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The mouse light/dark box test

Bourin, Michel, Hascoët, Martine·2003·European Journal of Pharmacology
DOI 10.1016/s0014-2999(03)01274-3
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Research works printed but not linked: 99

  1. Barnes, 1990, Ketotifen and its analogues reduce aversive responding in the rodent, Pharmacol. Biochem. Behav., 37, 785, 10.1016/0091-3057(90)90564-X · DOI
  2. Barnes, 1992, Profiles of interaction of R(+)/S(−)-zacopride and anxiolytic agents in a mouse model, Eur. J. Pharmacol., 218, 91, 10.1016/0014-2999(92)90151-S · DOI
  3. Barnes, 1992, The interaction of R(+) and S(−) zacopride with PCPA to modify rodent aversive behaviour, Eur. J. Pharmacol., 218, 15, 10.1016/0014-2999(92)90142-Q · DOI
  4. Barret, 1993, 5-HT receptors as targets for the development of novel anxiolytic drugs/models, mechanisms and future directions, Psychopharmacology, 112, 1, 10.1007/BF02247357 · DOI · Paper page
  5. Barry, 1987, A simple habituation test in the mouse, Br. J. Pharmacol., 92
  6. Belzung, 1994, Comparison of different behavioural test situations used in Psychopharmacology for measurement of anxiety, Physiol. Behav., 3, 623, 10.1016/0031-9384(94)90311-5 · DOI · Paper page
  7. Belzung, 1987, Anxiogenic effects of methyl-β-carboline-carboxylate in a light/dark choice situation, Pharmacol. Biochem. Behav., 28, 29, 10.1016/0091-3057(87)90006-2 · DOI · Paper page
  8. Belzung, 1989, Behavioural effects of the benzodiazepine receptor partial agonist RO 16-6028 in mice, Psychopharmacology, 97, 388, 10.1007/BF00439456 · DOI
  9. Belzung, 1994, PD135158, a CCK-B antagonist, reduces “state”, but not “trait” anxiety in mice, Pharmacol. Biochem. Behav., 49, 433, 10.1016/0091-3057(94)90445-6 · DOI
  10. Bill, 1989, Actions of 5HT1A ligands and standard anxiolytics on mouse exploratory behaviour in a two compartment light: dark arena, Br. J. Pharmacol., 98
  11. Bill, 1992, Behavioural studies of WAY 100289, a novel 5-HT3 receptor antagonist, in two animal models of anxiety, Eur. J. Pharmacol., 218, 327, 10.1016/0014-2999(92)90186-8 · DOI
  12. Blumstein, 1983, Further characterisation of a simple, automated exploratory model for the anxiolytic effects of benzodiazepines, Pharmacol. Biochem. Behav., 18, 37, 10.1016/0091-3057(83)90247-2 · DOI
  13. Bodnoff, 1989, A comparison of the effects of diazepam versus several typical and atypical antidepressant drugs in an animal model of anxiety, Psychopharmacology, 97, 277, 10.1007/BF00442264 · DOI · Paper page
  14. Borsini, 1993, The effects of DAU 6215, a novel 5HT3 antagonist in animal models of anxiety, Pharmacol. Res., 27, 151, 10.1006/phrs.1993.1015 · DOI
  15. Bourin, 1997, Animal models of anxiety: are they suitable for predicting drug action in humans?, Pol. J. Pharmacol., 49, 79
  16. Bourin, 1998, Cholecystokinin as a target for neuropsychiatric drugs, Drug News Perspect., 11, 342, 10.1358/dnp.1998.11.6.657281 · DOI
  17. Bourin, 1996, A schematic representation of the psychopharmacological profile of antidepressants, Prog. Psychopharmacol. Biol. Psychiatry, 20, 1389, 10.1016/S0278-5846(96)00134-0 · DOI
  18. Bourin, 1998, Neurobiology of panic disorder, J. Psychosom. Res., 44, 161, 10.1016/S0022-3999(97)00203-1 · DOI
  19. Bourin, 2001, Cyamemazine as an anxiolytic drug on the elevated plus maze and light/dark paradigm in mice, Behav. Brain Res., 124, 87, 10.1016/S0166-4328(01)00238-8 · DOI
  20. Cheng, 1994, Actions of 5-hydroxytryptophan to inhibit and disinhibit mouse behaviour in the light/dark test, Eur. J. Pharmacol., 255, 39, 10.1016/0014-2999(94)90080-9 · DOI
  21. Costall, 1992, Anxiolytic potential of 5-HT3 receptor antagonists, Pharmacol. Toxicol., 70, 157, 10.1111/j.1600-0773.1992.tb00448.x · DOI
  22. Costall, 1995, Behavioural interactions between 5-hydroxytryptophan neuroleptic agents and 5-HT receptor antagonists in modifying rodent responding to aversive situations, Br. J. Pharmacol., 116, 2989, 10.1111/j.1476-5381.1995.tb15954.x · DOI
  23. Costall, 1997, The influence of 5-HT2 and 5-HT4 receptor antagonists to modify drug induced disinhibitory effects in the mouse light/dark test, Br. J. Pharmacol., 122, 1105, 10.1038/sj.bjp.0701513 · DOI
  24. Costall, 1988, Actions of buspirone in a putative model of anxiety in the mouse, J. Pharm. Pharmacol., 40, 494, 10.1111/j.2042-7158.1988.tb05284.x · DOI
  25. Costall, 1988, Effects of the 5-HT receptors antagonist GR38032F, ICS 205-930 and BRL 43694 in tests for anxiolytic activity, Br. J. Pharmacol., 93
  26. Costall, 1989, Exploration of mice in a black and white box: validation as a model of anxiety, Pharmacol. Biochem. Behav., 32, 777, 10.1016/0091-3057(89)90033-6 · DOI · Paper page
  27. Costall, 1990, Sites of action of ondansetron to inhibit withdrawal from drugs of abuse, Pharmacol. Biochem. Behav., 36, 97, 10.1016/0091-3057(90)90132-2 · DOI
  28. Costall, 1991, Anxiolytic effects of CCK-B antagonists, Neuropeptides, 19, 65, 10.1016/0143-4179(91)90084-V · DOI
  29. Costall, 1993, The effect of the 5-HT3 receptor antagonist, RS 42358-197, in animal models of anxiety, Eur. J. Pharmacol., 234, 91, 10.1016/0014-2999(93)90710-Y · DOI
  30. Crawley, 1981, Neuropharmacologic specificity of a simple model for the behavioural actions of benzodiazepines, Pharmacol. Biochem. Behav., 15, 695, 10.1016/0091-3057(81)90007-1 · DOI · Paper page
  31. Crawley, 1985, Exploratory behaviour models of anxiety in mice, Neurosci. Biobehav. Rev., 9, 37, 10.1016/0149-7634(85)90030-2 · DOI · Paper page
  32. Crawley, 1982, Base line exploratory activity predicts anxiolytics responsiveness to diazepam in five mouse strains, Brain Res. Bull., 8, 609, 10.1016/0361-9230(82)90087-9 · DOI · Paper page
  33. Crawley, 1980, Preliminary report of a simple animal behaviour for the anxiolytic effects of benzodiazepines, Pharmacol. Biochem. Behav., 13, 167, 10.1016/0091-3057(80)90067-2 · DOI · Paper page
  34. Crawley, 1984, Absence of intrinsic antagonist actions of benzodiazepine antagonist on an exploratory model of anxiety in the mouse, Neuropharmacology, 5, 531, 10.1016/0028-3908(84)90026-1 · DOI
  35. Crawley, 1997, Behavioural phenotypes of inbred mouse strains: implication and recommendations for molecular studies, Psychopharmacology, 132, 107, 10.1007/s002130050327 · DOI · Paper page
  36. De Angelis, 1992, The anxiogenic-like effects of pentylenetetrazole in mice treated chronically with carbamazepine or valproate, Methods Find. Exp. Clin. Pharmacol., 14, 767
  37. De Angelis, 2000, The anxiolytic like properties of two selective MAOIs, moclobemide and selegiline, in a standard and an enhanced light/dark aversion test, Pharmacol. Biochem. Behav., 65, 649, 10.1016/S0091-3057(99)00237-3 · DOI
  38. De Vry, 1993, Shock-induced ultrasonic vocalization in young adults rats: a model for testing putative anti-anxiety drugs, Eur. J. Pharmacol., 249, 331, 10.1016/0014-2999(93)90530-U · DOI · Paper page
  39. Fernandez-Guasti, 1990, Evidence for the Involvement of the 5-HT1A receptor in the anxiolytic action of indorate and ipsapirone, Psychopharmacology, 107, 354, 10.1007/BF02244053 · DOI
  40. File, 1985, Can animal test of anxiety detect anti-panic compounds?, Neurosci. Abstr., 11, 273
  41. File, 1992, Usefulness of animal models with newer anxiolytics, Clin. Neuropharcol., 15, 525A, 10.1097/00002826-199201001-00273 · DOI
  42. Fink, 1994, Behavioural and neurochemical effects of CCK-fragments in animal models of anxiety, Behav. Pharmacol., 5, 30
  43. Gao, 1992, Effect of acute administration of the 5-HT3 receptor antagonist, BRL 46470A, on the behavior of mice in a two compartment light–dark box and during social interactions in their home cage and an unfamiliar neutral cage, Neuropharmacology, 31, 743, 10.1016/0028-3908(92)90035-N · DOI
  44. Gao, 1993, Effect of acute and subchronic administration of ritanserin on the social behaviour of mice, Neuropharmacology, 32, 265, 10.1016/0028-3908(93)90110-O · DOI
  45. Górka, 1986, Effects of repeated treatment with antidepressant drugs on the 24 hour behaviour in the light–dark synchronised mice, Pol. J. Pharmacol. Pharm., 38, 493
  46. Griebel, 1995, 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more then 30 years of research, Pharmacol. Ther., 65, 319, 10.1016/0163-7258(95)98597-J · DOI · Paper page
  47. Griebel, 1996, Variability in the effects of -5HT related compounds in experimental models of anxiety: evidence for multiple mechanisms of 5-HT in anxiety or never ending story?, Pol. J. Pharmacol., 48, 129
  48. Griebel, 1991, m-Chlorophenyl-piperazine enhances neophobic and anxious behaviour in mice, NeuroReport, 2, 627, 10.1097/00001756-199110000-00019 · DOI
  49. Griebel, 1994, Acute and chronic treatment with 5-HT reuptake inhibitors differentially modulate emotional responses in anxiety models in rodents, Psychopharmacology, 113, 463, 10.1007/BF02245224 · DOI
  50. Griebel, 1996, Preclinical profile of the mixed 5-HT1A/5-HT2A receptor antagonist S21357, Pharmacol. Biochem. Behav., 54, 509, 10.1016/0091-3057(95)02215-5 · DOI
  51. Griebel, 1997, CCK receptor antagonists in animal models of anxiety: comparison between exploration tests, conflict procedures and a model based on defensive behaviours, Behav. Pharmacol., 8, 549, 10.1097/00008877-199711000-00013 · DOI
  52. Griebel, 1997, A comparative study of the effects of selective and non-selective 5-HT2C receptor subtype antagonists in rat and mouse models of anxiety, Neuropharmacology, 36, 793, 10.1016/S0028-3908(97)00034-8 · DOI
  53. Griebel, 1998, Characterization of the behavioral profile of the non-peptide CRF receptor antagonist CP-154,526 in anxiety models in rodents. Comparison with diazepam and buspirone, Psychopharmacology, 138, 55, 10.1007/s002130050645 · DOI · Paper page
  54. Griebel, 2002, J. Pharmacol. Exp. Ther., 301, 333, 10.1124/jpet.301.1.333 · DOI · Paper page
  55. Handley, 1995, 5-Hydroxytryptamine pathways in anxiety and its treatment, Pharmacol. Ther., 66, 103, 10.1016/0163-7258(95)00004-Z · DOI · Paper page
  56. Handley, 1993, Serotonin mechanisms in animal models of anxiety, Braz. J. Med. Biol. Res., 26, 1
  57. Handley, 1993, Multiple serotonin mechanisms in animal models of anxiety: environmental, emotional and cognitive factors, Behav. Brain Res., 58, 203, 10.1016/0166-4328(93)90104-X · DOI
  58. Hascoët, 1998, A new approach to the light/dark procedure in mice, Pharmacol. Biochem. Behav., 60, 645, 10.1016/S0091-3057(98)00031-8 · DOI · Paper page
  59. Hascoët, 1999, Influence of age on behavioural response in the light–dark paradigm, Physiol. Behav., 66, 567, 10.1016/S0031-9384(98)00333-3 · DOI
  60. Hascoët, 2000, Anxiolytic like effects of antidepressants after acute administration in a four plate test in mice, Pharmacol. Biochem. Behav., 65, 339, 10.1016/S0091-3057(99)00191-4 · DOI
  61. Hascoët, 2000, The influence of buspirone and its metabolite1-PP on the activity of paroxetine in the mouse light dark paradigm and four plates test, Pharmacol. Biochem. Behav., 67, 45, 10.1016/S0091-3057(00)00293-8 · DOI
  62. Higgins, 1991, Evidence that the amygdala is involved in the disinhibitory effects of 5-HT3 receptor antagonists, Psychopharmacology, 104, 545, 10.1007/BF02245664 · DOI
  63. Hoggs, 1996, A review of the validity and variability of the elevated plus maze as an animal model of anxiety, Pharmacol. Biochem. Behav., 54, 21, 10.1016/0091-3057(95)02126-4 · DOI · Paper page
  64. Hughes, 1990, Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity, Proc. Natl. Acad. Sci. U. S. A., 87, 6728, 10.1073/pnas.87.17.6728 · DOI · Paper page
  65. Imaizumi, 1993, The behavioural and biochemical effects of thioperamide, a histamine H3-receptor antagonist, in a light/dark test measuring anxiety in mice, Life Sci., 53, 1675, 10.1016/0024-3205(93)90204-G · DOI
  66. Imaizumi, 1994, Effects of xanthine derivatives in a light/dark test in mice and contribution of adenosine receptors, Methods Find. Exp. Clin. Pharmacol., 16, 639
  67. Imaizumi, 1994, A fully automated apparatus for a light/dark test measuring anxiolytic or anxiogenic effects of drugs in mice, Jpn. J. Psychopharmacol., 14, 83
  68. Kennett, 1994, Evidence that 5-HT2C receptor antagonists are anxiolytic in the rat Geller-Seifter model of anxiety, Psychopharmacology, 114, 90, 10.1007/BF02245448 · DOI
  69. Kilfoil, 1989, Effects of anxiolytic and anxiogenic drugs on exploratory activity in a simple model of anxiety in mice, Neuropharmacology, 28, 901, 10.1016/0028-3908(89)90188-3 · DOI
  70. Kilpatrick, 1990, 5-HT3 receptors, Med. Res. Rev., 10, 441, 10.1002/med.2610100404 · DOI · Paper page
  71. Lapin, 1999, A decreased frequency of peeking out from the dark compartment—the only constant index of the effect of anxiogenes on the behaviour of mice in light–darkness chamber, Zh. Vyssh. Nervn. Deiat. IM. I. P. Pavlova May–June, 49, 521
  72. Lightowler, 1994, Anxiolytic like effect of paroxetine in a rat social interaction test, Pharmacol. Biochem. Behav., 49, 281, 10.1016/0091-3057(94)90422-7 · DOI
  73. Lister, 1990, Ethologically-based models of anxiety disorders, Pharmacol. Ther., 46, 321, 10.1016/0163-7258(90)90021-S · DOI · Paper page
  74. Lopez-Rubalcava, 1992, Interaction of GABA and serotonin in the anxiolytic action of diazepam and serotonergic anxiolytics, Pharmacol. Biochem. Behav., 43, 433, 10.1016/0091-3057(92)90173-D · DOI
  75. Matto, 1995, The mechanism of anxiogenic-like effect of antidepressants on exploratory behaviour in rats, Pharmacol. Toxicol., 76, 53
  76. Metzenauer, 1992, Anxiolytic like action of anpirtoline in a mouse light/dark aversion paradigm, NeuroReport, 3, 527, 10.1097/00001756-199206000-00019 · DOI
  77. Misslin, 1990, Anxiolytic and sedative effects of 5-HT1A ligands, 8-OH-DPAT and MDL 73005EF, in mice, NeuroReport, 1, 267, 10.1097/00001756-199011000-00025 · DOI
  78. Nic Dhonnchadha, 2003, Anxiolytic-like effects of 5-HT2 ligands on three mouse models of anxiety, Behav. Brain Res., 10.1016/S0166-4328(02)00311-X · DOI · Paper page
  79. Njung'e, 1991, Evaluation of marble-burying behavior as a model of anxiety, Pharmacol. Biochem. Behav., 38, 63, 10.1016/0091-3057(91)90590-X · DOI · Paper page
  80. Olivier, 2000, 5-HT3 receptor antagonists and anxiety; a preclinical and clinical review, Eur. Neuropsychopharmacol., 10, 77, 10.1016/S0924-977X(99)00065-6 · DOI
  81. Onaivi, 1989, Neuropharmacological and physiological validation of a computer-controlled two compartment black and white box for the assessment of anxiety, Prog. Neuro-psychopharmacol. Biol. Psychiatry, 13, 963, 10.1016/0278-5846(89)90047-X · DOI
  82. Pellow, 1985, Validation of open/closed arm entries in an elevated plus-maze as a measure of anxiety in the rat, J. Neurosci. Methods, 14, 145, 10.1016/0165-0270(85)90031-7 · DOI · Paper page
  83. Pletnikov, 1996, Relationship between memory and fear: developmental and pharmacological studies, Pharmacol. Biochem. Behav., 54, 93, 10.1016/0091-3057(95)02167-1 · DOI
  84. Rodgers, 1993, Influence of prior maze experience on behaviour response to diazepam in the elevated plus maze and light/dark test of anxiety in mice, Psychopharmacology, 113, 237, 10.1007/BF02245704 · DOI · Paper page
  85. Sanchez, 1995, Serotonergic mechanisms involved in the exploratory behaviour of mice in a fully automated two-compartment black and white test box, Pharmacol. Toxicol., 77, 71, 10.1111/j.1600-0773.1995.tb01916.x · DOI
  86. Sanchez, 1996, 5HT1A receptors play an important role in modulation of behaviour of rats in a two-compartment black and white box, Behav. Pharmacol., 7, 788
  87. Sanchez, 1997, The selective sigma 2-ligand Lu 28-179 has potent anxiolytic-like effects in rodents, J. Pharmacol. Exp. Ther., 283, 1323
  88. Shimada, 1995, The modified light/dark transition test in mice: evaluation of classic and putative anxiolytic and anxiogenic drugs, Gen. Pharmacol., 26, 205, 10.1016/0306-3623(94)00148-G · DOI
  89. Singh, 1991, The behavioural properties of CI-988, a selective cholecystokininB receptor antagonist, Br. J. Pharmacol., 104, 239, 10.1111/j.1476-5381.1991.tb12413.x · DOI
  90. Smith, 1986, Anxiolytic action of CGS 9896 on mouse explorator behaviour, Eur. J. Pharmacol., 132, 259, 10.1016/0014-2999(86)90613-8 · DOI
  91. Stefanski, 1993, Serotonergic innervation of the hippocampus and nucleus accumbens septi and the anxiolytic-like action of the 5-HT3 receptor antagonists, Neuropharmacology, 32, 987, 10.1016/0028-3908(93)90063-9 · DOI
  92. Tyers, 1987, The anxiolytic activities of 5-HT3 antagonists in laboratory animals, Neurosci. Lett., 29, S68
  93. Van Megen, 1996, Cholecystokinin in anxiety, Eur. Neuropsychopharmacol., 6, 263, 10.1016/S0924-977X(96)00038-7 · DOI
  94. Wieland, 1991, Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-ol-20-one, Brain Res., 565, 263, 10.1016/0006-8993(91)91658-N · DOI · Paper page
  95. Yasumatsu, 1994, The pharmacological properties of Y-23684, a benzodiazepine receptor partial agonist, Br. J. Pharmacol., 11, 1170, 10.1111/j.1476-5381.1994.tb14868.x · DOI
  96. Young, 1988, Comparative effects of zacopride, GR 38032F, buspirone and diazepam in the mouse light/dark exploratory model, Soc. Neurosci. Abstr., 14, 207
  97. Young, 1991, A fully automated light/dark apparatus useful for comparing anxiolytic agents, Pharmacol. Biochem. Behav., 40, 739, 10.1016/0091-3057(91)90078-G · DOI
  98. Young, 1991, Comparison of routes of administration and time course effects of zacopride and buspirone in mice using an automated light/dark test, Pharmacol. Biochem. Behav., 40, 733, 10.1016/0091-3057(91)90077-F · DOI
  99. Zernig, 1993, Different behavioral profiles of the non-peptide substance P (NK1) antagonists CP-96,345 and RP 67580 in Swiss albino mice in the black-and-white box, Neurosci. Lett., 151, 64, 10.1016/0304-3940(93)90046-N · DOI

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Metadata

Authors
Bourin, M., & Hascoët, M.
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
2003-02
Volume
463
Issue
1-3
Pages
55-65
ISSN
0014-2999 (ISSN-L)
DOI
10.1016/s0014-2999(03)01274-3
OpenAlex
W2153592313
Cited by
1,427
References
7
FWCI
5.11
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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