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Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin‐like activity
Open accessAbstract
Some synthetic agonists of the VR1 vanilloid (capsaicin) receptor also inhibit the facilitated transport into cells of the endogenous cannabinoid anandamide (arachidonoylethanolamide, AEA). Here we tested several AEA derivatives containing various derivatized phenyl groups or different alkyl chains as either inhibitors of the AEA membrane transporter (AMT) in intact cells or functional agonists of the VR1 vanilloid receptor in HEK cells transfected with the human VR1. We found that four known AMT inhibitors, AM404, arvanil, olvanil and linvanil, activate VR1 receptors at concentrations 400–10 000‐fold lower than those necessary to inhibit the AMT. However, we also found three novel AEA derivatives, named VDM11, VDM12 and VDM13, which inhibit the AMT as potently as AM404 but exhibit little or no agonist activity at hVR1. These compounds are weak inhibitors of AEA enzymatic hydrolysis and poor CB 1/CB 2 receptor ligands. We show for the first time that, despite the overlap between the chemical moieties of AMT inhibitors and VR1 agonists, selective inhibitors of AEA uptake that do not activate VR1 (e.g. VDM11) can be developed.
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“TRPV1 (and also cannabinoid CB 1 ) receptors are present in pain and thermoregulatory pathways (66,111,165,209,210,216).”
From Paracetamol: New Vistas of an Old Drug (2006) · cites this paper as [66]
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“N-arachidonoylphenolamine is an agonist at TRPV1 receptors and an inhibitor of cellular anandamide uptake, which leads to increased levels of endogenous cannabinoids”
From Paracetamol: New Vistas of an Old Drug (2006) · cites this paper as [66]
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“At analgesic doses of paracetamol, AM404 that is formed in rat brain regions expressing high levels of FAAH, can indirectly activate CB 1 receptors and directly activate TRPV1 receptors (66,102,235).”
From Paracetamol: New Vistas of an Old Drug (2006) · cites this paper as [66]
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“At this concentration AM404 activates both rat (102,235) and human (66) TRPV1 receptors, while significant COX-1 and COX-2 inhibition and prostaglandin E 2 formation reduction are obtained at micromolar concentrations (102).”
From Paracetamol: New Vistas of an Old Drug (2006) · cites this paper as [66]
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Cites
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,132
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633
Self-citationCannabinoid receptor localization in brain.
Herkenham, M., Lynn, A. B., Little, M. D., Johnson, M. R., Melvin, L. S., de Costa, B. R., & Rice, K. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1932 · Cited by 2,321
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H.-H., Sørgård, M., Di Marzo, V., Julius, D., & Högestätt, E. D. (1999) · Nature · doi:10.1038/22761 · Cited by 2,142
Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.
Holzer, P. D. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06664-5 · Cited by 1,784
Formation and inactivation of endogenous cannabinoid anandamide in central neurons
Marzo, V. D., Fontana, A., Cadas, H., Schinelli, S., Cimino, G., Schwartz, J.-C., & Piomelli, D. (1994) · Nature · doi:10.1038/372686a0 · Cited by 1,585
Pharmacology of cannabinoid CB1 and CB2 receptors
Pertwee, R. G. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(97)82001-3 · Cited by 1,526
Self-citationMezey, É., Tóth, Z. E., Cortright, D. N., Arzubi, M. K., Krause, J. E., Elde, R., Guo, A., Blumberg, P. M., & Szallasi, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3655 · Cited by 850
Functional Role of High-Affinity Anandamide Transport, as Revealed by Selective Inhibition
Beltramo, M., Stella, N., Calignano, A., Lin, S. Y., Makriyannis, A., & Piomelli, D. (1997) · Science · doi:10.1126/science.277.5329.1094 · Cited by 813
The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)
Smart, D., Gunthorpe, M. J., Jerman, J. C., Nasir, S., Gray, J., Muir, A. I., Chambers, J. K., Randall, A. D., & Davis, J. B. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703050 · Cited by 775
Self-citation
Research works printed but not linked: 6
- Ueda N. Puffenbarger R.A. Yamamoto S. and Deutsch D. (2000) Chem. Phys. Lipids in press.
- Holzer P., 1991, Pharmacol. Rev., 43, 143
- Di Marzo V. Breivogel C. Bisogno T. Melck D. Patrick G. Tao Q. Szallasi A. Razdan R.K. and Martin B.R. (2000) Eur. J. Pharmacol. in press.
- Jerman J.C., 2000, Br. J. Pharmacol. (Proc. Suppl.), 129, 73P
- Hayes P. Meadows H.J. Gunthorpe M.J. Harries M.H. et al. (2000) Pain in press.
- Bisogno T. Melck D. Bobrov Y. De Petrocellis L. Gretskaya N.M. Bezuglov V.V. and Di Marzo V. (2000) Biochem. J. in press.
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Howlett, A. C., Barth, F., Bonner, T. I., Cabral, G., Casellas, P., Devane, W. A., Felder, C. C., Herkenham, M., Mackie, K., Martin, B. R., et al. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.161 · Cited by 2,819
Self-citationThe Endocannabinoid System as an Emerging Target of Pharmacotherapy
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Self-citationRole of Endogenous Cannabinoids in Synaptic Signaling
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Van Sickle, M. D., Duncan, M., Kingsley, P. J., Mouihate, A., Urbani, P., Mackie, K., Stella, N., Makriyannis, A., Piomelli, D., Davison, J. S., et al. (2005) · Science · doi:10.1126/science.1115740 · Cited by 1,470
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PETROCELLIS, L. D., Bisogno, T., Maccarrone, M., Davis, J. B., Finazzi‐Agrò, A., & Marzo, V. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008555200 · Cited by 350
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D’Argenio, G., Valenti, M., Scaglione, G., Cosenza, V., Sorrentini, I., & Marzo, V. D. (2006) · The FASEB Journal · doi:10.1096/fj.05-4943fje · Cited by 223
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“quent studies have shown that AM404 is also a potent activator of the capsaicin receptor TRPV1 and an inhibitor of COX in vitro [12,22,23].”
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Self-citationNovel selective and metabolically stable inhibitors of anandamide cellular uptake
Ortar, G., Ligresti, A., PETROCELLIS, L. D., Morera, E., & Marzo, V. D. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00109-6 · Cited by 149
Rossi, F., Siniscalco, D., Luongo, L., PETROCELLIS, L. D., Bellini, G., Petrosino, S., Torella, M., Santoro, C., Nobili, B., Perrotta, S., et al. (2008) · Bone · doi:10.1016/j.bone.2008.10.056 · Cited by 149
Further evidence for the existence of a specific process for the membrane transport of anandamide
Ligresti, A., Morera, E., van der Stelt, M., Monory, K., Lutz, B., Ortar, G., & Marzo, V. D. (2004) · Biochemical Journal · doi:10.1042/bj20031812 · Cited by 149
Dual effect of cannabinoid CB 1 receptor stimulation on a vanilloid VR1 receptor-mediated response
Hermann, H., PETROCELLIS, L. D., Bisogno, T., Moriello, A. S., Lutz, B., & Marzo, V. D. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s000180300052 · Cited by 144
Self-citationLastres‐Becker, I., de Miguel, R., PETROCELLIS, L. D., Makriyannis, A., Marzo, V. D., & Fernández‐Ruíz, J. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01595.x · Cited by 143
Tzavara, E. T., Li, D. L., Moutsimilli, L., Bisogno, T., Marzo, V. D., Phebus, L. A., Nomikos, G. G., & Bruno Giros, A. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.019 · Cited by 141
Self-citationEvidence for Bidirectional Endocannabinoid Transport across Cell Membranes
Chicca, A., Marazzi, J., Nicolussi, S., & Gertsch, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.373241 · Cited by 148
Molecular Identification of Albumin and Hsp70 as Cytosolic Anandamide-Binding Proteins
Oddi, S., Fezza, F., Pasquariello, N., D'Agostino, A., Catanzaro, G., Simone, C. D., Rapino, C., Finazzi‐Agrò, A., & Maccarrone, M. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2009.05.004 · Cited by 140
Toussaint, K., Yang, X. C., Zielinski, M. A., Reigle, K. L., Sacavage, S. D., Nagar, S., & Raffa, R. B. (2010) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/j.1365-2710.2009.01143.x · Cited by 135
Cabranes, A., Venderová, K., de Lago, E., Fezza, F., Sánchez, A., Mestre, L., Valenti, M., García‐Merino, A., Ramos, J. A., Marzo, V. D., et al. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.03.002 · Cited by 135
The endogenous cannabinoid system and the basal ganglia
Romero, J., Lastres‐Becker, I., de Miguel, R., Berrendero, F., Ramos, J. A., & Fernández‐Ruíz, J. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00253-x · Cited by 134
Therapeutic Utility of Cannabinoid Receptor Type 2 (CB2) Selective Agonists
Han, S., Thatte, J., Buzard, D. J., & Jones, R. M. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm4005626 · Cited by 136
The complications of promiscuity: endocannabinoid action and metabolism
Alexander, S. P. H., & Kendall, D. A. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707456 · Cited by 136
Novel bioactive metabolites of dipyrone (metamizol)
Rogosch, T., Sinning, C., Podlewski, A., Watzer, B., Schlosburg, J. E., Lichtman, A. H., Cascio, M. G., Bisogno, T., Marzo, V. D., Nüsing, R. M., et al. (2011) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2011.11.028 · Cited by 139
Self-citationAn endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice
Izzo, A. A., Capasso, F., Costagliola, A., Bisogno, T., Marsicano, G., Ligresti, A., Matias, I., Capasso, R., Pinto, L., Borrelli, F., et al. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00892-8 · Cited by 132
Self-citationCannabinoids for gastrointestinal diseases: potential therapeutic applications
Carlo, G. D., & Izzo, A. A. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.1.39 · Cited by 136
Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues
Marzo, V. D., Lastres‐Becker, I., Bisogno, T., PETROCELLIS, L. D., Milone, A., Davis, J. B., & Fernández‐Ruíz, J. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01012-3 · Cited by 126
Self-citationRole of endocannabinoids in the pathogenesis of cirrhotic cardiomyopathy in bile duct‐ligated rats
Gaskari, S. A., Liu, H., Moezi, L., Li, Y., Baik, S. K., & Lee, S. S. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706331 · Cited by 128
Endocannabinoid Transport Revisited
Nicolussi, S., & Gertsch, J. (2015) · Vitamins and hormones · doi:10.1016/bs.vh.2014.12.011 · Cited by 130
The Endocannabinoid System and Extinction Learning
Lutz, B. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-8004-x · Cited by 124
Pálóczi, J., Varga, Z. V., Hasko, G., & Pacher, P. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7144 · Cited by 129
Sharkey, K. A., Cristino, L., Oland, L. D., Sickle, M. D. V., Starowicz, K., Pittman, Q. J., Guglielmotti, V., Davison, J. S., & Marzo, V. D. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05521.x · Cited by 124
Marzo, V. D., Bisogno, T., PETROCELLIS, L. D., Brandi, I., Jefferson, R. G., Winckler, R., Davis, J. B., DASSE, O. A., Mahadevan, A., Razdan, R. K., et al. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4354 · Cited by 120
Self-citationMarzo, V. D., Bisogno, T., & PETROCELLIS, L. D. (2007) · Chemistry & Biology · doi:10.1016/j.chembiol.2007.05.014 · Cited by 118
Self-citationCannabinoids and Multiple Sclerosis
Pertwee, R. G. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-0005-2 · Cited by 112
Self-citation
Metadata
- Authors
- De Petrocellis, L., Bisogno, T., Davis, J. B., Pertwee, R. G., & Di Marzo, V.
- Affiliations
- National Research Council (IT)
- University of Aberdeen (GB)
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2000-10-09
- Volume
- 483
- Issue
- 1
- Pages
- 52-56
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2005828463
- Cited by
- 347
- References
- 33
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 8 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 10 · 2016: 5 · 2015: 11 · 2014: 7 · 2013: 14 · 2012: 14
- FWCI
- 15.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- capsaicin receptor, AM404, olvanil, receptor selectivity, cannabinoid signaling
- MeSH terms
- Animals, Arachidonic Acids, Binding, Competitive, Biological Transport, Calcium, Capsaicin, Cell Line, Dose-Response Relationship, Drug, Humans, Ligands, Receptors, Drug, Tumor Cells, Cultured, Receptors, Cannabinoid, TRPV Cation Channels, Rats, Polyunsaturated Alkamides, Endocannabinoids
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