Smoking and schizophrenia: abnormal nicotinic receptor expression
Abstract
Biological and genetic evidence suggests a role for the neuronal nicotinic receptors in the neuropathophysiology of schizophrenia. Nicotine normalizes an auditory evoked potential deficit seen in subjects who suffer from the disease. Nicotinic receptors with both high and low affinity for nicotine are decreased in postmortem brain of schizophrenics compared to control subjects. The chromosomal locus of the human alpha-7 gene (15q14) is linked to the gating deficit with a lod of 5.3, and antagonists of the alpha-7 receptor (alpha-bungarotoxin and methyllycaconitine) induce a loss of gating in rodents. We have cloned the human alpha-7 gene and found it to be partially duplicated proximal to the full-length gene. The duplication is expressed in both the brain and in peripheral blood cells of normal subjects, but is missing in some schizophrenic subjects. The results of these studies suggest the presence of abnormal expression and function of the neuronal nicotinic receptor gene family in schizophrenia.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
α7 nAChRs are implicated in prepulse inhibition, a physiological marker associated with schizophrenia.
“Genetic and functional studies have implicated α7 nAChRs in prepulse inhibition, a physiological marker associated with schizophrenia (Leonard et al. 2000;Freedman et al. 2003).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Leonard et al. 2000
Cites
Progress in experimental personality research
Maher, W. B., & Maher, B. A. (1964) · Academic Press eBooks · Cited by 2,347 · see citing works
Schizotaxia, schizotypy, schizophrenia.
Meehl, P. E. (1962) · American Psychologist · doi:10.1037/h0041029 · Cited by 2,036 · see citing works
Séguéla, P., Wadiche, J. I., Dineley‐Miller, K., Dani, J., & Jw, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00596.1993 · Cited by 1,471 · see citing works
Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus
Freedman, R., Coon, H., Myles-Worsley, M., Orr-Urtreger, A., Olincy, A., Davis, A., Polymeropoulos, M., Holik, J., Hopkins, J., Hoff, M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.587 · Cited by 1,141 · see citing works
Self-citationPrevalence of smoking among psychiatric outpatients
(1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.8.993 · Cited by 1,058 · see citing works
Gating and Habituation of the Startle Reflex in Schizophrenic Patients
Braff, D. L. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820030038005 · Cited by 1,027 · see citing works
Physiological Diversity of Nicotinic Acetylcholine Receptors Expressed by Vertebrate Neurons
McGehee, D. S., & Role, L. W. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.002513 · Cited by 1,022 · see citing works
Couturier, S., Bertrand, D., Matter, J., Hernandez, M., Bertrand, S., Millar, N. S., Valera, S., BARKAS, T., & Ballivet, M. (1990) · Neuron · doi:10.1016/0896-6273(90)90344-f · Cited by 941 · see citing works
Adler, L. E., Pachtman, E., Franks, R. D., Pecevich, M., Waldo, M. C., & Freedman, R. (1982) · PubMed · Cited by 896 · see citing works
Self-citationSchizophrenia, sensory gating, and nicotinic receptors
Adler, L. E., Olincy, A., Waldo, M., Harris, J. G., Griffith, J., Stevens, K., Flach, K., Nagamoto, H., Bickford, P., Leonard, S., et al. (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033320 · Cited by 690 · see citing works
Self-citationNormalization of auditory physiology by cigarette smoking in schizophrenic patients
Adler, L. E., Hoffer, L., Wiser, A., & Freedman, R. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.12.1856 · Cited by 679 · see citing works
Self-citationFreedman, R., Hall, M., Adler, L. E., & Leonard, S. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(94)00252-x · Cited by 678 · see citing works
Self-citationCigarette smoking in schizophrenia: relationship to psychopathology and medication side effects
GOFF, D. C., Henderson, D. C., & Amico, E. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.9.1189 · Cited by 580 · see citing works
INPUT DYSFUNCTION IN SCHIZOPHRENIA.
Ph, V. (1964) · PubMed · Cited by 473 · see citing works
Cigarette Smoking, Major Depression, and Other Psychiatric Disorders among Adolescents
BROWN, R. A., LEWINSOHN, P. M., SEELEY, J. R., & WAGNER, E. F. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199612000-00011 · Cited by 435 · see citing works
Wessler, I. K., Kirkpatrick, C. J., & Racké, K. (1998) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(97)00085-5 · Cited by 415 · see citing works
Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics
Adler, L. E., Hoffer, L., Griffith, J. M., Waldo, M. C., & Freedman, R. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90073-9 · Cited by 412 · see citing works
Self-citationEffect of smoking history on [3H]nicotine binding in human postmortem brain
Breese, C. R., Marks, M. J., Logel, J., Adams, C. E., Sullivan, B., Collins, A. C., & Leonard, S. (1997) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36798-9 · Cited by 396 · see citing works
Self-citationAbnormal Regulation of High Affinity Nicotinic Receptors in Subjects with Schizophrenia
Breese, C. R. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00121-4 · Cited by 343 · see citing works
Self-citationGenetic linkage and complex diseases, with special reference to psychiatric disorders
RISCH, N. J., & Rao, D. C. (1990) · Genetic Epidemiology · doi:10.1002/gepi.1370070103 · Cited by 280 · see citing works
The Positive-Negative Distinction in Schizophrenia
McGlashan, T. H. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820010063008 · Cited by 269 · see citing works
Selective α 7 -nicotinic agonists normalize inhibition of auditory response in DBA mice
Stevens, K. E., Kem, W. R., Mahnir, V. M., & Freedman, R. (1998) · Psychopharmacology · doi:10.1007/s002130050573 · Cited by 269 · see citing works
Self-citationNicotinic Receptor Function in Schizophrenia
Leonard, S. S., Adams, C., Breese, C. R., Adler, L. E., Bickford, P. C., Byerley, W., Coon, H. H., Griffith, J. M., Miller, C., Myles‐Worsley, M., et al. (1996) · Schizophrenia Bulletin · doi:10.1093/schbul/22.3.431 · Cited by 263 · see citing works
Self-citationCholinergic gating of response to auditory stimuli in rat hippocampus
Luntz‐Leybman, V., Bickford, P. C., & Freedman, R. (1992) · Brain Research · doi:10.1016/0006-8993(92)91437-j · Cited by 260 · see citing works
Self-citationD, A. O. M., Young, D. A., & Freedman, R. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00302-2 · Cited by 252 · see citing works
Self-citationElementary neuronal dysfunctions in schizophrenia
Freedman, R., Waldo, M. C., Bickford, P. C., & Nagamoto, H. T. (1991) · Schizophrenia Research · doi:10.1016/0920-9964(91)90035-p · Cited by 251 · see citing works
Self-citationGault, J., Robinson, M., Berger, R., Drebing, C. J., Logel, J., Hopkins, J., Moore, T., Jacobs, S., Meriwether, J., Choi, M. J., et al. (1998) · Genomics · doi:10.1006/geno.1998.5363 · Cited by 245 · see citing works
Self-citation22q11 deletion syndrome in adults with schizophrenia
Bassett, A. S., Hodgkinson, K. A., Chow, E. W. C., Correia, S., Scutt, L. E., & Weksberg, R. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19980710)81:4 · Cited by 228 · see citing works
Self-citationHaloperidol increases smoking in patients with schizophrenia
McEvoy, J. P., Freudenreich, O., Levin, E. D., & Rose, J. E. (1995) · Psychopharmacology · doi:10.1007/bf02246063 · Cited by 225 · see citing works
Auditory sensory gating in hippocampal neurons: A model system in the rat
Bickford, P. C., Nagamoto, H. T., Johnson, R., Adler, L. E., Egan, M. F., Rose, G., & Freedman, R. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90648-l · Cited by 224 · see citing works
Self-citationStevens, K. E. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00178-g · Cited by 203 · see citing works
Self-citationNeuronal nicotinic receptors : pharmacology and therapeutic opportunities
Arnerić, S. P., & Brioni, J. D. (1999) · Wiley-Liss eBooks · Cited by 202 · see citing works
Gating of auditory P50 in schizophrenics: Unique effects of clozapine
Nagamoto, H. T., Adler, L. E., Hea, R., Griffith, J. M., McRae, K. A., & Freedman, R. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00371-1 · Cited by 201 · see citing works
Self-citationClozapine decreases smoking in patients with chronic schizophrenia
McEvoy, J. P., Freudenreich, O., McGee, M., VanderZwaag, C. J., Levin, E. D., & Rose, J. E. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(94)00365-a · Cited by 195 · see citing works
Lukas, R. J., Norman, S. A., & Lucero, L. M. (1993) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1993.1001 · Cited by 192 · see citing works
Replication and Extension of P50 Findings in Schizophrenia
Boutros, N. N., Zouridakis, G., & Overall, J. E. (1991) · Clinical Electroencephalography · doi:10.1177/155005949102200109 · Cited by 188 · see citing works
Smoking and therapeutic response to clozapine in patients with schizophrenia
McEvoy, J. P., Freudenreich, O., & Wilson, W. H. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00377-1 · Cited by 172 · see citing works
Jacobsen, L. K., & Rapoport, J. L. (1998) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00305 · Cited by 156 · see citing works
Source location of a 50 msec latency auditory evoked field component
Reite, M., Teale, P. D., Zimmerman, J. E., Davis, K. M., & Whalen, J. (1988) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(88)90147-2 · Cited by 148 · see citing works
Improvement in Smooth Pursuit Eye Movements after Cigarette Smoking in Schizophrenic Patients
D, A. O. M. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00095-x · Cited by 136 · see citing works
The time course of information-processing deficits in schizophrenia
BRAFF, D. L., & Saccuzzo, D. P. (1985) · American Journal of Psychiatry · doi:10.1176/ajp.142.2.170 · Cited by 134 · see citing works
The fall and rise of neuronal α-bungarotoxin binding proteins
Clarke, P. B. S. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90125-p · Cited by 133 · see citing works
Genetic Linkage in Schizophrenia: Perspectives From Genetic Epidemiology
McGue, M., & Gottesman, I. I. (1989) · Schizophrenia Bulletin · doi:10.1093/schbul/15.3.453 · Cited by 133 · see citing works
Codistribution of a sensory gating deficit and schizophrenia in multi-affected families
Waldo, M. C., Carey, G., Myles‐Worsley, M., Cawthra, E. M., Adler, L. E., Nagamoto, H. T., Wender, P. H., Byerley, W., Plaetke, R., & Freedman, R. (1991) · Psychiatry Research · doi:10.1016/0165-1781(91)90092-4 · Cited by 129 · see citing works
Self-citationGenomic survey of bipolar illness in the NIMH genetics initiative pedigrees: A preliminary report
Nürnberger, J. I., DePaulo, J. R., Gershon, E. S., Reich, T., Blehar, M. C., Edenberg, H. J., Foroud, T., Miller, M., Bowman, E. S., Mayeda, A. R., et al. (1997) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19970531)74:3 · Cited by 121 · see citing works
Turning point in the design of linkage studies of schizophrenia
Cloninger, C. R. (1994) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320540202 · Cited by 102 · see citing works
Smoking and movement disorders in psychiatric patients
Menza, M. A., Grossman, N., Horn, M. V., Cody, R., & Forman, N. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90163-g · Cited by 95 · see citing works
Quik, M., Chan, J., & Patrick, J. (1994) · Brain Research · doi:10.1016/0006-8993(94)91610-1 · Cited by 92 · see citing works
Familial transmission of two independent saccadic abnormalities in schizophrenia
Ross, R. G., Harris, J. G., D, A. O. M., Radant, A. D., Adler, L. E., & Freedman, R. (1998) · Schizophrenia Research · doi:10.1016/s0920-9964(97)00133-3 · Cited by 88 · see citing works
Self-citationα‐Bungarotoxin Binds to Low‐Affinity Nicotine Binding Sites in Rat Brain
Wonnacott, S. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb13078.x · Cited by 84 · see citing works
Clarke, P. B. S. (1993) · Progress in brain research · doi:10.1016/s0079-6123(08)62383-3 · Cited by 80 · see citing works
Genotypes, Phenotypes, and the Brain
Tsuang, M. T. (1993) · The British Journal of Psychiatry · doi:10.1192/bjp.163.3.299 · Cited by 78 · see citing works
Anticipatory saccades during smooth pursuit eye movements and familial transmission of schizophrenia
Ross, R. G., D, A. O. M., Harris, J. G., Radant, A. D., Adler, L. E., & Freedman, R. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00052-3 · Cited by 77 · see citing works
Self-citationSensory gating deficits in parents of schizophrenics
Waldo, M. C., Myles‐Worsley, M., Madison, A., Byerley, W., & Freedman, R. (1995) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320600605 · Cited by 74 · see citing works
Self-citationMedial septal neuron activity in relation to an auditory sensory gating paradigm
Miller, C. L., & Freedman, R. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90506-b · Cited by 71 · see citing works
Self-citationNegative Effects of a Smoking Ban on an Inpatient Psychiatry Service
Greeman, M., & McClellan, T. A. (1991) · Psychiatric Services · doi:10.1176/ps.42.4.408 · Cited by 69 · see citing works
Psychosocial competence of unselected young adults with sex chromosome abnormalities
Bender, B. G., Harmon, R. J., Linden, M. G., Bucher‐Bartelson, B., & Robinson, A. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19990416)88:2 · Cited by 61 · see citing works
Self-citationNicotinic Receptors, Smoking and Schizophrenia
Leonard, S. S., Gault, J., Adams, C. E., Breese, C. R., Rollins, Y. D., Adler, L. E., D, A. O. M., & Freedman, R. (1998) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-1998-00036 · Cited by 60 · see citing works
Self-citationPolydipsia and chronic hyponatremia in schizophrenic inpatients.
Kirch, D. G., Bigelow, L. B., Weinberger, D. R., Lawson, W. B., & Wyatt, R. J. (1985) · PubMed · Cited by 52 · see citing works
Chromosome workshop: Chromosomes 11, 14, and 15
Craddock, N. J., Lendon, C. L., Cichon, S., Culverhouse, R., Detera‐Wadleigh, S. D., Devon, R. S., Faraone, S. V., Foroud, T., Gejman, P. V., Leonard, S. S., et al. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19990618)88:3 · Cited by 51 · see citing works
Self-citationSource origin of a 50-msec latency auditory evoked field component in young schizophrenic men
Reite, M., Teale, P. D., Zimmerman, J., Davis, K. M., Whalen, J., & EDRICH, J. (1988) · Biological Psychiatry · doi:10.1016/0006-3223(88)90160-6 · Cited by 42 · see citing works
Lebargy, F., Benhammou, K., Morin, D., Zini, R., Urien, S., Brée, F., Bignon, J., Branellec, A., & Lagrue, G. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.3.8630545 · Cited by 40 · see citing works
Self-citationCarrasco-Serrano, C., Campos‐Caro, A., Viniegra, S., Ballesta, J. J., & Criado, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20021 · Cited by 38 · see citing works
Stitzel, J. A., Farnham, D. A., & Collins, A. C. (1996) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00149-0 · Cited by 36 · see citing works
Expression of the Nicotinic Receptor α7 Gene in Tendon and Periosteum During Early Development
Romano, S. J., Corriveau, R. A., Schwarz, R. I., & Berg, D. K. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68020640.x · Cited by 34 · see citing works
Linkage studies of psychiatric disorders
RISCH, N. J., & Merikangas, K. R. (1993) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02190720 · Cited by 31 · see citing works
The genetic epidemiology of schizophrenia.
Tsuang, M. T., & Faraone, S. V. (1994) · PubMed · Cited by 12 · see citing works
Genetic epidemiology of schizophrenia
Tsuang, M. T. (1993) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(93)90007-l · Cited by 8 · see citing works
Flagged first, then by citations
2 of the 70 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Hilmas, C., Pereira, E., Alkondon, M., Rassoulpour, A., Schwarcz, R., & Albuquerque, E. X. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07463.2001 · Cited by 772 · see citing works
Cholinergic modulation of microglial activation by α7 nicotinic receptors
Shytle, R. D., Mori, T., Townsend, K. P., Vendrame, M., Sun, N., Zeng, J., Ehrhart, J. C., Silver, A. A., Sanberg, P. R., & Tan, J. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2004.02347.x · Cited by 537 · see citing works
Nicotinic acetylcholine receptors: from structure to brain function
Hogg, R. C., Raggenbass, M., & Bertrand, D. (2003) · Springer eBooks · doi:10.1007/s10254-003-0005-1 · Cited by 529 · see citing works
Leonard, S. S., Gault, J., Hopkins, J., Logel, J., Vianzon, R., Short, M., Drebing, C. J., Berger, R., Venn, D., Sirota, P., et al. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.12.1085 · Cited by 443 · see citing works
Self-citationNicotinic receptor subtypes and cognitive function
Levin, E. D. (2002) · Journal of Neurobiology · doi:10.1002/neu.10151 · Cited by 354 · see citing works
P50 sensory gating ratios in schizophrenics and controls: A review and data analysis
Patterson, J. V., Hetrick, W. P., Boutros, N. N., Jin, Y., Sandman, C. A., Stern, H. S., Potkin, S. G., & Bunney, W. E. (2008) · Psychiatry Research · doi:10.1016/j.psychres.2007.02.009 · Cited by 352 · see citing works
Sharma, G. G., & Vijayaraghavan, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071540198 · Cited by 351 · see citing works
Leonard, S. S., Adler, L. E., Benhammou, K., Berger, R., Breese, C. R., Drebing, C. J., Gault, J., Lee, M. J., Logel, J., D, A. O. M., et al. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00677-3 · Cited by 298 · see citing works
Self-citationPicciotto, M. R., Caldarone, B. J., Brunzell, D. H., Zachariou, V., Stevens, T. R., & King, S. L. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00161-9 · Cited by 221 · see citing works
A review on phytochemistry, pharmacology and toxicology studies of Aconitum
Eric, N., Xu, Y., Li, Y., Wang, Y., Agyemang, K., & Zhang, Y. (2014) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12310 · Cited by 220 · see citing works
Neuronal nicotinic receptors: A perspective on two decades of drug discovery research
Arneric, S. P., Holladay, M., & Williams, M. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.06.033 · Cited by 208 · see citing works
Satta, R., Maloku, E., Zhubi, A., Pibiri, F., Hajós, M., Costa, E., & Guidotti, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808699105 · Cited by 202 · see citing works
Unconventional ligands and modulators of nicotinic receptors
Pereira, E. F. R., Hilmas, C. J., Santos, M. D., Alkondon, M., Maelicke, A., & Albuquerque, E. X. (2002) · Journal of Neurobiology · doi:10.1002/neu.10146 · Cited by 202 · see citing works
Evins, A. E., Mays, V. K., Rigotti, N. A., Tisdale, T., Cather, C., & Goff, D. C. (2001) · Nicotine & Tobacco Research · doi:10.1080/14622200110073920 · Cited by 191 · see citing works
Molecular Mechanisms Underlying Behaviors Related to Nicotine AddictionPreprint
Picciotto, M. R., & Kenny, P. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a012112 · Cited by 178 · see citing works
Mechanisms of Nicotine Addiction
Picciotto, M. R., & Kenny, P. J. (2021) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a039610 · Cited by 157 · see citing works
Therapeutic Potential of α7 Nicotinic Acetylcholine Receptors
Bertrand, D., Lee, C., Flood, D. G., Marger, F., & Donnelly‐Roberts, D. L. (2015) · Pharmacological Reviews · doi:10.1124/pr.113.008581 · Cited by 139 · see citing works
Smoking Induces Long-Lasting Effects through a Monoamine-Oxidase Epigenetic Regulation
Launay, J., Pino, M. D., Chironi, G. N., Callebert, J., Peoc’h, K., Mégnien, J. L., Mallet, J. J., Simon, A. C., & Rendu, F. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007959 · Cited by 137 · see citing works
RELATIONSHIP BETWEEN TOBACCO SMOKING AND POSITIVE AND NEGATIVE SYMPTOMS IN SCHIZOPHRENIA
Patkar, A. A., Gopalakrishnan, R., Lundy, A. C., Leone, F. T., Certa, K., & Weinstein, S. P. (2002) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-200209000-00005 · Cited by 132 · see citing works
Levin, E. D., & Rezvani, A. H. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.019 · Cited by 129 · see citing works
Cigarette smoking topography in smokers with schizophrenia and matched non-psychiatric controls
Tidey, J. W., Rohsenow, D. J., Kaplan, G. B., & Swift, R. M. (2005) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2005.04.002 · Cited by 128 · see citing works
Genetics of Smoking and Schizophrenia
Leonard, S. S., Mexal, S., & Freedman, R. (2007) · Journal of Dual Diagnosis · doi:10.1300/j374v03n03_05 · Cited by 124 · see citing works
Self-citationCalkins, M. E., Iacono, W. G., & Öneş, D. S. (2008) · Brain and Cognition · doi:10.1016/j.bandc.2008.09.001 · Cited by 118 · see citing works
Brunzell, D. H., & McIntosh, J. M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.299 · Cited by 114 · see citing works
Nicotinic receptors and schizophrenia
Ripoll, N., Grall‐Bronnec, M., & Bourin, M. (2004) · Current Medical Research and Opinion · doi:10.1185/030079904125004060 · Cited by 106 · see citing works
The therapeutic promise of positive allosteric modulation of nicotinic receptors
Uteshev, V. V. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.01.072 · Cited by 105 · see citing works
Barnes, M., Lawford, B. R., Burton, S. C., Heslop, K., Noble, E. P., Hausdorf, K., & Young, R. M. (2006) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.2006.01841.x · Cited by 104 · see citing works
Inside-out neuropharmacology of nicotinic drugs
Henderson, B. J., & Lester, H. A. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.01.022 · Cited by 102 · see citing works
Fernandes, C., Hoyle, E., Dempster, E. L., Schalkwyk, L. C., & Collier, D. A. (2005) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2005.00176.x · Cited by 97 · see citing works
Parikh, V., Kutlu, M. G., & Gould, T. J. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.01.020 · Cited by 95 · see citing works
Mexal, S., Frank, M., Berger, R., Adams, C. E., Ross, R. G., Freedman, R., & Leonard, S. S. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.06.006 · Cited by 93 · see citing works
Self-citationExpression of an α7 duplicate nicotinic acetylcholine receptor-related protein in human leukocytes
Villiger, Y., Szántó, I., Jaconi, S., Blanchet, C., Buisson, B., Krause, K.-H., Bertrand, D., & Romand, J.-A. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00057-7 · Cited by 92 · see citing works
Tobacco Smoking within Psychiatric Inpatient Settings: Biopsychosocial Perspective
Olivier, D. H., Lubman, D. I., & Fraser, R. (2007) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670701392809 · Cited by 90 · see citing works
Castner, S. A., Smagin, G. N., Piser, T. M., Wang, Y., Smith, J. S., Christian, E. P., Mrzljak, L., & Williams, G. V. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.006 · Cited by 90 · see citing works
Broad, L. M., Zwart, R., Pearson, K. H., Lee, M. W., Wallace, L., McPhie, G. I., Emkey, R., Hollinshead, S. P., Dell, C. P., Baker, S., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.104505 · Cited by 88 · see citing works
Self-citationThe effects of nicotine on specific eye tracking measures in schizophrenia
Sherr, J. D., Myers, C. S., Avila, M. T., Elliott, A., Blaxton, T. A., & Thaker, G. K. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01342-2 · Cited by 86 · see citing works
Allosteric Modulators of the α7 Nicotinic Acetylcholine Receptor
Faghih, R., Gopalakrishnan, M., & Briggs, C. A. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm070256g · Cited by 86 · see citing works
Sensory gating impairment associated with schizophrenia persists into REM sleep
Kisley, M. A., D, A. O. M., Robbins, E., Polk, S. D., Adler, L. E., Waldo, M. C., & Freedman, R. (2003) · Psychophysiology · doi:10.1111/1469-8986.00004 · Cited by 83 · see citing works
Self-citationThe vulnerability to alcohol and substance abuse in individuals diagnosed with schizophrenia
Krystal, J., d'Souza, D. C., Gallinat, J., Driesen, N., Abi-Dargham, A., Petrakis, I., Heinz, A., & Pearlson, G. (2006) · Neurotoxicity research · doi:10.1007/bf03033360 · Cited by 84 · see citing works
Gault, J., Hopkins, J. A., Berger, R., Drebing, C. J., Logel, J., Walton, C., Short, M., Vianzon, R., D, A. O. M., Ross, R. G., et al. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20061 · Cited by 83 · see citing works
Self-citationTsuang, D. W., Skol, A. D., Faraone, S. V., Bingham, S. F., Young, K. A., Prabhudesai, S., Haverstock, S. L., Mena, F., Menon, A. S., Bisset, D., et al. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1550 · Cited by 80 · see citing works
Lawn, S. (2004) · International Journal of Social Psychiatry · doi:10.1177/0020764004043129 · Cited by 78 · see citing works
Etter, M., Mohr, S., Garin, C., & Etter, J. (2004) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007092 · Cited by 75 · see citing works
Cotinine: Beyond that Expected, More than a Biomarker of Tobacco Consumption
Echeverrı́a, V. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00173 · Cited by 73 · see citing works
Winterer, G., Gallinat, J., Brinkmeyer, J., Musso, F., Kornhuber, J., Thuerauf, N., Rujescu, D., Favis, R., Sun, Y., Franc, M. A., et al. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.040 · Cited by 70 · see citing works
α7 Nicotinic ACh Receptors as a Ligand-Gated Source of Ca2+ Ions: The Search for a Ca2+ Optimum
Uteshev, V. V. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2888-2_27 · Cited by 71 · see citing works
Neurocognitive endophenotypes in schizophrenia: Modulation by nicotinic receptor systems
Mackowick, K. M., Barr, M. S., Wing, V. C., Rabin, R. A., Ouellet‐Plamondon, C., & George, T. P. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.07.010 · Cited by 65 · see citing works
Papke, R. L., Trocmé, C., Guendisch, D., Rubaiy, S. A. A. A., & Bloom, S. A. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.177485 · Cited by 61 · see citing works
Benfante, R., Antonini, R. A., Pizzol, M. D., Gotti, C., Clementi, F., Locati, M., & Fornasari, D. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.09.008 · Cited by 59 · see citing works
Aznavour, N., Mechawar, N., & Descarries, L. (2002) · Hippocampus · doi:10.1002/hipo.1108 · Cited by 60 · see citing works
Perl, O., Ilani, T., Strous, R. D., Lapidus, R., & Fuchs, S. (2003) · The FASEB Journal · doi:10.1096/fj.03-0104fje · Cited by 59 · see citing works
Recent advances in the genetics of schizophrenia
Waterworth, D. M., Bassett, A. S., & Brzustowicz, L. M. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8426-6 · Cited by 57 · see citing works
Faghih, R., Gopalakrishnan, S. M., Grønlien, J. H., Malysz, J., Briggs, C. A., Wetterstrand, C., Ween, H., Curtis, M. P., Sarris, K., Gfesser, G. A., et al. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm9003818 · Cited by 56 · see citing works
Effects of Donepezil Adjunctive Treatment to Ziprasidone on Cognitive Deficits in Schizophrenia
Fagerlund, B., Søholm, B., Fink‐Jensen, A., Lublin, H., & Glenthoj, B. Y. (2007) · Clinical Neuropharmacology · doi:10.1097/01.wnf.0000240940.67241.f6 · Cited by 52 · see citing works
Miwa, J. M., Lester, H. A., & Walz, A. (2012) · Physiology · doi:10.1152/physiol.00002.2012 · Cited by 52 · see citing works
Radek, R. J., Miner, H. M., Bratcher, N. A., Decker, M. W., Gopalakrishnan, M., & Bitner, R. S. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0394-3 · Cited by 49 · see citing works
Terry, A. V., Gearhart, D. A., Mahadik, S. P., Warsi, S., Davis, L. W., & Waller, J. L. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.006 · Cited by 49 · see citing works
Noda, Y., Barr, M. S., Zomorrodi, R., Cash, R. F. H., Rajji, T. K., Farzan, F., Chen, R. E., George, T. P., Daskalakis, Z. J., & Blumberger, D. M. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx041 · Cited by 48 · see citing works
Nicotine Effects on Mismatch Negativity in Nonsmoking Schizophrenic Patients
Inami, R., Kirino, E., Inoue, R., Suzuki, T., & Arai, H. (2007) · Neuropsychobiology · doi:10.1159/000111536 · Cited by 45 · see citing works
Sun, F., Jin, K., & Uteshev, V. V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073581 · Cited by 46 · see citing works
Terry, A. V., Gearhart, D. A., Mahadik, S. P., Warsi, S., & Waller, J. L. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.03.011 · Cited by 46 · see citing works
Aznavour, N., Watkins, K. C., & Descarries, L. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20501 · Cited by 45 · see citing works
Almeida, L. E. F., Pereira, E. F. R., Alkondon, M., Fawcett, W. P., Randall, W. R., & Albuquerque, E. X. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00157-x · Cited by 45 · see citing works
AhnAllen, C. G., Nestor, P. G., Shenton, M. E., McCarley, R. W., & Niznikiewicz, M. A. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.07.030 · Cited by 44 · see citing works
Jacklin, D. L., Goel, A., Clementino, K. J., Hall, A. W. M., Talpos, J. C., & Winters, B. D. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.84 · Cited by 43 · see citing works
Brunzell, D. H., McIntosh, J. M., & Papke, R. L. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12421 · Cited by 40 · see citing works
Noda, M., & Kobayashi, A. (2016) · The Journal of Physiological Sciences · doi:10.1007/s12576-016-0460-5 · Cited by 40 · see citing works
Event-Related Potentials in Psychiatry
Pogarell, O. M., Mulert, C., & Hegerl, U. (2007) · Clinical EEG and Neuroscience · doi:10.1177/155005940703800108 · Cited by 39 · see citing works
Brown, R. W., Gass, J. T., & Kostrzewa, R. M. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00730-x · Cited by 38 · see citing works
Brown, R. W., Thompson, K. D., Thompson, K. N., Ward, J. J., Thacker, S. K., Williams, M. T., & Kostrzewa, R. M. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03199.x · Cited by 37 · see citing works
Smoking cue reactivity in schizophrenia: Effects of a nicotinic receptor antagonist
Fonder, M. A., Sacco, K. A., Termine, A., Boland, B. S., Seyal, A. A., Dudas, M. M., Vessicchio, J. C., & George, T. P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.12.027 · Cited by 36 · see citing works
Nicotinic-antipsychotic drug interactions and cognitive function
Levin, E. D., & Rezvani, A. H. (2006) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-7772-4_10 · Cited by 36 · see citing works
Specific α4β2 nicotinic acetylcholine receptor binding of [F‐18]nifene in the rhesus monkey
Hillmer, A. T., Wooten, D., Moirano, J. M., Slesarev, M. S., Barnhart, T. E., Engle, J. W., Nickles, R. J., Murali, D., Schneider, M. L., Mukherjee, J., et al. (2011) · Synapse · doi:10.1002/syn.20965 · Cited by 34 · see citing works
Hua, S., Ek, C. J., Mallard, C. E., & Johansson, M. E. (2014) · BioMed Research International · doi:10.1155/2014/718769 · Cited by 33 · see citing works
Neurobiological Links Between Nicotine Addiction and Schizophrenia
George, T. P. (2007) · Journal of Dual Diagnosis · doi:10.1300/j374v03n03_04 · Cited by 33 · see citing works
Potentiation of α7-Containing Nicotinic Acetylcholine Receptors by Select Albumins
Conroy, W. G., Liu, Q., Nai, Q., Margiotta, J. F., & Berg, D. K. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.2.419 · Cited by 32 · see citing works
Outcome from a Community-based Smoking Cessation Program for Persons with Serious Mental Illness
Currie, S. R., Karltyn, J., Lussier, D., de Denus, E., Brown, D., & el‐Guebaly, N. (2007) · Community Mental Health Journal · doi:10.1007/s10597-007-9113-8 · Cited by 31 · see citing works
Brašić, J. R., Cascella, N. G., Kumar, A., Zhou, Y., Hilton, J., Raymont, V., Crabb, A. H., Guevara, M. R., Horti, A. G., & Wong, D. F. (2011) · Synapse · doi:10.1002/syn.21520 · Cited by 31 · see citing works
Gargus, M., Ben‐Azu, B., Landwehr, A., Dunn, J., Errico, J. P., & Tremblay, M. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1527842 · Cited by 32 · see citing works
Eskildsen, J., Redrobe, J. P., Sams, A. G., Dekermendjian, K., Laursen, M., Boll, J. B., Papke, R. L., Bundgaard, C., Frederiksen, K., & Bastlund, J. F. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.11.022 · Cited by 29 · see citing works
Pfrimmer, D. M. (2009) · The Journal of Continuing Education in Nursing · doi:10.3928/00220124-20090201-04 · Cited by 28 · see citing works
Lennox, J. R., Turner, S. C. M., & Rapoport, H. (2001) · The Journal of Organic Chemistry · doi:10.1021/jo010534y · Cited by 27 · see citing works
Nicotinic Receptors Containing the α7 Subunit: A Model for Rational Drug Design
Sharma, G., & Vijayaraghavan, S. (2008) · Current Medicinal Chemistry · doi:10.2174/092986708786848703 · Cited by 27 · see citing works
Tobacco Smoking: Current Concepts in Etiology and Treatment
Patkar, A. A., Vergare, M. J., Batra, V., Weinstein, S. P., & Leone, F. T. (2003) · Psychiatry · doi:10.1521/psyc.66.3.183.25159 · Cited by 27 · see citing works
Chapter 5. Targeting nicotinic acetylcholine receptors: Advances in molecular design and therapies
Schmitt, J. D., & Bencherif, M. (2000) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(00)35006-0 · Cited by 27 · see citing works
Smucny, J., Visani, A. V., & Tregellas, J. R. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00043 · Cited by 26 · see citing works
Othman, A. A., Lenz, R. A., Zhang, J., Li, J., Awni, W. M., & Dutta, S. (2011) · The Journal of Clinical Pharmacology · doi:10.1177/0091270010370460 · Cited by 24 · see citing works
Guseva, M., Hopkins, D. M., & Pauly, J. R. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.04.002 · Cited by 24 · see citing works
Perinatal choline deficiency produces abnormal sensory inhibition in Sprague–Dawley rats
Stevens, K. E., Adams, C. E., Mellott, T. J., Robbins, E., & Kisley, M. A. (2008) · Brain Research · doi:10.1016/j.brainres.2008.08.047 · Cited by 24 · see citing works
Self-citationSensorimotor gating and spatial learning in α7‐nicotinic receptor knockout mice
Azzopardi, E., Typlt, M., Jenkins, B. W., & Schmid, S. (2013) · Genes Brain & Behavior · doi:10.1111/gbb.12038 · Cited by 23 · see citing works
Effective Cessation Strategies for Smokers with Schizophrenia
Evins, A. E., & Cather, C. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.08.001 · Cited by 23 · see citing works
Inhibitory Gating of Single Unit Activity in Amygdala: Effects of Ketamine, Haloperidol, or Nicotine
Cromwell, H. C., & Woodward, D. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.037 · Cited by 23 · see citing works
Rassoulpour, A., Wu, H., Albuquerque, E. X., & Schwarcz, R. M. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300583 · Cited by 22 · see citing works
Marquis, K. L., Comery, T. A., Jow, F., Navarra, R. L., Grauer, S. M., Pulicicchio, C. M., Kelley, C., Brennan, J. A., Roncarati, R., Scali, C., et al. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2357-6 · Cited by 20 · see citing works
Perkins, K. A., Chengappa, K. N. R., Karelitz, J. L., Boldry, M. C., Michael, V., Herb, T., Gannon, J. M., Brar, J. S., Ford, L., Rassnick, S., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.292 · Cited by 20 · see citing works
Ohara, K., Tanabu, S., Yoshida, K., Ishibashi, K., Ikemoto, K., & Shibuya, H. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00154-4 · Cited by 20 · see citing works
Kakkar, R. A., Haneen, M. A., Parida, A. C., & Sharma, G. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1139215 · Cited by 19 · see citing works
Palma, E., Mileo, A. M., Martínez‐Torres, A., Eusebi, F., & Miledi, R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052699299 · Cited by 19 · see citing works
α7-Nicotinic Acetylcholine Receptor: Role in Early Odor Learning Preference in Mice
Hellier, J. L., Arevalo, N. L., Smith, L. P., Xiong, K.-N., & Restrepo, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035251 · Cited by 18 · see citing works
Using rodents to model schizophrenia and substance use comorbidity
Ng, E., McGirr, A., Wong, A. H. C., & Roder, J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.03.025 · Cited by 17 · see citing works
- Authors
- Leonard, S., Breese, C., Adams, C., Benhammou, K., Gault, J., Stevens, K., Lee, M., Adler, L., Olincy, A., Ross, R., & Freedman, R.
- Affiliations
- Veterans Health Administration (US)
- Auburn University (US)
- Corresponding author
- Leonard, Sherry
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2000-03
- Volume
- 393
- Issue
- 1-3
- Pages
- 237-242
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2058494585
- Cited by
- 177
- References
- 70
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 7 · 2015: 7 · 2014: 10 · 2013: 8 · 2012: 12
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- schizophrenia, smoking, neuronal nicotinic acetylcholine receptors, gene expression, gene duplication, receptor gating, postmortem brain, alpha-bungarotoxin, methyllycaconitine, genetic linkage
- MeSH terms
- Animals, Brain, Chromosome Mapping, Chromosomes, Human, Pair 15, Cloning, Molecular, Disease Models, Animal, Humans, Leukocytes, Mononuclear, Nicotine, Receptors, Nicotinic, Schizophrenia, Smoking, Gene Expression, Mice, alpha7 Nicotinic Acetylcholine Receptor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review