The DOI matches its Crossref record; 24 of the 31 references it cites were found in a registry or an index, and 7 are not checked yet.
LPS and TNFα induce SOCS3 mRNA and inhibit IL‐6‐induced activation of STAT3 in macrophages
Abstract
Recent findings indicate that cytokine signaling can be modulated by other mediators of simultaneously activated signal transduction pathways. In this study we show that LPS and TNFα are potent inhibitors of IL‐6‐mediated STAT3 activation in human monocyte derived macrophages, rat liver macrophages and RAW 264.7 mouse macrophages but not in human hepatoma cells (HepG2) or in rat hepatocytes. Accordingly, LPS and TNFα were found to induce the expression of SOCS3 mRNA in each of the investigated type of macrophages but not in HepG2 cells. Using a specific inhibitor, evidence is presented that the p38 MAP kinase might be involved, especially for the inhibitory effect of TNFα.
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“Moreover, both hepatocytes in vivo and in culture respond to IL-6 treatment in a similar manner; that is, only STAT-3 homodimers (SIF A) are found (unpublished observations and ref. 30).”
From Expression of suppressors of cytokine signaling during liver regeneration (2001) · cites this paper as [30]
In the citing paper
“One notable exception is the human hepatoma cell line, HepG2 (Figure 1c), where SIF A, B (STAT-3:STAT-1), and C (STAT-1:STAT-1) DNA complexes are all detected after IL-6 treatment (30).”
From Expression of suppressors of cytokine signaling during liver regeneration (2001) · cites this paper as [30]
Citations
Cites
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Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
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Self-citationA family of cytokine-inducible inhibitors of signalling
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Principles of interleukin (IL)-6-type cytokine signalling and its regulation
HEINRICH, P. C., BEHRMANN, I., HAAN, S., HERMANNS, H. M., MÜLLER-NEWEN, G., & SCHAPER, F. (2003) · Biochemical Journal · doi:10.1042/bj20030407 · Cited by 3,272
Self-citationRole of interleukin-6 in cancer progression and therapeutic resistance
Kumari, N., Dwarakanath, B. S. R., Das, A., & Bhatt, A. N. (2016) · Tumor Biology · doi:10.1007/s13277-016-5098-7 · Cited by 1,132
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
Yasukawa, H., Ohishi, M., Mori, H., Murakami, M., Chinen, T., Aki, D., Hanada, T., Takeda, K., Akira, S., Hoshijima, M., et al. (2003) · Nature Immunology · doi:10.1038/ni938 · Cited by 771
Regulation of cytokine signaling and inflammation
Hanada, T., & Yoshimura, A. (2002) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(02)00026-6 · Cited by 753
Suppressors of cytokine signaling and immunity
Kubo, M., Hanada, T., & Yoshimura, A. (2003) · Nature Immunology · doi:10.1038/ni1012 · Cited by 617
Metadata
- Authors
- Bode, J. G., Nimmesgern, A., Schmitz, J., Schaper, F., Schmitt, M., Frisch, W., Häussinger, D., Heinrich, P. C., & Graeve, L.
- Affiliations
- Universitätsklinikum Aachen (DE)
- RWTH Aachen University (DE)
- Düsseldorf University Hospital (DE)
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1999-12-17
- Volume
- 463
- Issue
- 3
- Pages
- 365-370
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2000974116
- Semantic Scholar
- 7c9e34a7b209b7772b86c66230245c02502400ce
- Cited by
- 196
- References
- 31
- Citations by year
- 2024: 6 · 2023: 2 · 2021: 3 · 2020: 8 · 2019: 5 · 2018: 2 · 2017: 7 · 2016: 6 · 2015: 5 · 2014: 10 · 2013: 6 · 2012: 13
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- SOCS3, STAT3 activation, IL-6 signaling, lipopolysaccharide, TNF-α, macrophages, p38 MAPK, hepatic macrophages, hepatocytes
- MeSH terms
- Interleukin-6 Inhibitors, Animals, Cell Line, DNA-Binding Proteins, Gene Expression Regulation, Humans, Kupffer Cells, Lipopolysaccharides, Liver, Macrophages, Male, Tumor Cells, Cultured, Tumor Necrosis Factor-alpha, Signal Transduction, Trans-Activators, Genes, Suppressor, Rats, Wistar, Mitogen-Activated Protein Kinases, p38 Mitogen-Activated Protein Kinases, STAT3 Transcription Factor, Mice, Rats
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