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Enhanced acquisition of cocaine self-administration in adult rats with neonatal isolation stress experience
Open accessAbstract
That stress enhances the behavioral effects of cocaine is well-documented in adult rats, but whether early life stress endures into adulthood to affect responsivity to cocaine is less clear. We now report that neonatal isolation stress (1 h per day isolation on postnatal days 2-9) enhances acquisition of cocaine self-administration in adult rats. This effect was specific to cocaine and not due to learning or performance differences. Neither acquisition of operant responding for food nor locomotor activity differed between groups. These results have important implications for the role of early childhood stress in vulnerability to cocaine addiction.
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Simple Method of Harvesting Limnoria from Nature
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Cited by
Chronic stress, drug use, and vulnerability to addiction
Sinha, R. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1441.030 · Cited by 1,904
Sensitive periods of substance abuse: Early risk for the transition to dependence
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Metadata
- Authors
- Kosten, T. A., Miserendino, M. J. D., & Kehoe, P.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2000-09
- Volume
- 875
- Issue
- 1-2
- Pages
- 44-50
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2084679231
- Cited by
- 205
- References
- 7
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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