Cited by 171Cancer Treatment and PharmacologyPain Mechanisms and TreatmentsIon Channels and Receptors

The DOI matches its Crossref record; 40 of the 41 references it cites were found in a registry or an index.

Description of a short-term Taxol®-induced nociceptive neuropathy in rats

Authier, Nicolas, Gillet, Jean-Pierre, Fialip, Joseph, Eschalier, Alain, Coudore, François·2000·Brain Research

Open this paper in CoChat — free account

Abstract

This work describes a new animal model of neuropathic pain produced by the single intraperitoneal administration of Taxol (32 mg/kg) to male Sprague-Dawley rats. During the course of the experiment, the clinical status of the rats remained satisfactory and motor function was not altered. A number of classical behavioural tests of nociception as well as histological and electrophysiological investigations were performed. Taxol administration produced an important and rapidly developing mechanical hyperalgesia, a thermal hypoalgesia but no mechanical or thermal allodynia. Degenerative changes were observed in the sciatic nerve, the nerve fibres in the paw subcutaneous tissue and in the lumbar spinal cord. When Taxol or vehicle (a mix of Cremophor and ethanol) were repeatedly injected once a week for 5 weeks, similar nociceptive disorders were observed in addition to a decrease in peripheral nerve conduction velocity. The selective dysfunction of high-diameter myelinated fibres observed after one single administration of Taxol (32 mg/kg) may be attributable to paclitaxel-induced neuropathy, however other mechanisms causing neurochemical dysfunction must also be involved.

Integrity signals

Registry

Crossref · 10.1016/s0006-8993(00)02910-3

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Pain mechanisms: a new theory.
Melzack, R., & Wall, P. D. (1965) · Science · doi:10.1126/science.150.3699.971 · Cited by 11,108
Ethical guidelines for investigations of experimental pain in conscious animals.
Zimmermann, M. (1983) · Pain · doi:10.1016/0304-3959(83)90201-4 · Cited by 7,762
Quantitative assessment of tactile allodynia in the rat paw
Chaplan, S. R., Bach, F. W., Pogrel, J. W., Chung, J. M., & Yaksh, T. L. (1994) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)90144-9 · Cited by 7,740
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155
An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
Ho Kim, S., & Mo Chung, J. (1992) · Pain · doi:10.1016/0304-3959(92)90041-9 · Cited by 3,069
Textbook of pain
Bonica, J. J., Melzack, R., & Wall, P. D. (1999) · Cited by 2,537
A method for measurement of analgesic activity on inflamed tissue.
Randall, L. O., & Selitto, J. J. (1957) · PubMed · Cited by 1,568
THE GATE CONTROL THEORY OF PAIN MECHANISMS
Wall, P. D. (1978) · Brain · doi:10.1093/brain/101.1.1 · Cited by 472
Streptozocin-induced diabetic rats: behavioural evidence for a model of chronic pain
Courteix, C., Eschalier, A., & Lavarenne, J. (1993) · Pain · doi:10.1016/0304-3959(93)90059-x · Cited by 454
Self-citation

Show all 41 references

Sorted by citations

Items 101–170 of 170

Physiologically-based modeling and interspecies prediction of paclitaxel pharmacokinetics
Zang, X., & Kagan, L. (2018) · Journal of Pharmacokinetics and Pharmacodynamics · doi:10.1007/s10928-018-9586-9 · Cited by 17
Distinct roles of srGAP3‐Rac1 in the initiation and maintenance phases of neuropathic pain induced by paclitaxel
Chen, Z., Zhang, S., Nie, B., Huang, J., Han, Z., Chen, X. F., Bai, X., & Ouyang, H. (2020) · The Journal of Physiology · doi:10.1113/jp279525 · Cited by 16
Safety Pharmacology
Redfern, W. S., & Wakefield, I. D. (2006) · CRC Press eBooks · doi:10.1201/b14280-4 · Cited by 16
Paclitaxel-Associated Mechanical Sensitivity and Neuroinflammation Are Sex-, Time-, and Site-Specific and Prevented through Cannabigerol Administration in C57Bl/6 Mice
Li, H., & Ward, S. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084277 · Cited by 15
Evolution of Taxanes in the Treatment of Metastatic Breast Cancer
Binder, S. (2013) · Clinical journal of oncology nursing · doi:10.1188/13.cjon.s1.9-14 · Cited by 15
Pain Testing in the Laboratory Mouse
Langford, D. J., & Mogil, J. S. (2008) · Elsevier eBooks · doi:10.1016/b978-012373898-1.50027-9 · Cited by 15
Abnormal muscle afferent function in a model of Taxol chemotherapy-induced painful neuropathy
Chen, X., Green, P. G., & Levine, J. D. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00141.2011 · Cited by 14
Models of chemotherapy drug-induced peripheral neuropathy
Golden, J. P., & Johnson, E. M. (2004) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2004.09.005 · Cited by 14
Paclitaxel inhibits the activity and membrane localization of PKCα and PKCβI/II to elicit a decrease in stimulated calcitonin gene-related peptide release from cultured sensory neurons
Darby, L. M., Meng, H., & Fehrenbacher, J. C. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2017.04.001 · Cited by 13
Comparison of Peripheral Neuropathy Induced by Standard and Nanoparticle Albumin–Bound Paclitaxel in Rats
Yamashita, Y., Egashira, N., Masuguchi, K., Ushio, S., Kawashiri, T., & Oishi, R. (2011) · Journal of Pharmacological Sciences · doi:10.1254/jphs.11062sc · Cited by 13
Expression, distribution and glutamate uptake activity of high affinity-excitatory aminoacid transporters in in vitro cultures of embryonic rat dorsal root ganglia
Carozzi, V., Zoia, C., Maggioni, D., Verga, E., Marmiroli, P., Ferrarese, C., & Cavaletti, G. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.05.065 · Cited by 13
Neuropathy, its Profile and Experimental Nerve Injury Neuropathic Pain Models: A Review
Sharma, K. K., Fatima, N., Ali, Z., Moshin, M., Chandra, P., Verma, A. K., Goshain, O., & Kumar, G. (2023) · Current Pharmaceutical Design · doi:10.2174/0113816128274200231128065425 · Cited by 12
A prospective comparison study utilizing patient-reported outcomes of taxane-related peripheral neuropathy between nab-paclitaxel and standard paclitaxel in patients with breast cancer
Kida, K., Yamada, A., Shimada, K., Narui, K., Sugae, S., Shimizu, D., Doi, T., Oba, M. S., Endo, I., & Ishikawa, T. (2024) · Breast Cancer · doi:10.1007/s12282-024-01551-z · Cited by 12
Dynamic long-term microstructural and ultrastructural alterations in sensory nerves of rats of paclitaxel-induced neuropathic pain
Yuan, W., Li, J., Junfei, Z., & Feng, Y. (2014) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.20140727 · Cited by 12
Polymeric micelles for oral drug delivery: progress and innovations in preclinical studies
Al-Lawati, H., & Binkhathlan, Z. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126373 · Cited by 11
Methods and protocols for chemotherapy-induced peripheral neuropathy (CIPN) mouse models using paclitaxel
Pennypacker, S. D., Fonseca, M. M., Morgan, J. W., Dougherty, P. M., Cubillos‐Ruiz, J. R., Strowd, R. E., III, & Romero-Sandoval, E. A. (2022) · Methods in cell biology · doi:10.1016/bs.mcb.2021.12.019 · Cited by 11
IUPHAR review- Preclinical models of neuropathic pain: Evaluating multifunctional properties of natural cannabinoid receptors ligands
Benamar, K. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.107013 · Cited by 13
Paclitaxel-induced hyperalgesia modulates negative affective component of pain and NR1 receptor expression in the frontal cortex in rats
Noda, K., Akita, H., Ogata, M., & Saji, M. (2014) · Neuroscience Research · doi:10.1016/j.neures.2014.01.002 · Cited by 11
nab-Paclitaxel for the Treatment of Advanced Squamous Non–Small-Cell Lung Cancer: A Comprehensive Update
Simon, G. R. (2014) · Clinical Lung Cancer · doi:10.1016/j.cllc.2014.07.003 · Cited by 11
Antinociceptive effects of Cremophor EL orally administered to mice
Tabarelli, Z., Berlese, D. B., Sauzem, P. D., Mello, C. F., & Rubin, M. A. (2003) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2003000100016 · Cited by 11
Pain Testing in the Laboratory Mouse
Langford, D. J. (2008) · Elsevier eBooks · doi:10.1016/b978-012373898-1.00023-2 · Cited by 10
Neurobiological studies of chronic pain and analgesia: Rationale and refinements
Fairbanks, C. A., & Goracke‐Postle, C. J. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.049 · Cited by 9
Recovery Sleep Does Not Mitigate the Effects of Prior Sleep Loss on Paclitaxel-Induced Mechanical Hypersensitivity in Sprague-Dawley Rats
Kozachik, S., Opp, M. R., & Page, G. G. (2014) · Biological Research For Nursing · doi:10.1177/1099800414539385 · Cited by 9
Epothilones in breast cancer: current status and future directions
Atzori, F., & Fornier, M. N. (2008) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.8.8.1299 · Cited by 9
Chemotherapy-Induced Neuropathic Pain
Raffa, R. B., Langford, R. M., Pergolizzi, J. V., Porreca, F., & Tallarida, R. J. (2012) · CRC Press eBooks · doi:10.1201/b12366 · Cited by 10
A phase 1, dose-finding and pharmacokinetic study of gemcitabine with nab-paclitaxel in patients with metastatic breast cancer
Yoshitomi, S., Taira, N., Doihara, H., Mizoo, T., Nogami, T., Iwamoto, T., Motoki, T., Shien, T., Ogasawara, Y., Matsuoka, J., et al. (2016) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-016-3091-x · Cited by 8
A phase I/II study of weekly nab-paclitaxel plus cisplatin in chemotherapy-naïve patients with advanced non-small-cell lung cancer
Hattori, Y., Kono, Y., Itoh, S., Inoue, T., Urata, Y., Kawa, Y., Tohnai, R., Kumagai, T., Nishino, K., Uozumi, R., et al. (2020) · BMC Cancer · doi:10.1186/s12885-020-6588-y · Cited by 8
Nab-Paclitaxel Followed by 5-Fluorouracil, Epirubicin and Cyclophosphamide in Neoadjuvant Chemotherapy for Resectable Breast Cancer: A Phase II Trial
Kin, T., Ohtani, S., Maeda, R., Ueno, A., FUJIHARA, M., Takamatsu, Y., Kajiwara, Y., Ito, M., Kawasaki, K., Abé, K., et al. (2020) · World Journal of Oncology · doi:10.14740/wjon1333 · Cited by 8
Assessing the utility of in vitro microtubule assays for studying mechanisms of peripheral neuropathy with the microtubule inhibitor class of cancer chemotherapy
Genualdi, C., Feinstein, S. C., Wilson, L., Jordan, M. A., & Stagg, N. J. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.108906 · Cited by 8
Comparison of paclitaxel and cisplatin effects on the slowly adapting type I mechanoreceptor
Zhang, J., & Tuckett, R. P. (2008) · Brain Research · doi:10.1016/j.brainres.2008.01.069 · Cited by 8
Liquid Chromatography/Tandem Mass Spectrometry Method for Quantitation of Cremophor EL and Its Applications
Bhaskar, V. V., & Middha, A. K. (2013) · International Journal of Analytical Chemistry · doi:10.1155/2013/135613 · Cited by 7
Involvement of Charcot-Marie-Tooth disease gene mitofusin 2 expression in paclitaxel-induced mechanical allodynia in rats
Yamashita, Y., Irie, K., Kochi, A., Kimura, N., Hayashi, T., Matsuo, K., Myose, T., Sano, K., Nakano, T., Takase, Y., et al. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.05.069 · Cited by 7
Effect of chronic vincristine treatment on mechanical withdrawal response and pre-pulse inhibition in the rat
Borzan, J., LaGraize, S. C., & Fuchs, P. N. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.04.032 · Cited by 7
Behavior and electrophysiology studies of the peripheral neuropathy induced by individual and co-administration of paclitaxel and oxaliplatin in rat
Paniagua, N., Sánchez-Robles, E., Bagüés, A., Martı́n, M. I., Goicoechea, C., & Girón, R. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119397 · Cited by 5
Quality-of-Life Considerations With Taxane-Based Therapy in Metastatic Breast Cancer
Maxwell, C. L. (2013) · Clinical journal of oncology nursing · doi:10.1188/13.cjon.s1.35-40 · Cited by 5
Regulatable Transgene Expression for Prevention of Chemotherapy-Induced Peripheral Neuropathy
Kawata, D., & Wu, Z. (2017) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2017.06.004 · Cited by 5
Clinical development of Abraxane, albumin-bound paclitaxel
Yamada, K. (2009) · Drug Delivery System · doi:10.2745/dds.24.38 · Cited by 5
Management of paclitaxel-induced neurotoxicity
Bhutani, M., Colucci, P. M., Laird-Fick, H. S., & Conley, B. A. (2010) · Oncology Reviews · doi:10.1007/s12156-010-0048-x · Cited by 5
A Hyperresponsive HPA Axis May Confer Resilience Against Persistent Paclitaxel-Induced Mechanical Hypersensitivity
Kozachik, S., & Page, G. G. (2015) · Biological Research For Nursing · doi:10.1177/1099800415609418 · Cited by 4
Effects of Benfotiamine and Methylcobalamin on Paclitaxel Induced Peripheral Neuropathy
Dizaye, K. F., & Qadir, C. Y. (2014) · Middle East Journal of Internal Medicine · doi:10.5742/meim.2014.92404 · Cited by 4
Current Trials of a Nanoparticle Albumin-Bound Taxane Formulation in Metastatic Breast Cancer
Lee, D., O’Shaughnessy, J., & Jain, V. K. (2004) · Clinical Breast Cancer · doi:10.1016/s1526-8209(11)70819-9 · Cited by 4
Drosophila model of anti-retroviral therapy induced peripheral neuropathy and nociceptive hypersensitivity
Bush, K. M., Barber, K. R., Martinez, J. A., Tang, S., & Wairkar, Y. P. (2021) · Biology Open · doi:10.1242/bio.054635 · Cited by 5
Phase I study of Nedaplatin, a platinum based antineoplastic drug, combined with nab-paclitaxel in patients with advanced squamous non–small cell lung cancer
Igawa, S., Otani, S., Nakahara, Y., Ryuge, S., Hiyoshi, Y., Fukui, T., Mitsufuji, H., Kubota, M., Katagiri, M., Sato, Y., et al. (2017) · Investigational New Drugs · doi:10.1007/s10637-017-0472-x · Cited by 3
Predictivity/Translatability of Toxicities Observed in Nonclinical Toxicology Studies to Clinical Safety Outcomes in Drug Development: Case Examples
Stagg, N. J., Ghantous, H. N., Roth, R. A., & Hastings, K. L. (2019) · International Journal of Toxicology · doi:10.1177/1091581819894281 · Cited by 3
Determination of Cremophor EL in Rat Plasma by LC-MS/MS: Application to a Pharmacokinetic Study
Bhaskar, V. V. (2013) · Journal of Analytical & Bioanalytical Techniques · doi:10.4172/2155-9872.1000163 · Cited by 3
Classical Taxane versus the New Generation, Nab-Paclitaxel Chemotherapy in the Treatment of Breast Cancer
Ajabnoor, G. (2017) · MOJ Cell Science & Report · doi:10.15406/mojcsr.2017.04.00086 · Cited by 3
Taxus spp.: Botany, Horticulture, and Source of Anti‐Cancer Compounds
DeLong, J. M., & Prange, R. K. (2006) · Horticultural reviews · doi:10.1002/9780470767986.ch6 · Cited by 3
Plant-Derived Secondary Metabolites Tetrahydropalmatine and Rutaecarpine Alleviate Paclitaxel-Induced Neuropathic Pain via TRPV1 and TRPM8 Modulation
Park, K.-T., Yun, H., Kang, J., Lee, J.-C., & Kim, W. (2026) · Metabolites · doi:10.3390/metabo16010046 · Cited by 2
Protective effect of coenzyme Q10 in paclitaxel-induced peripheral neuropathy in rats
Çelebi, N., Çil, H., Çil, O., Canbay, Ö., Onur, R., & Aypar, Ü. (2013) · Neurosciences · doi:10.17712/1658-3183.2004 · Cited by 2
Antitumor Efficacy of Paclitaxel Injection Concentrate for Nanodispersion in Patient-Derived Breast, Head and Neck, and Non-Small Cell Lung Cancer Mouse Xenografts
Khopade, A. J., Shah, M. D., Borole, B., & Burade, V. (2025) · AAPS PharmSciTech · doi:10.1208/s12249-025-03153-0 · Cited by 2
Chemotherapy-Induced Peripheral Neuropathy Impairs Tertiary Dentine Formation: An In Vivo Study
He, J., Zhan, C., Lu, Y., Chen, J., Yang, X., & Hou, J. L. (2025) · International Dental Journal · doi:10.1016/j.identj.2025.100899 · Cited by 2
Dynamics of hippocampal morphological changes in condition of cisplatin and paclitaxel combined administration
Kulynych, H. B., Herashchenko, S. B., Fedorak, V. M., Yurah, H. Y., Polyvkan, M. I., & Атаманчук, О. В. (2026) · Reports of Morphology · doi:10.31393/morphology-journal-2026-32(1)-01 · Cited by 1
Histological examination of peripheral neuropathy caused by paclitaxel
Hashimoto, K., Sakuma, Y., & Kotani, J. (2004) · Journal of Osaka Dental University · doi:10.18905/jodu.38.1_53 · Cited by 1
Neurotoxicité périphérique des traitements oncologiques: aspects précliniques et cliniques
Authier, N., Ling, B., Balayssac, D., & Eschalier, A. (2010) · Springer eBooks · doi:10.1007/978-2-287-79501-5_17 · Cited by 1
Self-citation
Neuropathic Pain
M’Dahoma, S., Bourgoin, S., & Hamon, M. (2014) · Methods and principles in medicinal chemistry · doi:10.1002/9783527679348.ch14 · Cited by 2
Detection and Assessment of Xenobiotic‐Induced Sensory Neuropathy
Clark, J. D. (2004) · Current Protocols in Toxicology · doi:10.1002/0471140856.tx1113s22
Chemotherapy related cognitive impairment in the rat
Davis, J. B. (2007)
Expression, distribution and glutamate uptake activityof excitatory aminoacid transporters in vitro cultures of embryonic rat dorsal root ganglia cells
Cavaletti, G., Carozzi, V., Marmiroli, P., Tredici, G., & Nicolini, G. (2011) · Italian Journal of Anatomy and Embryology · doi:10.1400/182308
An in vitro study of the mechanisms that underlie changes in neuronal sensitivity and neurite morphology following treatment with microtubule targeting agents
Pittman, S. K. (2014) · IUScholarWorks (Indiana University) · doi:10.7912/c2/306
Mecanismos de dolor neuropático experimental
Ossipov, M. H., Lai, J. Y., & Porreca, F. (2007) · Elsevier eBooks · doi:10.1016/b978-84-8174-949-6.50059-9
The role of Protein Kinase C in the modulation of neuronal sensitivity and neurite morphology following treatment with paclitaxel in cultured sensory neurons
Darby, L. M. (2017) · IUScholarWorks (Indiana University) · doi:10.7912/c2/324
Albumin-Bound Paclitaxel in the Treatment of Metastatic Breast Cancer
Lovelle, A. S., Martín, M., Service, M. O., Universitario, H., & Marañón, G. (2010) · Clinical Medicine Reviews in Oncology · doi:10.4137/cmro.s3246
Neuropeptides in the RVM Promote Descending Facilitation and Abnormal Pain
Marshall, T. M. (2008) · UA Campus Repository (The University of Arizona)
Faculty Opinions recommendation of Evoked and Ongoing Pain-Like Behaviours in a Rat Model of Paclitaxel-Induced Peripheral Neuropathy.
Farquhar-Smith, P. W., & Gordon-Williams, R. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733427412.793571726
Artificial Light at Night Disrupts Pain Behavior and Cerebrovascular Structure in Mice
Bumgarner, J. R. (2023) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.12037
Preclinical Toxicity and Pharmacokinetic Evaluation of Paclitaxel Nanodispersion
Khopade, A. J., Shah, M. D., Borole, B. S., Patel, B., Pateliya, B., & BURADE, V. S. (2025) · AAPS PharmSciTech · doi:10.1208/s12249-025-03268-4
Implication des canaux ioniques dans l'hypersensibilité au froid induite par l'oxaliplatine
Descoeur, J. (2010) · doi:10.70675/1fd520c7z1729z43c8zad2czf9f78dfc132c
Evaluation de l'effet de molécules candidates dans des modèles murins de neuropathies périphériques induites par la chimiothérapie anticancéreuse
Bouchenaki, H. (2020) · doi:10.70675/44b49e72z57c7z47cfzbbabz2b20ae4f21ec
The Roundup Active® induced alterations in sensory neurons in a Neotropical fish (Piaractus orinoquensis)Preprint
Ramírez, E. G., Mocha, P. R. E., & Baldisserotto, B. (2026) · Research Square · doi:10.21203/rs.3.rs-9488375/v1
Clinical and non-clinical formulations of paclitaxel produce qualitatively and quantitatively different peripheral neuropathy in rats and mice
Giuvelis, D., Barlow, D. J., Meng, I. D., Houseknecht, K. L., & Tucker, K. L. (2026) · Journal of Pain · doi:10.1016/j.jpain.2026.106369

Authors: Authier, N., Gillet, J.-P., Fialip, J., Eschalier, A., & Coudore, F.
Affiliations: Inserm (FR)
ORCID: Authier, Nicolas
Eschalier, Alain
Venue: Brain Research
Publisher: Elsevier BV
Published: 2000-12
Volume: 887
Issue: 2
Pages: 239-249
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/s0006-8993(00)02910-3
OpenAlex: W2077039218
Cited by: 171
References: 41
Citations by year: 2026: 4 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 14 · 2016: 5 · 2015: 7 · 2014: 14 · 2013: 13 · 2012: 6
FWCI: 1.32
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: Ligue Contre le Cancer
Topics: Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: paclitaxel, chemotherapy-induced peripheral neuropathy, mechanical hyperalgesia, thermal hypoalgesia, peripheral nerve conduction velocity
MeSH terms: Animals, Hair, Hot Temperature, Hyperalgesia, Male, Motor Activity, Neural Conduction, Neuralgia, Nociceptors, Pain, Sciatic Nerve, Rats, Sprague-Dawley, Paclitaxel, Hand Strength, Somatosensory Disorders, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Description of a short-term Taxol®-induced nociceptive neuropathy in rats

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks