Cited by 196Cytokine Signaling Pathways and InteractionsProtein Tyrosine PhosphatasesNF-κB Signaling Pathways

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LPS and TNFα induce SOCS3 mRNA and inhibit IL‐6‐induced activation of STAT3 in macrophages

Bode, Johannes G., Nimmesgern, Ariane, Schmitz, Jochen, Schaper, Fred, Schmitt, Marcus, Frisch, Wiltrud, Häussinger, Dieter, Heinrich, Peter C., Graeve, Lutz·1999·FEBS Letters

DOI 10.1016/s0014-5793(99)01662-2

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Abstract

Recent findings indicate that cytokine signaling can be modulated by other mediators of simultaneously activated signal transduction pathways. In this study we show that LPS and TNFα are potent inhibitors of IL‐6‐mediated STAT3 activation in human monocyte derived macrophages, rat liver macrophages and RAW 264.7 mouse macrophages but not in human hepatoma cells (HepG2) or in rat hepatocytes. Accordingly, LPS and TNFα were found to induce the expression of SOCS3 mRNA in each of the investigated type of macrophages but not in HepG2 cells. Using a specific inhibitor, evidence is presented that the p38 MAP kinase might be involved, especially for the inhibitory effect of TNFα.

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Authors: Bode, J. G., Nimmesgern, A., Schmitz, J., Schaper, F., Schmitt, M., Frisch, W., Häussinger, D., Heinrich, P. C., & Graeve, L.
Affiliations: Universitätsklinikum Aachen (DE)
RWTH Aachen University (DE)
Düsseldorf University Hospital (DE)
ORCID: Bode, Johannes G.
Schaper, Fred
Graeve, Lutz
Venue: FEBS Letters
Publisher: Wiley
Published: 1999-12-17
Volume: 463
Issue: 3
Pages: 365-370
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/s0014-5793(99)01662-2
OpenAlex: W2000974116
Semantic Scholar: 7c9e34a7b209b7772b86c66230245c02502400ce
Cited by: 196
References: 31
Citations by year: 2024: 6 · 2023: 2 · 2021: 3 · 2020: 8 · 2019: 5 · 2018: 2 · 2017: 7 · 2016: 6 · 2015: 5 · 2014: 10 · 2013: 6 · 2012: 13
FWCI: 3.58
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 32 d)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
RWTH Publications (RWTH Aachen) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: SOCS3, STAT3 activation, IL-6 signaling, lipopolysaccharide, TNF-α, macrophages, p38 MAPK, hepatic macrophages, hepatocytes
MeSH terms: Interleukin-6 Inhibitors, Animals, Cell Line, DNA-Binding Proteins, Gene Expression Regulation, Humans, Kupffer Cells, Lipopolysaccharides, Liver, Macrophages, Male, Tumor Cells, Cultured, Tumor Necrosis Factor-alpha, Signal Transduction, Trans-Activators, Genes, Suppressor, Rats, Wistar, Mitogen-Activated Protein Kinases, p38 Mitogen-Activated Protein Kinases, STAT3 Transcription Factor, Mice, Rats

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LPS and TNFα induce SOCS3 mRNA and inhibit IL‐6‐induced activation of STAT3 in macrophages

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