Morphological evidence that CA1 hippocampal afferents monosynaptically innervate PV-containing neurons and NADPH-diaphorase reactive cells in the medial prefrontal cortex (Areas 25/32) of the rat
Abstract
Immunocytochemical and ultrastructural evidence is presented indicating that direct inputs from the hippocampal CA1 field to prelimbic (area 32) and infralimbic (area 25) cortices in the rat, innervate not only 'spiny' (presumed pyramidal) neurons but also monosynaptically contact NADPH-diaphorase reactive cells and parvalbumin-containing local circuit neurons-the latter cell type is shown to be GABA immunoreactive. Similar evidence of direct CA1 input to local circuit neurons containing either calbindin or calretinin was not found.
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The hippocampus-mPFC pathway makes synaptic contact both with glutamatergic pyramidal neurons and GABAergic interneurons within the mPFC.
“This hippocampus-mPFC pathway makes synaptic contact both with glutamatergic pyramidal neurons and GABAergic interneurons within the mPFC”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Gabbott et al., 2002
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- Authors
- Gabbott, P., Headlam, A., & Busby, S.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Gabbott, Paul
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 946
- Issue
- 2
- Pages
- 314-322
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2111161101
- Cited by
- 101
- References
- 43
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 6 · 2016: 7 · 2015: 2 · 2014: 8 · 2013: 6 · 2012: 4
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Open Research Online (The Open University) (submittedVersion)
- Funders
- Wellcome Trust
- Royal Society
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- hippocampal CA1, medial prefrontal cortex, parvalbumin, NADPH-diaphorase, local circuit neurons, GABA immunoreactivity, calbindin, calretinin, pyramidal neurons
- MeSH terms
- Afferent Pathways, Animals, Electrophysiology, gamma-Aminobutyric Acid, Hippocampus, Immunohistochemistry, Limbic System, Male, NADPH Dehydrogenase, Neurons, Afferent, Parvalbumins, Synapses, Rats, Sprague-Dawley, Prefrontal Cortex, Rats, Calbindins, S100 Calcium Binding Protein G, Calbindin 2
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