The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats
Abstract
The free radical theory of aging predicts that reactive oxygen species are involved in the decline in function associated with aging. The present paper reports that diets supplemented with either spinach, strawberries or blueberries, nutritional sources of antioxidants, reverse age-induced declines in beta-adrenergic receptor function in cerebellar Purkinje neurons measured using electrophysiological techniques. In addition the spinach diet improved learning on a runway motor task, previously shown to be modulated by cerebellar norepinephrine. Motor learning is important for adaptation to changes in the environment and is thus critical for rehabilitation following stroke, spinal cord injury, and the onset of some neurodegenerative diseases. These data are the first to indicate that age-related deficits in motor learning and memory can be reversed with nutritional interventions.
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“It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [46]
In the citing paper
“It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [46]
In the citing paper
“It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [46]
In the citing paper
“It was demonstrated that treatment with Spirulina-enriched diets increases cerebellar glutathione (GSH) levels, reduces malondialdehyde (MDA) levels, reduces pro-inflammatory cytokines, and ameliorates both spatial and motor learning in aged rats [24,46,47].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [46]
In the citing paper
“During aging and neurodegeneration, there is a decrease in normal antioxidant and anti-inflammatory defense mechanisms, making the brain more susceptible to the detrimental effects of oxidative stress [44,45,46].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [46]
Citations
Cites
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958
Mediterranean diet pyramid: a cultural model for healthy eating
Willett, W., Sacks, F., Trichopoulou, A., Drescher, G., Ferro-Luzzi, A., Helsing, E., & Trichopoulos, D. (1995) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.6.1402s · Cited by 2,461
A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380
Amyotrophic Lateral Ssclerosis and Structural Defects in Cu,Zn Superoxide Dismutase
Deng, H., Hentati, A., Tainer, J. A., Iqbal, Z., Cayabyab, A., Hung, W.-Y., Getzoff, E. D., Hu, P., Herzfeldt, B., Roos, R. P., et al. (1993) · Science · doi:10.1126/science.8351519 · Cited by 1,479
Orr, W. C., & Sohal, R. S. (1994) · Science · doi:10.1126/science.8108730 · Cited by 1,461
Antioxidant Capacity of Tea and Common Vegetables
Cao, G., Sofić, E., & Prior, R. (1996) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9602535 · Cited by 1,401
Diet and Health: What Should We Eat?
Willett, W. C. (1994) · Science · doi:10.1126/science.8160011 · Cited by 1,008
Beta‐carotene, carotenoids, and disease prevention in humans
Mayne, S. T. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.7.8635686 · Cited by 871
Joseph, J., Shukitt-Hale, B., Denisova, N., Prior, R., Cao, G., Martín, A., Taglialatela, G., & Bickford, P. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-08047.1998 · Cited by 436
Self-citationAutomated assay of oxygen radical absorbance capacity with the COBAS FARA II
Cao, G., Verdon, C. P., Wu, A. H., Wang, H., & Prior, R. L. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.12.1738 · Cited by 386
Aspects of Free Radical Reactions in Biological Systems: Aging
Leibovitz, B. E., & Siegel, B. V. (1980) · Journal of Gerontology · doi:10.1093/geronj/35.1.45 · Cited by 305
Micronutrients and cancer risk
Willett, W. (1994) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/59.5.1162s · Cited by 143
Motor learning deficits in aged rats are correlated with loss of cerebellar noradrenergic function
Bickford, P. C. (1993) · Brain Research · doi:10.1016/0006-8993(93)90279-v · Cited by 108
Self-citationCerebellar norepinephrine depletion and impaired acquisition of specific locomotor tasks in rats
Watson, M., & McElligott, J. G. (1984) · Brain Research · doi:10.1016/0006-8993(84)90518-3 · Cited by 102
Impaired acquisition of novel locomotor tasks in aged and norepinephrine-depleted F344 rats
Bickford, P. C., Heron, C., Young, D. A., Gerhardt, G. A., & de la Garza, R. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90075-9 · Cited by 87
Self-citationFreedman, R., Hoffer, B. J., Puro, D. G., & Woodward, D. J. (1976) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1976.tb10391.x · Cited by 81
Purkinje cell number related to rate of classical conditioning
Woodruff‐Pak, D. S., Cronholm, J., & Sheffield, J. B. (1990) · Neuroreport · doi:10.1097/00001756-199010000-00020 · Cited by 66
Spatial Learning and Memory Deficits Induced by Dopamine Administration with Decreased Glutathione
Shukitt‐Hale, B., Erat, S., & Joseph, J. A. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00399-7 · Cited by 46
Self-citationOn nonlinear random effects models for repeated measurements
Hirst, K., Zerbe, G. O., Boyle, D. W., & Wilkening, R. B. (1991) · Communications in Statistics - Simulation and Computation · doi:10.1080/03610919108812966 · Cited by 42
6-OHDA induced effects upon the acquisition and performance of specific locomotor tasks in rats
Watson, M., & McElligott, J. G. (1983) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(83)80016-1 · Cited by 38
Acquisition of a runway motor learning task is impaired by a beta adrenergic antagonist in F344 rats
Heron, C., Gould, T. J., & Bickford, P. C. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00252-9 · Cited by 31
Self-citationAging and Motor Learning: A Possible Role for Norepinephrine in Cerebellar Plasticity
Bickford, P. C. (1995) · Reviews in the Neurosciences · doi:10.1515/revneuro.1995.6.1.35 · Cited by 31
Self-citationDiet and coronary heart disease--a review.
Hughes, K. (1995) · PubMed · Cited by 20
Gould, T. J. (1998) · PubMed · Cited by 16
Self-citationGould, T. J. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01305-x · Cited by 14
Self-citation
Cited by
Sorted by citations
The Psychology of Learning and Motivation
Ross, B. H. (2012) · Cited by 2,631
Halliwell, B. (2001) · Drugs & Aging · doi:10.2165/00002512-200118090-00004 · Cited by 1,502
Blalock, E. M., Geddes, J. W., Chen, K. C., Porter, N. M., Markesbery, W. R., & Landfield, P. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308512100 · Cited by 1,025
Aerobic fitness reduces brain tissue loss in aging humans.
Colcombe, S. J., Erickson, K. I., Raz, N., Webb, A. G., Cohen, N. J., McAuley, E., & Kramer, A. F. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.2.m176 · Cited by 1,017
Berry anthocyanins as novel antioxidants in human health and disease prevention
Zafra‐Stone, S., Yasmin, T., Bagchi, M., Chatterjee, A., Vinson, J. A., & Bagchi, D. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700002 · Cited by 885
Metadata
- Authors
- Bickford, P. C., Gould, T., Briederick, L., Chadman, K., Pollock, A., Young, D., Shukitt-Hale, B., & Joseph, J.
- Affiliations
- Veterans Health Administration (US)
- University of Pennsylvania (US)
- University of Colorado Health (US)
- United States Department of Agriculture (US)
- Corresponding author
- Bickford, Paula C
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2000-06
- Volume
- 866
- Issue
- 1-2
- Pages
- 211-217
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2048534671
- Cited by
- 298
- References
- 27
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 10 · 2020: 7 · 2019: 5 · 2018: 6 · 2017: 11 · 2016: 2 · 2015: 7 · 2014: 9 · 2013: 11 · 2012: 14
- FWCI
- 8.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG04418, P01AG004418, AG00728)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- antioxidant diet, cerebellum, Purkinje cells, beta-adrenergic receptors, aging, motor learning, norepinephrine, reactive oxygen species, free radical theory of aging, spinach, strawberry, blueberry, dietary intervention, age-related decline
- MeSH terms
- Aging, Animals, Antioxidants, Cerebellar Cortex, Diet, Free Radicals, Fruit, Learning, Male, Motor Activity, Norepinephrine, Purkinje Cells, Rats, Inbred F344, Receptors, Adrenergic, beta, Neuroprotective Agents, Spinacia oleracea, Rats
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