The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats
Abstract
The free radical theory of aging predicts that reactive oxygen species are involved in the decline in function associated with aging. The present paper reports that diets supplemented with either spinach, strawberries or blueberries, nutritional sources of antioxidants, reverse age-induced declines in beta-adrenergic receptor function in cerebellar Purkinje neurons measured using electrophysiological techniques. In addition the spinach diet improved learning on a runway motor task, previously shown to be modulated by cerebellar norepinephrine. Motor learning is important for adaptation to changes in the environment and is thus critical for rehabilitation following stroke, spinal cord injury, and the onset of some neurodegenerative diseases. These data are the first to indicate that age-related deficits in motor learning and memory can be reversed with nutritional interventions.
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“It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [46]
In the citing paper
“It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [46]
In the citing paper
“It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [46]
In the citing paper
“It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [46]
In the citing paper
“During aging and neurodegeneration, there is a decrease in normal antioxidant and anti-inflammatory defense mechanisms, making the brain more susceptible to the detrimental effects of oxidative stress [44,45,46].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [46]
Citations
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Cited by
Sorted by citations
The Psychology of Learning and Motivation
Ross, B. H. (2012) · Cited by 2,631
Halliwell, B. (2001) · Drugs & Aging · doi:10.2165/00002512-200118090-00004 · Cited by 1,502
Blalock, E. M., Geddes, J. W., Chen, K. C., Porter, N. M., Markesbery, W. R., & Landfield, P. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308512100 · Cited by 1,025
Aerobic fitness reduces brain tissue loss in aging humans.
Colcombe, S. J., Erickson, K. I., Raz, N., Webb, A. G., Cohen, N. J., McAuley, E., & Kramer, A. F. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.2.m176 · Cited by 1,017
Berry anthocyanins as novel antioxidants in human health and disease prevention
Zafra‐Stone, S., Yasmin, T., Bagchi, M., Chatterjee, A., Vinson, J. A., & Bagchi, D. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700002 · Cited by 885
Metadata
- Authors
- Bickford, P. C., Gould, T., Briederick, L., Chadman, K., Pollock, A., Young, D., Shukitt-Hale, B., & Joseph, J.
- Affiliations
- Veterans Health Administration (US)
- University of Pennsylvania (US)
- University of Colorado Health (US)
- United States Department of Agriculture (US)
- Corresponding author
- Bickford, Paula C
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2000-06
- Volume
- 866
- Issue
- 1-2
- Pages
- 211-217
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2048534671
- Cited by
- 298
- References
- 27
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 10 · 2020: 7 · 2019: 5 · 2018: 6 · 2017: 11 · 2016: 2 · 2015: 7 · 2014: 9 · 2013: 11 · 2012: 14
- FWCI
- 8.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG04418, P01AG004418, AG00728)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- antioxidant diet, cerebellum, Purkinje cells, beta-adrenergic receptors, aging, motor learning, norepinephrine, reactive oxygen species, free radical theory of aging, spinach, strawberry, blueberry, dietary intervention, age-related decline
- MeSH terms
- Aging, Animals, Antioxidants, Cerebellar Cortex, Diet, Free Radicals, Fruit, Learning, Male, Motor Activity, Norepinephrine, Purkinje Cells, Rats, Inbred F344, Receptors, Adrenergic, beta, Neuroprotective Agents, Spinacia oleracea, Rats
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