Oxytocin Gene Polymorphisms Influence Human Dopaminergic Function in a Sex-Dependent Manner
Open accessAbstract
Background Oxytocin, classically involved in social and reproductive activities, is increasingly recognized as an antinociceptive and anxiolytic agent, effects which may be mediated via oxytocin's interactions with the dopamine system. Thus, genetic variation within the oxytocin gene (OXT) is likely to explain variability in dopamine-related stress responses. As such, we examined how OXT variation is associated with stress-induced dopaminergic neurotransmission in a healthy human sample.Methods Fifty-five young healthy volunteers were scanned using [¹¹C]raclopride positron emission tomography while they underwent a standardized physical and emotional stressor that consisted of moderate levels of experimental sustained deep muscle pain, and a baseline, control state. Four haplotype tagging single nucleotide polymorphisms located in regions near OXT were genotyped. Measures of pain, affect, anxiety, well-being and interpersonal attachment were also assessed.Results Female rs4813625 C allele carriers demonstrated greater stress-induced dopamine release, measured as reductions in receptor availability from baseline to the pain-stress condition relative to female GG homozygotes. No significant differences were detected among males. We also observed that female rs4813625 C allele carriers exhibited higher attachment anxiety, higher trait anxiety and lower emotional well-being scores. In addition, greater stress-induced dopamine release was associated with lower emotional well-being scores in female rs4813625 C allele carriers.Conclusions Our results suggest that variability within the oxytocin gene appear to explain interindividual differences in dopaminergic responses to stress, which are shown to be associated with anxiety traits, including those linked to attachment style, as well as emotional well-being in women.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Genetic variation in oxytocin influences dopamine signaling in brain reward centers.
“Genetic variability in OXT influences DA signaling in brain reward centers (15)”
From Oxytocin enhances brain reward system responses in men viewing the face of their female partner (2013) · cites this paper as [15]
The Results (Stress-Induced Activation of DA Neurotransmission; page unavailable) link OXT genotype to dopamine responses, and the Discussion locates the association in the right ventromedial caudate. The citing sentence omits important limits: the observed association was during a pain-stress challenge and was significant in female participants, not males. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433 · see citing works
The mental health continuum: from languishing to flourishing in life.
Keyes, C. L. M. (2002) · Journal of Health and Social Behavior · doi:10.2307/3090197 · Cited by 5,133 · see citing works
The reward circuit: linking primate anatomy and human imaging
Haber, S. N., & Knutson, B. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.129 · Cited by 3,718 · see citing works
Attachment theory and close relationships
(1998) · Choice Reviews Online · doi:10.5860/choice.35-6513 · Cited by 3,642 · see citing works
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089 · see citing works
Keyes, C. L. M. (1998) · Social Psychology Quarterly · doi:10.2307/2787065 · Cited by 2,924 · see citing works
Region of interest analysis using an SPM toolbox
Brett, M. (2002) · NeuroImage · Cited by 2,273 · see citing works
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091 · see citing works
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688 · see citing works
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645 · see citing works
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639 · see citing works
The effect of age on positive and negative affect: A developmental perspective on happiness.
Mroczek, D. K., & Kolarz, C. M. (1998) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.75.5.1333 · Cited by 1,573 · see citing works
Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U., & Fehr, E. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.009 · Cited by 1,258 · see citing works
The Psychobiology of Depression and Resilience to Stress: Implications for Prevention and Treatment
Southwick, S. M., Vythilingam, M., & Charney, D. S. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143948 · Cited by 1,160 · see citing works
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037 · see citing works
Selective activation of the mesocortical DA system by stress
Thierry, A. M., Tassin, J., BLANC, G., & Glowinski, J. (1976) · Nature · doi:10.1038/263242a0 · Cited by 1,033 · see citing works
Increased baseline occupancy of D <sub>2</sub> receptors by dopamine in schizophrenia
Abi-Dargham, A., Rodenhiser, J., Printz, D., Zea-Ponce, Y., Gil, R., Kegeles, L. S., Weiss, R., Cooper, T. B., Mann, J. J., Van Heertum, R. L., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.14.8104 · Cited by 1,020 · see citing works
On some physiological actions of ergot
Dale, H. H. (1906) · The Journal of Physiology · doi:10.1113/jphysiol.1906.sp001148 · Cited by 1,011 · see citing works
Becker, J. B., & Hu, M. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.07.003 · Cited by 1,003 · see citing works
Uvnäs-Moberg, K. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00056-0 · Cited by 966 · see citing works
Melzack, R., & Torgerson, W. S. (1971) · Anesthesiology · doi:10.1097/00000542-197101000-00017 · Cited by 930 · see citing works
Oxytocin attenuates amygdala responses to emotional faces regardless of valence
Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Braus, D. F., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.025 · Cited by 774 · cited 1× · see citing works
“Reports of sex differences in oxytocin functioning are not limited to animal models; for instance, empathy triggered oxytocin release is higher in women than in men (92) and intranasal oxytocin attenuates amygdala responses to emotional stimuli in men (93, 94) but enhances activity in this region in women (95).”
BackgroundPruessner, J. C., Champagne, F., Meaney, M. J., & Dagher, A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3422-03.2004 · Cited by 709 · see citing works
Neuropeptidergic regulation of affiliative behavior and social bonding in animals
Lim, M. M., & Young, L. J. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.028 · Cited by 624 · see citing works
Liu, Y., & Wang, Z. X. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00555-4 · Cited by 580 · see citing works
Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., Mattay, V. S., Weinberger, D. R., & Meyer–Lindenberg, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003296107 · Cited by 564 · see citing works
Positive Association of the Oxytocin Receptor Gene (OXTR) with Autism in the Chinese Han Population
Wu, S., Jia, M., Ruan, Y., Liu, J., Guo, Y., Mei, S., Gong, X., Zhang, Y., Yang, X., & Zhang, D. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.013 · Cited by 553 · see citing works
Pharmacology of penile erection.
Andersson, K. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01503-5 · Cited by 533 · see citing works
Effects of intranasal oxytocin on emotional face processing in women
Domes, G., Lischke, A., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., & Herpertz, S. C. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.016 · Cited by 521 · cited 1× · see citing works
“Reports of sex differences in oxytocin functioning are not limited to animal models; for instance, empathy triggered oxytocin release is higher in women than in men (92) and intranasal oxytocin attenuates amygdala responses to emotional stimuli in men (93, 94) but enhances activity in this region in women (95).”
BackgroundEmpathy toward strangers triggers oxytocin release and subsequent generosity
Barraza, J. A., & Zak, P. J. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04504.x · Cited by 489 · see citing works
Pedersen, C. A., Caldwell, J. D., Walker, C., Ayers, G., & Mason, G. A. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.6.1163 · Cited by 475 · see citing works
Aragona, B. J., Liu, Y., Yu, Y. J., Curtis, J. T., Detwiler, J. M., Insel, T. R., & Wang, Z. (2006) · Nature Neuroscience · doi:10.1038/nn1613 · Cited by 473 · see citing works
Meyer, C. R., Boes, J. L., Kim, B., Bland, P. H., Zasadny, K. R., Kison, P. V., Koral, K. F., Frey, K. A., & Wahl, R. L. (1997) · Medical Image Analysis · doi:10.1016/s1361-8415(97)85010-4 · Cited by 460 · see citing works
What’s in a smile? Maternal brain responses to infant facial cues
Strathearn, L., Li, J., Fonagy, P., & Montague, P. R. (2008) · Pediatrics · doi:10.1542/peds.2007-1566 · Cited by 460 · see citing works
Sex differences in oxytocin and vasopressin: Implications for autism spectrum disorders?
CARTER, C. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.025 · Cited by 432 · see citing works
Is social attachment an addictive disorder?
Insel, T. R. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00148-3 · Cited by 430 · see citing works
Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism
Jacob, S., Brune, C. W., Carter, C. S., Leventhal, B. L., Lord, C., & Cook, E. H. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.02.001 · Cited by 425 · see citing works
Fibromyalgia patients show an abnormal dopamine response to pain
Wood, P. B., Schweinhardt, P., Jaeger, E., Dagher, A., Hakyemez, H., Rabiner, E. A., Bushnell, M. C., & Chizh, B. A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05623.x · Cited by 406 · see citing works
Loup, F., Tribollet, E., Dubois-Dauphin, M., & Dreifuss, J. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)90345-v · Cited by 378 · see citing works
Oxytocin–dopamine interactions mediate variations in maternal behavior in the rat
Shahrokh, D. K., Zhang, T.-Y., Diorio, J., Gratton, A., & Meaney, M. J. (2010) · Endocrinology · doi:10.1210/en.2009-1271 · Cited by 366 · see citing works
Sex differences in striatal dopamine release in healthy adults.
Munro, C. A., Mccaul, M., Wong, D., Oswald, L., Zhou, Y., Brašić, J. R., Kuwabara, H., Kumar, A., Alexander, M., Ye, W., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.01.008 · Cited by 364 · see citing works
A critical role for nucleus accumbens dopamine in partner-preference formation in male prairie voles
Aragona, B. J., Liu, Y., Curtis, J. T., Stephan, F. K., & Wang, Z. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03483.2003 · Cited by 351 · see citing works
Lerer, E., Levi, S., Salomon, S., Darvasi, A., Yirmiya, N., & Ebstein, R. P. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002087 · Cited by 349 · see citing works
Gingrich, B., Liu, Y., Cascio, C., Wang, Z., & Insel, T. R. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.1.173 · Cited by 339 · see citing works
Neural systems for behavioral activation and reward
Kalivas, P. W., & Nakamura, M. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80031-2 · Cited by 335 · see citing works
Ring, R. H., Malberg, J. E., Potestio, L., Ping, J., Boikess, S., Luo, B., Schechter, L. E., Rizzo, S., Rahman, Z., & Rosenzweig-Lipson, S. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0293-z · Cited by 319 · see citing works
Scott, D., Heitzeg, M. M., Koeppe, R. A., Stohler, C. S., & Zubieta, J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2577-06.2006 · Cited by 298 · see citing works
Self-citationOxytocin receptor polymorphisms and adult attachment style in patients with depression
Costa, B., Pini, S., Gabelloni, P., Abelli, M., Lari, L., Cardini, A., Muti, M., Gesi, C., Landi, S., Galderisi, S., et al. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.006 · Cited by 282 · see citing works
Rougé‐Pont, F., Piazza, P. V., Kharouby, M., Moal, M. L., & Simon, H. (1993) · Brain Research · doi:10.1016/0006-8993(93)90260-t · Cited by 258 · see citing works
Keer, S. E., & Stern, J. M. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00116-x · Cited by 250 · see citing works
Mogenson, G. J., & Yang, C. R. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-0145-6_14 · Cited by 238 · see citing works
Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array
Hodgkinson, C. A., Yuan, Q., Xu, K., Shen, P., Heinz, E., Lobos, E. A., Binder, E. B., Cubells, J. F., Ehlers, C. L., Gelernter, J. E., et al. (2008) · Alcohol and Alcoholism · doi:10.1093/alcalc/agn032 · Cited by 235 · see citing works
Self-citationInterplay of oxytocin, vasopressin, and sex hormones in the regulation of social recognition
Gabor, C. S., Phan, A., Clipperton-Allen, A. E., Kavaliers, M., & Choleris, E. (2012) · Behavioral Neuroscience · doi:10.1037/a0026464 · Cited by 221 · see citing works
Stead, J. D. H., Clinton, S., Neal, C., Schneider, J., Jama, A., Miller, S., Vazquez, D. M., Watson, S. J., & Akil, H. (2006) · Behavior Genetics · doi:10.1007/s10519-006-9058-7 · Cited by 209 · see citing works
Brody, A. L., Mandelkern, M. A., Olmstead, R. E., Scheibal, D., Hahn, E. L., Shiraga, S., Zamora-Paja, E., Farahi, J. B., Saxena, S., London, E. D., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.7.808 · Cited by 208 · see citing works
Melis, M. R., Melis, T., Cocco, C., Succu, S., Sanna, F., Pillolla, G., Boi, A., Ferri, G., & Argiolas, A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05721.x · Cited by 198 · see citing works
Oxytocin and addiction: a review
L. Kovács, G., Sarnyai, Z., & Szabó, G. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00064-x · Cited by 195 · see citing works
The Structure of the Genetic and Environmental Influences on Mental Well-Being
Keyes, C. L. M., Myers, J., & Kendler, K. S. (2010) · American Journal of Public Health · doi:10.2105/ajph.2010.193615 · Cited by 195 · see citing works
Oxytocin-Induced Analgesia and Scratching Are Mediated by the Vasopressin-1A Receptor in the Mouse
Schorscher-Petcu, A., Sotocinal, S., Ciura, S., Dupre, A., Ritchie, J., Sorge, R. E., Crawley, J. N., Hu, S.-B., Nishimori, K., Young, L. J., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1594-10.2010 · Cited by 189 · see citing works
Rougé‐Pont, F., Deroche‐Gamonet, V., Moal, M. L., & Piazza, P. V. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00438.x · Cited by 184 · see citing works
Nomura, M., McKenna, E., Korach, K. S., Pfaff, D. W., & Ogawa, S. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00525-9 · Cited by 167 · see citing works
Wermter, A., Kamp‐Becker, I., Hesse, P., Schulte‐Körne, G., Strauch, K., & Remschmidt, H. (2010) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31032 · Cited by 163 · see citing works
Innis, R. B., Malison, R. T., Al‐Tikriti, M. S., Hoffer, P. B., Sybirska, E. H., Seibyl, J. P., Zoghbi, S. S., Baldwin, R. M., Laruelle, M. A., Smith, E. O., et al. (1992) · Synapse · doi:10.1002/syn.890100302 · Cited by 155 · see citing works
Anxiolytic-like effect of oxytocin in the simulated public speaking test
de Oliveira, D. C., Zuardi, A. W., Graeff, F. G., Queiroz, R. H., & Crippa, J. A. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111400642 · Cited by 154 · see citing works
Effects of stress and aversion on dopamine neurons: Implications for addiction
Ungless, M. A., Argilli, E., & Bonci, A. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.04.006 · Cited by 145 · see citing works
Anti-nociceptive effects of oxytocin in rats and mice
Lundeberg, T., Uvnäs‐Moberg, K., Ågren, G., & BRUZELIUS, G. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90262-3 · Cited by 139 · see citing works
Role of oxytocin in the neuroadaptation to drugs of abuse
Sarnyai, Z., & Kovács, G. L. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90062-0 · Cited by 138 · see citing works
Wang, Z., Liu, Y., Young, L. J., & Insel, T. R. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00435.x · Cited by 134 · see citing works
Vasopressin and oxytocin systems in the brain and upper spinal cord of <i>Macaca fascicularis</i>
Caffé, A. R., Van Ryen, P. C., Van Der Woude, T. P., & Van Leeuwen, F. W. (1989) · Journal of Comparative Neurology · doi:10.1002/cne.902870304 · Cited by 128 · see citing works
A relationship between oxytocin and anxiety of romantic attachment
Marazziti (2006) · Clinical Practice and Epidemiology in Mental Health · doi:10.1186/1745-0179-2-28 · Cited by 124 · see citing works
Sexual differentiation of motivation: a novel mechanism?
Becker, J. B. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.03.014 · Cited by 115 · see citing works
Fliers, E., Guldenaar, S. E. F., Wal, N. V. D., & Swaab, D. F. (1986) · Brain Research · doi:10.1016/0006-8993(86)90759-6 · Cited by 114 · see citing works
Developmental pathology, dopamine, stress and schizophrenia
Lodge, D. J., & Grace, A. A. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.08.002 · Cited by 109 · see citing works
Lataster, J., Collip, D., Ceccarini, J., Haas, D., Booij, L., van Os, J., Pruessner, J., Van Laere, K., & Myin-Germeys, I. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.030 · Cited by 109 · see citing works
Bales, K. L., Pfeifer, L. A., & Carter, C. S. (2004) · Developmental Psychobiology · doi:10.1002/dev.10165 · Cited by 107 · see citing works
Cabib, S., Puglisi-Allegra, S., & Ventura, R. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00422-3 · Cited by 106 · see citing works
Spatial and temporal summation of sensory and affective dimensions of deep somatic pain
Stohler, S., & Kowalski, J. C. (1999) · Pain · doi:10.1016/s0304-3959(98)00171-7 · Cited by 102 · see citing works
The role of oxytocin-dopamine interactions in cocaine-induced locomotor hyperactivity
Kovàcs, G. L., Sarnyai, Z., Babarczi, E., Szabó, G., & Telegdy, G. (1990) · Neuropharmacology · doi:10.1016/0028-3908(90)90095-9 · Cited by 101 · see citing works
Brinton, R. D., Wamsley, J. K., Gee, K. W., Wan, Y.-P., & Yamamura, H. I. (1984) · European Journal of Pharmacology · doi:10.1016/0014-2999(84)90270-x · Cited by 100 · see citing works
Riccardi, P., Zald, D. H., Li, R., Park, S., Ansari, M. S., Dawant, B. M., Anderson, S., Woodward, N. D., Schmidt, D. E., Baldwin, R. M., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1639 · Cited by 98 · see citing works
van Leeuwen, F. W., van Heerikhuize, J. J., van der Meulen, G., & Wolters, P. S. (1985) · Brain Research · doi:10.1016/0006-8993(85)91443-x · Cited by 95 · see citing works
Oxytocin Receptor Binding in Female Prairie Voles: Endogenous and Exogenous Oestradiol Stimulation
Witt, D. M., Carter, C. S., & Lnsel, T. R. (1991) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1991.tb00258.x · Cited by 91 · see citing works
Messinger, D. S., Fogel, A., & Dickson, K. L. (1999) · Developmental Psychology · doi:10.1037//0012-1649.35.3.701 · Cited by 87 · see citing works
Krémarik, P., Freund‐Mercier, M. J., & Stoeckel, M. E. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903330304 · Cited by 80 · see citing works
Oxytocin Receptors and Maternal Behavior
Insel, T. R., & SHAPIRO, L. E. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34350.x · Cited by 79 · see citing works
Ge, Y., Lundeberg, T., & Yu, L.-C. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03346-7 · Cited by 79 · see citing works
A closed-loop system for maintaining constant experimental muscle pain in man
Zhang, X., Ashton‐Miller, J. A., & Stohler, C. S. (1993) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.222327 · Cited by 78 · see citing works
Self-citationDopamine D2 and D3 receptors in human putamen, caudate nucleus, and globus pallidus
Seeman, P. M., Wilson, A. A., Gmeiner, P., & Kapur, S. (2006) · Synapse · doi:10.1002/syn.20298 · Cited by 76 · see citing works
Kovács, G. L., Horváth, Z., Sarnyai, Z., FALUDI, M., & Telegdy, G. (1985) · Neuropharmacology · doi:10.1016/0028-3908(85)90026-7 · Cited by 76 · see citing works
Involvement of Opioid Receptors in Oxytocin-Induced Antinociception in the Nucleus Accumbens of Rats
Gu, X., & Yu, L. (2006) · Journal of Pain · doi:10.1016/j.jpain.2006.07.001 · Cited by 73 · see citing works
Stress-induced cigarette craving: effects of the DRD2 TaqI RFLP and SLC6A3 VNTR polymorphisms
Erblich, J., Lerman, C. E., Self, D. W., Díaz, G. A., & Bovbjerg, D. H. (2004) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500227 · Cited by 63 · see citing works
Gao, L., & Yu, L. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2004.02.011 · Cited by 61 · see citing works
Variants in the oxytocin gene and risk for schizophrenia
de Souza, R. P., Ismail, P., Meltzer, H. Y., & Kennedy, J. L. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.04.019 · Cited by 54 · see citing works
Kovács, G. L., Izbéki, F., Horváth, Z., & Telegdy, G. (1984) · Behavioural Brain Research · doi:10.1016/0166-4328(84)90014-7 · Cited by 53 · see citing works
The galactagogue action of the thymus and corpus luteum
Ott, I., & Scott, J. C. (1910) · Experimental Biology and Medicine · doi:10.3181/00379727-8-28 · Cited by 45 · see citing works
Han, Y., & Yu, L. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.02.062 · Cited by 43 · see citing works
Oxytocin as a potential mediator and modulator of drug addiction
Sarnyai, Z. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00332.x · Cited by 38 · see citing works
Oxytocin attenuates the cocaine-induced exploratory hyperactivity in mice
Sarnyai, Z., Szabó, G., Kovács, G. L., & Telegdy, G. (1990) · NeuroReport · doi:10.1097/00001756-199011000-00006 · Cited by 37 · see citing works
Pfister, H. P., & Muir, J. L. (1989) · International Journal of Neuroscience · doi:10.3109/00207458908986235 · Cited by 21 · see citing works
Quantitative Distribution of Neurohypophysial Hormones in Human Brain and Spinal Cord
Jenkins, J. S., Ang, V. T. Y., Hawthorn, J., & Rossor, M. N. (1983) · Progress in brain research · doi:10.1016/s0079-6123(08)64380-0 · Cited by 12 · see citing works
Flagged first, then by citations
1 of the 101 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [45]Spielberger C 1983 State-Trait Anxiety Inventory (Form Y) Palo Alto, CA Consulting Psychologists Press
Cited by
Sorted by citations
Autism, oxytocin and interoception
Quattrocki, E., & Friston, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.012 · Cited by 393 · see citing works
Oxytocin, motivation and the role of dopamine
Love, T. M. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.06.011 · Cited by 369 · see citing works
Self-citationFeldman, R., Monakhov, M., Pratt, M., & Ebstein, R. P. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.08.008 · Cited by 352 · see citing works
Oxytocin enhances brain reward system responses in men viewing the face of their female partner
Scheele, D., Wille, A., Kendrick, K. M., Stoffel-Wagner, B., Becker, B., Güntürkün, O., Maier, W., & Hurlemann, R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314190110 · Cited by 345 · see citing works
Psychobiology of social support: The social dimension of stress buffering
Ditzen, B., & Heinrichs, M. (2014) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-139008 · Cited by 298 · see citing works
Feldman, R. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000048 · Cited by 271 · see citing works
Oxytocin, stress and social behavior: neurogenetics of the human oxytocin system
Kumsta, R., & Heinrichs, M. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.09.004 · Cited by 265 · see citing works
Johnson, Z. V., & Young, L. J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.034 · Cited by 242 · see citing works
Epigenetic regulation of the oxytocin receptor gene: implications for behavioral neuroscience
Kumsta, R., Hummel, E., Chen, F. S., & Heinrichs, M. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00083 · Cited by 207 · see citing works
Wigton, R., Radua, J., Allen, P., Averbeck, B., Meyer-Lindenberg, A., McGuire, P., Shergill, S. S., & Fusar-Poli, P. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130289 · Cited by 179 · see citing works
Making room for oxytocin in understanding depression
McQuaid, R. J., McInnis, O. A., Abizaid, A. B., & Anisman, H. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.005 · Cited by 172 · see citing works
Oxytocin׳s role in anxiety: A critical appraisal
MacDonald, K., & Feifel, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.025 · Cited by 139 · see citing works
Buisman‐Pijlman, F. T. A., Sumracki, N. M., Gordon, J. J., Hull, P. R., Carter, C. S., & Mattie Tops, A. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.09.005 · Cited by 143 · see citing works
Sex, Receptors, and Attachment: A Review of Individual Factors Influencing Response to Oxytocin
MacDonald, K. S. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00194 · Cited by 119 · see citing works
Gluskin, B. S., & Mickey, B. J. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.22 · Cited by 117 · see citing works
Self-citationOxytocin in learning and addiction: From early discoveries to the present
Sarnyai, Z., & Kovács, G. L. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.11.019 · Cited by 106 · see citing works
From Autism to Eating Disorders and More: The Role of Oxytocin in Neuropsychiatric Disorders
Romano, A., Tempesta, B., Bonaventura, M. V. M. D., & Gaetani, S. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00497 · Cited by 102 · see citing works
Epigenetic modification of <i>OXT</i> and human sociability
Haas, B. W., Filkowski, M. M., Cochran, R. N., Denison, L., Ishak, A., Nishitani, S., & Smith, A. K. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1602809113 · Cited by 91 · see citing works
Zhang, R., Zhang, H.-F., Han, J., & Han, S. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0120-7 · Cited by 78 · see citing works
The dopaminergic response to acute stress in health and psychopathology: A systematic review
Vaessen, T., Hernaus, D., Myin‐Germeys, I., & van Amelsvoort, T. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.07.008 · Cited by 76 · see citing works
Postpartum depression: psychoneuroimmunological underpinnings and treatment
Anderson, G., & Maes, M. H. J. (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s25320 · Cited by 75 · see citing works
Striepens, N., Matusch, A., Kendrick, K. M., Mihov, Y., Elmenhorst, D., Becker, B., Lang, M., Coenen, H. H., Maier, W., Hurlemann, R., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.026 · Cited by 71 · see citing works
Weiland, B., Heitzeg, M., Zald, D., Cummiford, C. M., Love, T. M., Zucker, R., & Zubieta, J. (2014) · Psychiatry Research · doi:10.1016/j.pscychresns.2014.05.015 · Cited by 60 · see citing works
Self-citationde la Mora, M. P., Pérez-Carrera, D., Crespo-Ramírez, M., Tarakanov, A., Fuxe, K., & Borroto-Escuela, D. O. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.07.004 · Cited by 63 · see citing works
Macdonald, K., Berlow, R., & Thomas, M. L. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.07.040 · Cited by 56 · see citing works
Blum, K., Febo, M., Smith, D. E., Roy, A. K., Demetrovics, Z., Cronje, F. J., Femino, J., Agan, G., Fratantonio, J. L., Pandey, S. C., et al. (2015) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2014.0146 · Cited by 62 · see citing works
Oxytocin and anxiety disorders
Gottschalk, M. G., & Domschke, K. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_25 · Cited by 61 · see citing works
Bisagno, V., & Cadet, J. L. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000049 · Cited by 60 · see citing works
Current findings on the role of oxytocin in the regulation of food intake
Spetter, M. S., & Hallschmid, M. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.03.007 · Cited by 58 · see citing works
Chang, W. H., Lee, I. H., Chen, K. C., Chi, M. H., Chiu, N.-T., Yao, W. J., Lu, R., Yang, Y. K., & Chen, P. S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.05.020 · Cited by 54 · see citing works
Drug addiction: An affective-cognitive disorder in need of a cure
Fattore, L., & Diana, M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.04.006 · Cited by 55 · see citing works
On the role of oxytocin in borderline personality disorder
Brüne, M. (2015) · British Journal of Clinical Psychology · doi:10.1111/bjc.12100 · Cited by 50 · see citing works
Sauer, C., Montag, C., Reuter, M., & Kirsch, P. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00045 · Cited by 47 · see citing works
Striatal Dopamine Release and Genetic Variation of the Serotonin 2C Receptor in Humans
Mickey, B. J., Sanford, B., Love, T., Shen, P., Hodgkinson, C. A., Stohler, C. S., Goldman, D. A., & Zubieta, J.-K. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1260-12.2012 · Cited by 47 · see citing works
Self-citationAudunsdottir, K., Sartorius, A. M., Kang, H., Glaser, B. D., Bøen, R., Nærland, T., Alaerts, K., Kildal, E. S.-M., Westlye, L. T., Andreassen, O. A., et al. (2024) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2024.107067 · Cited by 41 · see citing works
Bang, M., Kang, J. I., Kim, S. J., Park, J. Y., Kim, K. R., Lee, S. Y., Park, K., Lee, E. M., Lee, S., & An, S. K. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz016 · Cited by 39 · see citing works
A Novel Role of CD38 and Oxytocin as Tandem Molecular Moderators of Human Social Behavior
Tolomeo, S., Chiao, B., Lei, Z., Chew, S. H., & Ebstein, R. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.013 · Cited by 39 · see citing works
Oxytocin receptor gene methylation in male and female PTSD patients and trauma-exposed controls
Nawijn, L., Krzyzewska, I. M., van Zuiden, M., Henneman, P., Koch, S. B. J., Mul, A. N. P. M., Frijling, J. L., Veltman, D. J., Mannens, M. M. A. M., & Olff, M. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.10.006 · Cited by 38 · see citing works
The genetics of morality and prosociality
Israel, S., Hasenfratz, L., & Knafo‐Noam, A. (2015) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2015.03.027 · Cited by 36 · see citing works
Interactions of Oxytocin and Dopamine—Effects on Behavior in Health and Disease
Petersson, M., & Uvnäs‐Moberg, K. (2024) · Biomedicines · doi:10.3390/biomedicines12112440 · Cited by 42 · see citing works
An attachment theoretical perspective for the neural representation of close others
Laurita, A. C., Hazan, C., & Spreng, R. N. (2019) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsz010 · Cited by 31 · see citing works
Sexually dimorphic effects of oxytocin receptor gene (OXTR) variants on Harm Avoidance
Stankova, T., Eichhammer, P., Langguth, B., & Sand, P. G. (2012) · Biology of Sex Differences · doi:10.1186/2042-6410-3-17 · Cited by 27 · see citing works
Pharmacotherapy options for labor induction
Wing, D. A., & Sheibani, L. (2015) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2015.1060960 · Cited by 26 · see citing works
Francis, S. M., Kistner‐Griffin, E., Yan, Z., Guter, S. J., Cook, E. H., & Jacob, S. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00195 · Cited by 26 · see citing works
Evidence for Association Between OXTR Gene and ASD Clinical Phenotypes
Ribeiro, L. D. O. P., Vargas‐Pinilla, P., Kappel, D. B., Longo, D., Ranzan, J., Becker, M. M., Riesgo, R. D. S., Schüler‐Faccini, L., Roman, T., & Schuch, J. B. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1088-0 · Cited by 25 · see citing works
Williams, S. K., & Johns, J. M. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.07.004 · Cited by 26 · see citing works
Olofsdotter, S., Åslund, C., Furmark, T., Comasco, E., & Nilsson, K. W. (2017) · Development and Psychopathology · doi:10.1017/s0954579417000967 · Cited by 24 · see citing works
Haas, B. W., Anderson, I. W., & Smith, J. M. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00801 · Cited by 23 · see citing works
Kabelik, D., Alix, V. C., Singh, L. J., Johnson, A. L., Choudhury, S. C., Elbaum, C. C., & Scott, M. R. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.026 · Cited by 22 · see citing works
Qadri, Y. J., Bortsov, A. V., Orrey, D. C., Swor, R. A., Peak, D. A., Jones, J. S., Rathlev, N. K., Lee, D. C., Domeier, R. M., Hendry, P. L., et al. (2014) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000167 · Cited by 23 · see citing works
Oxytocin decreases colonic motility of cold water stressed ratsviaoxytocin receptors
Yang, X. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i31.10886 · Cited by 21 · see citing works
Bánki, L., Büki, A., Horváth, G., Kékesi, G., Kis, G., Somogyvári, F., Jancsó, G., Vécsei, L., Varga, E., & Tuboly, G. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134561 · Cited by 20 · see citing works
Sex differences in chronic pain-induced mental disorders: Mechanisms of cerebral circuitry
Shen, Z., Li, W., Chang, W., Yue, N., & Yu, J. M. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1102808 · Cited by 21 · see citing works
The role of D2 dopamine receptors in oxytocin induced place preference and anxiolytic effect
László, K., Péczely, L., Géczi, F., Kovács, A., Zagoracz, O., Ollmann, T., Kertes, E., Kállai, V., László, B., Berta, B., et al. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104777 · Cited by 18 · see citing works
Sex matters: The impact of oxytocin on healthy conditions and psychiatric disorders
Marazziti, D., Carter, C. S., Carmassi, C., Vecchia, A. D., Mucci, F., Pagni, G., Carbone, M. G., Baroni, S., Giannaccini, G., Palego, L., et al. (2022) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2022.100165 · Cited by 18 · see citing works
Attenuation of dopamine‐induced GABA release in problem gamblers
Møller, A., Thomsen, K. R., Brooks, D. J., Mouridsen, K., Blicher, J. U., Hansen, K. V., & Lou, H. C. (2019) · Brain and Behavior · doi:10.1002/brb3.1239 · Cited by 17 · see citing works
Lenz, B., Weinland, C., Bach, P., Kiefer, F., Grinevich, V., Zoicas, I., Kornhuber, J., & Mühle, C. (2021) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2021.04.015 · Cited by 17 · see citing works
The Social Psychology of Latin American Happiness
Yamamoto, J. (2015) · Springer eBooks · doi:10.1007/978-94-017-7203-7_3 · Cited by 17 · see citing works
Blending oxytocin and dopamine with everyday creativity
Chong, A., Tolomeo, S., Yue, X., Angeles, D. C., Cheung, M. W. ‐., Becker, B., Lai, P. S., Lei, Z., Malavasi, F., Tang, Q., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-95724-x · Cited by 16 · see citing works
Marazziti, D., Diep, P.-T., Carter, C. S., & Carbone, M. G. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220727120646 · Cited by 16 · see citing works
Dopamine D3 receptor knockout mice exhibit abnormal nociception in a sex‐different manner
Liu, P., Xing, B., Chu, Z., Liu, F., Lei, G., Zhu, L., Gao, Y., Chen, T., & Dang, Y. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23952 · Cited by 16 · see citing works
Shumay, E., Wiers, C. E., Kojori, E. S., Kim, S. W., Hodgkinson, C. A., Sun, H., Tomasi, D. G., Wong, C., Weinberger, D. R., Wang, G., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3155-16.2017 · Cited by 15 · see citing works
Self-citationA Re-evaluation of Candidate Gene Studies for Well-Being in Light of Genome-Wide Evidence
van de Weijer, M. P., Pelt, D. H. M., de Vries, L. P., Baselmans, B. M. L., & Bartels, M. (2022) · Journal of Happiness Studies · doi:10.1007/s10902-022-00538-x · Cited by 14 · see citing works
Sala, M., Han, K., Acevedo, S. F., Krawczyk, D. C., & McAdams, C. J. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.02183 · Cited by 14 · see citing works
Brain imaging studies of emotional well-being: a scoping review
Richter, C. G., Celine Mylx, L. I., Turnbull, A. G., Haft, S. L., Schneider, D., Luo, J., Lima, D. P., Lin, F. V., Davidson, R. J., & Hoeft, F. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1328523 · Cited by 11 · see citing works
Connectome dysfunction in patients at clinical high risk for psychosis and modulation by oxytocin
Davies, C., Martins, D., Dipasquale, O., McCutcheon, R. A., Micheli, A. D., Ramella‐Cravaro, V., Provenzani, U., Rutigliano, G., Cappucciati, M., Oliver, D., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02406-x · Cited by 9 · see citing works
Love, T., Cranford, J. A., Burmeister, M., Wojnar, M., Zucker, R. A., & Brower, K. J. (2017) · Alcohol and Alcoholism · doi:10.1093/alcalc/agx077 · Cited by 10 · see citing works
Self-citationRybicka, M., Kaźmierczak, M., Pawlicka, P., Łada‐Maśko, A., Anikiej‐Wiczenbach, P., & Bielawski, K. P. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105294 · Cited by 10 · see citing works
Senese, V. P., Shinohara, K., Venuti, P., Bornstein, M. H., Rosanio, V., Nasti, C., Neoh, M. J. Y., Maresca, M., & Esposito, G. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19095566 · Cited by 9 · see citing works
Chong, A., Chew, S. H., Lai, P. S., Ebstein, R. P., & Gouin, J. (2018) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.02.015 · Cited by 8 · see citing works
The Neurobiology of Adolescent-Onset Borderline Personality Disorder
Goodman, M. S., Pérez-Rodríguez, M. M., & Siever, L. J. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0591-1_9 · Cited by 8 · see citing works
Epigenetic Modification of OXTR is Associated with Openness to Experience
Haas, B. W., Smith, A. K., & Nishitani, S. (2018) · Personality Neuroscience · doi:10.1017/pen.2018.7 · Cited by 10 · see citing works
Sardari, M., Mohammadpourmir, F., Sahafi, O. H., & Rezayof, A. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111068 · Cited by 7 · see citing works
Weimer, K., Horing, B., Muth, E. R., Scisco, J. L., Klosterhalfen, S., & Enck, P. (2016) · Clinical Therapeutics · doi:10.1016/j.clinthera.2016.11.022 · Cited by 7 · see citing works
Neuroimaging genetics of oxytocin: A transcriptomics-informed systematic review
Prata, D. P., & Silva, M. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104912 · Cited by 7 · see citing works
Olazábal, D. E., Bertoni, B., Grandi, G., Musetti, D., Rey, G., Sandberg, N. Y., Fernández, L., Laporte, G., Medici, F., & Nicolaisen‐Sobesky, E. (2023) · Developmental Psychobiology · doi:10.1002/dev.22400 · Cited by 5 · see citing works
Opportunities for an enhanced integration of neuroscience and genomics
Moore, A. A., Sawyers, C. K., Adkins, D. E., & Docherty, A. R. (2017) · Brain Imaging and Behavior · doi:10.1007/s11682-017-9780-1 · Cited by 5 · see citing works
László, K., Vörös, D., Kiss, O., László, B. R., Ollmann, T., Péczely, L., Mintál, K., Tóth, A., Kovács, A., Zagorácz, O., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10092309 · Cited by 6 · see citing works
Is It in Our Genes: Oxytocin, Dopamine, Stress, and Sex
Abi‐Dargham, A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.05.007 · Cited by 4 · see citing works
Bruenig, D., Morris, C. P., Young, R. M., & Voisey, J. (2015) · Springer eBooks · doi:10.1007/978-3-319-08613-2_110-1 · Cited by 4 · see citing works
Epistatic interactions between oxytocin- and dopamine-related genes and trust
Koyama, Y., Nawa, N., Ochi, M., Surkan, P. J., & Fujiwara, T. (2024) · PLoS ONE · doi:10.1371/journal.pone.0308728 · Cited by 3 · see citing works
Interaction Between Oxytocin and Dopamine Signaling: Focus on the Striatum
Guidolin, D., Tortorella, C., Cervetto, C., Marcoli, M., Maura, G., & Agnati, L. F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178711 · Cited by 3 · see citing works
The Creative Mind: Blending Oxytocinergic, Dopaminergic and PersonalityPreprint
Chong, A., Becker, B., Angeles, D. C., Matos, M. G., Yue, X., Lai, P. S., Cheung, M. W. ‐., Lei, Z., Malavasi, F., Chew, S. H., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/700807 · Cited by 3 · see citing works
Phenotypic Plasticity, CYP19A1 Pleiotropy, and Maladaptive Selection in Developmental Disorders
Malone, J. P. (2013) · SAGE Open · doi:10.1177/2158244013484476 · Cited by 1 · see citing works
Bruenig, D., Morris, C. P., Young, R. M., & Voisey, J. (2015) · Springer eBooks · doi:10.1007/978-3-319-08359-9_110 · Cited by 5 · see citing works
Gene-Environment Interplay for Well-Being
van de Weijer, M. P. (2023) · doi:10.5463/thesis.236 · Cited by 1 · see citing works
The Impact of Genetic Polymorphisms on Neuroreceptor Imaging
Willeit, M., Kasper, S. F., & Praschak-Rieder, N. (2014) · Springer eBooks · doi:10.1007/978-3-642-42014-6_6
Genetic, Biomarker and Psychological Factors for Risk and Resilience of PTSD
Bruenig, D. (2017) · Queensland University of Technology · doi:10.5204/thesis.eprints.112180
Vulliez‐Coady, L., & Darnaudéry, M. (2015) · Elsevier eBooks · doi:10.1016/b978-2-294-74520-1.00010-9
Graf, I., Willeit, M., Kasper, S. F., & Praschak-Rieder, N. (2020) · Springer eBooks · doi:10.1007/978-3-030-53176-8_6
Neurobiologie de l’attachement
Vulliez‐Coady, L., & Darnaudéry, M. (2021) · Elsevier eBooks · doi:10.1016/b978-2-294-77731-8.00007-2
Mach, A., Klimkiewicz, A., Fudalej, S., Jakubczyk, A., Kopera, M., Burmeister, M., Brower, K. J., & Wojnar, M. (2021) · Alcoholism and Drug Addiction · doi:10.5114/ain.2021.109540
Oxytocin - not only a "social" neuropeptide
Brodmann, K. (2016) · doi:10.53846/goediss-5978
Oxytocin, Social Interactions and Coping: Implications for Depression
McInnis, O. A. (2016) · doi:10.22215/etd/2016-11454
Frank, G. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734669560.793558797
Single nucleotide variants and their association with subjective well-being
Ray, S., Dey, D., & Sengupta, M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-28842-5.00018-1
- Authors
- Love, T. M., Enoch, M.-A., Hodgkinson, C. A., Peciña, M., Mickey, B., Koeppe, R. A., Stohler, C. S., Goldman, D., & Zubieta, J.-K.
- Affiliations
- University of Michigan (US)
- National Institutes of Health (US)
- University of Maryland, Baltimore (US)
- Corresponding author
- Love, Tiffany M.
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 72
- Issue
- 3
- Pages
- 198-206
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC3392442
- OpenAlex
- W2078940490
- Cited by
- 97
- References
- 101
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 9 · 2016: 11 · 2015: 12 · 2014: 12 · 2013: 13 · 2012: 4
- FWCI
- 19.78
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R01 DA016423, R01 DA022520)
- National Institute on Alcohol Abuse and Alcoholism
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- oxytocin gene, dopamine release, stress response, sex differences, pain stress, attachment anxiety, trait anxiety, emotional well-being, [11C]raclopride PET, dopamine signaling
- MeSH terms
- Adult, Alleles, Anxiety, Dopamine, Emotions, Female, Genotype, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Synaptic Transmission, Object Attachment, Oxytocin, Pain, Polymorphism, Genetic, Sex Characteristics, Stress, Psychological, Linkage Disequilibrium, Receptors, Dopamine D2, Polymorphism, Single Nucleotide, Positron-Emission Tomography, Receptors, Dopamine D3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
