sustained attention, negative emotions, mental arithmetic task, stress response
MeSH terms
Adult, Anxiety, Brain, Cerebrovascular Circulation, Female, Heart Rate, Humans, Hydrocortisone, Magnetic Resonance Imaging, Male, Mathematics, Monitoring, Physiologic, Stress, Psychological

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