Cited by 137Muscle Physiology and DisordersHormonal and reproductive studiesMuscle metabolism and nutrition

Androgen regulation of satellite cell function

Open access
Chen, Yue, Zajac, Jeffrey D, MacLean, Helen E·2005·Journal of Endocrinology

Abstract

Androgen treatment can enhance the size and strength of muscle. However, the mechanisms of androgen action in skeletal muscle are poorly understood. This review discusses potential mechanisms by which androgens regulate satellite cell activation and function. Studies have demonstrated that androgen administration increases satellite cell numbers in animals and humans in a dose–dependent manner. Moreover, androgens increase androgen receptor levels in satellite cells. In vitro , the results are contradictory as to whether androgens regulate satellite cell proliferation or differentiation. IGF-I is one major target of androgen action in satellite cells. In addition, the possibility of non-genomic actions of androgens on satellite cells is discussed. In summary, this review focuses on exploring potential mechanisms through which androgens regulate satellite cells, by analyzing developments from research in this area.

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Crossref · 10.1677/joe.1.05976

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  • ARs are widely expressed in myoblasts, myofibers, and motoneurons in both males and females, and testosterone injected into the masseter of female guinea pigs leads to an increase in fiber size.

    “ARs are widely expressed in myoblasts, myofibers, and motoneurons in both males and females (17, 100), and testosterone injected into the masseter of female guinea pigs leads to an increase in fiber size (35).”

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Research works printed but not linked: 1

  1. Nnodim JO 1999a Effect of aging on myofiber and satellite cell numbers in rat levator ani muscle. FASEB Journal 13 (Part 2 suppl) A688.

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Authors
Chen, Y., Zajac, J. D., & MacLean, H. E.
Affiliations
The University of Melbourne (AU)
Venue
Journal of Endocrinology
Published
2005-07
Volume
186
Issue
1
Pages
21-31
ISSN
  • 0022-0795 (ISSN-L)
  • 1479-6805
OpenAlex
W2143587612
Cited by
137
References
113
Citations by year
2026: 4 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 8 · 2020: 9 · 2019: 5 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 9 · 2014: 11 · 2013: 3 · 2012: 6
FWCI
0.57
Type
journal article
Language
en
Open access
Locations
  • Journal of Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Medical Research Council
  • National Health and Medical Research Council (359226, 310636)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
androgens, satellite cells, skeletal muscle, androgen receptor, insulin-like growth factor I, satellite cell proliferation, satellite cell differentiation, muscle hypertrophy, muscle strength
MeSH terms
Aging, Androgens, Animals, Cell Differentiation, Humans, Hypogonadism, Insulin-Like Growth Factor I, Receptors, Androgen, Myoblasts, Satellite Cells, Skeletal Muscle, Cell Proliferation

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