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Description of a short-term Taxol®-induced nociceptive neuropathy in rats
Abstract
This work describes a new animal model of neuropathic pain produced by the single intraperitoneal administration of Taxol (32 mg/kg) to male Sprague-Dawley rats. During the course of the experiment, the clinical status of the rats remained satisfactory and motor function was not altered. A number of classical behavioural tests of nociception as well as histological and electrophysiological investigations were performed. Taxol administration produced an important and rapidly developing mechanical hyperalgesia, a thermal hypoalgesia but no mechanical or thermal allodynia. Degenerative changes were observed in the sciatic nerve, the nerve fibres in the paw subcutaneous tissue and in the lumbar spinal cord. When Taxol or vehicle (a mix of Cremophor and ethanol) were repeatedly injected once a week for 5 weeks, similar nociceptive disorders were observed in addition to a decrease in peripheral nerve conduction velocity. The selective dysfunction of high-diameter myelinated fibres observed after one single administration of Taxol (32 mg/kg) may be attributable to paclitaxel-induced neuropathy, however other mechanisms causing neurochemical dysfunction must also be involved.
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“A single injection of paclitaxel (32 mg/kg, intraperitoneal) in rats produces mechanical and thermal hyperalgesia, but does not elicit mechanical allodynia (Authier et al, 2000).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Authier et al, 2000
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Metadata
- Authors
- Authier, N., Gillet, J.-P., Fialip, J., Eschalier, A., & Coudore, F.
- Affiliations
- Inserm (FR)
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 887
- Issue
- 2
- Pages
- 239-249
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2077039218
- Cited by
- 171
- References
- 41
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 14 · 2016: 5 · 2015: 7 · 2014: 14 · 2013: 13 · 2012: 6
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ligue Contre le Cancer
- Topics
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- paclitaxel, chemotherapy-induced peripheral neuropathy, mechanical hyperalgesia, thermal hypoalgesia, peripheral nerve conduction velocity
- MeSH terms
- Animals, Hair, Hot Temperature, Hyperalgesia, Male, Motor Activity, Neural Conduction, Neuralgia, Nociceptors, Pain, Sciatic Nerve, Rats, Sprague-Dawley, Paclitaxel, Hand Strength, Somatosensory Disorders, Rats
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