Cited by 299Phytochemicals and Antioxidant ActivitiesMotor Control and AdaptationAntioxidant Activity and Oxidative Stress

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Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats

Bickford, Paula C, Gould, Thomas, Briederick, Lori, Chadman, Kathy, Pollock, Amber, Young, David, Shukitt-Hale, Barbara, Joseph, James·2000·Brain Research

DOI 10.1016/s0006-8993(00)02280-0

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Abstract

The free radical theory of aging predicts that reactive oxygen species are involved in the decline in function associated with aging. The present paper reports that diets supplemented with either spinach, strawberries or blueberries, nutritional sources of antioxidants, reverse age-induced declines in beta-adrenergic receptor function in cerebellar Purkinje neurons measured using electrophysiological techniques. In addition the spinach diet improved learning on a runway motor task, previously shown to be modulated by cerebellar norepinephrine. Motor learning is important for adaptation to changes in the environment and is thus critical for rehabilitation following stroke, spinal cord injury, and the onset of some neurodegenerative diseases. These data are the first to indicate that age-related deficits in motor learning and memory can be reversed with nutritional interventions.

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Authors: Bickford, P. C., Gould, T., Briederick, L., Chadman, K., Pollock, A., Young, D., Shukitt-Hale, B., & Joseph, J.
Affiliations: Veterans Health Administration (US)
University of Pennsylvania (US)
University of Colorado Health (US)
United States Department of Agriculture (US)
Corresponding author: Bickford, Paula C
ORCID: Bickford, Paula C
Gould, Thomas
Young, David
Joseph, James
Venue: Brain Research
Publisher: Elsevier BV
Published: 2000-06
Volume: 866
Issue: 1-2
Pages: 211-217
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/s0006-8993(00)02280-0
OpenAlex: W2048534671
Cited by: 298
References: 27
Citations by year: 2026: 1 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 10 · 2020: 7 · 2019: 5 · 2018: 6 · 2017: 11 · 2016: 2 · 2015: 7 · 2014: 9 · 2013: 11 · 2012: 14
FWCI: 8.68
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG04418, P01AG004418, AG00728)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: antioxidant diet, cerebellum, Purkinje cells, beta-adrenergic receptors, aging, motor learning, norepinephrine, reactive oxygen species, free radical theory of aging, spinach, strawberry, blueberry, dietary intervention, age-related decline
MeSH terms: Aging, Animals, Antioxidants, Cerebellar Cortex, Diet, Free Radicals, Fruit, Learning, Male, Motor Activity, Norepinephrine, Purkinje Cells, Rats, Inbred F344, Receptors, Adrenergic, beta, Neuroprotective Agents, Spinacia oleracea, Rats

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Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats

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