Cited by 416Advanced Fluorescence Microscopy TechniquesIon Channels and ReceptorsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.

Estimating Intracellular Calcium Concentrations and Buffering without Wavelength Ratioing

Open access

Maravall, M., Mainen, Z.F., Sabatini, B.L., Svoboda, K.·2000·Biophysical Journal

DOI 10.1016/s0006-3495(00)76809-3PMC PMC1300854

Open this paper in CoChat — free account Open PDF

Abstract

We describe a method for determining intracellular free calcium concentration ([Ca(2+)]) from single-wavelength fluorescence signals. In contrast to previous single-wavelength calibration methods, the proposed method does not require independent estimates of resting [Ca(2+)] but relies on the measurement of fluorescence close to indicator saturation during an experiment. Consequently, it is well suited to [Ca(2+)] indicators for which saturation can be achieved under physiological conditions. In addition, the method requires that the indicators have large dynamic ranges. Popular indicators such as Calcium Green-1 or Fluo-3 fulfill these conditions. As a test of the method, we measured [Ca(2+)] in CA1 pyramidal neurons in rat hippocampal slices using Oregon Green BAPTA-1 and 2-photon laser scanning microscopy (BAPTA: 1,2-bis(2-aminophenoxy)ethane-N,N,N', N'-tetraacetic acid). Resting [Ca(2+)] was 32-59 nM in the proximal apical dendrite. Monitoring action potential-evoked [Ca(2+)] transients as a function of indicator loading yielded estimates of endogenous buffering capacity (44-80) and peak [Ca(2+)] changes at zero added buffer (178-312 nM). In young animals (postnatal days 14-17) our results were comparable to previous estimates obtained by ratiometric methods (, Biophys. J. 70:1069-1081), and no significant differences were seen in older animals (P24-28). We expect our method to be widely applicable to measurements of [Ca(2+)] and [Ca(2+)]-dependent processes in small neur…

Integrity signals

Registry

Crossref · 10.1016/s0006-3495(00)76809-3

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A new generation of Ca2+ indicators with greatly improved fluorescence properties.
Grynkiewicz, G., Poenie, M., & Tsien, R. Y. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83641-4 · Cited by 21,562
Two-photon laser scanning fluorescence microscopy
Denk, W., Strickler, J. H., & Webb, W. W. (1990) · Science · doi:10.1126/science.2321027 · Cited by 9,488
Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023
Handbook Of Biological Confocal Microscopy
Pawley, J. B. (2006) · Springer eBooks · doi:10.1007/978-0-387-45524-2 · Cited by 3,685
Handbook of Biological Confocal Microscopy
Pawley, J. B. (1995) · Springer eBooks · doi:10.1007/978-1-4757-5348-6 · Cited by 1,872
Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores
Minta, A., Kao, J. P. Y., & Tsien, R. Y. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83165-9 · Cited by 1,621
A Synaptically Controlled, Associative Signal for Hebbian Plasticity in Hippocampal Neurons
Magee, J. C., & Johnston, D. (1997) · Science · doi:10.1126/science.275.5297.209 · Cited by 1,340
Dendritic spines as basic functional units of neuronal integration
Yuste, R., & Denk, W. (1995) · Nature · doi:10.1038/375682a0 · Cited by 950
In vivo dendritic calcium dynamics in neocortical pyramidal neurons
Svoboda, K., Denk, W. T., Kleinfeld, D., & Tank, D. W. (1997) · Nature · doi:10.1038/385161a0 · Cited by 820
Self-citation
Photochemically generated cytosolic calcium pulses and their detection by fluo-3
Kao, J. P. Y., Harootunian, A. T., & Tsien, R. Y. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83166-0 · Cited by 810

Show all 46 references

Sorted by citations

Items 101–200 of 416

A Neuron-Based Screening Platform for Optimizing Genetically-Encoded Calcium Indicators
Wardill, T. J., Chen, T., Schreiter, E. R., Hasseman, J. P., Tsegaye, G., Fosque, B. F., Behnam, R., Shields, B. C., Ramirez, M. H., Kimmel, B. E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077728 · Cited by 67
Self-citation
Vesicular ATPase Inserted into the Plasma Membrane of Motor Terminals by Exocytosis Alkalinizes Cytosolic pH and Facilitates Endocytosis
Zhang, Z., Nguyen, K. T. V., Barrett, E. F., & David, G. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.035 · Cited by 69
Cannabinoid receptor activation modifies NMDA receptor mediated release of intracellular calcium: Implications for endocannabinoid control of hippocampal neural plasticity
Hampson, R. E., Miller, F., Palchik, G. A., & Deadwyler, S. A. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.039 · Cited by 66
Monitoring intracellular nanomolar calcium using fluorescence lifetime imaging
Zheng, K., Jensen, T. P., & Rusakov, D. A. (2018) · Nature Protocols · doi:10.1038/nprot.2017.154 · Cited by 66
Calcium signals that determine vascular resistance
Ottolini, M., Hong, K., & Sonkusare, S. K. (2019) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1448 · Cited by 70
Novel Genetically Encoded Bright Positive Calcium Indicator NCaMP7 Based on the mNeonGreen Fluorescent Protein
Subach, O. M., Sotskov, V. P., Plusnin, V. V., Gruzdeva, A. M., Barykina, N. V., Ivashkina, O. I., Anokhin, K. V., Nikolaeva, A. Y., Korzhenevskiy, D. A., Vlaskina, A. V., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051644 · Cited by 65
Buffer mobility and the regulation of neuronal calcium domains
Matthews, E. A., & Dietrich, D. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00048 · Cited by 64
Analog Modulation of Mossy Fiber Transmission Is Uncoupled from Changes in Presynaptic Ca2+
Scott, R. S., Ruiz, A. J., Henneberger, C., Kullmann, D. M., & Rusakov, D. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1296-08.2008 · Cited by 68
Astrocytes as Regulators of Synaptic Function
Rusakov, D. A., Zheng, K., & Henneberger, C. (2011) · The Neuroscientist · doi:10.1177/1073858410387304 · Cited by 67
Nanoneedle Transistor-Based Sensors for the Selective Detection of Intracellular Calcium Ions
Son, D., Park, S. Y., Kim, B.-J., Koh, J. T., Kim, T. H., An, S., Jang, D., Kim, G. T., Jhe, W., & Hong, S. (2011) · ACS Nano · doi:10.1021/nn200262u · Cited by 61
Independent Regulation of Basal Neurotransmitter Release Efficacy by Variable Ca2+ Influx and Bouton Size at Small Central Synapses
Ermolyuk, Y. S., Alder, F. G., Henneberger, C., Rusakov, D. A., Kullmann, D. M., & Volynski, K. E. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001396 · Cited by 61
Distinct Intracellular Calcium Transients in Neurites and Somata Integrate Neuronal Signals
Johenning, F. W., Żochowski, M., Conway, S. J., Holmes, A. B., Koulen, P., & Ehrlich, B. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05344.2002 · Cited by 61
Module 2: Cell Signalling Pathways
Berridge, M. J. (2012) · Cell Signalling Biology · doi:10.1042/csb0001002 · Cited by 66
In Situ Calibration of Nucleoplasmic versus Cytoplasmic Ca2+ Concentration in Adult Cardiomyocytes
Ljubojević-Holzer, S., Walther, S., Asgarzoei, M., Sedej, S., Pieske, B. M., & Kockskämper, J. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2011.03.060 · Cited by 59
Reduced endogenous Ca 2+ buffering speeds active zone Ca 2+ signaling
Delvendahl, I., Jablonski, L., Baade, C., Matveev, V., Neher, E., & Hallermann, S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508419112 · Cited by 63
Measuring Cation Dependent DNA Polymerase Fidelity Landscapes by Deep Sequencing
Zamft, B. M., Marblestone, A. H., Kording, K. P., Schmidt, D., Martin-Alarcon, D. A., Tyo, K. E. J., Boyden, E. S., & Church, G. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043876 · Cited by 58
Mitochondrial Ca2+ Dynamics Reveals Limited Intramitochondrial Ca2+ Diffusion
Gerencser, A. A., & Ádám‐Vizi, V. (2004) · Biophysical Journal · doi:10.1529/biophysj.104.050062 · Cited by 57
Cav1.3 channels produce persistent calcium sparklets, but Cav1.2 channels are responsible for sparklets in mouse arterial smooth muscle
Navedo, M. F., Amberg, G. C., Westenbroek, R. E., Sinnegger-Brauns, M. J., Catterall, W. A., Striessnig, J., & Santana, L. F. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00450.2007 · Cited by 57
Ammonia Mediates Methamphetamine-Induced Increases in Glutamate and Excitotoxicity
Halpin, L. E., Northrop, N. A., & Yamamoto, B. K. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.306 · Cited by 58
A Close Association of RyRs with Highly Dense Clusters of Ca2+-activated Cl− Channels Underlies the Activation of STICs by Ca2+ Sparks in Mouse Airway Smooth Muscle
Bao, R.-F., Lifshitz, L. M., Tuft, R. A., Bellve, K. D., Fogarty, K. E., & ZhuGe, R. (2008) · The Journal of General Physiology · doi:10.1085/jgp.200709933 · Cited by 57
High Speed Two-Photon Imaging of Calcium Dynamics in Dendritic Spines: Consequences for Spine Calcium Kinetics and Buffer Capacity
Cornelisse, L. N., van Elburg, R. A. J., Meredith, R. M., Yuste, R., & Mansvelder, H. D. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001073 · Cited by 57
Heterogeneity of Activity-Induced Sodium Transients between Astrocytes of the Mouse Hippocampus and Neocortex: Mechanisms and Consequences
Ziemens, D., Oschmann, F., Gerkau, N. J., & Rose, C. R. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2029-18.2019 · Cited by 57
Burst discharges in neurons of the thalamic reticular nucleus are shaped by calcium-induced calcium release
Coulon, P., Herr, D., Kanyshkova, T. G., Meuth, P., Budde, T., & Pape, H. (2009) · Cell Calcium · doi:10.1016/j.ceca.2009.09.005 · Cited by 56
Mechanisms underlying variations in excitation–contraction coupling across the mouse left ventricular free wall
Dilly, K. W., Rossow, C. F., Votaw, V. S., Meabon, J. S., Cabarrus, J. L., & Santana, L. F. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.102020 · Cited by 54
Targeting calpain in synaptic plasticity
Baudry, M., Chou, M. M., & Bi, X. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.766169 · Cited by 60
β‐adrenergic‐mediated dynamic augmentation of sarcolemmal CaV1.2 clustering and co‐operativity in ventricular myocytes
Ito, D. W., Hannigan, K. I., Ghosh, D., Xu, B. Y., del Villar, S. G., Xiang, Y. K., Dickson, E. J., Navedo, M. F., & Dixon, R. E. (2019) · The Journal of Physiology · doi:10.1113/jp277283 · Cited by 57
Synaptically Activated Ca2+ Release From Internal Stores in CNS Neurons
Ross, W. N., Nakamura, T., Watanabe, S., Larkum, M. E., & Lasser‐Ross, N. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-005-3060-0 · Cited by 54
Ca 2+ -Independent Alterations in Diastolic Sarcomere Length and Relaxation Kinetics in a Mouse Model of Lipotoxic Diabetic Cardiomyopathy
Flagg, T. P., Cazorla, O., Remedi, M. S., Haim, T. E., Tones, M. A., Bahinski, A., Numann, R. E., Kovács, A. D., Schaffer, J. E., Nichols, C. G., et al. (2008) · Circulation Research · doi:10.1161/circresaha.108.186809 · Cited by 54
Inferring Neuronal Dynamics from Calcium Imaging Data Using Biophysical Models and Bayesian Inference
Rahmati, V., Kirmse, K., Marković, D., Holthoff, K., & Kiebel, S. J. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004736 · Cited by 53
LRP1 (Low-Density Lipoprotein Receptor–Related Protein 1) Regulates Smooth Muscle Contractility by Modulating Ca 2+ Signaling and Expression of Cytoskeleton-Related Proteins
Au, D. T., Ying, Z., Hernández‐Ochoa, E. O., Fondrie, W. E., Hampton, B., Migliorini, M. M., Galisteo, R., Schneider, M. F., Daugherty, A., Rateri, D. L., et al. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311197 · Cited by 53
Silicon carbide quantum dots for bioimaging
Beke, D., Szekrényes, Z., Pálfi, D., Róna, G., Balogh, I., Maák, P. A., Katona, G., Czigány, Z., Kamarás, K., Rózsa, B. J., et al. (2012) · Journal of materials research/Pratt's guide to venture capital sources · doi:10.1557/jmr.2012.296 · Cited by 51
Relation between activity‐induced intracellular sodium transients and ATP dynamics in mouse hippocampal neurons
Gerkau, N. J., Lerchundi, R., Nelson, J. S. E., Lantermann, M., Meyer, J., Hirrlinger, J., & Rose, C. R. (2019) · The Journal of Physiology · doi:10.1113/jp278658 · Cited by 49
AMPA receptors gate spine Ca 2+ transients and spike-timing-dependent potentiation
Holbro, N., Grunditz, Å., Wiegert, J. S., & Oertner, T. G. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004562107 · Cited by 45
Astrocyte Ca2+Signaling Drives Inversion of Neurovascular Coupling after Subarachnoid Hemorrhage
Pappas, A. C., Koide, M., & Wellman, G. C. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1551-15.2015 · Cited by 49
Differential distribution of NCX1 contributes to spine–dendrite compartmentalization in CA1 pyramidal cells
Lőrincz, A., Rózsa, B. J., Katona, G., Vizi, E. S., & Tamás, G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605412104 · Cited by 47
Approaches and tools for modeling signaling pathways and calcium dynamics in neurons
Blackwell, K. T. (2013) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2013.05.008 · Cited by 48
Calcium-Dependent Isoforms of Protein Kinase C Mediate Posttetanic Potentiation at the Calyx of Held
Fioravante, D., Chu, Y., Myoga, M. H., Leitges, M., & Regehr, W. G. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.019 · Cited by 49
Calpastatin simultaneously binds four calpains with different kinetic constants
Hanna, R. A., Garcia-Diaz, B. E., & Davies, P. L. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.05.035 · Cited by 47
Intracellular calcium store filling by an L‐type calcium current in the basolateral amygdala at subthreshold membrane potentials
Power, J., & Sah, P. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.076711 · Cited by 45
Modulation of Presynaptic Ca2+Entry by AMPA Receptors at Individual GABAergic Synapses in the Cerebellum
Rusakov, D. A., Saitow, F., Lehre, K. P., & Konishi, S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0338-05.2005 · Cited by 47
Presynaptic loss of dynamin‐related protein 1 impairs synaptic vesicle release and recycling at the mouse calyx of Held
Singh, M., Denny, H., Smith, C. R., Granados, J. Z., & Renden, R. (2018) · The Journal of Physiology · doi:10.1113/jp276424 · Cited by 47
Fueling the heartbeat: Dynamic regulation of intracellular ATP during excitation–contraction coupling in ventricular myocytes
Rhana, P., Matsumoto, C., Fong, Z., Costa, A. D., del Villar, S. G., Dixon, R. E., & Santana, L. F. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2318535121 · Cited by 45
A new design for a green calcium indicator with a smaller size and a reduced number of calcium-binding sites
Barykina, N. V., Subach, O. M., Doronin, D. A., Sotskov, V. P., Roshchina, M. A., Kunitsyna, T. A., Malyshev, A. Y., Смирнов, И. В., Azieva, A. M., Sokolov, I. S., et al. (2016) · Scientific Reports · doi:10.1038/srep34447 · Cited by 49
A positive feedback loop linking enhanced mGluR function and basal calcium in spinocerebellar ataxia type 2
Meera, P., Pulst, S. M., & Otis, T. S. (2017) · eLife · doi:10.7554/elife.26377 · Cited by 46
Distribution of IP3‐mediated calcium responses and their role in nuclear signalling in rat basolateral amygdala neurons
Power, J., & Sah, P. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.125062 · Cited by 46
A Single-Compartment Model of Calcium Dynamics in Nerve Terminals and DendritesPreprint
Helmchen, F., & Tank, D. W. (2015) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top085910 · Cited by 47
Calibration of Fluorescent Calcium IndicatorsPreprint
Helmchen, F. (2011) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top120 · Cited by 46
Structural dynamics of dendritic spines: Molecular composition, geometry and functional regulation
Ebrahimi, S., & Okabe, S. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.06.002 · Cited by 51
Abnormal excitability of oblique dendrites implicated in early Alzheimer's: a computational study
Morse, T. M. (2010) · Frontiers in Neural Circuits · doi:10.3389/fncir.2010.00016 · Cited by 43
CaMKII translocation requires local NMDA receptor‐mediated Ca2+ signaling
Thalhammer, A., Rudhard, Y., Tigaret, C. M., Volynski, K. E., Rusakov, D. A., & Schoepfer, R. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601420 · Cited by 40
Stimulation‐induced Ca2+ influx at nodes of Ranvier in mouse peripheral motor axons
Zhang, Z., & David, G. (2015) · The Journal of Physiology · doi:10.1113/jp271207 · Cited by 40
Nonlinearity of two-photon Ca2+imaging yields distorted measurements of tuning for V1 neuronal populations
Nauhaus, I., Nielsen, K. J., & Callaway, E. M. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00725.2011 · Cited by 39
Endoplasmic reticulum stress in spinal and bulbar muscular atrophy: a potential target for therapy
Montague-Cardoso, K., Malik, B. A., Gray, A. L., Spada, A. R. L., Hanna, M. G., Szabadkai, G., & Greensmith, L. (2014) · Brain · doi:10.1093/brain/awu114 · Cited by 39
Monitoring single-synapse glutamate release and presynaptic calcium concentration in organised brain tissue
Jensen, T. P., Zheng, K., Tyurikova, O., Reynolds, J. R., & Rusakov, D. A. (2017) · Cell Calcium · doi:10.1016/j.ceca.2017.03.007 · Cited by 39
In Situ Background Estimation in Quantitative Fluorescence Imaging
Chen, T., Lin, B., Brunner, E., & Schild, D. (2005) · Biophysical Journal · doi:10.1529/biophysj.105.070854 · Cited by 38
Near-Infrared Genetically Encoded Positive Calcium Indicator Based on GAF-FP Bacterial Phytochrome
Subach, O. M., Barykina, N. V., Anokhin, K. V., Piatkevich, K. D., & Subach, F. V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143488 · Cited by 37
Loss of calcium and increased apoptosis within the same neuron
Turner, C. P., Connell, J., Blackstone, K., & Ringler, S. L. (2006) · Brain Research · doi:10.1016/j.brainres.2006.10.039 · Cited by 37
Ketone body β-hydroxybutyrate (BHB) preserves mitochondrial bioenergetics
Llorente‐Folch, I., Düßmann, H., Watters, O., Connolly, N. M. C., & Prehn, J. H. M. (2023) · Scientific Reports · doi:10.1038/s41598-023-46776-8 · Cited by 37
Serotonin Modulates Dendritic Calcium Influx in Commissural Interneurons in the Mouse Spinal Locomotor Network
Díaz‐Ríos, M., Dombeck, D. A., Webb, W. W., & Harris‐Warrick, R. M. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00430.2007 · Cited by 36
Calpain-2 as a therapeutic target for acute neuronal injury
Wang, Y., Bi, X., & Baudry, M. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2018.1409723 · Cited by 37
A method for estimating intracellular ion concentration using optical nanosensors and ratiometric imaging
Rong, G., Kim, E. H., Poskanzer, K. E., & Clark, H. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-11162-8 · Cited by 35
Down‐regulation of CaV1.2 channels during hypertension: how fewer CaV1.2 channels allow more Ca2+ into hypertensive arterial smooth muscle
Tajada, S., Cidad, P., Colinas, O., Santana, L. F., López‐López, J. R., & Pérez-García, M. T. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.265751 · Cited by 35
Cord Blood-Derived Neurons Are Originated from CD133+/CD34 Stem/Progenitor Cells in a Cell-to-Cell Contact Dependent Manner
Zangiacomi, V., Balon, N., Maddens, S., Lapierre, V., Tiberghien, P., Schlichter, R., Versaux‐Botteri, C., & Deschaseaux, F. (2008) · Stem Cells and Development · doi:10.1089/scd.2007.0248 · Cited by 35
Heterogeneity and Specificity of Presynaptic Ca2+ Current Modulation by mGluRs at Individual Hippocampal Synapses
Rusakov, D. A. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh035 · Cited by 32
Hydrogen peroxide mediates oxidant-dependent stimulation of arterial smooth muscle L-type calcium channels
Chaplin, N. L., & Amberg, G. C. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00222.2011 · Cited by 34
Arterial Smooth Muscle Mitochondria Amplify Hydrogen Peroxide Microdomains Functionally Coupled to L-Type Calcium Channels
Chaplin, N. L., Nieves‐Cintrón, M., Fresquez, A. M., Navedo, M. F., & Amberg, G. C. (2015) · Circulation Research · doi:10.1161/circresaha.115.306996 · Cited by 34
The alpha7-nicotinic receptor contributes to gp120-induced neurotoxicity: implications in HIV-associated neurocognitive disorders
Capó-Vélez, C. M., Morales‐Vargas, B., García-González, A. P., Grajales‐Reyes, J. G., Delgado‐Vélez, M., Madera, B., Báez-Pagán, C. A., Quesada, O., & Lasalde‐Dominicci, J. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-20271-x · Cited by 33
Calcium Signaling in Neurons and Glial Cells: Role of Cav1 channels
Alves, V. S., Alves-Silva, H. S., Orts, D. J. B., Ribeiro-Silva, L., Arcisio-Miranda, M., & Oliveira, F. A. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.09.041 · Cited by 34
Axonal spheroids in neurodegeneration
Yu, Y., Hunter-Chang, S., Stepanova, E., & Deppmann, C. D. (2021) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2021.103679 · Cited by 35
Relationship between Ca2+sparklets and sarcoplasmic reticulum Ca2+load and release in rat cerebral arterial smooth muscle
Takeda, Y., Nystoriak, M. A., Nieves‐Cintrón, M., Santana, L. F., & Navedo, M. F. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00488.2011 · Cited by 34
Dynamics of Elongation Factor 2 Kinase Regulation in Cortical Neurons in Response to Synaptic Activity
Kenney, J. W., Sorokina, O., Genheden, M., Sorokin, A., Armstrong, J. D., & Proud, C. G. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2866-14.2015 · Cited by 33
Synaptotagmin isoforms confer distinct activation kinetics and dynamics to chromaffin cell granules
Rao, T. C., Santana‐Rodriguez, Z., Bradberry, M. M., Ranski, A. H., Dahl, P. J., Schmidtke, M. W., Jenkins, P. M., Axelrod, D., Chapman, E. R., Giovannucci, D. R., et al. (2017) · The Journal of General Physiology · doi:10.1085/jgp.201711757 · Cited by 33
A ratiometric two-photon probe for Ca2+ in live tissues and its application to spinal cord injury model
Kim, H. J., Lim, C. S., Lee, H. W., Lee, H. S., Um, Y. J., Kumar, H., Han, I., & Kim, H. M. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.07.006 · Cited by 33
Calcium signaling: breast cancer’s approach to manipulation of cellular circuitry
Pratt, S. J. P., Hernández‐Ochoa, E. O., & Martin, S. S. (2020) · Biophysical Reviews · doi:10.1007/s12551-020-00771-9 · Cited by 32
Cellular mechanisms of ventricular arrhythmias in a mouse model of Timothy syndrome (long QT syndrome 8)
Drum, B. M. L., Dixon, R. E., Yuan, C., Cheng, E. P., & Santana, L. F. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.10.021 · Cited by 33
Pentobarbitone modulates calcium transients in axons and synaptic boutons of hippocampal CA1 neurons
Baudoux, S., Empson, R. M., & Richards, C. D. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705519 · Cited by 32
Accurate action potential inference from a calcium sensor protein through biophysical modeling:Preprint
Greenberg, D. S., Wallace, D. J., Voit, K.-M., Wuertenberger, S., Czubayko, U., Monsees, A., Handa, T., Vogelstein, J. T., Seifert, R., Groemping, Y., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/479055 · Cited by 34
The stochastic nature of action potential backpropagation in apical tuft dendrites
Short, S. M., Oikonomou, K. D., Zhou, W., Acker, C. D., Popovic, M. A., Zečević, D., & Antic, S. D. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00800.2016 · Cited by 32
Optimizing Calcium Detection Methods in Animal Systems: A Sandbox for Synthetic Biology
Li, E. S., & Saha, M. S. (2021) · Biomolecules · doi:10.3390/biom11030343 · Cited by 31
Imaging Fast Calcium Currents beyond the Limitations of Electrode Techniques
Jaafari, N., WAARD, M. M. D., & Canepari, M. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2014.07.059 · Cited by 31
Alterations in Ca2+-Buffering in Prion-Null Mice: Association with Reduced Afterhyperpolarizations in CA1 Hippocampal Neurons
Powell, A. D., Toescu, E. C., Collinge, J., & Jefferys, J. G. R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0675-08.2008 · Cited by 31
Cell type‐specific and activity‐dependent dynamics of action potential‐evoked Ca2+ signals in dendrites of hippocampal inhibitory interneurons
Evstratova, A., Chamberland, S., & Topolnik, L. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.204255 · Cited by 31
Calcium permeability and flux through osmosensory transduction channels of isolated rat supraoptic nucleus neurons
Zhang, Z., & Bourque, C. W. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04670.x · Cited by 31
Dendritic nicotinic receptors modulate backpropagating action potentials and long‐term plasticity of interneurons
Rózsa, B. J., Katona, G., Kaszás, A., Szipöcs, R., & Vizi, E. S. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05999.x · Cited by 30
CaRuby-Nano: a novel high affinity calcium probe for dual color imaging
Collot, M., Wilms, C. D., Bentkhayet, A., Marcaggi, P., Couchman, K., Charpak, S., Dieudonné, S., Häusser, M., Feltz, A., & Mallet, J. (2015) · eLife · doi:10.7554/elife.05808 · Cited by 30
Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth
Okujeni, S., & Egert, U. (2019) · eLife · doi:10.7554/elife.47996 · Cited by 30
Tuning Local Calcium Availability: Cell-Type-Specific Immobile Calcium Buffer Capacity in Hippocampal Neurons
Matthews, E. A., Schoch, S., & Dietrich, D. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4118-12.2013 · Cited by 29
Functional Structure of the Mitral Cell Dendritic Tuft in the Rat Olfactory Bulb
Djurisic, M. R., Popovic, M. A., Carnevale, N. T., & Zečević, D. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5296-07.2008 · Cited by 30
IQ-motif proteins influence intracellular free Ca2+ in hippocampal neurons through their interactions with calmodulin.
Kubota, Y., Putkey, J., Shouval, H., & Waxham, M. (2008) · Journal of Neurophysiology · doi:10.1152/jn.00876.2007 · Cited by 32
FHL5 Controls Vascular Disease–Associated Gene Programs in Smooth Muscle Cells
Wong, D., Auguste, G. E., Cardenas, C. L. L., Turner, A. W., Chen, Y., Song, Y., Ma, L., Perry, R. N., Aherrahrou, R., Kuppusamy, M., et al. (2023) · Circulation Research · doi:10.1161/circresaha.122.321692 · Cited by 26
NTnC-like genetically encoded calcium indicator with a positive and enhanced response and fast kinetics
Barykina, N. V., Doronin, D. A., Subach, O. M., Sotskov, V. P., Plusnin, V. V., Ivleva, O. A., Gruzdeva, A. M., Kunitsyna, T. A., Ivashkina, O. I., Lazutkin, A. A., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-33613-6 · Cited by 28
Calmodulin binds to the N-terminal domain of the cardiac sodium channel Na v 1.5
Wang, Z., Vermij, S. H., Sottas, V., Шестак, А. Г., Ross‐Kaschitza, D., Zaklyazminskaya, E. V., Hudmon, A., Pitt, G. S., Rougier, J., & Abriel, H. (2020) · Channels · doi:10.1080/19336950.2020.1805999 · Cited by 28
Action Potential Backpropagation and Multiglomerular Signaling in the Rat Vomeronasal System
Ma, J., & Lowe, G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1782-04.2004 · Cited by 28
ATP competes with PIP2 for binding to gelsolin
Szatmári, D., Xue, B., Kannan, B., Burtnick, L. D., Bugyi, B., Nyitrai, M., & Robinson, R. C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201826 · Cited by 27
In Vitro Reconstitution of a CaMKII Memory Switch by an NMDA Receptor-Derived Peptide
Urakubo, H., Sato, M., Ishii, S., & Kuroda, S. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2014.01.026 · Cited by 26
Extrusion versus diffusion: mechanisms for recovery from sodium loads in mouse CA1 pyramidal neurons
Mondragão, M. A., Schmidt, H., Kleinhans, C., Langer, J., Kafitz, K. W., & Rose, C. R. (2016) · The Journal of Physiology · doi:10.1113/jp272431 · Cited by 26
Impaired Hippocampal Neurovascular Coupling in a Mouse Model of Alzheimer’s Disease
Li, L., Tong, X., Kahnouei, M. H., Vallerand, D., Hamel, É., & Girouard, H. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.715446 · Cited by 26
MRZ-99030 – A novel modulator of Aβ aggregation: II – Reversal of Aβ oligomer-induced deficits in long-term potentiation (LTP) and cognitive performance in rats and mice
Rammes, G., Gravius, A., Ruitenberg, M., Wegener, N., Chambon, C., Sroka, K., Jeggo, R., Staniaszek, L. E., Spanswick, D. C., O‘Hare, E., et al. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.12.037 · Cited by 51
ADVANCED OPTICAL TECHNIQUES TO EXPLORE BRAIN STRUCTURE AND FUNCTION
Silvestri, L., Mascaro, A. L. A., Lotti, J., Sacconi, L., & Pavone, F. S. (2012) · Journal of Innovative Optical Health Sciences · doi:10.1142/s1793545812300029 · Cited by 26
Mutational analysis of dendritic Ca2+ kinetics in rodent Purkinje cells: role of parvalbumin and calbindin D28k
Schmidt, H., Stiefel, K. M., Račay, P., Schwaller, B., & Eilers, J. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00013.x · Cited by 27

Authors: Maravall, M., Mainen, Z. F., Sabatini, B. L., & Svoboda, K.
Affiliations: Cold Spring Harbor Laboratory (US)
Corresponding author: Svoboda, K.
ORCID: Maravall, M.
Mainen, Z.F.
Sabatini, B.L.
Svoboda, K.
Venue: Biophysical Journal
Publisher: Elsevier BV
Published: 2000-05
Volume: 78
Issue: 5
Pages: 2655-2667
ISSN: 0006-3495 (ISSN-L)
DOI: 10.1016/s0006-3495(00)76809-3
PMC: PMC1300854
OpenAlex: W1981195606
Cited by: 416
References: 46
Citations by year: 2026: 8 · 2025: 11 · 2024: 18 · 2023: 13 · 2022: 11 · 2021: 10 · 2020: 13 · 2019: 19 · 2018: 25 · 2017: 18 · 2016: 17 · 2015: 23 · 2014: 22 · 2013: 21 · 2012: 31
FWCI: 5.44
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4824 d)
Locations: Biophysical Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: intracellular calcium concentration, CA1 pyramidal neurons, hippocampal slices, dendritic calcium
MeSH terms: Action Potentials, Animals, Biophysics, Buffers, Calcium, Intracellular Fluid, Models, Biological, Pyramidal Cells, Calcium Signaling, Rats, Biophysical Phenomena, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Estimating Intracellular Calcium Concentrations and Buffering without Wavelength Ratioing

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks