The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The small intestine can both absorb and glucuronidate luminal flavonoids
Abstract
We have studied the perfusion of the jejunum and ileum in an isolated rat intestine model with flavonoids and hydroxycinnamates and the influence of glycosylation on the subsequent metabolism. Flavone and flavonol glucosides and their corresponding aglycones are glucuronidated during transfer across the rat jejunum and ileum and this glucuronidation occurs without the need for gut microflora. Furthermore, this suggests the presence of glycosidases as well as UDP‐glucuronyl transferase in the jejunum. In contrast, quercetin‐3‐glucoside and rutin are mainly absorbed unmetabolised. The results suggest that the more highly reducing phenolics are absorbed predominantly as glucuronides (96.5%±4.6) of the amount absorbed, whereas monophenolic hydroxycinnamates and monophenolic B‐ring flavonoids are less predisposed to glucuronidation and higher levels of aglycone (88.1%±10.1) are detected on absorption through both the jejunum and ileum.
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Cites
Structure-antioxidant activity relationships of flavonoids and phenolic acids
Rice-Evans, C. A., Miller, N. J., & Paganga, G. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02227-9 · Cited by 9,085
Self-citation
Cited by
Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175
Plant Polyphenols as Dietary Antioxidants in Human Health and Disease
Pandey, K. B., & Rizvi, S. I. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.5.9498 · Cited by 3,942
Dietary Intake and Bioavailability of Polyphenols
Scalbert, A., & Williamson, G. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.8.2073s · Cited by 3,658
Flavonoids: antioxidants or signalling molecules?
Williams, R. J., Spencer, J. P. E., & Rice-Evans, C. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.01.001 · Cited by 2,016
Self-citationChlorogenic Acid and Caffeic Acid Are Absorbed in Humans
Olthof, M. R., Katan, M. B., & Hollman, P. C. H. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.1.66 · Cited by 975
Metadata
- Authors
- Spencer, J. P. E., Chowrimootoo, G., Choudhury, R., Debnam, E. S., Srai, S. K., & Rice-Evans, C.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1999-09-10
- Volume
- 458
- Issue
- 2
- Pages
- 224-230
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1975672084
- Cited by
- 405
- References
- 1
- FWCI
- 13.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Spencer, J. P. E., Chowrimootoo, G., Choudhury, R., Debnam, E. S., Srai, S. K., & Rice-Evans, C. (1999). The small intestine can both absorb and glucuronidate luminal flavonoids. FEBS Letters. https://doi.org/10.1016/s0014-5793(99)01160-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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