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The place of the hippocampus in fear conditioning

Sanders, Matthew J, Wiltgen, Brian J, Fanselow, Michael S·2003·European Journal of Pharmacology

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Abstract

Pavlovian fear conditioning is a phenomenon amenable to laboratory analysis of the neurobiology of fear and the investigation of neural mechanisms of learning and memory. Investigators have made much progress in delineating the neurocircuitry and neurochemistry of fear conditioning. The place of the hippocampus in context fear remains a controversial issue. In this review, we examine the evidence that the hippocampus plays a role in fear conditioning. We then critically examine hypotheses concerning its exact role in learning and memory for cued and context fear conditioning.

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Authors: Sanders, M. J., Wiltgen, B. J., & Fanselow, M. S.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Fanselow, Michael S
ORCID: Sanders, Matthew J
Wiltgen, Brian J
Fanselow, Michael S
Venue: European Journal of Pharmacology
Publisher: Elsevier BV
Published: 2003-02
Volume: 463
Issue: 1-3
Pages: 217-223
ISSN: 0014-2999 (ISSN-L)
DOI: 10.1016/s0014-2999(03)01283-4
OpenAlex: W1964772923
Cited by: 316
References: 37
Citations by year: 2026: 7 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 12 · 2021: 7 · 2020: 10 · 2019: 12 · 2018: 9 · 2017: 15 · 2016: 10 · 2015: 13 · 2014: 14 · 2013: 14 · 2012: 14
FWCI: 10.09
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Pharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
National Institute of Mental Health (R01-MH62122, R01MH062122)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords: hippocampus, fear conditioning, cued fear, learning and memory, neurobiology of fear, neurocircuitry, neurochemistry
MeSH terms: Animals, Conditioning, Psychological, Conditioning, Classical, Fear, Hippocampus, Memory, Nerve Net

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The place of the hippocampus in fear conditioning

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