The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.
The place of the hippocampus in fear conditioning
Abstract
Pavlovian fear conditioning is a phenomenon amenable to laboratory analysis of the neurobiology of fear and the investigation of neural mechanisms of learning and memory. Investigators have made much progress in delineating the neurocircuitry and neurochemistry of fear conditioning. The place of the hippocampus in context fear remains a controversial issue. In this review, we examine the evidence that the hippocampus plays a role in fear conditioning. We then critically examine hypotheses concerning its exact role in learning and memory for cued and context fear conditioning.
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“The hippocampus is an important component of contextual fear conditioning (Phillips and LeDoux [181]; Maren [182]; Sanders et al. [183]; Rudy et al. [184]).”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Sanders et al. [183]
In the citing paper
“It is well known that hippocampal damage or inactivation can interfere with contextual, but not cued, fear conditioning (Phillips and LeDoux [181]; Maren [182]; Sanders et al. [183]; Rudy et al. [184]).”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Sanders et al. [183]
In the citing paper
“Thus, the performance of rats given prolonged pretraining stress was equivalent to the severe contextual memory impairment which has been reported in rats with an inactivated or damaged hippocampus (Phillips and LeDoux [181]; Maren [182]; Sanders et al. [183]; Rudy et al. [184]).”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Sanders et al. [183]
Citations
Cites
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483
Self-citationNeurobiology of Pavlovian fear conditioning
Maren, S. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.897 · Cited by 1,543
The lateral amygdaloid nucleus: sensory interface of the amygdala in fear conditioning
LeDoux, J., Cicchetti, P., Xagoraris, A., & Romanski, L. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-04-01062.1990 · Cited by 1,167
Why We Think Plasticity Underlying Pavlovian Fear Conditioning Occurs in the Basolateral Amygdala
Fanselow, M. S., & LeDoux, J. E. (1999) · Neuron · doi:10.1016/s0896-6273(00)80775-8 · Cited by 933
Self-citationConjunctive representations in learning and memory: Principles of cortical and hippocampal function.
O'Reilly, R. C., & Rudy, J. W. (2001) · Psychological Review · doi:10.1037//0033-295x.108.2.311 · Cited by 865
Quirk, G. J., Repa, J. C., & LeDoux, J. E. (1995) · Neuron · doi:10.1016/0896-6273(95)90092-6 · Cited by 808
Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats
Maren, S., Aharonov, G., & Fanselow, M. S. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00088-0 · Cited by 765
Self-citationContextual fear, gestalt memories, and the hippocampus
Fanselow, M. S. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00186-2 · Cited by 752
Self-citationThe global record of memory in hippocampal neuronal activity
Wood, E. R., Dudchenko, P. A., & Eichenbaum, H. (1999) · Nature · doi:10.1038/17605 · Cited by 707
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CORTISOL EFFECTS ON EMOTIONAL MEMORY: INDEPENDENT OF STRESS EFFECTS
Jackson, E. D. (2007) · UA Campus Repository (The University of Arizona)
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c-fos Expression in Rodent Model of Traumatic Brain Injury and Anxiety-Like Behavior
Kornreich, E. (2015) · CU Scholar (University of Colorado Boulder)
Differential effects of central oxytocin on social versus cued fear in male rodents
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Metadata
- Authors
- Sanders, M. J., Wiltgen, B. J., & Fanselow, M. S.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Fanselow, Michael S
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 463
- Issue
- 1-3
- Pages
- 217-223
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W1964772923
- Cited by
- 316
- References
- 37
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 12 · 2021: 7 · 2020: 10 · 2019: 12 · 2018: 9 · 2017: 15 · 2016: 10 · 2015: 13 · 2014: 14 · 2013: 14 · 2012: 14
- FWCI
- 10.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- National Institute of Mental Health (R01-MH62122, R01MH062122)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- hippocampus, fear conditioning, cued fear, learning and memory, neurobiology of fear, neurocircuitry, neurochemistry
- MeSH terms
- Animals, Conditioning, Psychological, Conditioning, Classical, Fear, Hippocampus, Memory, Nerve Net
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