Context-dependent prefrontal cortex regulation of cocaine self-administration and reinstatement behaviors in rats
Abstract
Evidence of stimulus attribute-specificity within the prefrontal cortex (PFC) suggests that different prefrontal subregions may contribute to cocaine addiction in functionally distinct ways. Thus, the present study examined the effects of lidocaine-induced inactivation of two distinct PFC subregions, the prelimbic (PL) or dorsal agranular insular (AId) cortices, on drug-seeking and drug-taking behaviors under cocaine maintenance and reinstatement testing conditions in rats trained to self-administer 1 mg/kg cocaine under a second-order schedule of drug delivery. Throughout maintenance and reinstatement phases, rats were exposed to conditioned light cues and contextual odor or sound cues. Results showed that PL inactivation during maintenance test sessions significantly reduced drug-seeking and drug-taking behaviors, and disrupted patterns of responding in rats exposed to light-sound, but not light-odor, cues. Moreover, lidocaine-induced inactivation of the PL significantly attenuated drug-seeking behavior during cue-induced and cocaine prime-induced reinstatement in rats exposed to light-sound cues only. In contrast, AId inactivation significantly attenuated cue-induced reinstatement of drug-seeking behavior in rats exposed to light-odor cues only. Drug-seeking and drug-taking behaviors in these rats were not disrupted during maintenance and cocaine prime-induced reinstatement testing regardless of the type of contextual cues used. Together, these data suggest that PL and AId subregions play separate yet overlapping roles in regulating cocaine addiction in rats in ways that are dependent on the presence or absence of cocaine and on the types of contextual cues present in the cocaine self-administration environment.
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Lidocaine inactivation of the aAgIC attenuates cue+context-induced cocaine seeking when the context was established by odor but not by sound.
“Interestingly, lidocaine inactivation of the aAgIC attenuates cue+context-induced cocaine seeking when the context was established by odor but not by sound”
From The Insula: A Brain Stimulation Target for the Treatment of Addiction (2019) · cites this paper as Pietro et al., 2006
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- Authors
- Di Pietro, N. C., Black, Y. D., & Kantak, K. M.
- Affiliations
- Boston University (US)
- ORCID
- Kantak, Kathleen M.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2006-12
- Volume
- 24
- Issue
- 11
- Pages
- 3285-3298
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2168067951
- Cited by
- 107
- References
- 76
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 7 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 11 · 2016: 5 · 2015: 6 · 2014: 5 · 2013: 7 · 2012: 8
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Arca (British Columbia Electronic Library Network) (submittedVersion)
- Funders
- National Institute on Drug Abuse (R01DA011716, DA 11716)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- cocaine self-administration, cocaine reinstatement, cocaine dependence, prefrontal cortex, prelimbic cortex, drug-seeking behavior, drug use behavior, contextual cues, olfactory cues, acoustic cues, second-order schedules
- MeSH terms
- Acoustic Stimulation, Anesthetics, Local, Animals, Cocaine, Cues, Disease Models, Animal, Dose-Response Relationship, Drug, Environment, Environment, Controlled, Lidocaine, Male, Neural Pathways, Odorants, Photic Stimulation, Reward, Self Administration, Prefrontal Cortex, Dopamine Uptake Inhibitors, Cocaine-Related Disorders, Rats
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