Cited by 67Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Divisions of identified parvalbumin-expressing basket cells during working memory-guided decision making

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Lagler, Michael, Ozdemir, A. Tugrul, Lagoun, Sabria, Malagon-Vina, Hugo, Borhegyi, Zsolt, Hauer, Romana, Jelem, Anna, Klausberger, Thomas·2016·Neuron

Abstract

Parvalbumin-expressing basket cells tightly control cortical networks and fire remarkably stereotyped during network oscillations and simple behaviors. How can these cells support multifaceted situations with different behavioral options and complex temporal sequences? We recorded from identified parvalbumin-expressing basket cells in prefrontal cortex of freely moving rats performing a multidimensional delayed cue-matching-to-place task, juxtacellularly filled recorded neurons for unequivocal histological identification, and determined their activity during temporally structured task episodes, associative working-memory, and stimulus-guided choice behavior. We show that parvalbumin-expressing basket cells do not fire homogenously, but individual cells were recruited or inhibited during different task episodes. Firing of individual basket cells was correlated with amount of presynaptic VIP (vasoactive intestinal polypeptide)-expressing GABAergic input. Together with subsets of pyramidal neurons, activity of basket cells differentiated for sequential actions and stimulus-guided choice behavior. Thus, interneurons of the same cell type can be recruited into different neuronal ensembles with distinct firing patterns to support multi-layered cognitive computations.

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Crossref · 10.1016/j.neuron.2016.08.010

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  • PV+ basket cells dynamically oscillate between different states in response to neuronal activity, a process required for learning and memory in the adult brain.

    “For example, PV+ basket cells seem to dynamically oscillate between different “states” in response to neuronal activity, a process that is required for learning and memory in the adult brain (Donato et al., 2013; Lagler et al., 2016).”

    From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Lagler et al., 2016

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Authors
Lagler, M., Ozdemir, A. T., Lagoun, S., Malagon-Vina, H., Borhegyi, Z., Hauer, R., Jelem, A., & Klausberger, T.
Affiliations
Medical University of Vienna (AT)
Corresponding author
  • Lagler, Michael
  • Klausberger, Thomas
Venue
Neuron
Publisher
Elsevier BV
Published
2016-09
Volume
91
Issue
6
Pages
1390-1401
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2511715626
Cited by
67
References
78
Citations by year
2026: 2 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 3 · 2021: 8 · 2020: 11 · 2019: 9 · 2018: 11 · 2017: 7 · 2016: 1
FWCI
5.95
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Vienna Science and Technology Fund
  • Austrian Science Fund
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
prefrontal cortex, working memory, juxtacellular recording, neuronal ensembles, pyramidal neurons, cortical oscillations, rats
MeSH terms
Animals, Choice Behavior, Decision Making, Interneurons, Male, Memory, Short-Term, Parvalbumins, Vasoactive Intestinal Peptide, Prefrontal Cortex, Presynaptic Terminals, Pyramidal Cells, Rats, GABAergic Neurons

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