Influence of neurons on lipopolysaccharide-stimulated production of nitric oxide and tumor necrosis factor-α by cultured glia

Chang, Raymond C.C.; Hudson, Pearlie; Wilson, Belinda; Haddon, Lisa; Hong, Jau-Shyong

doi:10.1016/s0006-8993(99)02255-6

Cited by 68Neuroinflammation and Neurodegeneration MechanismsPain Mechanisms and TreatmentsNeuroscience and Neuropharmacology Research

Influence of neurons on lipopolysaccharide-stimulated production of nitric oxide and tumor necrosis factor-α by cultured glia

Chang, Raymond C.C., Hudson, Pearlie, Wilson, Belinda, Haddon, Lisa, Hong, Jau-Shyong·2000·Brain Research

DOI 10.1016/s0006-8993(99)02255-6

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Abstract

Cerebral inflammation often originates in a region where neuronal death occurs and thereafter slowly spreads outward. This study aimed to elucidate the roles of neurons in modulating the production of inflammatory factors stimulated by the bacterial endotoxin lipopolysaccharide (LPS). Culturing neurons with mixed glia reduced nitrite and tumor necrosis factor-alpha (TNF-alpha) production compared to cultures with only mixed glia, and shifted the dose-response curve to the right. The decreased nitrite and TNF-alpha production were not due to the cytotoxicity of LPS. Immunocytochemical analysis of glia-neuron co-cultures revealed the morphological changes in the activated microglia. Culturing PC12 cells with rat mixed-glia also reduced nitrite production. The influence of neurons on glial inflammation was partly due to the cell-cell contacts between neurons and glia via neural cell adhesion molecules (NCAM) because NCAM significantly reduced LPS-stimulated nitrite production. These results demonstrate that neurons reduce the production of inflammatory factors by glia. Since cerebral inflammation is important in many neurological disorders, this study might provide insight about the role of glia-neuron interactions in inflammatory responses in the brain.

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From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Chang et al., 2000

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Authors: Chang, R. C. C., Hudson, P., Wilson, B., Haddon, L., & Hong, J.-S.
Affiliations: National Institutes of Health (US)
Corresponding author: Hong, Jau-Shyong
ORCID: Chang, Raymond C.C.
Hong, Jau-Shyong
Venue: Brain Research
Publisher: Elsevier BV
Published: 2000-01
Volume: 853
Issue: 2
Pages: 236-244
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/s0006-8993(99)02255-6
OpenAlex: W2050094645
Cited by: 68
References: 27
Citations by year: 2025: 2 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 4 · 2013: 6 · 2012: 2
FWCI: 2.77
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: neuron-glia interactions, lipopolysaccharide, nitric oxide, TNF-α, microglial activation, neuroinflammation, CD56, PC12 cells, neuroprotection
MeSH terms: Animals, Animals, Newborn, Cell Communication, Cells, Cultured, Dose-Response Relationship, Drug, Inflammation, L-Lactate Dehydrogenase, Lipopolysaccharides, Neuroglia, Neurons, Nitric Oxide, Rats, Inbred F344, Tumor Necrosis Factor-alpha, Down-Regulation, PC12 Cells, Coculture Techniques, Nitric Oxide Synthase, Neural Cell Adhesion Molecules, Cell Size, Mice, Rats, Nitric Oxide Synthase Type II

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Influence of neurons on lipopolysaccharide-stimulated production of nitric oxide and tumor necrosis factor-α by cultured glia

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