Use of a levonorgestrel-releasing intrauterine device in the treatment of rectovaginal endometriosis
Open accessAbstract
Objective To evaluate the effectiveness of a levonorgestrel-releasing IUD as therapy for endometriosis of the rectovaginal septum.Design Prospective therapeutic non-randomized, self-controlled clinical trial analyzing changes in pain symptoms and size of lesions induced by the levonorgestrel-releasing IUD over 12 months.Setting Tertiary referral center for treatment of deep endometriosis.Patient(s) Eleven symptomatic patients with rectovaginal endometriosis.Intervention(s) A levonorgestrel-releasing IUD was inserted and maintained for 12 months.Main outcome measure(s) Severity of dysmenorrhea, pelvic pain, and deep dyspareunia were assessed before insertion of the IUD and throughout treatment. The size of rectovaginal endometriotic lesions were evaluated by using transrectal and transvaginal ultrasonography.Result(s) Dysmenorrhea, pelvic pain, and deep dyspareunia greatly improved and the size of the endometriotic lesions was significantly reduced by treatment.Conclusion(s) Insertion of a levonorgestrel-releasing IUD alleviates pain and reduces the size of lesions in patients with endometriosis of the rectovaginal septum.
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In the same study, rectovaginal lesion size was significantly reduced after six months of LNG-IUS therapy.
“Rectovaginal lesions size, evaluated through transrectal and transvaginal ultrasound, was significantly reduced after six months of therapy.”
From Oral and depot progestin therapy for endometriosis: towards a personalized medicine (2017) · cites this paper as [78]
In 11 women with symptomatic rectovaginal endometriosis, LNG-IUS improved the severity of all pain symptoms, including deep dyspareunia and dyschezia, at 1-year follow-up.
“One of the first studies evaluating the effectiveness of LNG-IUS in the treatment of endometriosis was performed on 11 women with symptomatic rectovaginal endometriosis [78]. At 1-year follow-up the severity of all pain symptoms, including deep dyspareunia and dyschezia, improved.”
From Oral and depot progestin therapy for endometriosis: towards a personalized medicine (2017) · cites this paper as [78]
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- Authors
- Fedele, L., Bianchi, S., Zanconato, G., Portuese, A., & Raffaelli, R.
- Affiliations
- University of Verona (IT)
- University of Milan (IT)
- Corresponding author
- Fedele, Luigi
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2001-03
- Volume
- 75
- Issue
- 3
- Pages
- 485-488
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2144527270
- Cited by
- 290
- References
- 14
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 13 · 2021: 9 · 2020: 10 · 2019: 3 · 2018: 14 · 2017: 14 · 2016: 9 · 2015: 18 · 2014: 9 · 2013: 14 · 2012: 17
- FWCI
- 11.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- levonorgestrel-releasing intrauterine system, rectovaginal endometriosis, deep infiltrating endometriosis, dysmenorrhea, pelvic pain, dyspareunia, analgesia, hormonal contraception
- MeSH terms
- Adult, Dysmenorrhea, Dyspareunia, Endometriosis, Female, Humans, Intrauterine Devices, Pain, Prospective Studies, Rectal Diseases, Ultrasonography, Vaginal Diseases, Levonorgestrel, Pelvic Pain
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