Androgen regulation of satellite cell function
Open accessAbstract
Androgen treatment can enhance the size and strength of muscle. However, the mechanisms of androgen action in skeletal muscle are poorly understood. This review discusses potential mechanisms by which androgens regulate satellite cell activation and function. Studies have demonstrated that androgen administration increases satellite cell numbers in animals and humans in a dose–dependent manner. Moreover, androgens increase androgen receptor levels in satellite cells. In vitro , the results are contradictory as to whether androgens regulate satellite cell proliferation or differentiation. IGF-I is one major target of androgen action in satellite cells. In addition, the possibility of non-genomic actions of androgens on satellite cells is discussed. In summary, this review focuses on exploring potential mechanisms through which androgens regulate satellite cells, by analyzing developments from research in this area.
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ARs are widely expressed in myoblasts, myofibers, and motoneurons in both males and females, and testosterone injected into the masseter of female guinea pigs leads to an increase in fiber size.
“ARs are widely expressed in myoblasts, myofibers, and motoneurons in both males and females (17, 100), and testosterone injected into the masseter of female guinea pigs leads to an increase in fiber size (35).”
From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [17]
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ESTERÓIDES ANABÓLICOS E EXERCÍCIO: AÇÃO E EFEITOS COLATERAIS
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Age-Dependent Changes in Skeletal MuscleRegeneration
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Perfil hormonal del envejecimiento muscular
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- Authors
- Chen, Y., Zajac, J. D., & MacLean, H. E.
- Affiliations
- The University of Melbourne (AU)
- Venue
- Journal of Endocrinology
- Publisher
- Bioscientifica
- Published
- 2005-07
- Volume
- 186
- Issue
- 1
- Pages
- 21-31
- ISSN
- 0022-0795 (ISSN-L)
- 1479-6805
- OpenAlex
- W2143587612
- Cited by
- 137
- References
- 113
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 8 · 2020: 9 · 2019: 5 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 9 · 2014: 11 · 2013: 3 · 2012: 6
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- National Health and Medical Research Council (359226, 310636)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- androgens, satellite cells, skeletal muscle, androgen receptor, insulin-like growth factor I, satellite cell proliferation, satellite cell differentiation, muscle hypertrophy, muscle strength
- MeSH terms
- Aging, Androgens, Animals, Cell Differentiation, Humans, Hypogonadism, Insulin-Like Growth Factor I, Receptors, Androgen, Myoblasts, Satellite Cells, Skeletal Muscle, Cell Proliferation
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